SUGAWARA AKIHIRO 菅原章公

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SUGAWARA Akihiro 菅原章公

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Researcher Number	50581683
Other IDs	https://orcid.org/0000-0003-1266-7497
Affiliation (Current)	2026: 北里大学, 大村智記念研究所, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 北里大学, 大村智記念研究所, 講師 2016 – 2022: 東北大学, 薬学研究科, 助教 2014 – 2015: 北里大学, 感染制御科学府, 助教 2012 – 2013: 北里大学, その他の研究科, 助教 2010 – 2011: 北里大学, 大学院・感染制御科学府, 助教
Review Section/Research Field	Principal Investigator Chemical pharmacy / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Science and Engineering
Keywords	Principal Investigator マクロライド / 天然物 / 全合成 / 抗嫌気性菌活性 / ルミナミシン / シスデカリン / エノールエーテル / ライブラリー / 創薬シーズ / 酸素架橋シスデカリン … More / ケミカルバイオロジー / 抗菌作用 / 創薬 / 標的タンパク質 / 半田ビーズ / EM900 / 抗炎症作用 / 構造活性相関 / DNAタグ / 効率的スクリーニング / 大規模ライブラリー / DNAエンコードライブラリー / ゲノムマイニング / 環状化合物 / ポリケチド / DNAコード化 / 天然化合物 / 異種発現 / 麹菌 / マクロ環ライブラリー / DNAタグ化 / 有機合成化学 / 合成生物学 / 多様性 / テルペノイド / ラジカル環化反応 / ケイ素 / ラジカル環化 / 新規骨格 / gem-ジフェニル基 / ケイ素原子含有デカリン / Birch還元 / 生物活性 / ケミカルスペース / デカリン / メロテルペノイド / ケイ素原子 / クロストリジウム / ネオペンチル / 偽膜性大腸炎 / 嫌気性菌 / 三置換オレフィン / クロストリジウム感染症 / １０員環ラクトン / シスデカリン骨格 / 14員環ラクトン / 1,6-oxa Michael / Juliaカップリング / 10員環ラクトン / 天然物全合成 / 誘導体合成 / 創薬研究 / COPD / 12員環マクロライド / 抗感染症薬 / クロストリジウム属 / 高歪み10員環ラクトン / 11-オキサトリシクロウンデカン / アフィニティ磁性微粒子 / エリスロマイシン / 免疫調節作用 / 抗菌活性のスイッチング / 共役14員環エノールエーテル / オキサトリシクロウンデカン / 酸素結束シスデカリン / トリシクロ[5.3.1.^<1, 7> 0^<3, 8>]ウンデカン Less

Construction of a Natural Product-like Library via DNA Encoding and Establishment of an Efficient Bioactivity Evaluation PlatformPrincipal Investigator
- Principal Investigator
  
  Akihiro Sugawara
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kitasato University
  Tohoku University
Construction of silicon atom-containing meroterpenoid-like compounds and expansion of chemical space.Principal Investigator
- Principal Investigator
  
  Sugawara Akihiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Tohoku University
Synthetic study of luminamicin toward development of therapeutic agents against clostridal infection and elucidation of mode of action for antibacterial activityPrincipal Investigator
- Principal Investigator
  
  Sugawara Akihiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tohoku University
半田ビーズを利用した新規マクロライドの標的同定と天然物探索及び創薬リードの創製Principal Investigator
- Principal Investigator
  
  菅原章公
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Kitasato University
Toward total synthesis of luminamicin, a specific anti-anaerobic bacteriacide and creation of a truncated analogPrincipal Investigator
- Principal Investigator
  
  Sugawara Akihiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
半田ビーズを利用した新規マクロライドの抗炎症作用の作用機序解明と創薬リードの創製Principal Investigator
- Principal Investigator
  
  菅原章公
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Kitasato University
Toward the total synthesis of a hybrid natural product that consists a highly functionalized 11-oxatricycloundecane/macrolide and its structure activity relationshipsPrincipal Investigator
- Principal Investigator
  
  SUGAWARA Akihiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
Toward the total synthesis of a hybrid natural product containing oxabridged cis-decaline-macrolide and it's structure-activity relationshipsPrincipal Investigator
- Principal Investigator
  
  SUGAWARA Akihiro
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University

All 2024 2022 2021 2020 2019 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Semi-synthesis of a DNA-Tagged Polyketide-Peptide Hybrid Macrocycle Using a Biosynthetically Prepared Fungal Macrolide as a Synthetic Component2024
- Author(s)
  Soya Koremura, Akihiro Sugawara, Yohei Morishita, Taro Ozaki, Teigo Asai
- Journal Title
  
  Org. Lett.
  
  Volume: 26 Issue: 42 Pages: 9151-9156
- DOI
  10.1021/acs.orglett.4c03588
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06519, KAKENHI-PROJECT-23K24038
[Journal Article] Glycidyl Silanes Enable Regioselective Hydrosilylation of Internal Propargyl Alcohols and Direct Transformation into Activated Silanes for Further Chemical Transformation2022
- Author(s)
  Akihiro Sugawara, Soya Koremura, Yusuke Sasano, Haruhisa Kikuchi
- Journal Title
  
  ChemRxiv
  
  Volume: NA
- DOI
  10.26434/chemrxiv-2022-3dsm2
- Open Access
- Data Source
  KAKENHI-PROJECT-19K06989
[Journal Article] Toward the total synthesis of luminamicin; an anaerobic antibiotic: construction of highly functionalized cis-decalin containing a bridged ether moiety.2017
- Author(s)
  Hiroyasu Ando, Aoi Kimishima, Motoyoshi Ohara, Tomoyasu Hirose, Takanori Matsumaru, Hirokazu Takada, Keisuke Morodome, Takehiro Miyamoto, Akihiro Sugawara, Satoshi Omura and Toshiaki Sunazuka
- Journal Title
  
  J. Antibiot.
  
  Volume: 71 Issue: 2 Pages: 268-272
- DOI
  10.1038/ja.2017.77
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08174, KAKENHI-PROJECT-16K08175, KAKENHI-PROJECT-15K07866
[Journal Article] Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines.2016
- Author(s)
  Mukai S, Moriya S, Hiramoto M, Kazama H, Kokuba H, Che XF, Yokoyama T, Sakamoto S, Sugawara A, Sunazuka T, Omura S, Handa H, Itoi T, Miyazawa K.
- Journal Title
  
  Int J Oncol
  
  Volume: 48 Issue: 1 Pages: 45-54
- DOI
  10.3892/ijo.2015.3237
- NAID
  120005845877
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-26460478, KAKENHI-PLANNED-23102002, KAKENHI-PUBLICLY-26102737, KAKENHI-PROJECT-25860398, KAKENHI-PROJECT-16K19187, KAKENHI-PROJECT-16K21388
[Journal Article] 12-Membered non-antibiotic macrolides EM900 series; Design, synthesis, biological evaluation, and effect in cigarette-smoking model2016
- Author(s)
  Sugawara A, Shima H, Sueki A, Hirose T, Matsui H, Hanaki H, Akagawa KS, Omura S, Sunazuka T
- Journal Title
  
  J. Antibiot.
  
  Volume: 69 Issue: 4 Pages: 319-326
- DOI
  10.1038/ja.2015.91
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-26102737
[Journal Article] Macrolides promote CCL2-mediated macrophage recruitment and clearance of nasopharyngeal pneumococcal colonies in mice.2015
- Author(s)
  Naoki Iwanaga, Shigeki Nakamura, Kazuhiro Oshima, Toshiki Kajihara, Takahiro Takazono, Taiga Miyazaki, Koichi Izumikawa, Katsunori Yanagihara, Akihiro Sugawara, Toshiaki Sunazuka, Satoshi Omura and Shigeru Kohno
- Journal Title
  
  J. Infect. Dis.
  
  Volume: - Issue: 7 Pages: 1150-1159
- DOI
  10.1093/infdis/jiv157
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-26102737, KAKENHI-PROJECT-15K09573, KAKENHI-PROJECT-25461515
[Journal Article] Jietacins with potent nematocidal activity; efficient isolation of novel analogues and divergent total synthesis of jietacin A, B, C, and D2015
- Author(s)
  4) Akihiro Sugawara, Masahiko Kubo, Takuji Nakashima, Tomoyasu Hirose, Noriaki Tsunoda, Kyoichi Yahagi, Yukihiro Asami, Takeshi Yamada, Kazuro Shiomi, Yoko Takahashi, Satoshi Omura, Toshiaki Sunazuka
- Journal Title
  
  Tetrahedron
  
  Volume: 71 Issue: 14 Pages: 2149-2157
- DOI
  10.1016/j.tet.2015.02.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590019, KAKENHI-PROJECT-25460020, KAKENHI-PROJECT-26860015, KAKENHI-PROJECT-15K07866, KAKENHI-PROJECT-15K18836
[Journal Article] An architectonic macrolide library based on a C2-symmetric macrodiolide toward pharmaceutical compositions.2015
- Author(s)
  Hayato Nakano, Akihiro Sugawara, Tomoyasu Hirose, Hiroaki Gouda, Shuichi Hirono, Satoshi Omura and Toshiaki Sunazuka
- Journal Title
  
  Tetrahedron
  
  Volume: 71 Issue: 37 Pages: 000-000
- DOI
  10.1016/j.tet.2015.01.030
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23105012, KAKENHI-PROJECT-24590019, KAKENHI-PROJECT-25460020, KAKENHI-PUBLICLY-26102737
[Journal Article] Crystal structures of HIV-1 gp120 envelope glycoprotein in complex with NBD analogues that target the CD4-binding site2014
- Author(s)
  Young Do Kwon, Judith M. LaLonde, Yongping Yang, Mark A. Elban, Akihiro Sugawara, Joel R. Courter, David M. Jones, Amos B. Smith III, Asim K. Debnath, Peter D. Kwong
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 1 Pages: e85940-e85940
- DOI
  10.1371/journal.pone.0085940
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24102527, KAKENHI-PROJECT-24790022
[Journal Article] Leucomycin A3, a 16-membered macrolide antibiotic, inhibits influenza A virus infection and disease progression2014
- Author(s)
  Ryuichi Sugamata, Akihiro Sugawara, Tomokazu Nagao, Koya Suzuki, Tomoyasu Hirose, Ki-ichi Yamamoto, Masamichi Oshima, Kazuo Kobayashi, Toshiaki Sunazuka, Kiyoko S Akagawa, Satoshi Omura, Toshinori Nakayama, Kazuo Suzuki
- Journal Title
  
  J Antibiot
  
  Volume: 67 Issue: 3 Pages: 213-222
- DOI
  10.1038/ja.2013.132
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24102527, KAKENHI-PROJECT-24790022
[Journal Article] Borrelidin analogues with antimalarial activity: design, synthesis and biological evaluation against Plasmodium falciparum parasites2013
- Author(s)
  Akihiro Sugawara, Toshiaki Tanaka, Tomoyasu Hirose, Aki Ishiyama, Masato Iwatsuki, Yoko Takahashi, Kazuhiko Otoguro, Satoshi Omura, Toshiaki Sunazuka
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 23 Issue: 8 Pages: 2302-2305
- DOI
  10.1016/j.bmcl.2013.02.075
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23105012, KAKENHI-PUBLICLY-24102527, KAKENHI-PROJECT-24790022, KAKENHI-PROJECT-25460020
[Journal Article] Human acidic mammalian chitinase as a novel target for anti-asthma drug design using in silico screening2013
- Author(s)
  Masaki Wakasugi, Hiroaki Gouda, Tomoyasu Hirose, Akihiro Sugawara, Tsuyoshi Yamamoto, Kazuro Shiomi, Toshiaki Sunazuka, Satoshi Omura, Shuichi Hirono
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 21 Issue: 11 Pages: 3214-3220
- DOI
  10.1016/j.bmc.2013.03.047
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23105012, KAKENHI-PUBLICLY-24102527, KAKENHI-PROJECT-24590058, KAKENHI-PROJECT-24790022, KAKENHI-PROJECT-25460020
[Journal Article] Asymmetric total synthesis of neoxaline2013
- Author(s)
  Tetsuya Ideguchi, Takeshi Yamada, Tatsuya Shirahata, Tomoyasu Hirose, Akihiro Sugawara, Yoshinori Kobayashi, Satoshi Omura, Toshiaki Sunazuka
- Journal Title
  
  J Am Chem Soc
  
  Volume: 135 Issue: 34 Pages: 12568-12571
- DOI
  10.1021/ja406657v
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23105012, KAKENHI-PUBLICLY-24102527, KAKENHI-PROJECT-24790021, KAKENHI-PROJECT-24790022, KAKENHI-PROJECT-25460020, KAKENHI-PROJECT-25860010
[Journal Article] Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor2013
- Author(s)
  Hirose T, Maita N, Taniguchi H, Sharpless KB, Omura S, Sunazuka T
- Journal Title
  
  Proc.Natl.Acad.Sci. USA.
  
  Volume: 110 Issue: 40 Pages: 15892-15897
- DOI
  10.1073/pnas.1315049110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370042, KAKENHI-PLANNED-23105012, KAKENHI-PROJECT-23570139, KAKENHI-PUBLICLY-24102527, KAKENHI-PROJECT-24580104, KAKENHI-PROJECT-24590058, KAKENHI-PROJECT-24790022, KAKENHI-PROJECT-25460020
[Journal Article] Toward the total synthesis of Luminamicin : construction of 14-membered lactone framework possessing versatile enol ether moiety2012
- Author(s)
  Aoi Kimishima, Tomoyasu Hirose, Akihiro Sugawara, Takanori Matsumaru, Kaoru Nakamura, Ken Katsuyama, Masaki Toda, Hirokazu Takada, Rokuro Masuma, Satoshi?mura, Toshiaki Sunazuka
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 53 Issue: 23 Pages: 2813-2816
- DOI
  10.1016/j.tetlet.2012.03.098
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790022, KAKENHI-PLANNED-23105012, KAKENHI-PUBLICLY-24102527
[Journal Article] Novel 12-membered non-antibiotic macrolides, EM900 series with anti-inflammatory and/or immunomodulatory activity; synthesis, structure?activity relationships and in vivo study2012
- Author(s)
  Akihiro Sugawara, Akito Sueki, Tomoyasu Hirose, Hideaki Shima, Kiyoko S Akagawa, Satoshi?mura and Toshiaki Sunazuka
- Journal Title
  
  J. Antibiot.
  
  Volume: 65 Issue: 9 Pages: 487-490
- DOI
  10.1038/ja.2012.51
- NAID
  10031044227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790022, KAKENHI-PLANNED-23105012, KAKENHI-PUBLICLY-24102527
[Journal Article] Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening2011
- Author(s)
  Lalonde JM, Elban MA, Courter JR, Sugawara A, Soeta T, Madani N, Princiotto AM, Kwon YD, Kwong PD, Schon A, Freire E, Sodroski J
- Journal Title
  
  Bioorg & Med. Chem
  
  Volume: 19 Issue: 1 Pages: 91-101
- DOI
  10.1016/j.bmc.2010.11.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890175
[Journal Article] Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening.2011
- Author(s)
  Lalonde JM, Elban MA, Courter JR, Sugawara A, Soeta T, Madani N, Princiotto AM, Kwon YD, Kwong PD, Schon A, Freire E, Sodroski J, Smith AB 3rd.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 19 Pages: 91-101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890175
[Journal Article] An inducible cell-cell fusion system with integrated ability to measure the efficiency and specificity of HIV-1 entry inhibitors2011
- Author(s)
  Herschhorn A, Finzi A, Jones DM, Courter JR, Sugawara A
- Journal Title
  
  Sodroski JG PLoS One
  
  Volume: 6 Issue: 11 Pages: e26731-e26731
- DOI
  10.1371/journal.pone.0026731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890175
[Journal Article] Solution-phase total synthesis of the hydrophilic natural product argifin using 3,4,5-tris(octadecyloxy)benzyl tag2011
- Author(s)
  T.Hirose, T.Kasai, T.Akimoto, A.Endo, A.Sugawara, K.Nagasawa, K.Shiomi, S.Omura, T.Sunazuka
- Journal Title
  
  Tetrahedron
  
  Volume: 67 Issue: 35 Pages: 6633-6643
- DOI
  10.1016/j.tet.2011.05.073
- NAID
  130006995593
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580129, KAKENHI-PROJECT-22790017, KAKENHI-PROJECT-22890175
[Journal Article] Effects of a novel nonantibiotic macrolide, EM900, on cytokine and mucin gene expression in a human airway epithelial cell line.2011
- Author(s)
  Otsu K, Ishinaga H, Suzuki S, Sugawara A, Sunazuka T, Omura S, Jono H, Takeuchi K.
- Journal Title
  
  Pharmacology
  
  Volume: 88 Issue: 5-6 Pages: 327-32
- DOI
  10.1159/000334339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591899, KAKENHI-PROJECT-22890175, KAKENHI-PROJECT-23790091
[Journal Article] Novel 12-membered non-antibiotic macrolides from erythromycin A ; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents2011
- Author(s)
  Akihiro Sugawara, Akito Sueki, Tomoyasu Hirose, Kenichiro Nagai, Hiroaki Gouda, Shuichi Hirono, Hideaki Shima, Kiyoko S. Akagawa, Satoshi Omura, Toshiaki Sunazuka
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 21(11) Issue: 11 Pages: 3373-3376
- DOI
  10.1016/j.bmcl.2011.04.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590046, KAKENHI-PROJECT-21590122, KAKENHI-PROJECT-22790017, KAKENHI-PROJECT-22890175
[Journal Article] NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin.2010
- Author(s)
  Gouda H, Sunazuka T, Hirose T, Iguchi K, Yamaotsu N, Sugawara A, Noguchi Y, Saito Y, Yamamoto T, Watanabe T, Shiomi K, Omura S, Hirono S.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 18 Pages: 5835-5844
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890175
[Journal Article] NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin2010
- Author(s)
  Hiroaki Gouda, Toshiaki Sunazuka, Tomoyasu Hirose, Kanami Iguchi, Noriyuki Yamaotsu, Akihiro Sugawara, Yoshihiko Noguchi, Yoshifumi Saito, Tsuyoshi Yamamoto, Takeshi Watanabe, Kazuro Shiomi, Satoshi Omura, Shuichi Hirono
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 18(16) Issue: 16 Pages: 5835-5844
- DOI
  10.1016/j.bmc.2010.06.093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590046, KAKENHI-PROJECT-21590122, KAKENHI-PROJECT-22590042, KAKENHI-PROJECT-22790017, KAKENHI-PROJECT-22890175
[Presentation] DNAエンコードライブラリーの構築を指向したポリケチド-ペプチドハイブリッド様マクロ環化合物のDNA上での合成法の確立2024
- Author(s)
  惟村壮哉, 菅原章公, 森下陽平, 尾﨑太郎, 浅井禎吾
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06519
[Presentation] 天然物をパーツとして用いるDNA タグ化マクロ環化合物の合成研究2024
- Author(s)
  惟村壮哉、菅原章公、森下陽平、尾﨑太郎、浅井禎吾
- Organizer
  万有シンポジウム（仙台）
- Data Source
  KAKENHI-PROJECT-22K06519
[Presentation] DNA エンコードライブラリーの構築を指向したポリケチド-ペプチドハイブリッド様マクロ環化合物のDNA 上での合成法の確立2024
- Author(s)
  惟村壮哉、菅原章公、森下陽平、尾﨑太郎、浅井禎吾
- Organizer
  日本薬学会第144 年会
- Data Source
  KAKENHI-PROJECT-22K06519
[Presentation] DNA でタグ化されたポリケチド-ペプチドハイブリッド様マクロ環化合物の半合成的構築法の確立2024
- Author(s)
  惟村壮哉、菅原章公、森下陽平、尾﨑太郎、浅井禎吾
- Organizer
  第10 回食品薬学シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06519
[Presentation] Regioselective Hydrosilylation and Rapid Derivatization of Alkynes using Epoxide-Bearing Silanes2021
- Author(s)
  Soya Koremura, Akihiro Sugawara, Yusuke Sasano, Haruhisa Kikuchi
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06989
[Presentation] 官能基化ヒドロシランを用いた非対称内部アルキンに対するβ-E 選択的ヒドロシリル化反応2021
- Author(s)
  惟村壮哉, 菅原章公, 菊地晴久
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K06989
[Presentation] Regioselective Hydrosilylation and Rapid Derivatization of Alkynes using Epoxide-bearing silanes2021
- Author(s)
  惟村壮哉, 菅原章公, 笹野裕介, 菊地晴久
- Organizer
  令和3年度化学系学協会東北大会
- Data Source
  KAKENHI-PROJECT-19K06989
[Presentation] エポキシドを有するシランを用いた位置選択的ヒドロシリル化の開発とその応用2021
- Author(s)
  惟村壮哉, 菅原章公, 笹野裕介, 菊地晴久
- Organizer
  仙台万有前日ミニシンポジウム
- Data Source
  KAKENHI-PROJECT-19K06989
[Presentation] 構造多様性を指向したケイ素原子含有メロテルペノイド様化合物群の構築2020
- Author(s)
  菅原章公，宮有希，前野勝光，大島吉輝，菊地晴久
- Organizer
  日本薬学会　第１４０年会
- Data Source
  KAKENHI-PROJECT-19K06989
[Presentation] 官能基化ヒドロシランを用いた非対称内部アルキンに対するβ-E 選択的ヒドロシリル化反応2020
- Author(s)
  惟村壮哉, 菅原章公, 菊地晴久
- Organizer
  第59回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-19K06989
[Presentation] 構造多様性を指向したケイ素原子含有天然物様化合物群の創出2020
- Author(s)
  菅原章公
- Organizer
  京都大学第５回有機若手ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-19K06989
[Presentation] 官能基化ヒドロシランを用いた非対称内部アルキンに対するβ-E 選択的ヒドロシリル化反応2020
- Author(s)
  惟村壮哉, 菅原章公, 菊地晴久
- Organizer
  第24回ケイ素化学協会シンポジウム
- Data Source
  KAKENHI-PROJECT-19K06989
[Presentation] ケミカルスペースの拡大を指向したケイ素原子含有天然物様ライブラリーの構築2019
- Author(s)
  菅原章公，前野勝光，宮有希，大島吉輝，菊地晴久
- Organizer
  第６１回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-19K06989
[Presentation] ケミカルスペースの拡大を指向したケイ素原子含有天然物様ライブラリーの構築2019
- Author(s)
  菅原章公，前野勝光，宮有希，大島吉輝，菊地晴久
- Organizer
  第４５回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-19K06989
[Presentation] ケミカルスペースの拡大を指向したケイ素原子含有天然物様ライブラリーの構築2019
- Author(s)
  菅原章公，前野勝光，宮有希，大島吉輝，菊地晴久
- Organizer
  第３７回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19K06989
[Presentation] Construction of Silicon Containing Natural Product-like Libraries toward Expanding Chemical Space2019
- Author(s)
  Akihiro Sugawara
- Organizer
  2nd Tohoku University Sichuan University Pharmaceutical Sciences Collaboration Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06989
[Presentation] 微生物由来生物活性天然物ルミナミシンの不斉全合成研究2017
- Author(s)
  安藤博康、大原基義、廣瀬友靖、宮本岳洋、君嶋葵、高田拓和、菅原章公、大村智、砂塚敏明
- Organizer
  第10回北里化学シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08175
[Presentation] 抗嫌気性菌活性を有するルミナミシンの全合成研究 ; 三置換オレフィンを含むサザンパートの合成2017
- Author(s)
  安藤博康, 菅原章公, 廣瀬友靖, 大原基義, 君嶋葵, 高田拓和, 大村智, 砂塚敏明
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K08175
[Presentation] 抗炎症作用を有する12員環マクロライドの創製と標的タンパク質の探索2016
- Author(s)
  菅原章公、廣瀬友靖、坂本聡、半田宏、大村智、砂塚敏明
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PUBLICLY-26102737
[Presentation] 抗嫌気性菌活性を有するルミナミシンの全合成研究共役エノールエーテル含有 14 員環マクロラクトンの構築2016
- Author(s)
  安藤博康、君嶋葵、高田拓和、諸留圭介、松丸尊紀、菅原章公、廣瀬友靖、大村智、砂塚敏明
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26860015
[Presentation] 抗炎症作用を有する新規12員環マクロライドの創製と標的タンパク質の探索2016
- Author(s)
  菅原章公、廣瀬友靖、坂本聡、半田宏、大村智、砂塚敏明
- Organizer
  新学術領域研究「天然物ケミカルバイオロジー～分子標的と活性制御～」地区ミニシンポジウム・京都大学「天然物ケミカルバイオロジーの更なる発展をめざして」
- Place of Presentation
  京都大学（京都府京都市）
- Year and Date
  2016-02-23
- Data Source
  KAKENHI-PUBLICLY-26102737
[Presentation] 抗嫌気性菌活性を有するルミナミシンの全合成研究酸素架橋含有シスデカリン-10 員環ラクトンの構築2016
- Author(s)
  君嶋葵、安藤博康、諸留圭介、松丸尊紀、菅原章公、廣瀬友靖、大村智、砂塚敏明
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26860015
[Presentation] 抗嫌気性菌活性を有するルミナミシンの全合成研究2015
- Author(s)
  君嶋葵、高田拓和、菅原章公、安藤博康、諸留圭介、松丸尊紀、山田健、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第57回天然有機化合物討論会
- Place of Presentation
  神奈川県民ホール（神奈川県横浜市）
- Year and Date
  2015-09-09
- Data Source
  KAKENHI-PROJECT-26860015
[Presentation] Toward the total synthesis of Luminamicin; construction of 11?oxatricyclo[5.3.1. ^1,70^3,8]undecane skeleton2013
- Author(s)
  Aoi Kimishima, Akihiro Sugawara, Tomoyasu Hirose, Hirokazu Takada, Takanori Matsumaru, Satoshi?mura and Toshiaki Sunazuka
- Organizer
  ICCA-13
- Place of Presentation
  山梨県(富士ビューホテル)
- Data Source
  KAKENHI-PROJECT-24790022
[Presentation] マクロライド骨格をテンプレートとした新規キチナーゼ阻害剤の創製2013
- Author(s)
  菅原章公、真板宣夫、廣瀬友靖、木村紗穂莉、斉藤佳史、井上浄、山本剛、渡邉剛志、塩見和朗、中野洋文、谷口寿章、大村智、砂塚敏明
- Organizer
  日本ケミカルバイオロジー学会第８回年会
- Place of Presentation
  東京都（東京医科歯科大学）
- Data Source
  KAKENHI-PUBLICLY-24102527
[Presentation] Luminamicinの全合成研究(2)；11-oxatricyclo[5.3.1.0]undecane骨格の構築2013
- Author(s)
  君嶋葵、菅原章公、廣瀬友靖、高田拓和、松丸尊紀、戸田正輝、大村智、砂塚敏明
- Organizer
  日本薬学会第１３３年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790022
[Presentation] マクロライド骨格をテンプレートとした新規キチナーゼ阻害剤の創製2013
- Author(s)
  菅原章公、真板宣夫、廣瀬友靖、合田浩明、木村紗穂莉、斉藤佳史、井上浄、山本剛、渡邉剛志、塩見和朗、中野洋文、広野修一、谷口寿章、大村智、砂塚敏明
- Organizer
  第５５回天然有機化合物討論会
- Place of Presentation
  京都府（同志社大学寒梅館）
- Data Source
  KAKENHI-PUBLICLY-24102527
[Presentation] マクロライド骨格をテンプレートとした新規キチナーゼ阻害剤の創製2013
- Author(s)
  菅原章公、真板宣夫、廣瀬友靖、木村紗穂莉、斉藤佳史、山本剛、渡邉剛志、塩見和朗、中野洋文、谷口寿章、大村智、砂塚敏明
- Organizer
  日本薬学会第１３３年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-27
- Data Source
  KAKENHI-PUBLICLY-24102527
[Presentation] Toward the total synthesis of Luminamicin, a specific anti-anaerobic bacteriacide2013
- Author(s)
  Akihiro Sugawara, Aoi Kimishima, Hirokazu Takada, Tomoyasu Hirose, Takanori Matsumaru, Satoshi?mura, Toshiaki Sunazuka
- Organizer
  Annual Meeting of the American Society of Pharmacognosy
- Place of Presentation
  USA (St. Louis)
- Data Source
  KAKENHI-PROJECT-24790022
[Presentation] マクロライド骨格をテンプレートとした新規キチナーゼ阻害剤の創製2013
- Author(s)
  菅原章公、真板宣夫、廣瀬友靖、木村紗穂莉、斉藤佳史、山本剛、渡邉剛志、塩見和朗、中野洋文、谷口寿章、大村智、砂塚敏明
- Organizer
  日本薬学会第１３３年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790022
[Presentation] Luminamicinの全合成研究 (1)；共役無水マレイン酸含有14員環マクロライドの合成法の確立2013
- Author(s)
  高田拓和、菅原章公、廣瀬友靖、君嶋葵、松丸尊紀、戸田正輝、大村智、砂塚敏明
- Organizer
  日本薬学会第１３３年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790022
[Presentation] Luminamicinの全合成研究(2)；11-oxatricyclo[5.3.1.0]undecane骨格の構築2013
- Author(s)
  君嶋葵、菅原章公、廣瀬友靖、高田拓和、松丸尊紀、戸田正輝、大村智、砂塚敏明
- Organizer
  日本薬学会第１３３年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-27
- Data Source
  KAKENHI-PUBLICLY-24102527
[Presentation] 半田ビーズを利用した新規マクロライドの抗炎症作用の作用機序解明と創薬リードの創製2013
- Author(s)
  菅原章公、廣瀬友靖、大村智、砂塚敏明
- Organizer
  新学術領域第４回公開シンポジウム
- Place of Presentation
  茨城県（筑波国際会議場）
- Data Source
  KAKENHI-PUBLICLY-24102527
[Presentation] Toward The Total Synthesis Of Luminamicin, A Specific Anti-Anaerobic Bacteriacide2013
- Author(s)
  Akihiro Sugawara, Aoi Kimishima, Hirokazu Takada, Tomoyasu Hirose, Takanori Matsumaru, Satoshi Omura, Toshiaki Sunazuka
- Organizer
  Annual Meeting of the American Society of Pharmacognosy
- Place of Presentation
  USA (St. Louis)
- Data Source
  KAKENHI-PROJECT-24790022
[Presentation] Toward the total synthesis of Luminamicin; construction of 14-membered macrolide with enol ether conjugated with a maleic anhydride2013
- Author(s)
  Hirokazu Takada, Akihiro Sugawara, Tomoyasu Hirose, Aoi Kimishima, Takanori Matsumaru, Masaki Toda, Takeshi Yamada, Satoshi Omura and Toshiaki Sunazuka
- Organizer
  ICCA-13
- Place of Presentation
  Japan (Yamanashi)
- Data Source
  KAKENHI-PROJECT-24790022
[Presentation] Luminamicinの全合成研究 (1)；共役無水マレイン酸含有14員環マクロライドの合成法の確立2013
- Author(s)
  高田拓和、菅原章公、廣瀬友靖、君嶋葵、松丸尊紀、戸田正輝、大村智、砂塚敏明
- Organizer
  日本薬学会第１３３年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-27
- Data Source
  KAKENHI-PUBLICLY-24102527
[Presentation] Toward the total synthesis of Luminamicin; construction of 14-membered macrolide with enol ether conjugated with a maleic anhydride2013
- Author(s)
  Hirokazu Takada, Akihiro Sugawara, Tomoyasu Hirose, Aoi Kimishima, Takanori Matsumaru, Masaki Toda, Takeshi Yamada, Satoshi?mura and Toshiaki Sunazuka
- Organizer
  ICCA-13
- Place of Presentation
  山梨県(富士ビューホテル)
- Data Source
  KAKENHI-PROJECT-24790022
[Presentation] Toward the total synthesis of Luminamicin; construction of 11–oxatricyclo[5.3.1. 1,703,8]undecane skeleton2013
- Author(s)
  Aoi Kimishima, Akihiro Sugawara, Tomoyasu Hirose, Hirokazu Takada, Takanori Matsumaru, Satoshi Omura and Toshiaki Sunazuka
- Organizer
  ICCA-13
- Place of Presentation
  Japan (Yamanashi)
- Data Source
  KAKENHI-PROJECT-24790022
[Presentation] Novel 12-membered non-antibiotic macrolides ; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents2011
- Author(s)
  Sugawara A, Sueki A, Hirose T, Nagai K, Gouda H, Hirono S, Shima H, Akagawa KS, . mura S, Sunazuka T
- Organizer
  ICCA12
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-22890175
[Presentation] 抗炎症作用に特化した新規12員環マクロライドEM900の創製と構造活性相関研究2011
- Author(s)
  菅原章公, 末木啓人, 廣瀬友靖, 赤川清子, 大村智, 砂塚敏明
- Organizer
  バイオサイエンスフォーラム
- Place of Presentation
  神奈川県(北里大学)
- Data Source
  KAKENHI-PROJECT-22890175
[Presentation] Novel 12-membered Non-antibiotic Macrolides ; EM900 Series As Novel Leads For Anti-inflammatory And/Or Immunomodulatory Agents2011
- Author(s)
  Sugawara A, Sueki A, Hirose T, Nagai K, Gouda K, Hirono S, Shima H, Akagawa KS, Omura S, Sunazuka T
- Organizer
  8th Asian Federation for Medicinal Chemistry(AFMC) International Medicinal Chemistry Symposium(AIMECS11)
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-22890175
[Presentation] 抗炎症作用に特化した新規12員環マクロライドEM900の創製と構造活性相関研究2011
- Author(s)
  菅原章公, 末木啓人, 廣瀬友靖, 赤川清子, 大村智, 砂塚敏明
- Organizer
  日本薬学会第131回年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-22890175
[Presentation] Novel 12-membered non-antibiotic macrolides ; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents2011
- Author(s)
  Sugawara A, Sueki A, Hirose T, Nagai K, Gouda H, Hirono S, Shima H, Akagawa KS, Omura S, Sunazuka T
- Organizer
  8^<th> Asian Federation for Medicinal Chemistry (AFMC) International Medicinal Chemistry Symposium (AIMECS11)
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-22890175
[Presentation] 抗炎症作用に特化した新規12員環マクロライドの創製と構造活性相関研究2011
- Author(s)
  菅原章公、末木啓人、廣瀬友靖、赤川清子、大村智、砂塚敏明
- Organizer
  日本薬学会第131回年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-22890175
[Presentation] 抗炎症作用に特化した新規12員環マクロライドの創製と構造活性相関研究2010
- Author(s)
  菅原章公、末木啓人、廣瀬友靖、赤川清子、大村智、砂塚敏明
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22890175
[Presentation] 抗炎症作用に特化した新規12員環マクロライドEM900の創製と構造活性相関研究2010
- Author(s)
  菅原章公, 末木啓人, 廣瀬友靖, 赤川清子, 大村智, 砂塚敏明
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22890175
[Presentation] 創薬テンプレートとしてのマクロライドの展開
- Author(s)
  菅原章公
- Organizer
  新学術領域研究「天然物ケミカルバイオロジー」地区ミニシンポジウム
- Place of Presentation
  千葉県（千葉大学）
- Invited
- Data Source
  KAKENHI-PUBLICLY-24102527
[Presentation] 抗炎症作用に特化した新規12員環マクロライドEM900の創製と半田ビーズを利用した標的タンパク質の探索
- Author(s)
  菅原章公
- Organizer
  新学術領域研究「天然物ケミカルバイオロジー～分子標的と活性制御～」第6回公開シンポジウム
- Place of Presentation
  愛知県、名古屋大学
- Year and Date
  2014-05-28 – 2014-05-29
- Data Source
  KAKENHI-PUBLICLY-26102737
[Presentation] 抗嫌気性菌活性を有するLuminamicinの合成研究
- Author(s)
  君嶋葵、諸留圭介、高田拓和、松丸尊紀、菅原章公、廣瀬友靖、大村智、砂塚敏明
- Organizer
  日本薬学会第135年会
- Place of Presentation
  兵庫県、神戸学院大学
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26860015

1. KAZURO Shiomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. ISHINAGA Hajime

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. TAKEUCHI Kazuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 宮澤啓介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 砂塚敏明

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
6. 廣瀬友靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 真板宣夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 谷口寿章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 合田浩明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 山乙教之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 広野修一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

SUGAWARA AKIHIRO 菅原 章公

SUGAWARA Akihiro 菅原 章公

Research Projects

Research Products

Co-Researchers

Construction of a Natural Product-like Library via DNA Encoding and Establishment of an Efficient Bioactivity Evaluation PlatformPrincipal Investigator

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Construction of silicon atom-containing meroterpenoid-like compounds and expansion of chemical space.Principal Investigator

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Synthetic study of luminamicin toward development of therapeutic agents against clostridal infection and elucidation of mode of action for antibacterial activityPrincipal Investigator

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半田ビーズを利用した新規マクロライドの標的同定と天然物探索及び創薬リードの創製Principal Investigator

Principal Investigator

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Toward total synthesis of luminamicin, a specific anti-anaerobic bacteriacide and creation of a truncated analogPrincipal Investigator

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半田ビーズを利用した新規マクロライドの抗炎症作用の作用機序解明と創薬リードの創製Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Toward the total synthesis of a hybrid natural product that consists a highly functionalized 11-oxatricycloundecane/macrolide and its structure activity relationshipsPrincipal Investigator

Principal Investigator

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Toward the total synthesis of a hybrid natural product containing oxabridged cis-decaline-macrolide and it's structure-activity relationshipsPrincipal Investigator

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Research Institution

[Journal Article] Semi-synthesis of a DNA-Tagged Polyketide-Peptide Hybrid Macrocycle Using a Biosynthetically Prepared Fungal Macrolide as a Synthetic Component2024

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[Journal Article] Glycidyl Silanes Enable Regioselective Hydrosilylation of Internal Propargyl Alcohols and Direct Transformation into Activated Silanes for Further Chemical Transformation2022

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[Journal Article] Toward the total synthesis of luminamicin; an anaerobic antibiotic: construction of highly functionalized cis-decalin containing a bridged ether moiety.2017

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[Journal Article] Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines.2016

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NAID

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[Journal Article] 12-Membered non-antibiotic macrolides EM900 series; Design, synthesis, biological evaluation, and effect in cigarette-smoking model2016

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[Journal Article] Macrolides promote CCL2-mediated macrophage recruitment and clearance of nasopharyngeal pneumococcal colonies in mice.2015

SUGAWARA AKIHIRO 菅原章公

SUGAWARA Akihiro 菅原章公