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Yamane Hiromichi  山根 弘路

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YAMANE Hiromichi  山根 弘路

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Researcher Number 50624897
Other IDs
Affiliation (Current) 2025: 川崎医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2016 – 2024: 川崎医科大学, 医学部, 准教授
2014: 川崎医科大学, 医学部, 准教授
2012 – 2013: 川崎医科大学, 医学部, 講師
Review Section/Research Field
Principal Investigator
Basic Section 56020:Orthopedics-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Except Principal Investigator
Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine
Keywords
Principal Investigator
治療シークエンス / 新規抗がん剤 / IC50値 / 耐性株 / アポトーシス / Eribulin / Trabectedin / Doxorubicin / 軟部肉腫 / 炎症性サイトカイン … More / 血清CRP値 / ヘプシジン / がん性悪液質 / 固形腫瘍 / 肺癌 / 予後予測因子 / Paps / 予後相関 / 赤血球沈降速度 / フェリチン / CRP / 鉄代謝 / 炎症性マーカー / 終末期患者予後 / 鉄代謝機構 / 予後予測モデル / フェロポルチン / 血清フェリチン値 … More
Except Principal Investigator
薬剤耐性 / EGFR / ALK / 肺癌 / プロテオーム / JAK2 / トランスクリプトーム / メタボローム / 代謝 / チロシンキナーゼ阻害剤 / APOBEC / APOBEC3B / チロシンキナーゼ阻害 / プロテオーム解析 / 血管新生 / 遺伝子改変マウス / STAT3 / mTOR Less
  • Research Projects

    (6 results)
  • Research Products

    (13 results)
  • Co-Researchers

    (7 People)
  •  Analysis of drug-resistant cells induced by molecular target agents and prevention of the resistance

    • Principal Investigator
      瀧川 奈義夫
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Kawasaki Medical School
  •  Basic research for the establishment of adequate sequence of chemotherapy in the treatment of advanced soft tissue sarcomaPrincipal Investigator

    • Principal Investigator
      山根 弘路
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Kawasaki Medical School
  •  Overcoming treatment resistance based on metabolic properties of EGFR gene mutations

    • Principal Investigator
      Takigawa Nagio
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Kawasaki Medical School
  •  Study of the cancer cachexia for the establishment of new treatment modality using the analysis of the iron metabolic pathwayPrincipal Investigator

    • Principal Investigator
      Yamane Hiromichi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Kawasaki Medical School
  •  Identification and overcoming specific signals in EGFR-TKI resistant lung cancer

    • Principal Investigator
      Takigawa Nagio
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Kawasaki Medical School
  •  Effects of molecular-targeted drugs on nonsmoking-related lung cancer models

    • Principal Investigator
      TAKIGAWA Nagio
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Kawasaki Medical School

All 2024 2023 2021 2020 2017 2016

All Journal Article Presentation

  • [Journal Article] The complexity of EGFR exon 19 deletion and L858R mutant cells as assessed by proteomics, transcriptomics, and metabolomics2023

    • Author(s)
      Ochi Nobuaki、Takeyama Masami、Miyake Noriko、Fuchigami Maki、Yamane Hiromichi、Fukazawa Takuya、Nagasaki Yasunari、Kawahara Tatsuyuki、Nakanishi Hidekazu、Takigawa Nagio
    • Journal Title

      Experimental Cell Research

      Volume: 424 Issue: 1 Pages: 113503-113503

    • DOI

      10.1016/j.yexcr.2023.113503

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K08191
  • [Journal Article] Targeting ROR1 in combination with osimertinib in EGFR mutant lung cancer cells2021

    • Author(s)
      Nakagawa N, Miyake N, Ochi N, Yamane H, Takeyama M, Nagasaki Y, Ikeda T, Yokota E, Fukazawa T, Nakanishi H, Harada D, Kiura K, Takigawa N.
    • Journal Title

      Exp Cell Res.

      Volume: 409 Issue: 2 Pages: 112940-112940

    • DOI

      10.1016/j.yexcr.2021.112940

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K08191
  • [Journal Article] Effects of (−)-epigallocatechin-3-gallate on EGFR- or Fusion Gene-driven Lung Cancer Cells2017

    • Author(s)
      Honda Y, Takigawa N, Ichihara E, Ninomiya T, Kubo T, Ochi N, Yasugi M, Murakami T, Yamane H, Tanimoto M, Kiura K.
    • Journal Title

      Acta Medica Okayama

      Volume: 71 Issue: 6 Pages: 505-512

    • DOI

      10.18926/AMO/55587

    • NAID

      120006370714

    • URL

      https://ousar.lib.okayama-u.ac.jp/55587

    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09594
  • [Journal Article] Synergistic effect of pacritinib with erlotinib on JAK2-mediated resistance in epidermal gowth factor receptor mutation-positive non-small cell lung Cancer.2016

    • Author(s)
      Ochi N, Isozaki H, Takeyama M, Singer JW, Yamane H, Honda Y, Kiura K, Takigawa N.
    • Journal Title

      Exp Cell Res.

      Volume: 344 Issue: 2 Pages: 194-200

    • DOI

      10.1016/j.yexcr.2016.05.008

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K09594
  • [Presentation] トラベクテジンによる化学療法が効果的であったFUS/CHOP融合遺伝子陽性粘液型脂肪肉腫患者4症例2024

    • Author(s)
      切士博仁、山根弘路、砂田有哉、三村彩香、市山成彦、河原辰由樹 長﨑泰有、小坂陽子、越智宣昭、中西秀和、瀧川奈義夫1)
    • Organizer
      第21回日本臨床腫瘍学会学術集会(JSMO2024)
    • Data Source
      KAKENHI-PROJECT-22K09436
  • [Presentation] EGFRエクソン19欠失とエクソン21 L858R遺伝子変異を有する肺癌細胞株のマルチオミクス解析2023

    • Author(s)
      越智 宣昭, 竹山 雅美, 三宅 規子, 山根 弘路, 深澤 拓哉, 長﨑 泰有, 河原 辰由樹, 中西 秀和, 瀧川 奈義夫
    • Organizer
      第82回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K08191
  • [Presentation] A novel molecular target, superoxide dismutase 1, in ALK inhibitor-resistant lung cancer cells, detected through proteomic analysis2023

    • Author(s)
      Nagio Takigawa, Noriko Miyake, Nobuaki Ochi, Masami Takeyama, Hideko Isozaki, Eiki Ichihara, Hiromichi Yamane, Takuya Fukazawa, Yasunari Nagasaki, Tatsuyuki Kawahara, Hidekazu Nakanishi, Katsuyuki Kiura
    • Organizer
      American College of CHEST Physician 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08191
  • [Presentation] EGFR遺伝子変異肺癌におけるROR1標的治療の基礎的検討2021

    • Author(s)
      三宅規子、越智宣昭、中川 望、竹山雅美、山根弘路、長﨑泰有、岩井美樹、横田悦子、深澤拓也、瀧川奈義夫
    • Organizer
      第62回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K08191
  • [Presentation] 進行期がん患者における血清炎症性マーカーおよび血清ヘプシジン25濃度と患者予後との関係性について2020

    • Author(s)
      山根弘路 越智宜昭 中西秀和 小原弘之 六原純子 瀧川奈義夫
    • Organizer
      第25回 日本緩和医療学会学術大会
    • Data Source
      KAKENHI-PROJECT-18K07279
  • [Presentation] 終末期肺がん患者予後に影響する血清炎症性マーカーの検討と新たな予後予測指標の提案2020

    • Author(s)
      山根弘路 越智宜昭 中川望 長崎康有 河原辰由樹 市山成彦 田岡征高 三村彩香 小原弘之 瀧川奈義夫
    • Organizer
      第61回 日本肺癌学会 学術集会
    • Data Source
      KAKENHI-PROJECT-18K07279
  • [Presentation] 肺がん患者におけるACPを考える2020

    • Author(s)
      山根弘路
    • Organizer
      第61回 日本肺癌学会 学術集会 ワークショップ5
    • Data Source
      KAKENHI-PROJECT-18K07279
  • [Presentation] ドライバーオンコジーンを有する肺がんに対するエピガロカテキンガレート(EGCG)の効果2017

    • Author(s)
      本多宣裕, 瀧川奈義夫, 越智宣昭, 二宮崇, 八杉昌幸, 久保寿夫, 磯崎英子, 市原英基, 堀田勝幸, 山根弘路, 谷本光音, 木浦勝行
    • Organizer
      第57回日本呼吸器学会学術講演会
    • Data Source
      KAKENHI-PROJECT-16K09594
  • [Presentation] PacritinibによるJAK2を介したEGFR-TKI耐性の克服2016

    • Author(s)
      越智宣昭、山根弘路、本多宣裕、磯崎英子、木浦勝行、瀧川奈義夫
    • Organizer
      第57回日本肺癌学会学術集会
    • Place of Presentation
      福岡サンパレス(福岡県福岡市)
    • Data Source
      KAKENHI-PROJECT-16K09594
  • 1.  TAKIGAWA Nagio (60325107)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 10 results
  • 2.  OCHI Nobuaki (80611615)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 10 results
  • 3.  中西 秀和 (50309548)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 6 results
  • 4.  KIURA Katsuyuki (10243502)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  TABAYASHI Takayuki (60624898)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  本多 宣裕 (80746876)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  國定 俊之 (80346428)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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