Okuyama Yuko 奥山祐子

Researcher Number	50624475
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2022: 東北大学, 医学系研究科, 助教 2015: 東北大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Immunology / Basic Section 49070:Immunology-related Except Principal Investigator Biological pharmacy
Keywords	Principal Investigator 自然リンパ球 / 補助刺激分子 / ILC / アレルギー / GITR / ILC2 / アレルギ性疾患 / TNF受容体型T細胞補助刺激分子 / アレルギー疾患 / ２型自然リンパ球 … More / 補助刺激 / TNFRSF / NFκB / IL-9 / アレルギー性肺炎症 / NFAT / IQGAP1 / TCR補助刺激シグナル / 自己免疫疾患 / OX40 / T細胞補助刺激 … More Except Principal Investigator T細胞 / 免疫学 / シグナル伝達 / TRAF / 免疫 / TNF / サイトカイン / 炎症 Less

Regulatory mechanism of innate lymphoid cells by TNFRSF co-stimulatory moleculesPrincipal Investigator
- Principal Investigator
  
  Okuyama Yuko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Tohoku University
GITR signaling regulates ILC2 functionPrincipal Investigator
- Principal Investigator
  
  Okuyama Yuko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
IQGAP1 regulates OX40 costimulatory signaling in CD4+ T cellsPrincipal Investigator
- Principal Investigator
  
  Okuyama Yuko
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Regulation of inflammatory cytokine signaling by TRAF5
- Principal Investigator
  
  SO TAKANORI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Toyama
  Tohoku University

All 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] アレルギー2018
- Author(s)
  石井直人,奥山祐子
- Total Pages
  89
- Publisher
  株式会社杏林舎
- ISBN
- Data Source
  KAKENHI-PROJECT-17K08875
[Journal Article] Phenotypic heterogeneity in individuals with MECOM variants in 2 families.2022
- Author(s)
  Niihori T, Tanoshima R, Sasahara Y, Sato A, Irie M, Saito-Nanjo Y, Funayama R, Shirota M, Abe T, Okuyama Y, Ishii N, Nakayama K, Kure S, Imaizumi M, Aoki Y.
- Journal Title
  
  Blood Adv.
  
  Volume: - Issue: 18 Pages: 5257-5261
- DOI
  10.1182/bloodadvances.2020003812
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03637, KAKENHI-PROJECT-21H02458, KAKENHI-PROJECT-19K08855, KAKENHI-PROJECT-20K07546, KAKENHI-PROJECT-20K08766
[Journal Article] OX40 Ligand-Mannose-Binding Lectin Fusion Protein Induces Potent OX40 Cosignaling in CD4<sup>+</sup> T Cells2022
- Author(s)
  Sato A, Azuma M, Nagai H, Imai W, Kawaguchi K, Morita M, Okuyama Y, Ishii N, So T.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 12 Pages: 1798-1804
- DOI
  10.1248/bpb.b22-00493
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-12-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07817, KAKENHI-PROJECT-20K07546, KAKENHI-PROJECT-20K08766
[Journal Article] IL-33-ILC2 axis promotes anti-tumor CD8+ T cell responses via OX40 signaling2022
- Author(s)
  Okuyama Y, Okajima A, Sakamoto N, Hashimoto A, Tanabe R, Kawajiri A, Kawabe T, Ishii N
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 637 Pages: 9-16
- DOI
  10.1016/j.bbrc.2022.11.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19418, KAKENHI-PROJECT-20KK0362, KAKENHI-PROJECT-20K07546, KAKENHI-PROJECT-20K08766, KAKENHI-PROJECT-23K24146
[Journal Article] TNF Receptor-Associated Factor 5 Limits IL-27 Receptor Signaling in CD4 + T Lymphocytes2022
- Author(s)
  Kawahara E, Azuma M, Nagashima H, Omori K, Akiyama S, Fujimori Y, Oishi M, Shibui N, Kawaguchi K, Morita M, Okuyama Y, Ishii N, So T.
- Journal Title
  
  J Immunol.
  
  Volume: 208(3) Issue: 3 Pages: 642-650
- DOI
  10.4049/jimmunol.2001358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07546, KAKENHI-PROJECT-22K07817, KAKENHI-PROJECT-20K08766
[Journal Article] Dysregulation of Rnf 213 gene contributes to T cell response via antigen uptake, processing, and presentation2021
- Author(s)
  Tashiro R, Niizuma K, Kasamatsu J, Okuyama Y, Rashad S, Kikuchi A, Fujimura M, Kure S, Ishii N, Tominaga T.
- Journal Title
  
  J Cell Physiol.
  
  Volume: 236(11) Issue: 11 Pages: 7554-7564
- DOI
  10.1002/jcp.30396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07546, KAKENHI-PROJECT-20K08766
[Journal Article] TRAF5 Deficiency Ameliorates the Severity of Dextran Sulfate Sodium Colitis by Decreasing TRAF2 Expression in Nonhematopoietic Cells2020
- Author(s)
  Phung Hai The、Nagashima Hiroyuki、Kobayashi Shuhei、Asano Naoki、Machiyama Tomoaki、Sakurai Tsuyoshi、Tayama Shun-ichi、Asao Atsuko、Imatani Akira、Kawabe Takeshi、Okuyama Yuko、Ishii Naoto、So Takanori
- Journal Title
  
  ImmunoHorizons
  
  Volume: 4 Issue: 3 Pages: 129-139
- DOI
  10.4049/immunohorizons.2000007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02572, KAKENHI-PROJECT-17K08875, KAKENHI-PROJECT-20K16272
[Journal Article] GITR controls intestinal inflammation by suppressing IL-15-dependent NK cell activity.2020
- Author(s)
  Sakurai T, Okuyama Y, Kobayashi S, Phung HT, Asao A, Kawabe T, Ndhlovu LC, Riccardi C, Kudo H, Wada M, Nio M, So T, Ishii N.
- Journal Title
  
  FASEB J.
  
  Volume: 34(11) Issue: 11 Pages: 14820-14831
- DOI
  10.1096/fj.202001675r
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07546, KAKENHI-PROJECT-20K08766, KAKENHI-PROJECT-20K16272, KAKENHI-PROJECT-18H02572
[Journal Article] IQGAP1 restrains T‐cell cosignaling mediated by OX402019
- Author(s)
  Okuyama Yuko、Nagashima Hiroyuki、Ushio‐Fukai Masuko、Croft Michael、Ishii Naoto、So Takanori
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Issue: 1 Pages: 540-554
- DOI
  10.1096/fj.201900879rr
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02572, KAKENHI-PROJECT-17K08875
[Journal Article] Biallelic variants/mutations of IL1RAP in patients with steroid-sensitive nephrotic syndrome2019
- Author(s)
  Niitsuma Sou、Kudo Hiroki、Kikuchi Atsuo、Hayashi Takaya、Kumakura Satoshi、Kobayashi Shuhei、Okuyama Yuko、Kumagai Naonori、Niihori Tetsuya、Aoki Yoko、So Takanori、Funayama Ryo、Nakayama Keiko、Shirota Matsuyuki、Kondo Shuji、Kagami Shoji、Tsukaguchi Hiroyasu、Iijima Kazumoto、Kure Shigeo、Ishii Naoto
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 4 Pages: 283-292
- DOI
  10.1093/intimm/dxz081
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09719, KAKENHI-PUBLICLY-18H04795, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-18H02572, KAKENHI-PROJECT-17K08875, KAKENHI-PROJECT-18K19281, KAKENHI-PROJECT-19H03612, KAKENHI-PROJECT-18KK0244
[Journal Article] GITR2019
- Author(s)
  石井直人、奥山祐子
- Journal Title
  
  アレルギー
  
  Volume: 68(3) Pages: 159-160
- NAID
  130007650857
- Data Source
  KAKENHI-PROJECT-17K08875
[Journal Article] The Role of Fatty Acid Binding Protein 7 in Spinal Cord Astrocytes in a Mouse Model of Experimental Autoimmune Encephalomyelitis2019
- Author(s)
  Kamizato Kenyu、Sato Sho、Shil Subrata Kumar、Umaru Banlanjo A.、Kagawa Yoshiteru、Yamamoto Yui、Ogata Masaki、Yasumoto Yuki、Okuyama Yuko、Ishii Naoto、Owada Yuji、Miyazaki Hirofumi
- Journal Title
  
  Neuroscience
  
  Volume: - Pages: 120-129
- DOI
  10.1016/j.neuroscience.2019.03.050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K00856, KAKENHI-PROJECT-19K05899, KAKENHI-PROJECT-17K08875, KAKENHI-PROJECT-19H04026
[Journal Article] IQ motif-containing GTPase-activating protein 1 is essential for the optimal maintenance of lung ILC2s2019
- Author(s)
  Tayama Shunichi、Okuyama Yuko、Phung Hai The、Asao Atsuko、Kobayashi Shuhei、Musha Tomomi、Machiyama Tomoaki、Sakurai Tsuyoshi、Zhang Chengming、Ushio-Fukai Masuko、Kawabe Takeshi、So Takanori、Ishii Naoto
- Journal Title
  
  International Immunology
  
  Volume: - Issue: 4 Pages: 233-241
- DOI
  10.1093/intimm/dxz077
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02572, KAKENHI-PROJECT-17K08875, KAKENHI-PROJECT-20K16272
[Journal Article] GITR cosignal in ILC2s controls allergic lung inflammation.2018
- Author(s)
  Nagashima H, Okuyama Y, Fujita T, Takeda T, Motomura Y, Moro K, Hidaka T, Omori K, Sakurai T, Machiyama T, Ndhlovu LC, Riccardi C, So T, Ishii N.
- Journal Title
  
  J Allergy Clin Immunol.
  
  Volume: - Issue: 5 Pages: 1939-1943.e8
- DOI
  10.1016/j.jaci.2018.01.028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08875, KAKENHI-PROJECT-15H04640, KAKENHI-PROJECT-15H04742, KAKENHI-PROJECT-16K15508, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-18H05286, KAKENHI-PROJECT-18H02572
[Journal Article] Bmi1 Regulates IκBα Degradation via Association with the SCF Complex.2018
- Author(s)
  Okuyama Y, Tanaka Y, Jiang JJ, Kamimura D, Nakamura A, Ota M, Ohki T, Higo D, Ogura H, Ishii N, Atsumi T, Murakami M.
- Journal Title
  
  J Immunol.
  
  Volume: 201(8) Issue: 8 Pages: 2264-2272
- DOI
  10.4049/jimmunol.1701223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08875, KAKENHI-PROJECT-17K19537
[Journal Article] TRAF2 and TRAF5 associated with the signal transducing receptor gp130 limit IL-6-driven transphosphorylation of JAK1 through the inhibition of proximal JAK-JAK interaction.2018
- Author(s)
  Kimura M, Nagashima H, Okuyama Y, Ishii N, and So T
- Journal Title
  
  Int. Immunol
  
  Volume: - Issue: 7 Pages: 219-299
- DOI
  10.1093/intimm/dxy029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04742, KAKENHI-PROJECT-16K15508, KAKENHI-PROJECT-17K08875, KAKENHI-PROJECT-18H02572
[Journal Article] TNF receptor associated factor 5 controls oncostatin M-mediated lung inflammation.2018
- Author(s)
  Machiyama T, So T, Okuyama Y, Kobayashi S, Phung HT, Asao A, Harigae H, Ishii N.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: - Issue: 3 Pages: 544-550
- DOI
  10.1016/j.bbrc.2018.03.186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08875, KAKENHI-PROJECT-15H04742, KAKENHI-PROJECT-16K15508, KAKENHI-PROJECT-18H02572
[Journal Article] Rbm10 regulates inflammation development via alternative splicing of Dnmt3b.2017
- Author(s)
  Atsumi T, Suzuki H, Jiang JJ, Okuyama Y, Nakagawa I, Ota M, Tanaka Y, Ohki T, Katsunuma K, Nakajima K, Hasegawa Y, Ohara O, Ogura H, Arima Y, Kamimura D, Murakami M.
- Journal Title
  
  Int Immunol.
  
  Volume: 29(12) Issue: 12 Pages: 581-591
- DOI
  10.1093/intimm/dxx067
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08875, KAKENHI-PROJECT-17K19537, KAKENHI-PROJECT-15H04741, KAKENHI-PROJECT-15K06927
[Journal Article] TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development2016
- Author(s)
  Nagashima, H., Okuyama, Y., Hayashi, T., Ishii, N., So, T.
- Journal Title
  
  J Immunol
  
  Volume: 196 Issue: 10 Pages: 4082-4089
- DOI
  10.4049/jimmunol.1501610
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04640, KAKENHI-PROJECT-15H04742, KAKENHI-PROJECT-16K15508
[Journal Article] TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development2016
- Author(s)
  Hiroyuki Nagashima, Yuko Okuyama, Takaya Hayashi, Naoto Ishii, Takanori So
- Journal Title
  
  J. Immunol.
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04640
[Journal Article] Mesenteric lymph nodes contribute to proinflammatory Th17-cell generation during inflammation of the samall intestine in mice.2016
- Author(s)
  Kawabe, T., Suzuki, N., Yamaki, S., Sun, S. L., Asao, A., Okuyama, Y., So, T., Iwakura, Y., and Ishii, N.
- Journal Title
  
  Eur. J. Immunol.
  
  Volume: 46 Issue: 5 Pages: 1119-1131
- DOI
  10.1002/eji.201545907
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-15H04640, KAKENHI-PROJECT-15H04742
[Presentation] Mitochondrial cysteinyl-tRNA synthetase (CARS2)-dependent sulfur metabolism exacerbates experimental autoimmune encephalomyelitis in mice2022
- Author(s)
  Kyoga Hiraide, Yuya Kitamura, Shunichi Tayama, Yuko Okuyama, Kosuke Sato, Hibiki Suzuki, Keita Koinuma, Takeshi Kawabe, Naoto Ishii
- Organizer
  The 51st Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K07546
[Presentation] Excess proliferation and activation of self-reactive memory-phenotype CD4+ T lymphocytes are tonically inhibited by regulatory T cells in steady state2022
- Author(s)
  Jing Li, Ziying Yang, Akihisa Kawajiri, Kosuke Sato, Shunichi Tayama, Yuko Okuyama, Naoto Ishii, Takeshi Kawabe
- Organizer
  The 51st Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K07546
[Presentation] CARS2-dependent sulfur metabolism controls intestinal inflammation by suppressing CD4+ T cell proliferation2022
- Author(s)
  Shunichi Tayama, Takeshi Kawabe, Kyoga Hiraide, Jing Li, Ziying Yang, Kosuke Sato, Akihisa Kawajiri, Yuko Okuyama, Naoto Ishii
- Organizer
  The 51st Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K07546
[Presentation] Self-reactive memory-phenotype CD4+ T lymphocytes can induce mild and systemic inflammation by differentiating into effector and regulatory T cells2022
- Author(s)
  Akihisa Kawajiri, Jing Li, Ziying Yang, Keita Koinuma, Kosuke Sato, Shunichi Tayama, Yuko Okuyama, Hideo Harigae, Naoto Ishii, Jinfang Zhu, Kwang Soon Kim, Takeshi Kawabe.
- Organizer
  The 51st Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K07546
[Presentation] Immunological Functions of Memory-Phenotype CD4+ T lymphocytes in Anti-Tumor Responses and Graft- versus-Host Disease2022
- Author(s)
  Ziying Yang, Hideaki Watanabe, Jing Li, Akihisa Kawajiri, Kosuke Sato, Shunichi Tayama, Yuko Okuyama, Naoto Ishii, Takeshi Kawabe
- Organizer
  The 51st Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K07546
[Presentation] Rapid accumulation of circulating memory-phenotype CD4+ T lymphocytes in the gut critically contributes to tissue injury driven by intestinal ischemia and reperfusion2022
- Author(s)
  Kosuke Sato, Jing Li, Ziying Yang, Akihisa Kawajiri, Shunichi Tayama, Yuko Okuyama, Motoshi Wada, Naoto Ishii, Takeshi Kawabe
- Organizer
  The 51st Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K07546
[Presentation] ILC2-derived OX40L-OX40 signal promotes cytotoxic CD8+ T cell-mediated antitumor immunity in murine melanoma2022
- Author(s)
  Yuko Okuyama, Akira Okajima, Nao Sakamoto, Ryuto Tanabe, Ayaka Hashimoto, Atsuko Asao, Ziying Yang, Akihisa Kawajiri, Takeshi Kawabe, Naoto Ishii.
- Organizer
  The 51st Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K07546
[Presentation] Regulation of OX40 co-signaling by OX40 ligand-mannose-binding lectin fusion protein2022
- Author(s)
  Ayaka Sato, Takanori So, Mitsuki Azuma, Hodaka Nagai, Masashi Morita, Yuko Okuyama, Naoto Ishii.
- Organizer
  The 51st Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K07546
[Presentation] Characterization and composition of innate lymphoid cells in pediatric and adult allergic patients2021
- Author(s)
  Yuko Okuyama, Tomomi Musha, Mizuna Fujita, Takeshi Kawabe, Atsuko Asao, Rina Morishita, Toshiya Takahashi, Maki Ozawa, Kenshi Yamasaki, Yohei Watanabe, Satoshi Horino, Yuji Saita, Yuji Nagano, Masaki Abe, Setsuya Aiba, Katsushi Miura, Naoto Ishii.
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K07546
[Presentation] Inflammatory potential of self-driven memory-phenotype CD4+ T cells2021
- Author(s)
  Akihisa Kawajiri, Minami Ishii, Li Jing, Yang Ziying, Kosuke Sato, Shunichi Tayama, Yuko Okuyama, Hideo Harigae, Naoto Ishii, Takeshi Kawabe
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K07546
[Presentation] Reactive sulfide species generated by cysteinyl-tRNA synthetase plays a regulatory role in T cell-induced colitis in a T cell-intrinsic manner2021
- Author(s)
  Shunichi Tayama, Takeshi Kawabe, Yuya Kitamura, Kyoga Hiraide, Jing Li, Ziying Yang, Akihisa Kawajiri, Kosuke Sato, Yuko Okuyama, Masanobu Morita, Takaaki Akaike, Naoto Ishii
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K07546
[Presentation] TNF receptor-associated factor 5 reciprocally controls signals through IL-27 receptor and GITR in CD4+ T-lymphocytes2021
- Author(s)
  Mitsuki Azuma, Masashi Morita, Yuko Okuyama, Naoto Ishii, Takanori So
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K07546
[Presentation] GITR co-signaling controls group 2 innate lymphoid cells in allergic lung inflammation.2019
- Author(s)
  Yuko Okuyama, Hiroyuki Nagashima, Kazuyo Moro, Lishomwa C. Ndhlovu, Carlo Riccardi, Takanori So, Naoto Ishii.
- Organizer
  第17回国際免疫学会議 (ICI 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08875
[Presentation] TNF receptor-associated factor 5 inhibits IL-27 receptor signaling in CD4+ T-lymphocytes2019
- Author(s)
  Eigo Kawahara, Yuka Fujimori, Mayu Oishi, Masashi Morita, Yuko Okuyama, Naoto Ishii, Takanori So.
- Organizer
  第48回日本免疫学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08875
[Presentation] IQGAP1 regulates ILC2 apoptosis in the lung2019
- Author(s)
  Shun-ichi Tayama, Yuko Okuyama, Phung The Hai, Takeshi Kawabe, Takanori So, Naoto Ishii.
- Organizer
  第48回日本免疫学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08875
[Presentation] Understanding the role of TRAF family proteins in gp130 signaling2019
- Author(s)
  Yuka Fujimori, Eigo Kawahara, Masashi Morita, Yuko Okuyama, Naoto Ishii, Takanori So.
- Organizer
  第48回日本免疫学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08875
[Presentation] GITR signaling negatively controls DSS-induced intestinal inflammation by regulating NK cells function.2019
- Author(s)
  Tsuyoshi Sakurai, Yuko Okuyama, Phung The Hai, Takanori So, Naoto Ishii.
- Organizer
  第48回日本免疫学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08875
[Presentation] TNFR-associated factor (TRAF) 5 expressed by intestinal epithelial cells promotes NF-kB-mediated inflammation via controlling TRAF2 stability in dextran sulfate sodium-induced colitis2019
- Author(s)
  Hai T Phung, Hiroyuki Nagashima, Shuhei Kobayashi, Tomoaki Machiyama, Tsuyoshi Sakurai, Shun-ichi Tayama, Atsuko Asao, Yuko Okuyama, Naoto Ishii, Takanori So.
- Organizer
  第48回日本免疫学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08875
[Presentation] TRAF5 maintains the expression level of TRAF2 in non-hematopoietic cells and exacerbates DSS-colitis in mice2018
- Author(s)
  Hai The Phung, Hiroyuki Nagashima, Shuhei Kobayashi, Tomoaki Machiyama, Atsuko Asao, Yuko Okuyama, Naoto Ishii, Takanori So
- Organizer
  第47回日本免疫学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08875
[Presentation] GITR signaling regulates intestinal inflammation by suppressing NK cells function in DSS-induced colitis model2018
- Author(s)
  Tsuyoshi Sakurai, Yuko Okuyama, Shuhei Kobayashi, Masaki Nio, Naoto Ishii
- Organizer
  第47回日本免疫学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08875
[Presentation] 炎症性腸疾患におけるGITRを介したNK細胞による制御機構2018
- Author(s)
  櫻井毅,奥山祐子,小林周平,仁尾正記,石井直人
- Organizer
  第72回日本細菌学会東北支部総会
- Data Source
  KAKENHI-PROJECT-17K08875
[Presentation] GITRによる2型自然リンパ球の活性化を介したアレルギー性肺炎症の制御機構2018
- Author(s)
  奥山祐子,長島宏行,宗孝紀,石井直人
- Organizer
  第72回日本細菌学会東北支部総会
- Data Source
  KAKENHI-PROJECT-17K08875
[Presentation] TNF receptor-associated factor 5 expressed in non-hematopoietic cells augments acute colonic damage induced by dextran sulfate sodium2018
- Author(s)
  Hai The Phung, Hiroyuki Nagashima, Shuhei Kobayashi, Tomoaki Machiyama, Atsuko Asao, Yuko Okuyama, Naoto Ishii, Takanori So
- Organizer
  The 11th Vietnam-Japan Scientific Exchange Meeting
- Data Source
  KAKENHI-PROJECT-17K08875
[Presentation] GITR co-signaling controls group 2 innate lymphoid cells through IL-9 induction in allergic lung inflammation2018
- Author(s)
  Yuko Okuyama, Hiroyuki Nagashima, Yasutaka Motomura, Kazuyo Moro, Lishomwa C. Ndhlovu, Carlo Riccardi, Takanori So, Naoto Ishii
- Organizer
  第47回日本免疫学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08875
[Presentation] IQGAP1 is essencial for ILC2 maintenance in the lung2018
- Author(s)
  Shunichi Tayama, Yuko Okuyama, Takanori So, Naoto Ishii
- Organizer
  The 11th Vietnam-Japan Scientific Exchange Meeting
- Data Source
  KAKENHI-PROJECT-17K08875
[Presentation] A new regulator of OX40 co-signaling controls autoimmune neuroin ammation mediated by CD4+ T cells2017
- Author(s)
  Yuko Okuyama, Hiroyuki Nagashima, Masuko Ushio-Fukai, Michael Croft, Naoto Ishii, Takanori So
- Organizer
  第46回日本免疫学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08875
[Presentation] TNF受容体型分子 GITRによる2型自然リンパ球制御機構2017
- Author(s)
  宗孝紀, 長島宏行, 藤田剛, 武田武生, 奥山祐子, 本村泰隆, 茂呂和世, 大森公貴, Ndhlovu LC, Riccardi C, 石井直人
- Organizer
  第3回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-15H04640
[Presentation] novel regulatory role for TRAF2 and TRAF5 in the IL-6-driven Th17 development2017
- Author(s)
  Nagashima, H., Okuyama, Y., Hayashi, T., Ishii, N., So, T.
- Organizer
  The 2017 Japan-NIH Joint Symposium on Advances in Biomedical Reserch and Disease
- Place of Presentation
  Seiryo Auditorium, Tohoku University, Sendai, Japan
- Year and Date
  2017-02-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04640
[Presentation] A new regulator of OX40 co-signaling controls autoimmune neuroinflammation mediated by CD4+ T cells2017
- Author(s)
  Okuyama Y, Nagashima H, Ushio-Fukai M, Croft M, Ishii N, So T
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04640
[Presentation] Early activation of group 2 innate lymphoid cells in the lung is critically controlled by the TNFR superfamily molecule GITR2017
- Author(s)
  So T, Nagashima H, Okuyama Y, Motomura Y, Moro K, Ndhlovu LC, Riccardi C, Ishii N
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04640
[Presentation] Early activation of group 2 innate lymphoid cells in the lung is critically controlled by the TNFR superfamily molecule GITR2017
- Author(s)
  Takanori So, Hiroyuki Nagashima, Yuko Okuyama, Yasutaka Motomura, Kazuyo Moro, Lishomwa C. Ndhlovu, Carlo Ricardi, Naoto Ishii
- Organizer
  第46回日本免疫学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08875
[Presentation] OX40 binding and regulation of T cell activation by the scaffolding IQGAP1 protein2017
- Author(s)
  Okuyama, Y., Nagashima, H., Ushio-Fukai, M., Croft, M., Ishii, N., So, T.
- Organizer
  The 2017 Japan-NIH Joint Symposium on Advances in Biomedical Reserch and Disease
- Place of Presentation
  Seiryo Auditorium, Tohoku University, Sendai, Japan
- Year and Date
  2017-02-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04640
[Presentation] TNF receptor-associated factor 5 expressed in non-hematopoietic cells augments acute colonic damage induced by dextran sulfate sodium2017
- Author(s)
  Phung HT, Nagashima H, Okuyama Y, Kobayashi S, Asao A, Ishii N, So T
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04640
[Presentation] アレルギー性肺炎症における 2型自然リンパ球のGITRによる制御機構2017
- Author(s)
  奥山祐子, 長島宏行 , 藤田剛 , 宗孝紀 , 石井直人
- Organizer
  第71回日本細菌学会東北支部総会
- Data Source
  KAKENHI-PROJECT-17K08875
[Presentation] OX40 binding and regulation of T cell activation by the scaffolding IQGAP1 protein2016
- Author(s)
  Okuyama, Y., Nagashima,H., Machiyama, T., Ushio-Fukai, M., Croft, M., Ishii, N., So, T.
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15H04640
[Presentation] CD4+ T cell-intrinsic TRAF5 negatively regulates Th17 cell-dependent experimental autoimmune encephalomyelitis2016
- Author(s)
  Nagashima, H., Okuyama, Y., Hayashi, T., Asao, A., Kawabe, T., Yamaki, S., Nakano, H., Croft, M., Ishii, N., So, T.
- Organizer
  16th International Congress of Immunology
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04640
[Presentation] TRAF2 and TRAF5 have redundant but unequal inhibitory roles in Th17 differentiation mediated by IL-62016
- Author(s)
  NAGASHIMA Hiroyuki, OKUYAMA Yuko, HAYASHI Takaya, ISHII Naoto, SO Takanori
- Organizer
  The 45th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  沖縄コンベンションセンター・ラグナガーデンホテル（沖縄県宜野湾市）
- Year and Date
  2016-12-07
- Data Source
  KAKENHI-PROJECT-15K19123
[Presentation] TRAF2 and TRAF5 have redundant but unequal inhibitory roles in Th17 differentiation mediated by IL-62016
- Author(s)
  Nagashima, H., Okuyama,Y., Hayashi, T., Ishii, N., So, T.
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15H04640
[Presentation] OX40 binding and regulation of T cell activation by the scaffolding IQGAP1 protein2016
- Author(s)
  OKUYAMA Yuko, NAGASHIMA Hiroyuki, MACHIYAMA Tomoaki, USHIO-FUKAI Masuko, CROFT Michael, ISHII Naoto, SO Takanori
- Organizer
  The 45th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  沖縄コンベンションセンター・ラグナガーデンホテル（沖縄県宜野湾市）
- Year and Date
  2016-12-07
- Data Source
  KAKENHI-PROJECT-15K19123
[Presentation] TRAF adaptors limit IL-6 receptor signaling through an unexpected binding to the signaling transducer receptor gp1302016
- Author(s)
  So, T., Nagashima, H., Okuyama, Y., Hayashi, T., Asao, A., Kawabe, T., Yamaki, S., Nakano, H., Croft, M., Ishii, N.
- Organizer
  16th International Congress of Immunology
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04640
[Presentation] TRAF2 and TRAF5 limit the differentiation of Th17 cells mediated by IL-62015
- Author(s)
  Hiroyuki Nagashima, Yuko Okuyama, Takaya Hayashi, Naoto Ishii, Takanori So
- Organizer
  The 44th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15H04640
[Presentation] Hepatocyte growth factor-regulated tyrosine kinase substrate is required for T cell development and survival2015
- Author(s)
  SUZUKI Nobu, MURATA Kazuko, OKUYAMA Yuko, ASAO Atuko, SO Takanori, TANAKA Nobuyuki, ISHII Naoto
- Organizer
  The 44th Annual Meeting of The Japanese Society of Immunology
- Place of Presentation
  札幌コンベンションセンター (北海道札幌市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15K19123
[Presentation] IQGAP1 regulates OX40 co-signaling in CD4+ T cells2015
- Author(s)
  Yuko Okuyama, Hiroyuki Nagashima, Masuko Ushio-Fukai, Michael Croft, Naoto Ishii, Takanori So
- Organizer
  The 44th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15H04640
[Presentation] IQGAP1 regulates OX40 co-signaling in CD4＋ T cells2015
- Author(s)
  OKUYAMA Yuko, NAGASHIMA Hiroyuki, USHIO-FUKAI Masuko, CROFT Michael, ISHII Naoto, SO Takanori
- Organizer
  The 44th Annual Meeting of The Japanese Society of Immunology
- Place of Presentation
  札幌コンベンションセンター (北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K19123
[Presentation] TRAF2 and TRAF5 limit the differentiation of Th17 cells mediated by IL-62015
- Author(s)
  NAGASHIMA Hiroyuki, OKUYAMA Yuko, HAYASHI Takaya, ISHII Naoto, SO Takanori
- Organizer
  The 44th Annual Meeting of The Japanese Society of Immunology
- Place of Presentation
  札幌コンベンションセンター (北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K19123

1. SO TAKANORI (60294964)

# of Collaborated Projects: 2 results

# of Collaborated Products: 34 results
2. 石井直人 (60291267)

# of Collaborated Projects: 2 results

# of Collaborated Products: 40 results
3. 河部剛史 (50834652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
4. NIIHORI Tetsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. YAMAMOTO YUI

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 塚口裕康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 青木洋子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 阿部太紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 岩倉洋一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 大和田祐二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okuyama Yuko 奥山 祐子

Research Projects

Research Products

Co-Researchers

Regulatory mechanism of innate lymphoid cells by TNFRSF co-stimulatory moleculesPrincipal Investigator

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GITR signaling regulates ILC2 functionPrincipal Investigator

Principal Investigator

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IQGAP1 regulates OX40 costimulatory signaling in CD4+ T cellsPrincipal Investigator

Principal Investigator

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Regulation of inflammatory cytokine signaling by TRAF5

Principal Investigator

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[Book] アレルギー2018

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[Journal Article] Phenotypic heterogeneity in individuals with MECOM variants in 2 families.2022

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[Journal Article] OX40 Ligand-Mannose-Binding Lectin Fusion Protein Induces Potent OX40 Cosignaling in CD4<sup>+</sup> T Cells2022

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[Journal Article] IL-33-ILC2 axis promotes anti-tumor CD8+ T cell responses via OX40 signaling2022

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[Journal Article] TNF Receptor-Associated Factor 5 Limits IL-27 Receptor Signaling in CD4 + T Lymphocytes2022

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[Journal Article] Dysregulation of Rnf 213 gene contributes to T cell response via antigen uptake, processing, and presentation2021

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[Journal Article] TRAF5 Deficiency Ameliorates the Severity of Dextran Sulfate Sodium Colitis by Decreasing TRAF2 Expression in Nonhematopoietic Cells2020

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[Journal Article] GITR controls intestinal inflammation by suppressing IL-15-dependent NK cell activity.2020

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[Journal Article] IQGAP1 restrains T‐cell cosignaling mediated by OX402019

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[Journal Article] Biallelic variants/mutations of IL1RAP in patients with steroid-sensitive nephrotic syndrome2019

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Okuyama Yuko 奥山祐子