KANAI RYUTA 金井隆太

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KANAI Ryuta 金井隆太

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Researcher Number	50598472
Other IDs
Affiliation (Current)	2025: 東京大学, 定量生命科学研究所, 特任講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 東京大学, 定量生命科学研究所, 特任講師 2020 – 2022: 東京大学, 定量生命科学研究所, 特任助教 2017 – 2019: 東京大学, 定量生命科学研究所, 助教 2011 – 2017: 東京大学, 分子細胞生物学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 43040:Biophysics-related / Structural biochemistry Except Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Biological Sciences / Basic Section 43040:Biophysics-related / Biophysics
Keywords	Principal Investigator X線結晶構造解析 / Na+,K+-ATPase / イオン選択性 / 能動輸送 / 膜蛋白質 / クライオ電顕単粒子解析 / 電子顕微鏡単粒子解析 / イオンポンプ / Na+ポンプ / イオン能動輸送 … More / K+選択性 / クライオ電顕 / 量子化学計算 / イオン選択機構 / 脂質二重膜 / イオンの能動輸送 / パリトキシン … More Except Principal Investigator 結晶解析 / 膜蛋白質 / イオンポンプ / 構造生物学 / 能動輸送 / クライオ電子顕微鏡 / カルシウムポンプ / エネルギー変換 / 構造解析 / 変異体 / 立体障害 / 反応中間体 / クライオ電顕 / 作動機構 / 原子構造 / X線結晶解析 / 強心ステロイド / ATPアーゼ / ナトリウムポンプ / 生物物理 / 蛋白質 / エネルギー交換 Less

ナトリウムポンプのイオン能動輸送と毒物による陽イオンチャネル化の構造生物学Principal Investigator
- Principal Investigator
  
  金井隆太
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  The University of Tokyo
イオンポンプ蛋白質作動機構の構造的理解の完成とその高次機能の構造生物学への発展
- Principal Investigator
  
  豊島近
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  The University of Tokyo
Development of artificial reaction intermediates by introduction of steric hindrance
- Principal Investigator
  
  豊島近
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
Structural basis for K+-selective binding of Na+,K+-ATPasePrincipal Investigator
- Principal Investigator
  
  Kanai Ryuta
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  The University of Tokyo
Structural biology of active transport and its regulation by P-type ATPases
- Principal Investigator
  
  Toyoshima Chikashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
Structural basis for Na+-selectivity of the sodium pumpPrincipal Investigator
- Principal Investigator
  
  Kanai Ryuta
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  The University of Tokyo
structural basis of channelization of Na+-pump by palytoxinPrincipal Investigator
- Principal Investigator
  
  Kanai Ryuta
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokyo
Structural elucidation of active transport by P-type ATPases
- Principal Investigator
  
  Toyoshima Chikashi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biophysics
- Research Institution
  The University of Tokyo
Structural biology of membrane transporters with a view to drug development
- Principal Investigator
  
  TOYOSHIMA Chikashi
- Project Period (FY)
  2011 – 2016
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Structural biology of ion transporters
- Principal Investigator
  
  TOYOSHIMA Chikashi
- Project Period (FY)
  2007 – 2011
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018 2017 2015 2014 2013 2011

All Journal Article Presentation

[Journal Article] The role of the C-terminal tail region as a plug to regulate XKR8 lipid scramblase2024
- Author(s)
  Sakuragi Takaharu、Kanai Ryuta、Otani Mayumi、Kikkawa Masahide、Toyoshima Chikashi、Nagata Shigekazu
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 300 Issue: 3 Pages: 105755-105755
- DOI
  10.1016/j.jbc.2024.105755
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18106, KAKENHI-PROJECT-22K06102, KAKENHI-PROJECT-21K06109, KAKENHI-PLANNED-21H05248, KAKENHI-PROJECT-21H04770, KAKENHI-PROJECT-23K27136
[Journal Article] Crystal structures of Na+,K+‐ATPase reveal the mechanism that converts the K+‐bound form to Na+‐bound form and opens and closes the cytoplasmic gate2023
- Author(s)
  Kanai Ryuta、Vilsen Bente、Cornelius Flemming、Toyoshima Chikashi
- Journal Title
  
  FEBS Letters
  
  Volume: 597 Issue: 15 Pages: 1957-1976
- DOI
  10.1002/1873-3468.14689
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18106, KAKENHI-PROJECT-21K06109, KAKENHI-PROJECT-23K27136
[Journal Article] Cryoelectron microscopy of Na+,K+-ATPase in the two E2P states with and without cardiotonic steroids.2022
- Author(s)
  Ryuta Kanai , Flemming Corneliusb , Bente Vilsenb , Chikashi Toyoshima
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 15
- DOI
  10.1073/pnas.2123226119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20376, KAKENHI-PROJECT-19H00975
[Journal Article] Cryo‐electron microscopy of Na+,K+‐ATPase reveals how the extracellular gate locks in the E2・2K+ state2022
- Author(s)
  Kanai Ryuta、Cornelius Flemming、Vilsen Bente、Toyoshima Chikashi
- Journal Title
  
  FEBS Letters
  
  Volume: 596 Issue: 19 Pages: 2513-2524
- DOI
  10.1002/1873-3468.14437
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06109, KAKENHI-PROJECT-19H00975
[Journal Article] The tertiary structure of the human Xkr8-Basigin complex that scrambles phospholipids at plasma membranes2021
- Author(s)
  Sakuragi Takaharu、Kanai Ryuta、Tsutsumi Akihisa、Narita Hirotaka、Onishi Eriko、Nishino Kohei、Miyazaki Takuya、Baba Takeshi、Kosako Hidetaka、Nakagawa Atsushi、Kikkawa Masahide、Toyoshima Chikashi、Nagata Shigekazu
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: 28 Issue: 10 Pages: 825-834
- DOI
  10.1038/s41594-021-00665-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06148, KAKENHI-PROJECT-20K15731, KAKENHI-PROJECT-21H04770, KAKENHI-PROJECT-21K06109, KAKENHI-PROJECT-19H00975
[Journal Article] Binding of cardiotonic steroids to Na+,K+-ATPase in the E2P state2020
- Author(s)
  Kanai Ryuta、Cornelius Flemming、Ogawa Haruo、Motoyama Kanna、Vilsen Bente、Toyoshima Chikashi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 1 Pages: 1-12
- DOI
  10.1073/pnas.2020438118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06148, KAKENHI-PROJECT-20K20376, KAKENHI-PROJECT-19H00975
[Journal Article] Suppressor mutation analysis combined with 3D modeling explains cohesin’s capacity to hold and release DNA2018
- Author(s)
  Xu Xingya、Kanai Ryuta、Nakazawa Norihiko、Wang Li、Toyoshima Chikashi、Yanagida Mitsuhiro
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 21
- DOI
  10.1073/pnas.1803564115
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06148, KAKENHI-PROJECT-16H02499, KAKENHI-PROJECT-16K18500
[Journal Article] General and specific lipid-protein interactions in Na, K-ATPase2015
- Author(s)
  F. Cornelius, M. Habeck, R. Kanai, C. Toyoshima and S. J. D. Karlish
- Journal Title
  
  Biochimica et Biophysica Acta-Biomembranes
  
  Volume: 1848 Issue: 9 Pages: 1729-1743
- DOI
  10.1016/j.bbamem.2015.03.012
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23000014
[Journal Article] ATPase-dependent auto-phosphorylation of the open condensin hinge diminishes DNA binding2014
- Author(s)
  Y. Akai, R. Kanai, N. Nakazawa, M. Ebe, C. Toyoshima and M. Yanagida
- Journal Title
  
  Open Biol.
  
  Volume: 4 Issue: 12 Pages: 140193-140193
- DOI
  10.1098/rsob.140193
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23000014, KAKENHI-PROJECT-25840013
[Journal Article] Crystal structure of a Na^+-bound Na^+, K^+-ATPase preceding the E1P state.2013
- Author(s)
  R. Kanai, H. Ogawa, B. Vilsen, F. Cornelius and C. Toyoshima
- Journal Title
  
  Nature
  
  Volume: 502 Issue: 7470 Pages: 201-206
- DOI
  10.1038/nature12578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23000014, KAKENHI-PUBLICLY-25136702, KAKENHI-PROJECT-25291012, KAKENHI-PROJECT-25650020
[Journal Article] Cornelius : First crystal structures of Na+, K^+-ATPase : New light on the oldestion pump2011
- Author(s)
  C. Toyoshima, R. Kanai and F
- Journal Title
  
  Structure
  
  Volume: 19 Pages: 1732-1738
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19002013
[Presentation] Na+,K+-ATPaseのNa+選択性の構造的理解2023
- Author(s)
  金井隆太、Bente Vilsen, Flemming Cornelius, 豊島近
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K27136
[Presentation] Na+,K+-ATPaseのNa+選択性の構造的理解2023
- Author(s)
  金井隆太、Bente Vilsen, Flemming Cornelius, 豊島近
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21K06109
[Presentation] 陽チャネル化したNa+,K+-ATPaseの構造解析2023
- Author(s)
  金井隆太、Bente Vilsen, Flemming Cornelius, 豊島近
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K27136
[Presentation] 陽チャネル化したNa+,K+-ATPaseの構造解析2023
- Author(s)
  金井隆太、Bente Vilsen, Flemming Cornelius, 豊島近
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06109
[Presentation] Na+,K+-ATPaseのNa+選択性の構造的理解2023
- Author(s)
  金井隆太、Bente Vilsen, Flemming Cornelius, 豊島近
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K18106
[Presentation] 陽チャネル化したNa+,K+-ATPaseの構造解析2023
- Author(s)
  金井隆太、Bente Vilsen, Flemming Cornelius, 豊島近
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K18106
[Presentation] パリトキシンを結合したNa+,K+-ATPaseの構造解析2022
- Author(s)
  金井隆太、Bente Vilsen, Flemming Cornelius, 豊島近
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06109
[Presentation] Na+,K+-ATPase と脂質二重膜との相互作用の結晶学的解析2022
- Author(s)
  金井隆太、Bente Vilsen, Flemming Cornelius, 豊島近
- Organizer
  第 22 回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21K06109
[Presentation] Na+を結合した非燐酸化状態のNa+,K+-ATPaseの結晶構造解析2021
- Author(s)
  金井隆太、Bente Vilsen, Flemming Cornelius, 豊島近
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06148
[Presentation] Na+を結合した非燐酸化状態のNa+,K+-ATPaseの結晶構造解析2021
- Author(s)
  金井隆太、Bente Vilsen, Flemming Cornelius, 豊島近
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06109
[Presentation] Crystal structure of Na+-bound Na+,K+-ATPase in an unphosphorylated state2019
- Author(s)
  金井隆太、Bente Vilsen, Flemming Cornelius, 豊島近
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06148
[Presentation] BHQ誘導体と結合したカルシウムポンプの結晶構造解析2018
- Author(s)
  金井隆太、中路絢美、淡島美香、乗松良行、豊島近
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K18500
[Presentation] BHQ誘導体と結合したカルシウムポンプの結晶構造解析2018
- Author(s)
  金井隆太、中路絢美、淡島美香、乗松良行、豊島近
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06148
[Presentation] Crystal structures of Na+,K+-ATPase revisited2017
- Author(s)
  Ryuta Kanai, Bente Vilsen, Flemming Cornelius, Chikashi Toyoshima
- Organizer
  The 15th International Conference on Na,K-ATPase Related Transport ATPases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18500
[Presentation] Visualization of the lipid bilayer in crystals of ion pumps2017
- Author(s)
  金井隆太、杖田淳子、中路絢美、小川治夫、椛島佳樹、豊島近
- Organizer
  第90回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K18500

1. TOYOSHIMA Chikashi (70172210)

# of Collaborated Projects: 6 results

# of Collaborated Products: 11 results
2. OGAWA Haruo (40292726)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. KABASHIMA Yoshiki (00580573)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. MIMURA Hisatoshi (30463904)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 西山尚志 (30647011)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. Vilsen Bente

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. Cornelius Flemming

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. TSUDA Takeo (10345233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KONDOU Youhei (30436604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ISHIKITA Hiroshi (00508111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 恒川直樹 (90638800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Inesi Giuseppe

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Karlish Steven

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

KANAI RYUTA 金井 隆太

KANAI Ryuta 金井 隆太

Research Projects

Research Products

Co-Researchers

ナトリウムポンプのイオン能動輸送と毒物による陽イオンチャネル化の構造生物学Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

イオンポンプ蛋白質作動機構の構造的理解の完成とその高次機能の構造生物学への発展

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of artificial reaction intermediates by introduction of steric hindrance

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural basis for K+-selective binding of Na+,K+-ATPasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural biology of active transport and its regulation by P-type ATPases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural basis for Na+-selectivity of the sodium pumpPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

structural basis of channelization of Na+-pump by palytoxinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural elucidation of active transport by P-type ATPases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural biology of membrane transporters with a view to drug development

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural biology of ion transporters

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] The role of the C-terminal tail region as a plug to regulate XKR8 lipid scramblase2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystal structures of Na+,K+‐ATPase reveal the mechanism that converts the K+‐bound form to Na+‐bound form and opens and closes the cytoplasmic gate2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cryoelectron microscopy of Na+,K+-ATPase in the two E2P states with and without cardiotonic steroids.2022

Author(s)

Journal Title

DOI

Data Source

KANAI RYUTA 金井隆太

KANAI Ryuta 金井隆太

[Presentation] Na+,K+-ATPase と脂質二重膜との相互作用の結晶学的解析2022