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KOSO Hideto  高祖 秀登

Researcher Number 50612876
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-8986-7617
Affiliation (based on the past Project Information) *help 2016 – 2019: 東京大学, 医科学研究所, 特任講師
2012 – 2015: 東京大学, 医科学研究所, 特任助教
Review Section/Research Field
Principal Investigator
Tumor biology / Biological Sciences / Ophthalmology
Keywords
Principal Investigator
脳腫瘍 / トランスポゾン / ミュータジェネシス / グリオーマ / 腫瘍微小環境 / トランスポゾン・ミュータジェネシス / マイクログリア / 脳・神経 / 癌 / 細胞競合 … More / マウスモデル / 小脳髄芽腫 / LARP4B / がん抑制遺伝子 / グリオブラストーマ / 再生 / グリア / 変性 / 視細胞 / 網膜 / モデルマウス / マウス / 網膜変性 Less
  • Research Projects

    (4 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (4 People)
  •  ミュータジェネシスによる脳腫瘍ドライバー遺伝子の同定と、腫瘍微小環境の解析Principal Investigator

    • Principal Investigator
      高祖 秀登
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Tumor biology
    • Research Institution
      The University of Tokyo
  •  ミュータジェネシスによる脳腫瘍マウスモデルを用いた細胞競合の解析Principal Investigator

    • Principal Investigator
      高祖 秀登
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Functional analysis of candidate brain cancer-causing genes that were identified by transposon mutagenesisPrincipal Investigator

    • Principal Investigator
      Koso Hideto
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor biology
    • Research Institution
      The University of Tokyo
  •  Generation of a new mouse model of inducible rod photoreceptor degenerationPrincipal Investigator

    • Principal Investigator
      KOSO Hideto
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Ophthalmology
    • Research Institution
      The University of Tokyo

All 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Other

  • [Journal Article] Light Stress-Induced Increase of Sphingosine 1-Phosphate in Photoreceptors and Its Relevance to Retinal Degeneration.2019

    • Author(s)
      Terao R, Honjo M, Ueta T, Obinata H, Izumi T, Kurano M, Yatomi Y, Koso H, Watanabe S, Aihara M.
    • Journal Title

      Int J Mol Sci.

      Volume: epub Issue: 15 Pages: 3670-3670

    • DOI

      10.3390/ijms20153670

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04988
  • [Journal Article] Ras activation in retinal progenitor cells induces tumor formation in the eye2019

    • Author(s)
      Koso Hideto、Tsuhako Asano、Matsubara Daisuke、Fujita Yasuyuki、Watanabe Sumiko
    • Journal Title

      Experimental Eye Research

      Volume: 180 Pages: 39-42

    • DOI

      10.1016/j.exer.2018.11.025

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08672, KAKENHI-PUBLICLY-17H05760, KAKENHI-PROJECT-17H04988, KAKENHI-PROJECT-17K19583, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18H03994
  • [Journal Article] The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development2018

    • Author(s)
      Kawamura Yuichi、Yamanaka Kyohei、Poh Boonmin、Kuribayashi Hiroshi、Koso Hideto、Watanabe Sumiko
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 503 Issue: 4 Pages: 3023-3030

    • DOI

      10.1016/j.bbrc.2018.08.088

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-17H05760, KAKENHI-PROJECT-17H04988, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06279
  • [Journal Article] Sall1 Regulates Microglial Morphology Cell Autonomously in the Developing Retina2018

    • Author(s)
      Koso Hideto、Nishinakamura Ryuichi、Watanabe Sumiko
    • Journal Title

      Advances in Experimental Medicine and Biol

      Volume: 1047 Pages: 209-215

    • DOI

      10.1007/978-3-319-75402-4_26

    • ISBN
      9783319754017, 9783319754024
    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-17H05760, KAKENHI-PROJECT-17H04988, KAKENHI-PROJECT-16H06276
  • [Journal Article] Spontaneous development of intratumoral heterogeneity in a transposon-induced mouse model of glioma.2018

    • Author(s)
      Sumiyoshi K, Koso H, Watanabe S.
    • Journal Title

      Cancer Sci.

      Volume: 109 Issue: 5 Pages: 1513-1523

    • DOI

      10.1111/cas.13579

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04988, KAKENHI-PROJECT-16H06276
  • [Journal Article] Forkhead box protein P1 is essential for lens epithelium transition to the fiber cells during development but does not play roles for retinal development.2017

    • Author(s)
      Suzuki-Kerr H, Baba Y, Tsuhako A, Koso H, Dekker JD, Tucker H, Kuribayashi H, Watanabe S.
    • Journal Title

      Invest. Ophthalmol. Vis. Sci.

      Volume: 58 Issue: 4 Pages: 1916-1929

    • DOI

      10.1167/iovs.16-20085

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01482, KAKENHI-PROJECT-26430108, KAKENHI-PROJECT-15H04695
  • [Journal Article] Role of transcription factor Tgif2 in photoreceptor differentiation in the mouse retina.2016

    • Author(s)
      Kuribayashi H, Tsuhako A, Kikuchi M, Yoshida N, Koso H, Watanabe S.
    • Journal Title

      Experimental Eye Research

      Volume: 152 Pages: 34-42

    • DOI

      10.1016/j.exer.2016.09.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-15H01482, KAKENHI-PROJECT-26430108
  • [Journal Article] Conditional rod photoreceptor ablation reveals Sall1 as a microglial marker and regulator of microglial morphology in the retina.2016

    • Author(s)
      Koso H, Tsuhako A, Lai CY, Baba Y, Otsu M, Ueno K, Nagasaki M, Suzuki Y, Watanabe S.
    • Journal Title

      Glia

      Volume: 64 Issue: 11 Pages: 2005-2024

    • DOI

      10.1002/glia.23038

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-15H01482, KAKENHI-PROJECT-26430108, KAKENHI-PROJECT-15K15628
  • [Journal Article] Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration.2015

    • Author(s)
      Kohno H, Koso H, Okano K, Sundermeier TR, Saito S, Watanabe S, Tsuneoka H, Sakai T.
    • Journal Title

      Journal of Neuroinflammation

      Volume: 12 Issue: 1 Pages: 188-188

    • DOI

      10.1186/s12974-015-0408-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26430108, KAKENHI-PROJECT-15K15628, KAKENHI-PROJECT-15K20288, KAKENHI-PUBLICLY-15H01482, KAKENHI-PROJECT-26861472
  • [Journal Article] Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression.2015

    • Author(s)
      Takeda H, Wei Z, Koso H, Rust AG, Yew CC, Mann MB, Ward JM, Adams DJ, Copeland NG, Jenkins NA.
    • Journal Title

      Nature Genetics

      Volume: 47 Issue: 2 Pages: 142-150

    • DOI

      10.1038/ng.3175

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860230, KAKENHI-PROJECT-26430108
  • [Journal Article] Identification of FoxR2 as an oncogene in medulloblastoma2014

    • Author(s)
      Koso H, Tsuhako A, Lyons E, Ward JM, Rust AG, Adams DJ, Jenkins NA, Copeland NG, Watanabe S
    • Journal Title

      Cancer Research

      Volume: 74 (8) Issue: 8 Pages: 2351-61

    • DOI

      10.1158/0008-5472.can-13-1523

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26430108
  • [Journal Article] Profiling of MicroRNA in Human and Mouse ES and iPS Cells Reveals Overlapping but Distinct MicroRNA Expression Patterns.2013

    • Author(s)
      Razak SR, Ueno K, Takayama N, Nariai N, Nagasaki M, Saito R, Koso H, Lai CY, Murakami M, Tsuji K, Michiue T, Nakauchi H, Otsu M, Watanabe S.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 9 Pages: e73532-e73532

    • DOI

      10.1371/journal.pone.0073532

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-23106004, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24791840, KAKENHI-PUBLICLY-25118708, KAKENHI-PROJECT-25670471, KAKENHI-PROJECT-25670489
  • [Journal Article] Musashi-CreERT2 : A new cre line for conditional mutagenesis in neural stem cells2013

    • Author(s)
      Takeda H, Koso H, Tessarollo L, Copeland NG, Jenkins NA
    • Journal Title

      Genesis

      Volume: 51 (2) Issue: 2 Pages: 128-34

    • DOI

      10.1002/dvg.22357

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24791840
  • [Journal Article] Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells2012

    • Author(s)
      Koso Hideto
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 109 Issue: 44 Pages: 2998-3007

    • DOI

      10.1073/pnas.1215899109

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650150, KAKENHI-PROJECT-24791840
  • [Presentation] 脳腫瘍形成におけるミクログリアの役割の解析2018

    • Author(s)
      高祖秀登
    • Organizer
      次世代脳プロジェクト 冬のシンポジウム
    • Data Source
      KAKENHI-PROJECT-17H04988
  • [Presentation] トランスポゾン・ミュタージェネシスによる脳腫瘍の原因遺伝子の探索2018

    • Author(s)
      高祖秀登
    • Organizer
      先端モデル動物支援プラットフォーム成果発表会
    • Data Source
      KAKENHI-PROJECT-17H04988
  • [Presentation] Spontaneous development of intratumoral heterogeneity in a transposon-induced mouse model of glioma2018

    • Author(s)
      高祖秀登
    • Organizer
      第77回日本癌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04988
  • [Presentation] Foxr2 promotes formation of CNS-embryonal tumors in a Trp53-deficient background2018

    • Author(s)
      高祖秀登
    • Organizer
      19th International Congress of Neuropathology (ICN 2018)
    • Data Source
      KAKENHI-PROJECT-17H04988
  • [Presentation] マウス神経系における細胞競合の検討2017

    • Author(s)
      高祖秀登
    • Organizer
      細胞競合・ダイイングコード 合同若手ワークショップ
    • Place of Presentation
      大坂
    • Data Source
      KAKENHI-PROJECT-26430108
  • [Presentation] マウス神経系における細胞競合の検討2017

    • Author(s)
      高祖秀登
    • Organizer
      細胞競合・ダイイングコード 合同若手ワークショップ
    • Place of Presentation
      大坂
    • Data Source
      KAKENHI-PUBLICLY-15H01482
  • [Presentation] Cancer Gene Discovery Using Transposon-based Insertional Mutagenesis2017

    • Author(s)
      高祖秀登
    • Organizer
      Advanced Genome Science International Symposium
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-26430108
  • [Presentation] Cancer Gene Discovery Using Transposon-based Insertional Mutagenesis2017

    • Author(s)
      高祖秀登
    • Organizer
      Advanced Genome Science International Symposium
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PUBLICLY-15H01482
  • [Presentation] グリオーマにおける新規がん抑制遺伝子LARP4Bの同定2016

    • Author(s)
      高祖秀登
    • Organizer
      癌学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PUBLICLY-15H01482
  • [Presentation] グリオーマにおける新規がん抑制遺伝子LARP4Bの同定2016

    • Author(s)
      高祖秀登
    • Organizer
      癌学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-26430108
  • [Presentation] Identification of RNA-binding protein LARP4B as a tumor suppressor gene in glioma2016

    • Author(s)
      高祖秀登
    • Organizer
      細胞競合コロキウム
    • Place of Presentation
      定山渓ビューホテル(北海道 札幌市)
    • Year and Date
      2016-03-18
    • Data Source
      KAKENHI-PUBLICLY-15H01482
  • [Presentation] Identification of RNA-binding protein LARP4B as a tumor suppressor gene in glioma2016

    • Author(s)
      高祖秀登
    • Organizer
      細胞競合コロキウム
    • Place of Presentation
      定山渓ビューホテル(北海道 札幌市)
    • Year and Date
      2016-03-18
    • Data Source
      KAKENHI-PROJECT-26430108
  • [Presentation] 誘導型杆体視細胞変性モデルマウスの作成と解析2015

    • Author(s)
      高祖 秀登、津波古あさの、頼貞儀、馬場行広、大津真、植野和子、長﨑正朗、鈴木穰、渡邉すみ子
    • Organizer
      Retina Research Meeting
    • Place of Presentation
      JPタワー(東京都 千代田区)
    • Year and Date
      2015-10-31
    • Data Source
      KAKENHI-PROJECT-26430108
  • [Presentation] 誘導型杆体視細胞変性モデルマウスの作成と解析2015

    • Author(s)
      高祖秀登、津波古あさの、頼貞儀、馬場行広、大津真、植野和子、長﨑正朗、鈴木穰、渡邉すみ子
    • Organizer
      Retina Research Meeting
    • Place of Presentation
      JPタワー(東京都 千代田区)
    • Year and Date
      2015-10-31
    • Data Source
      KAKENHI-PUBLICLY-15H01482
  • [Presentation] Transposon mutagenesis identifies genes that transform neural stem cells into cancer-initiating cells2015

    • Author(s)
      Hideto Koso
    • Organizer
      1st International Symposium on Cell Competition
    • Place of Presentation
      京都大学(京都府 京都市)
    • Year and Date
      2015-09-10
    • Data Source
      KAKENHI-PUBLICLY-15H01482
  • [Presentation] Transposon mutagenesis identifies genes that transform neural stem cells into cancer-initiating cells2015

    • Author(s)
      Hideto Koso
    • Organizer
      1st International Symposium on Cell Competition
    • Place of Presentation
      京都大学(京都府 京都市)
    • Year and Date
      2015-09-10
    • Data Source
      KAKENHI-PROJECT-26430108
  • [Presentation] トランスポゾン・ミュータジェネシスによる小脳髄芽腫の新規原因遺伝子の同定2014

    • Author(s)
      高祖秀登
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-26
    • Data Source
      KAKENHI-PROJECT-26430108
  • []

  • []

  • 1.  MATSYBARA Daisuk
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 2.  渡辺 すみ子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 3.  中内 啓光
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  武田 はるな
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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