Amano Yuji 天野勇治

… Alternative Names

AMANO Yuji 天野勇治

Less

Researcher Number	50624681
Affiliation (based on the past Project Information) *help	2018 – 2023: 信州大学, 学術研究院医学系, 助教 2014 – 2015: 信州大学, 学術研究院医学系, 助教 2013: 信州大学, 医学部, 助教 2011: 信州大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 52050:Embryonic medicine and pediatrics-related / General physiology Except Principal Investigator Pediatrics / Immunology
Keywords	Principal Investigator サイトカインシグナル伝達 / 免疫抑制薬 / シグナル伝達 / エンドソーム / JAK3 / インターロイキン4受容体 / pooled genome sequencing / 遺伝子解析 / IVIG療法抵抗性 / 川崎病 … More / ユビキチン / ユビキチン非依存性小胞輸送 / インターロイキン４受容体 / インターロイキン２受容体 / 小胞輸送 … More Except Principal Investigator 小胞輸送シグナル / サイトカイン受容体 / 受容体遺伝子多型 / アレルギー / サイトカイン / ユビキチン / エンドソーム / 小胞輸送 Less

Elucidation of the spatiotemporal control mechanism of JAK3 activation to discover highly selective JAK3 inhibitorsPrincipal Investigator
- Principal Investigator
  
  Amano Yuji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Shinshu University
Exploring novel genetic factors associated with intravenous immunoglobulin therapy-unresponsiveness in Kawasaki disease patientsPrincipal Investigator
- Principal Investigator
  
  Amano Yuji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Shinshu University
Ubiquitin-independent endosomal sorting of cytokine receptorsPrincipal Investigator
- Principal Investigator
  
  AMANO Yuji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Shinshu University
Endosomal sorting signal of cytokine receptors and its single nucleotide polymorphism in allergy disease
- Principal Investigator
  
  TAKESHITA Toshikazu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Shinshu University
Identification of ubiquitin-dependent endosomal sorting signal in cytokine receptors
- Principal Investigator
  
  TAKESHITA Toshikazu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Shinshu University

All 2023 2019 2014 2013 2011 2010 2009 Other

All Journal Article Presentation Patent

[Journal Article] Essential role of an acidic endosomal environment in JAK3-mediated signal transduction2023
- Author(s)
  Amano Yuji、Tanaka Nobuyuki、Takeshita Toshikazu、Kojima Katsuhiko
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2023.09.07.556780
- Open Access
- Data Source
  KAKENHI-PROJECT-21K08474
[Journal Article] A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease.2019
- Author(s)
  Yuji Amano, Yohei Akazawa, Jun Yasud, Kazuhisa Yoshino, Katsuhiko Kojima, Norimoto Kobayashi, Satoshi Matsuzaki, Masao Nagasaki, Yosuke Kawai, Naoko Minegishi, Noriko Ishida, Noriko Motoki, Akira Hachiya, Yozo Nakazawa, Masayuki Yamamoto, Kenichi Koike, Toshikazu Takeshita
- Journal Title
  
  Pediatr Rheumatol
  
  Volume: 17 Issue: 1 Pages: 1-11
- DOI
  10.1186/s12969-019-0337-2
- NAID
  120007113478
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10432, KAKENHI-PROJECT-18K15666
[Journal Article] ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation2014
- Author(s)
  Kojima, K., Amano, Y., Yoshino, K., Tanaka, N., Sugamura, K., Takeshita, T.
- Journal Title
  
  J Biol Chem
  
  Volume: 289 Issue: 48 Pages: 33296-33310
- DOI
  10.1074/jbc.m114.578245
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24300326, KAKENHI-PROJECT-25461586, KAKENHI-PROJECT-25860161
[Journal Article] A hydrophobic amino acid cluster inserted into the C-terminus of a recycling cell surface receptor functions as an endosomal sorting signal2013
- Author(s)
  Amano Y., Yoshino K., Kojima K., Takeshita T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 441 Issue: 1 Pages: 164-168
- DOI
  10.1016/j.bbrc.2013.10.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701099, KAKENHI-PROJECT-25461586, KAKENHI-PROJECT-25860161
[Journal Article] Hrs recognizes a hydrophobic amino acid cluster in cytokine receptors during ubiquitin-independent endosomal sorting2011
- Author(s)
  Amano Y, Yamashita Y, Tanaka N, Sugamura K, 他
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Issue: 17 Pages: 15458-15472
- DOI
  10.1074/jbc.m110.191924
- NAID
  120007110518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590517, KAKENHI-PROJECT-21590530, KAKENHI-PROJECT-22591925
[Patent] カチオン選択性イオノフォアを用いてγ cサイトカインのシグナル伝達を阻害する方法2023
- Inventor(s)
  天野勇治
- Industrial Property Rights Holder
  天野勇治
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-043568
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-21K08474
[Presentation] Hrs recognizes a hydrophobic amino acid cluster in cytokine receptors during ubiquitin-independent endosomal sorting2011
- Author(s)
  天野勇治、小嶋克彦、吉野和寿、竹下敏一
- Organizer
  日本免疫学会
- Place of Presentation
  千葉
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-21590530
[Presentation] Identification of Hrs-binding motif in the cytokine receptors delivered to lysosome in ubiquitin-independent manner2010
- Author(s)
  天野勇治、小嶋克彦、山下勇毅、吉野和寿、竹下敏一
- Organizer
  国際免疫学会
- Place of Presentation
  神戸
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-21590530
[Presentation] Identification of Hrs-binding motif in the cytokine receptors delivered to lysosome in ubiquitin-independent manner.2010
- Author(s)
  天野勇治
- Organizer
  国際免疫学会
- Place of Presentation
  神戸
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-21590530
[Presentation] Identification of Hrs-binding motif in the cytokine receptors delivered to lysosome in ubiquitin-independent manner2010
- Author(s)
  天野勇治、小嶋克彦、山下勇毅、吉野和寿、竹下敏一
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21590530
[Presentation] Identification of Hrs-binding motif in the cytokine receptors delivered to lysosome in ubiquitin-independent manner.2010
- Author(s)
  天野勇治
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21590530
[Presentation] ユビキチン非依存性に小胞輸送されるサイトカイン受容体のHrs会合モチーフの同定2009
- Author(s)
  天野勇治
- Organizer
  日本免疫学会
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-21590530
[Presentation] ユビキチン非依存的に小胞輸送されるサイトカイン受容体のHrs会合モチーフの同定2009
- Author(s)
  天野勇治、小嶋克彦、山下勇毅、吉野和寿、竹下敏一
- Organizer
  日本免疫学会
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-21590530
[Presentation] 細胞内小胞輸送と細胞増殖におけるIL-2受容体β鎖のHrs結合領域の役割2009
- Author(s)
  山下勇毅、小嶋克彦、天野勇治、吉野和寿、竹下敏一
- Organizer
  日本免疫学会
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-21590530
[Presentation] Hydrophobic amino acid cluster in the cytoplasmic tail of interleukin-2 receptor β chain acts as a sorting signal for lysosome
- Author(s)
  天野勇治
- Organizer
  国際免疫学会
- Place of Presentation
  ミラノ(イタリア）
- Data Source
  KAKENHI-PROJECT-25860161
[Presentation] Hydrophobic amino acid cluster in the cytoplasmic tail of interleukin-2 receptor βchain acts as a sorting signal for lysosome
- Author(s)
  天野勇治、その他
- Organizer
  国際免疫学会
- Place of Presentation
  ミラノ（イタリア）
- Data Source
  KAKENHI-PROJECT-25461586

1. TAKESHITA Toshikazu (60212023)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
2. KOJIMA Katsuhiko (80345743)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. YOSHINO Kazuhisa (40551859)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
4. 石田典子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 菅村和夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 田中伸幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Amano Yuji 天野 勇治

AMANO Yuji 天野 勇治

Research Projects

Research Products

Co-Researchers

Elucidation of the spatiotemporal control mechanism of JAK3 activation to discover highly selective JAK3 inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring novel genetic factors associated with intravenous immunoglobulin therapy-unresponsiveness in Kawasaki disease patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Ubiquitin-independent endosomal sorting of cytokine receptorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Endosomal sorting signal of cytokine receptors and its single nucleotide polymorphism in allergy disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of ubiquitin-dependent endosomal sorting signal in cytokine receptors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Essential role of an acidic endosomal environment in JAK3-mediated signal transduction2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease.2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A hydrophobic amino acid cluster inserted into the C-terminus of a recycling cell surface receptor functions as an endosomal sorting signal2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hrs recognizes a hydrophobic amino acid cluster in cytokine receptors during ubiquitin-independent endosomal sorting2011

Author(s)

Journal Title

DOI

NAID

Data Source

[Patent] カチオン選択性イオノフォアを用いてγ cサイトカインのシグナル伝達を阻害する方法2023

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] Hrs recognizes a hydrophobic amino acid cluster in cytokine receptors during ubiquitin-independent endosomal sorting2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Identification of Hrs-binding motif in the cytokine receptors delivered to lysosome in ubiquitin-independent manner2010

Author(s)

Organizer

Place of Presentation

Year and Date

Amano Yuji 天野勇治

AMANO Yuji 天野勇治