HAYAKAWA KOJI 早川晃司

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HAYAKAWA Koji 早川晃司

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Researcher Number	50636800
Other IDs	https://orcid.org/0000-0003-0453-1303
Affiliation (Current)	2025: 岡山理科大学, 獣医学部, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 岡山理科大学, 獣医学部, 准教授 2020 – 2022: 岡山理科大学, 獣医学部, 講師 2015 – 2016: 東京大学, 大学院農学生命科学研究科(農学部), 特任助教 2012 – 2015: 東京大学, 農学生命科学研究科, 助教 2013: 東京大学, 農学生命科学研究科, 特任助教
Review Section/Research Field	Principal Investigator Applied molecular and cellular biology / Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Basic Section 42040:Laboratory animal science-related Except Principal Investigator Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Integrative animal science
Keywords	Principal Investigator エピジェネティクス / ヒストン修飾 / クロマチン / リンカーヒストン / アンメットメディカルニーズ / 特異的分解法 / 胎盤 / 栄養膜細胞 / ヒストン糖修飾 / 妊娠糖尿病 … More / 核小体 / ヒストン / エピゲノム / DNAメチル化 / 卵子特異的 … More Except Principal Investigator 発生工学 / ゲノムワイド / グリコシル化 / ゲノムダメージ / Nアセチルグルコサミン（GlcNAc） / 進化 / 胚性幹細胞 / 栄養膜幹細胞 / グルコース感受性 / ゲノム修復 / H2A-アセチルグルコサミン（GlcNAc）修飾 / ヒストン修飾 / エピジェネティクス Less

アンメットメディカルニーズ克服を目指した修飾ヒストン分解技術ProHM法の開発Principal Investigator
- Principal Investigator
  
  早川晃司
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Okayama University of Science
ヒストン糖修飾による新たな視点での妊娠糖尿病分子メカニズムの解明と治療基盤の構築Principal Investigator
- Principal Investigator
  
  早川晃司
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Okayama University of Science
Study of nuclear-cytoplasmic incompatibility for the interspecies cloning.
- Principal Investigator
  
  Fujii Wataru
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  The University of Tokyo
Role of linker histone in the formation and function of nucleolus.Principal Investigator
- Principal Investigator
  
  Hayakawa Koji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  The University of Tokyo
Epigenetics of trophoblast and embryonic stem cells by a novel histone-glycosylation
- Principal Investigator
  
  Shiota Kunio
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Integrative animal science
- Research Institution
  Waseda University
  The University of Tokyo
Role of oocyte-specific linker histone H1foo on establishment of epigenomePrincipal Investigator
- Principal Investigator
  
  HAYAKAWA Koji
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  The University of Tokyo

All 2016 2015 2013 2012 Other

All Journal Article Presentation Patent

[Journal Article] Linker histone variant H1T targets rDNA repeats.2016
- Author(s)
  Tani R, Hayakawa K, Tanaka S, Shiota K.
- Journal Title
  
  Epigenetics
  
  Volume: 11(4) Issue: 4 Pages: 288-302
- DOI
  10.1080/15592294.2016.1159369
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26252052, KAKENHI-PROJECT-26850230
[Journal Article] Novel O-GlcNAcylation on Ser40 of canonical H2A isoforms specific to viviparity.2016
- Author(s)
  Hirosawa M, Hayakawa K, Yoneda C, Arai D, Shiota H, Suzuki T, Tanaka S, Dohmae N, Shiota K.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1
- DOI
  10.1038/srep31785
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26252052, KAKENHI-PROJECT-26850230, KAKENHI-PROJECT-15K07836
[Journal Article] An epigenetic regulatory element of the Nodal gene in the mouse and human genomes.2015
- Author(s)
  Arai D, Hayakawa K, Ohgane J, Hirosawa M, Nakao Y, Tanaka S, Shiota K.
- Journal Title
  
  Mech Dev.
  
  Volume: 136 Pages: 143-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26252052
[Journal Article] Isolation and manipulation of mouse trophoblast stem cells2015
- Author(s)
  Hayakawa K, Himeno E, Tanaka S, Kunath T.
- Journal Title
  
  Curr Protoc Stem Cell Biol
  
  Volume: 32 Issue: 1 Pages: 1-32
- DOI
  10.1002/9780470151808.sc01e04s32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26850230, KAKENHI-PROJECT-26252052
[Journal Article] N-Acetylmannosamine improves sleep-wake quality in middle-aged mice: relevance to autonomic nervous function.2015
- Author(s)
  Kuwahara M, Ito K, Hayakawa K, Yagi S, Shiota K.
- Journal Title
  
  Auton Neurosci
  
  Volume: 187 Pages: 56-62
- DOI
  10.1016/j.autneu.2014.11.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26850230
[Journal Article] An epigenetic regulatory element of the Nodal gene in the mouse and human genomes2015
- Author(s)
  Daisuke Arai, Koji Hayakawa, Jun Ohgane, Mitsuko Hirosawa, Yoichi Nakao, Satoshi Tanaka, Kunio Shiota
- Journal Title
  
  Mechanisms of Development
  
  Volume: 136 Pages: 143-154
- DOI
  10.1016/j.mod.2014.12.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25850219, KAKENHI-PROJECT-26850230, KAKENHI-PROJECT-15K07836, KAKENHI-PROJECT-25450472, KAKENHI-PROJECT-25303008, KAKENHI-PROJECT-15H01749
[Journal Article] Putative Epimutagens in Maternal Peripheral and Cord Blood Samples Identified Using Human Induced Pluripotent Stem Cells.2015
- Author(s)
  Arai Y, Hayakawa K, Arai D, Ito R, Iwasaki Y, Saito K, Akutsu K, Takatori S, Ishii R, Hayashi R, Izumi S, Sugino N, Kondo F, Horie M, Nakazawa H, Makino T, Hirosawa M, Shiota K, Ohgane J.
- Journal Title
  
  Biomed Res Int.
  
  Volume: 2015 Pages: 1-13
- DOI
  10.1155/2015/876047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07836, KAKENHI-PROJECT-25450472, KAKENHI-PROJECT-15H01749, KAKENHI-PROJECT-26252052
[Journal Article] N-Acetylmannosamine improves sleep-wake quality in middle-aged mice: relevance to autonomic nervous function.2015
- Author(s)
  Kuwahara M, Ito K, Hayakawa K, Yagi S, Shiota K.
- Journal Title
  
  Auton Neurosci.
  
  Volume: 187 Pages: 56-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26252052
[Journal Article] Epigenetics of Placental Development and Function2013
- Author(s)
  Shuhei Ito, Mitsuko Hirosawa, Koji Hayakawa, Shintaro Yagi, Satoshi Tanaka, Kunio Shiota
- Journal Title
  
  The Guide to Investigation of Mouse Pregnancy
  
  Volume: 24 Pages: 285-295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24880015
[Journal Article] A Method for Obtaining Epigenomic Data2013
- Author(s)
  Koji Hayakawa, Mitsuko Hirosawa, Kunio Shiota
- Journal Title
  
  The Guide to Investigation of Mouse Pregnancy
  
  Volume: 70 Pages: 773-776
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24880015
[Journal Article] Oocyte-specific linker histone H1foo is an epigenomic modulator that decondenses chromatin and impairs pluripotency2012
- Author(s)
  Koji Hayakawa
- Journal Title
  
  Epigenetics
  
  Volume: 7(9) Issue: 9 Pages: 1029-36
- DOI
  10.4161/epi.21492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24880015
[Journal Article] Oocyte - specific linker histone H1foo is an epigenomic modulator that decondenses chromatin and impairs pluripotency2012
- Author(s)
  Hayakawa K, Ohgane J, Tanaka S, Yagi S, Shiota K
- Journal Title
  
  Epigenetics
  
  Volume: 7(9) Pages: 1029-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24880015
[Journal Article] A Method for Obtaining Epigenomic Data
- Author(s)
  Hayakawa K, Hirosawa M, Shiota K
- Journal Title
  
  The Guide to Investigation of Mouse Pregnancy
  
  Volume: (英語総説) Pages: 773-776
- Data Source
  KAKENHI-PROJECT-24880015
[Patent] 糖感知エピゲノムバイオマーカー2016
- Inventor(s)
  塩田邦郎、廣澤瑞子、早川晃司
- Industrial Property Rights Holder
  塩田邦郎、廣澤瑞子、早川晃司
- Industrial Property Rights Type
  特許
- Filing Date
  2016-09-08
- Overseas
- Data Source
  KAKENHI-PROJECT-26252052
[Patent] グルコース感受性細胞の保護剤2016
- Inventor(s)
  塩田邦郎、早川晃司、廣澤ー高森瑞子、藤井遼介、伊藤幸成
- Industrial Property Rights Holder
  塩田邦郎、早川晃司、廣澤ー高森瑞子、藤井遼介、伊藤幸成
- Industrial Property Rights Type
  特許
- Filing Date
  2016-04-01
- Overseas
- Data Source
  KAKENHI-PROJECT-26252052
[Patent] グルコース感受性細胞の保護剤2015
- Inventor(s)
  塩田邦郎・早川晃司・廣澤瑞子・藤井遼介・伊藤幸成
- Industrial Property Rights Holder
  塩田邦郎・早川晃司・廣澤瑞子・藤井遼介・伊藤幸成
- Industrial Property Rights Type
  特許
- Filing Date
  2015-04-03
- Data Source
  KAKENHI-PROJECT-26252052
[Patent] 糖感知エピゲノムバイオマーカー2015
- Inventor(s)
  塩田邦郎・廣澤瑞子・早川晃司
- Industrial Property Rights Holder
  塩田邦郎・廣澤瑞子・早川晃司
- Industrial Property Rights Type
  特許
- Filing Date
  2015-09-09
- Data Source
  KAKENHI-PROJECT-26252052
[Presentation] ヒストンH2A O-GlcNAc修飾による哺乳類特有DNA修復機構2016
- Author(s)
  早川晃司・廣澤瑞子・谷瑠依子・米田智佳子・田中智・塩田邦郎
- Organizer
  第３９回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26252052
[Presentation] 遺伝子領域におけるリンカーヒストンバリアントH1Tの標的および機能2016
- Author(s)
  早川　晃司、谷　瑠依子、田中　智
- Organizer
  第10回日本エピジェネティクス研究会年会
- Place of Presentation
  千里ライフサイエンスセンター (大阪府豊中市)
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26850230
[Presentation] ヒストンH2AのL1領域におけるアイソフォーム特異的な新規O-GlcNAc修飾2016
- Author(s)
  廣澤瑞子・早川晃司・米田智佳子・新井大祐・塩田仁志・鈴木健裕・田中智・堂前直・塩田邦郎
- Organizer
  第３９回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26252052
[Presentation] リンカーヒストンバリアントH1TはrDNA領域を標的とし、rRNAの発現を抑制する2015
- Author(s)
  谷　瑠依子、早川　晃司、田中　智、塩田　邦郎
- Organizer
  第108回日本繁殖生物学会大会
- Place of Presentation
  宮崎大学木花キャンパス、宮崎
- Year and Date
  2015-09-16
- Data Source
  KAKENHI-PROJECT-26850230
[Presentation] Oocyte-specific linker histone H1foo is an epigenomic modulator that decondenses chromatin and impairs pluripotency2013
- Author(s)
  4. Koji Hayakawa
- Organizer
  Seminar in University of British Columbia (Host; Dr. Peter C.K. Leung)
- Place of Presentation
  バンクーバー,カナダ
- Year and Date
  2013-02-18
- Invited
- Data Source
  KAKENHI-PROJECT-24880015
[Presentation] 卵特異的リンカーヒストンH1fooはクロマチン脱凝縮を促すエピジェネティクス因子である2013
- Author(s)
  3.早川晃司他
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡,福岡
- Data Source
  KAKENHI-PROJECT-24880015
[Presentation] 卵子特異的リンカーヒストンH1fooのゲノム標的領域およびその特徴2013
- Author(s)
  1.早川晃司他
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド,兵庫
- Data Source
  KAKENHI-PROJECT-24880015
[Presentation] Histone H1foo, an oocyte - specific linker histone member, decondenses chromatin at unique targets loci in mouse genome2013
- Author(s)
  2. Koji Hayakawa et al
- Organizer
  EMBO Conference Series, Chromatin and Epigenetics
- Place of Presentation
  ハイデルベルグ,ドイツ
- Data Source
  KAKENHI-PROJECT-24880015
[Presentation] Histone H1foo, an oocyte-specific linker histone member, decondenses chromatin at unique target loci in mouse genome2013
- Author(s)
  Koji Hayakawa
- Organizer
  EMBO Conference Series, Chromatin and Epigenetics
- Place of Presentation
  Heidelberg, Germany
- Data Source
  KAKENHI-PROJECT-24880015
[Presentation] 卵子特異的リンカーヒストンH1fooのゲノム標的領域およびその特徴2013
- Author(s)
  早川　晃司
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸ポートアイランド、兵庫
- Data Source
  KAKENHI-PROJECT-24880015
[Presentation] 卵特異的リンカーヒストンH1fooはクロマチン脱凝縮を促すエピジェネティクス因子である2012
- Author(s)
  早川　晃司
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24880015
[Presentation] Glucose causes neurodegeneration in induced orexin neurons
- Author(s)
  Koji Hayakawa,Kunio Shiota
- Organizer
  The 2014 ASCB/IFCB meeting
- Place of Presentation
  フィラデルフィア、アメリカ
- Year and Date
  2014-12-06 – 2014-12-10
- Data Source
  KAKENHI-PROJECT-26252052
[Presentation] The influence of glucose concentration on the pluripotency of mouse embryonic stem cells
- Author(s)
  Chikako Yoneda, Koji Hayakawa, Mitsuko Hirosawa, Satoshi Tanaka, Kunio Shiota
- Organizer
  The 2014 ASCB/IFCB meeting
- Place of Presentation
  フィラデルフィア、アメリカ
- Year and Date
  2014-12-06 – 2014-12-10
- Data Source
  KAKENHI-PROJECT-26252052
[Presentation] O-linked N-acetylglucosamine transderase accumulates at Mgea5, β-N-acetylglucosaminidase gene loci in mouse trophoblast stem cell
- Author(s)
  Kenta Nishitani, Koji Hayakawa, Mitusko HIrosawa, Satoshi Tanaka, Kunio Shiota
- Organizer
  The 2014 ASCB/IFCB meeting
- Place of Presentation
  フィラデルフィア、アメリカ
- Year and Date
  2014-12-06 – 2014-12-10
- Data Source
  KAKENHI-PROJECT-26252052
[Presentation] Oocyte-specific linker histone H1foo is an epigenomic modulator that decondenses chromatin and impairs pluripotency
- Author(s)
  Koji Hayakawa
- Organizer
  Seminar in University of British Columbia (host; Dr. Peter C.K. Leung)
- Place of Presentation
  Vancouver, BC, Canada
- Invited
- Data Source
  KAKENHI-PROJECT-24880015
[Presentation] Linker histone variant H1T targets rDNA repeats
- Author(s)
  Ruiko Tani, Koji Hayakawa, Satoshi Tanaka, Kunio Shiota
- Organizer
  The 2014 ASCB/IFCB meeting
- Place of Presentation
  フィラデルフィア、アメリカ
- Year and Date
  2014-12-06 – 2014-12-10
- Data Source
  KAKENHI-PROJECT-26850230
[Presentation] リンカーヒストンバリアントH1TはrDNA領域のクロマチン構造を凝集させる
- Author(s)
  谷　瑠依子、早川　晃司、田中　智、塩田　邦郎
- Organizer
  第87回　日本生化学会大会
- Place of Presentation
  国立京都国際会館、京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26850230
[Presentation] 卵子特異的リンカーヒストンH1fooによる卵子特異的エピゲノム形成
- Author(s)
  早川　晃司、中西　もも、田中　智、塩田　邦郎
- Organizer
  第8回　日本エピジェネティクス研究会年会
- Place of Presentation
  伊藤国際学術研究センター、東京
- Year and Date
  2014-05-25 – 2014-05-27
- Invited
- Data Source
  KAKENHI-PROJECT-26850230
[Presentation] 単糖によるオレキシン神経誘導の多重エピジェネティック制御
- Author(s)
  早川　晃司
- Organizer
  第87回　日本生化学会大会
- Place of Presentation
  国立京都国際会館、京都
- Year and Date
  2014-10-15 – 2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-26252052

1. Fujii Wataru (40708161)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Shiota Kunio (80196352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
3. 廣澤瑞子 (60533982)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. 新井大祐 (20624951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 山内啓太郎 (70272440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HAYAKAWA KOJI 早川 晃司

HAYAKAWA Koji 早川 晃司

Research Projects

Research Products

Co-Researchers

アンメットメディカルニーズ克服を目指した修飾ヒストン分解技術ProHM法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒストン糖修飾による新たな視点での妊娠糖尿病分子メカニズムの解明と治療基盤の構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of nuclear-cytoplasmic incompatibility for the interspecies cloning.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of linker histone in the formation and function of nucleolus.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Epigenetics of trophoblast and embryonic stem cells by a novel histone-glycosylation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of oocyte-specific linker histone H1foo on establishment of epigenomePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Linker histone variant H1T targets rDNA repeats.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel O-GlcNAcylation on Ser40 of canonical H2A isoforms specific to viviparity.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An epigenetic regulatory element of the Nodal gene in the mouse and human genomes.2015

Author(s)

Journal Title

Data Source

[Journal Article] Isolation and manipulation of mouse trophoblast stem cells2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] N-Acetylmannosamine improves sleep-wake quality in middle-aged mice: relevance to autonomic nervous function.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An epigenetic regulatory element of the Nodal gene in the mouse and human genomes2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Putative Epimutagens in Maternal Peripheral and Cord Blood Samples Identified Using Human Induced Pluripotent Stem Cells.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] N-Acetylmannosamine improves sleep-wake quality in middle-aged mice: relevance to autonomic nervous function.2015

Author(s)

Journal Title

Data Source

[Journal Article] Epigenetics of Placental Development and Function2013

HAYAKAWA KOJI 早川晃司

HAYAKAWA Koji 早川晃司