Yamashita Yukiko 山下ユキコ

Researcher Number	50616745
Other IDs
Affiliation (Current)	2025: 広島国際大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help	2018 – 2020: 広島国際大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related
Keywords	Principal Investigator FXR

Research Projects
(1 results)
Research Products
(6 results)

Focused library approach to develop novel type of FXR ligandsPrincipal Investigator
- Principal Investigator
  
  Yamashita Yukiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Hiroshima International University

All 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] N1-Substituted benzimidazole scaffold for farnesoid X receptor (FXR) agonists accompanying prominent selectivity against vitamin D receptor (VDR)2020
- Author(s)
  Masuda Arisa、Gohda Keigo、Iguchi Yusuke、Fujimori Ko、Yamashita Yukiko、Oda Keisuke、Une Mizuho、Teno Naoki
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 28 Issue: 14 Pages: 115512-115512
- DOI
  10.1016/j.bmc.2020.115512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14359
[Journal Article] Identification of potent farnesoid X receptor (FXR) antagonist showing favorable PK profile and distribution toward target tissues: Comprehensive understanding of structure-activity relationship of FXR antagonists2019
- Author(s)
  Naoki Teno, Yukiko Yamashita, Arisa Masuda, Yusuke Iguchi, Keisuke Oda, Ko Fujimori, Takie Hiramoto, Tomoko Nishimaki-Mogami, Mizuho Une, and Keigo Gohda.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 11 Pages: 2220-2227
- DOI
  10.1016/j.bmc.2019.04.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14359
[Journal Article] Nonacidic Chemotype Possessing N-Acylated Piperidine Moiety as Potent Farnesoid X Receptor (FXR) Antagonists2018
- Author(s)
  Naoki Teno, Yukiko Yamashita, Yusuke Iguchi, Ko Fujimori, Mizuho Une, Tomoko Nishimaki-Mogami, Takie Hiramoto, and Keigo Gohda.
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 9 Issue: 2 Pages: 78-83
- DOI
  10.1021/acsmedchemlett.7b00363
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14359
[Presentation] N1置換ベンゾイミダゾール骨格を有する farnesoid X receptor (FXR)アゴニストの構造活性相関研究2021
- Author(s)
  増田有沙、井口裕介、藤森功、合田圭吾、山下ユキコ、手納直規
- Organizer
  日本薬学会第１４１年会
- Data Source
  KAKENHI-PROJECT-18K14359
[Presentation] Farnesoid X receptor (FXR)アンタゴニストの構造活性相関研究：薬物動態と標的組織分布の評価2020
- Author(s)
  増田　有沙、山下　ユキコ、井口　裕介、小田　啓祐、藤森　功、合田　圭吾、手納　直規
- Organizer
  日本薬学会第１４０年会
- Data Source
  KAKENHI-PROJECT-18K14359
[Presentation] Hit-to-lead approachから得られたFarnesoid X receptor (FXR)アンタゴニストの創出と、脂肪細胞の分化抑制作用2019
- Author(s)
  増田　有沙、山下　ユキコ、井口　裕介、藤森　功、合田　圭吾、手納　直規
- Organizer
  日本薬学会第１３９年会
- Data Source
  KAKENHI-PROJECT-18K14359

Yamashita Yukiko 山下 ユキコ

Research Projects

Research Products

Focused library approach to develop novel type of FXR ligandsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] N1-Substituted benzimidazole scaffold for farnesoid X receptor (FXR) agonists accompanying prominent selectivity against vitamin D receptor (VDR)2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of potent farnesoid X receptor (FXR) antagonist showing favorable PK profile and distribution toward target tissues: Comprehensive understanding of structure-activity relationship of FXR antagonists2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nonacidic Chemotype Possessing N-Acylated Piperidine Moiety as Potent Farnesoid X Receptor (FXR) Antagonists2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] N1置換ベンゾイミダゾール骨格を有する farnesoid X receptor (FXR)アゴニストの構造活性相関研究2021

Author(s)

Organizer

Data Source

[Presentation] Farnesoid X receptor (FXR)アンタゴニストの構造活性相関研究：薬物動態と標的組織分布の評価2020

Author(s)

Organizer

Data Source

[Presentation] Hit-to-lead approachから得られたFarnesoid X receptor (FXR)アンタゴニストの創出と、脂肪細胞の分化抑制作用2019

Author(s)

Organizer

Data Source

Yamashita Yukiko 山下ユキコ