KOSO Hideto 高祖秀登

Researcher Number	50612876
Other IDs	https://orcid.org/0000-0002-8986-7617
Affiliation (based on the past Project Information) *help	2016 – 2019: 東京大学, 医科学研究所, 特任講師 2012 – 2015: 東京大学, 医科学研究所, 特任助教
Review Section/Research Field	Principal Investigator Tumor biology / Ophthalmology / Biological Sciences
Keywords	Principal Investigator ミュータジェネシス / トランスポゾン / 脳腫瘍 / グリオーマ / 網膜変性 / マウス / モデルマウス / 網膜 / 視細胞 / 変性 … More

ミュータジェネシスによる脳腫瘍ドライバー遺伝子の同定と、腫瘍微小環境の解析Principal Investigator
- Principal Investigator
  
  高祖秀登
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo
ミュータジェネシスによる脳腫瘍マウスモデルを用いた細胞競合の解析Principal Investigator
- Principal Investigator
  
  高祖秀登
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Functional analysis of candidate brain cancer-causing genes that were identified by transposon mutagenesisPrincipal Investigator
- Principal Investigator
  
  Koso Hideto
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo
Generation of a new mouse model of inducible rod photoreceptor degenerationPrincipal Investigator
- Principal Investigator
  
  KOSO Hideto
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  The University of Tokyo

All 2019 2018 2017 2016 2015 2014 2013 2012

All Journal Article Presentation

[Journal Article] Light Stress-Induced Increase of Sphingosine 1-Phosphate in Photoreceptors and Its Relevance to Retinal Degeneration.2019
- Author(s)
  Terao R, Honjo M, Ueta T, Obinata H, Izumi T, Kurano M, Yatomi Y, Koso H, Watanabe S, Aihara M.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: epub
- DOI
  10.3390/ijms20153670
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04988
[Journal Article] Ras activation in retinal progenitor cells induces tumor formation in the eye2019
- Author(s)
  Koso H, Tsuhako A, Matsubara D, Fujita Y, Watanabe S.
- Journal Title
  
  Exp, Eye Res.
  
  Volume: 180 Pages: 39-42
- DOI
  10.1016/j.exer.2018.11.025
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08672, KAKENHI-PUBLICLY-17H05760, KAKENHI-PROJECT-17H04988, KAKENHI-PROJECT-17K19583, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18H03994
[Journal Article] Foxr2 promotes formation of CNS-embryonal tumors in a Trp53-deficient background.2019
- Author(s)
  Poh Boonmin、Koso Hideto、Momota Hiroyuki、Komori Takashi、Suzuki Yutaka、Yoshida Nobuaki、Ino Yasushi、Todo Tomoki、Watanabe Sumiko
- Journal Title
  
  Neuro Oncol
  
  Volume: 21 Pages: 993-1004
- DOI
  10.1093/neuonc/noz067
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03939, KAKENHI-PROJECT-17H04988, KAKENHI-PROJECT-16K08731
[Journal Article] The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development2018
- Author(s)
  Kawamura Y, Yamanaka K, Poh B, Kuribayashi H. Koso H, Watanabe S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 503 Issue: 4 Pages: 3023-3030
- DOI
  10.1016/j.bbrc.2018.08.088
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05760, KAKENHI-PROJECT-17H04988, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06279
[Journal Article] Salll regulates microglial morphology cell autonomously in the developing retina2018
- Author(s)
  Koso H, Nishinakamura R, Watanabe S
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: 1047 Pages: 209-215
- DOI
  10.1007/978-3-319-75402-4_26
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05760, KAKENHI-PROJECT-17H04988, KAKENHI-PROJECT-16H06276
[Journal Article] Spontaneous development of intratumoral heterogeneity in a transposon-induced mouse model of glioma2018
- Author(s)
  Sumiyoshi K, Koso H, Watanabe S.
- Journal Title
  
  Cancer Sci.
  
  Volume: 109 Issue: 5 Pages: 1513-1523
- DOI
  10.1111/cas.13579
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04988, KAKENHI-PROJECT-16H06276
[Journal Article] Forkhead Box Protein P1 Is Dispensable for Retina but Essential for Lens Development2017
- Author(s)
  Suzuki-Kerr H, Baba Y, Tsuhako A, Koso H, Dekker JD, Tucker H, Kuribayashi H, Watanabe S.
- Journal Title
  
  Inv Ophtal Vis Sci
  
  Volume: 58 Pages: 1916-1916
- DOI
  10.1167/iovs.16-20085
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01482, KAKENHI-PROJECT-26430108, KAKENHI-PROJECT-15H04695
[Journal Article] Role of transcription factor Tgif2 in photoreceptor differentiation in the mouse retina.2016
- Author(s)
  Kuribayashi H, Tsuhako A, Kikuchi M, Yoshida N, Koso H, Watanabe S.
- Journal Title
  
  Experimental Eye Research
  
  Volume: 152 Pages: 34-42
- DOI
  10.1016/j.exer.2016.09.005
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01482, KAKENHI-PROJECT-26430108
[Journal Article] Identification of RNA-binding protein LARP4B as a tumor suppressor in glioma2016
- Author(s)
  Koso H, Yi H, Sheridan P, Miyano S, Ino Y, Todo T, Watanabe S.
- Journal Title
  
  Cancer Res
  
  Volume: 76 Pages: 2254-2264
- DOI
  10.1158/0008-5472.can-15-2308
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01482, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-26430108
[Journal Article] Conditional rod photoreceptor ablation reveals Sall1 as a microglial marker and regulator of microglial maturation2016
- Author(s)
  Koso H, Tsuhako A, Lai CY, Baba Y, Otsu M, Ueno K, Nagasaki M, Suzuki Y, Watanabe S.
- Journal Title
  
  Glia
  
  Volume: 64 Pages: 2005-2024
- DOI
  10.1002/glia.23038
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01482, KAKENHI-PROJECT-26430108, KAKENHI-PROJECT-15K15628
[Journal Article] Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration2015
- Author(s)
  Kohno H, Koso H, Okano K, Sundermeier TR, Saito S, Watanabe S, Tsuneoka H, Sakai T.
- Journal Title
  
  J Neuroinflammation.
  
  Volume: 12 Pages: 1-12
- DOI
  10.1186/s12974-015-0408-3
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430108, KAKENHI-PROJECT-15K15628, KAKENHI-PROJECT-15K20288, KAKENHI-PUBLICLY-15H01482, KAKENHI-PROJECT-26861472
[Journal Article] Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression2015
- Author(s)
  Takeda H, Wei Z, Koso H, Rust AG, Yew CC, Mann MB, Ward JM, Adams DJ, Copeland NG, Jenkins NA.
- Journal Title
  
  Nature Genetics
  
  Volume: 47 Pages: 142-150
- DOI
  10.1038/ng.3175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860230, KAKENHI-PROJECT-26430108
[Journal Article] Identification of FoxR2 as an oncogene in medulloblastoma2014
- Author(s)
  Koso H, Tsuhako A, Lyons E, Ward JM, Rust AG, Adams DJ, Jenkins NA, Copeland NG, Watanabe S
- Journal Title
  
  Cancer Research
  
  Volume: 74 (8) Pages: 2351-61
- DOI
  10.1158/0008-5472.can-13-1523
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430108
[Journal Article] Profiling of microRNA in human and mouse ES and iPS cells reveals overlapping but distinct microRNA expression patterns2013
- Author(s)
  Razak SR, Ueno K, Takayama N, Nariai N, Nagasaki M, Saito R, Koso H, Lai CY, Murakami M, Tsuji K, Michiue T, Nakauchi H, Otsu M, Watanabe S.
- Journal Title
  
  Plos One
  
  Volume: 8
- DOI
  10.1371/journal.pone.0073532
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23106004, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24791840, KAKENHI-PUBLICLY-25118708, KAKENHI-PROJECT-25670471, KAKENHI-PROJECT-25670489
[Journal Article] Musashi-CreERT2 : A new cre line for conditional mutagenesis in neural stem cells2013
- Author(s)
  Takeda H, Koso H, Tessarollo L, Copeland NG, Jenkins NA
- Journal Title
  
  Genesis
  
  Volume: 51 (2) Pages: 128-34
- DOI
  10.1002/dvg.22357
- Data Source
  KAKENHI-PROJECT-24791840
[Journal Article] Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells2012
- Author(s)
  Koso Hideto
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 109 Pages: 2998-3007
- DOI
  10.1073/pnas.1215899109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650150, KAKENHI-PROJECT-24791840
[Presentation] 脳腫瘍形成におけるミクログリアの役割の解析2018
- Author(s)
  高祖秀登
- Organizer
  次世代脳プロジェクト　冬のシンポジウム
- Data Source
  KAKENHI-PROJECT-17H04988
[Presentation] トランスポゾン・ミュタージェネシスによる脳腫瘍の原因遺伝子の探索2018
- Author(s)
  高祖秀登
- Organizer
  先端モデル動物支援プラットフォーム成果発表会
- Data Source
  KAKENHI-PROJECT-17H04988
[Presentation] Spontaneous development of intratumoral heterogeneity in a transposon-induced mouse model of glioma2018
- Author(s)
  高祖秀登
- Organizer
  第77回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04988
[Presentation] Foxr2 promotes formation of CNS-embryonal tumors in a Trp53-deficient background2018
- Author(s)
  高祖秀登
- Organizer
  19th International Congress of Neuropathology (ICN 2018)
- Data Source
  KAKENHI-PROJECT-17H04988
[Presentation] マウス神経系における細胞競合の検討2017
- Author(s)
  高祖秀登
- Organizer
  細胞競合・ダイイングコード　合同若手ワークショップ
- Place of Presentation
  大坂
- Data Source
  KAKENHI-PROJECT-26430108
[Presentation] マウス神経系における細胞競合の検討2017
- Author(s)
  高祖秀登
- Organizer
  細胞競合・ダイイングコード　合同若手ワークショップ
- Place of Presentation
  大坂
- Data Source
  KAKENHI-PUBLICLY-15H01482
[Presentation] Cancer Gene Discovery Using Transposon-based Insertional Mutagenesis2017
- Author(s)
  高祖秀登
- Organizer
  Advanced Genome Science International Symposium
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-26430108
[Presentation] Cancer Gene Discovery Using Transposon-based Insertional Mutagenesis2017
- Author(s)
  高祖秀登
- Organizer
  Advanced Genome Science International Symposium
- Place of Presentation
  東京
- Data Source
  KAKENHI-PUBLICLY-15H01482
[Presentation] グリオーマにおける新規がん抑制遺伝子LARP4Bの同定2016
- Author(s)
  高祖秀登
- Organizer
  癌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PUBLICLY-15H01482
[Presentation] グリオーマにおける新規がん抑制遺伝子LARP4Bの同定2016
- Author(s)
  高祖秀登
- Organizer
  癌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-26430108
[Presentation] Identification of RNA-binding protein LARP4B as a tumor suppressor gene in glioma2016
- Author(s)
  高祖秀登
- Organizer
  細胞競合コロキウム
- Place of Presentation
  定山渓ビューホテル（北海道　札幌市）
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PUBLICLY-15H01482
[Presentation] Identification of RNA-binding protein LARP4B as a tumor suppressor gene in glioma2016
- Author(s)
  高祖秀登
- Organizer
  細胞競合コロキウム
- Place of Presentation
  定山渓ビューホテル（北海道　札幌市）
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-26430108
[Presentation] 誘導型杆体視細胞変性モデルマウスの作成と解析2015
- Author(s)
  高祖秀登、津波古あさの、頼貞儀、馬場行広、大津真、植野和子、長﨑正朗、鈴木穰、渡邉すみ子
- Organizer
  Retina Research Meeting
- Place of Presentation
  JPタワー（東京都　千代田区）
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-26430108
[Presentation] 誘導型杆体視細胞変性モデルマウスの作成と解析2015
- Author(s)
  高祖秀登、津波古あさの、頼貞儀、馬場行広、大津真、植野和子、長﨑正朗、鈴木穰、渡邉すみ子
- Organizer
  Retina Research Meeting
- Place of Presentation
  JPタワー（東京都　千代田区）
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PUBLICLY-15H01482
[Presentation] Transposon mutagenesis identifies genes that transform neural stem cells into cancer-initiating cells2015
- Author(s)
  Hideto Koso
- Organizer
  1st International Symposium on Cell Competition
- Place of Presentation
  京都大学（京都府　京都市）
- Year and Date
  2015-09-10
- Data Source
  KAKENHI-PUBLICLY-15H01482
[Presentation] Transposon mutagenesis identifies genes that transform neural stem cells into cancer-initiating cells2015
- Author(s)
  Hideto Koso
- Organizer
  1st International Symposium on Cell Competition
- Place of Presentation
  京都大学（京都府　京都市）
- Year and Date
  2015-09-10
- Data Source
  KAKENHI-PROJECT-26430108
[Presentation] トランスポゾン・ミュータジェネシスによる小脳髄芽腫の新規原因遺伝子の同定2014
- Author(s)
  高祖秀登
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-26430108

1. MATSYBARA Daisuk

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. MOMOTA Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 渡辺すみ子

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
4. 神野英生

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# of Collaborated Products: 1 results
5. 中内啓光

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# of Collaborated Products: 1 results
6. 大津真

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7. 藤田恭之

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8. 中村卓郎

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9. 宮野悟

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10. 小森隆司

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# of Collaborated Products: 1 results
11. 武田はるな

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# of Collaborated Products: 1 results

KOSO Hideto 高祖 秀登

Research Projects

Research Products

Co-Researchers

ミュータジェネシスによる脳腫瘍ドライバー遺伝子の同定と、腫瘍微小環境の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ミュータジェネシスによる脳腫瘍マウスモデルを用いた細胞競合の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of candidate brain cancer-causing genes that were identified by transposon mutagenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Generation of a new mouse model of inducible rod photoreceptor degenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Light Stress-Induced Increase of Sphingosine 1-Phosphate in Photoreceptors and Its Relevance to Retinal Degeneration.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ras activation in retinal progenitor cells induces tumor formation in the eye2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Foxr2 promotes formation of CNS-embryonal tumors in a Trp53-deficient background.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Salll regulates microglial morphology cell autonomously in the developing retina2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Spontaneous development of intratumoral heterogeneity in a transposon-induced mouse model of glioma2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Forkhead Box Protein P1 Is Dispensable for Retina but Essential for Lens Development2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of transcription factor Tgif2 in photoreceptor differentiation in the mouse retina.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of RNA-binding protein LARP4B as a tumor suppressor in glioma2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conditional rod photoreceptor ablation reveals Sall1 as a microglial marker and regulator of microglial maturation2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration2015

Author(s)

KOSO Hideto 高祖秀登