Takaba Hiroyuki 高場啓之

Researcher Number	50637444
Other IDs
Affiliation (Current)	2025: 東京大学, 大学院医学系研究科(医学部), 助教
Affiliation (based on the past Project Information) *help	2017 – 2024: 東京大学, 大学院医学系研究科(医学部), 助教 2016: 東京大学, 大学院医学系研究科(医学部), 特任助教 2014 – 2015: 東京大学, 医学(系)研究科(研究院), 研究員
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Pathology, Infection/Immunology, and related fields / Experimental pathology / Immunology
Keywords	Principal Investigator 獲得免疫 / 免疫寛容 / T細胞 / がん免疫 / 自己免疫 / 自己免疫疾患 / 制御性T細胞 / 胸腺 / 腫瘍微小環境 / 末梢組織抗原 … More / 転写因子 / 胸腺上皮細胞 / 免疫監視 / 負の選択 / 抗原提示 / 自己抗原 / T細胞抗原受容体 / 中枢神経組織 / 神経性疾患 / ホルモン / 制御性Ｔ細胞 / 組織恒常性 / 中枢性免疫寛容 / 自己抗原発現 / Autoimmunity / 次世代シーケンス解析 / クロマチンリモデリング / エピジェネティックス / 転写制御因子 / 転写制御 / クロマチン制御因子 / ストローマ細胞 / 自己免疫寛容 / T細胞の選択 / 中枢寛容 / 中枢免疫寛容 / 自己寛容 / Self tolerance Less

Research contributing to the development of an innovative therapic approach that control the immunosuppressive network at the tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  高場啓之
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  The University of Tokyo
Investigation of new products expressed by Treg cells for immune homeostasisPrincipal Investigator
- Principal Investigator
  
  Takaba Hiroyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  The University of Tokyo
Elucidation of Mechanisms of T cell Selection for Self-TolerancePrincipal Investigator
- Principal Investigator
  
  Takaba Hiroyuki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  The University of Tokyo
Investigation of Molecular Mechanisms of Self-antigen expression for Central Immune TolerancePrincipal Investigator
- Principal Investigator
  
  Takaba Hiroyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Pathology, Infection/Immunology, and related fields
- Research Institution
  The University of Tokyo
Negative selection of T cells by the factor suppressing autoimmunityPrincipal Investigator
- Principal Investigator
  
  Takaba Hiroyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokyo
Elucidation of the mechanisms of TRAs expression independently of AirePrincipal Investigator
- Principal Investigator
  
  Takaba Hiroyuki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2018 2017 2016 2015 Other

All Journal Article Presentation Book

[Book] 胸腺におけるT細胞の選択機構2017
- Author(s)
  高場啓之、高柳広
- Total Pages
  6
- Publisher
  臨床免疫・アレルギー科
- Data Source
  KAKENHI-PROJECT-26670231
[Book] 胸腺におけるT細胞の選択機構2017
- Author(s)
  高場啓之、高柳広
- Total Pages
  6
- Publisher
  臨床免疫・アレルギー科
- Data Source
  KAKENHI-PROJECT-16H06228
[Book] 自己免疫疾患を抑制する重要因子の同定2016
- Author(s)
  高場啓之
- Total Pages
  7
- Publisher
  臨床免疫・アレルギー科
- Data Source
  KAKENHI-PROJECT-26670231
[Journal Article] ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts2022
- Author(s)
  Yan Minglu、Komatsu Noriko、Muro Ryunosuke、Huynh Nam Cong-Nhat、Kitazawa Riko、Kitazawa Sohei、Pluemsakunthai Warunee、Mitsui Yuichi、Satoh Takashi、Okamura Tadashi、Nitta Takeshi、Im Sin-Hyeog、Kim Chan Johng、Kollias George、Tanaka Sakae、Okamoto Kazuo、Tsukasaki Masayuki、Takayanagi Hiroshi
- Journal Title
  
  Nature Immunology
  
  Volume: 23 Issue: 9 Pages: 1330-1341
- DOI
  10.1038/s41590-022-01285-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06981, KAKENHI-PROJECT-22K07114, KAKENHI-PROJECT-21K18254, KAKENHI-PROJECT-21K19354, KAKENHI-ORGANIZER-22H05060, KAKENHI-PLANNED-22H05061, KAKENHI-PROJECT-21H05046, KAKENHI-PROJECT-20H03465, KAKENHI-PROJECT-21H03104, KAKENHI-PROJECT-22F22108, KAKENHI-PROJECT-21K19371, KAKENHI-PROJECT-23K20314, KAKENHI-PROJECT-23K24106, KAKENHI-PROJECT-23K24148, KAKENHI-PROJECT-23K24454
[Journal Article] Chd4 choreographs self-antigen expression for central immune tolerance2020
- Author(s)
  Yoshihiko Tomofuji, Hiroyuki Takaba, Hiroshi I Suzuki, Rayene Benlaribi, Cristian David Pena Martinez, Yoshihiro Abe, Yasuyuki Morishita, Tadashi Okamura, Akashi Taguchi, Tatsuhiko Kodama, Hiroshi Takayanagi
- Journal Title
  
  Nature Immunology
  
  Volume: 8 Issue: 8 Pages: 892-901
- DOI
  10.1038/s41590-020-0717-2
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21514, KAKENHI-PROJECT-20H03465, KAKENHI-PROJECT-19K24694
[Journal Article] The mechanisms of T cell selection in the thymus2017
- Author(s)
  Hiroyuki Takaba and Hiroshi Takayanagi
- Journal Title
  
  Trends in immunology
  
  Volume: 38, 11 Issue: 11 Pages: 805-8016
- DOI
  10.1016/j.it.2017.07.010
- NAID
  40021132352
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19545, KAKENHI-PROJECT-16H06228, KAKENHI-PROJECT-15H05703
[Journal Article] Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance.2015
- Author(s)
  H. Takaba et al.,
- Journal Title
  
  Cell
  
  Volume: 163 Pages: 975-987
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26670231
[Presentation] The effector molecule derived from Tregs on lung cancer progression2024
- Author(s)
  Qiao Gou; Hiroyuki Takaba; Hiroshi Takayanagi.
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-20H03465
[Presentation] A thymic programme for immune surveillance2023
- Author(s)
  Rayene Benlaribi; Hiroyuki Takaba; Hiroshi Suzuki, Hiroshi Takayanagi.
- Organizer
  日本炎症再生学会
- Data Source
  KAKENHI-PROJECT-20H03465
[Presentation] A mileue molecule from Tregs orchestrates lung cancer progression2023
- Author(s)
  Qiao Gou; Hiroyuki Takaba; Hiroshi Takayanagi.
- Organizer
  日本炎症再生学会
- Data Source
  KAKENHI-PROJECT-20H03465
[Presentation] The effector molecule derived from Tregs on lung cancer progression2022
- Author(s)
  Qiao Gou; Hiroyuki Takaba; Hiroshi Takayanagi.
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-20H03465
[Presentation] Promiscuous Gene Regulators for Central Immune Tolerance2021
- Author(s)
  Hiroyuki Takaba, Yoshihiko Tomofuji, Hiroshi Takayanagi
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20H03465
[Presentation] Promiscuous Gene Regulators for Central Immune Tolerance2021
- Author(s)
  Hiroyuki Takaba, Yoshihiko Tomofuji, Hiroshi Takayanagi
- Organizer
  The 42th Annual Meeting of the Japanese Society of Inflammation and Regeneration.
- Data Source
  KAKENHI-PROJECT-20H03465
[Presentation] Promiscuous Gene Regulators for Central Immune Tolerance2021
- Author(s)
  Hiroyuki Takaba, Yoshihiko Tomofuji, Hiroshi Takayanagi
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K21514
[Presentation] Epigenetic regulation of thymic self-antigen expression for immune tolerance2018
- Author(s)
  Hiroyuki Takaba, Yoshihiko Tomofuji, Hiroshi Takayanagi
- Organizer
  Gordon conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06228
[Presentation] Distinct features of Fezf2-dependent promiscuous gene expression2018
- Author(s)
  Yoshihiko Tomofuji, Hiroyuki Takaba and Hiroshi Takayanagi
- Organizer
  ThymOZ8
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06228
[Presentation] Self-Reflection by Tolerogenic Factors: Promiscuous Gene Expression in the Thymus2018
- Author(s)
  Hiroyuki Takaba
- Organizer
  Japanese Society for Immunology(JSI)
- Invited
- Data Source
  KAKENHI-PROJECT-16H06228
[Presentation] 免疫学のセントラルドグマ2017
- Author(s)
  高場啓之
- Organizer
  Conbio2017
- Invited
- Data Source
  KAKENHI-PROJECT-17K19545
[Presentation] T cell selection mediated by Fezf2 in the thymus2017
- Author(s)
  Hiroyuki Takaba and Hiroshi Takayanagi
- Organizer
  KTCC 2017
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2017-03-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06228
[Presentation] 免疫学のセントラルドグマ2017
- Author(s)
  高場啓之
- Organizer
  Conbio2017
- Invited
- Data Source
  KAKENHI-PROJECT-16H06228
[Presentation] T cell selection mediated by Fezf2 in the thymus2017
- Author(s)
  Hiroyuki Takaba and Hiroshi Takayanagi
- Organizer
  KTCC 2017
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2017-03-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670231
[Presentation] A novel key regulator of autoimmunity2016
- Author(s)
  Hiroyuki Takaba and Hiroshi Takayanagi
- Organizer
  Gordon Research Conference
- Place of Presentation
  Lucca, Italy
- Year and Date
  2016-06-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670231
[Presentation] Identification of a key regulator of autoimmunity2016
- Author(s)
  Hiroyuki Takaba and Hiroshi Takayanagi
- Organizer
  ThymUS 2016
- Place of Presentation
  Hawaii, USA
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670231
[Presentation] Identification of a novel key regulator of immune tolerance
- Author(s)
  Hiroyuki Takaba and Hiroshi Takayanagi
- Organizer
  Keystone symposia, T Cells: Regulation and Effector Function (oral presentation)
- Place of Presentation
  Snowbird, Utah, USA
- Year and Date
  2015-03-29 – 2015-04-03
- Data Source
  KAKENHI-PROJECT-26670231

1. TAKAYANAGI Hiroshi (20334229)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. 北澤理子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takaba Hiroyuki 高場 啓之

Research Projects

Research Products

Co-Researchers

Research contributing to the development of an innovative therapic approach that control the immunosuppressive network at the tumor microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of new products expressed by Treg cells for immune homeostasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of Mechanisms of T cell Selection for Self-TolerancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of Molecular Mechanisms of Self-antigen expression for Central Immune TolerancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Negative selection of T cells by the factor suppressing autoimmunityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanisms of TRAs expression independently of AirePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 胸腺におけるT細胞の選択機構2017

Author(s)

Total Pages

Publisher

Data Source

[Book] 胸腺におけるT細胞の選択機構2017

Author(s)

Total Pages

Publisher

Data Source

[Book] 自己免疫疾患を抑制する重要因子の同定2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chd4 choreographs self-antigen expression for central immune tolerance2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The mechanisms of T cell selection in the thymus2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance.2015

Author(s)

Journal Title

Data Source

[Presentation] The effector molecule derived from Tregs on lung cancer progression2024

Author(s)

Organizer

Data Source

[Presentation] A thymic programme for immune surveillance2023

Takaba Hiroyuki 高場啓之