KATSUYAMA YOHEI 勝山陽平

… Alternative Names

Katsuyama Yohei 勝山陽平

KATSUYAMA Yohei 勝山陽平

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Researcher Number	50646437
Other IDs	https://orcid.org/0000-0003-4905-5320
Affiliation (Current)	2024: 東京大学, 大学院農学生命科学研究科(農学部), 准教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 東京大学, 大学院農学生命科学研究科(農学部), 准教授 2013 – 2014: 東京大学, 農学生命科学研究科, 講師
Review Section/Research Field	Principal Investigator Science and Engineering / Applied microbiology / Basic Section 37010:Bio-related chemistry / Transformative Research Areas, Section (II) / Basic Section 38040:Bioorganic chemistry-related Except Principal Investigator Transformative Research Areas, Section (II)
Keywords	Principal Investigator 生合成 / 放線菌 / 天然物 / biosynthesis / 酵素 / 二次代謝 / ジアゾ基 / ポリケタイド合成酵素 / polyketide / secondary metabolite … More / nonribosomal peptide / X線結晶構造解析 / 非リボソームペプチド合成酵素 / 二次代謝産物 / 非リボソームペプチド / ポリケタイド / 亜硝酸 / ペプチド / クライオ電子顕微鏡 / natural products / Streptomyces / polyketide synthase / 芳香族化合物 / ポリエン / enzymes / actinobacteria / enzyme / JBIR-34 / ヘテロ環化 / 進化工学 / 微生物生産 / 合成生物学 / 指向性進化 / バイオセンサー / biosensor / directed evolution / engineering / 有機化学 / 応用微生物 … More Except Principal Investigator 情報科学 / 計算科学 / 有機合成 / 生物合成 / 天然物化学 / 反応機構 / 酵素 / 生物活性物質 / 生合成 Less

Enhancing the diversity of peptides by amino acids with reactive functional groupsPrincipal Investigator
- Principal Investigator
  
  勝山陽平
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo
予知生合成科学・研究総括班
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo
Study on the biosynthesis of secondary metabolites with unique nitrogen-containing functional group produced by actinobacteriaPrincipal Investigator
- Principal Investigator
  
  勝山陽平
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  The University of Tokyo
Study on biosynthesis of thiotemplate enzymesPrincipal Investigator
- Principal Investigator
  
  勝山陽平
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Study on biosynthetic machinery of type II polyketide synthasePrincipal Investigator
- Principal Investigator
  
  Katsuyama Yohei
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  The University of Tokyo
Analysis of reaction mechanism of nonribosomal peptide synthetase.Principal Investigator
- Principal Investigator
  
  勝山陽平
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Development of method using synthetic biology to design artificial biosynthetic pathway.Principal Investigator
- Principal Investigator
  
  Katsuyama Yohei
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied microbiology
- Research Institution
  The University of Tokyo
ユニークな骨格を持つ放線菌由来二次代謝産物の生合成経路の解明Principal Investigator
- Principal Investigator
  
  勝山陽平
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Study on biosynthesis of natural products with diazo groupPrincipal Investigator
- Principal Investigator
  
  KATSUYAMA Yohei
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied microbiology
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017 2015 2014 2013

All Journal Article Presentation

[Journal Article] Structural and functional analyses of the tridomain‐nonribosomal peptide synthetase FmoA3 for 4‐methyloxazoline ring formation2021
- Author(s)
  Katsuyama Yohei、Sone Kaoru、Harada Ayaka、Kawai Seiji、Urano Naoki、Adachi Naruhiko、Moriya Toshio、Kawasaki Masato、Shin-ya Kazuo、Senda Toshiya、Ohnishi Yasuo
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 未定 Issue: 26 Pages: 14554-14562
- DOI
  10.1002/anie.202102760
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-19H04645, KAKENHI-PROJECT-19H03197
[Journal Article] Complete Biosynthetic Pathway of Alazopeptin, a Tripeptide Consisting of Two Molecules of 6‐Diazo‐5‐oxo‐ l ‐norleucine and One Molecule of Alanine2021
- Author(s)
  Kawai Seiji、Sugaya Yuko、Hagihara Ryota、Tomita Hiroya、Katsuyama Yohei、Ohnishi Yasuo
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 60 Issue: 18 Pages: 10319-10325
- DOI
  10.1002/anie.202100462
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-19H04645, KAKENHI-PLANNED-19H05685
[Journal Article] Recent Advance in the Biosynthesis of Nitrogen-Nitrogen Bond-Containing Natural Products2020
- Author(s)
  Yohei Katsuyama, Kenichi Matsuda
- Journal Title
  
  Current opinion in Chemical Biology
  
  Volume: 59 Pages: 62-68
- DOI
  10.1016/j.cbpa.2020.05.002
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-19H04645, KAKENHI-PROJECT-19K16390
[Journal Article] Structural basis for selectivity in a highly reducing type II polyketide synthase.2020
- Author(s)
  Danyao Du, Yohei Katsuyama, Masanobu Horiuchi, Shinya Fushinobu, Aochiu Chen, Tony D. Davis, Michael D. Burkart, Yasuo Ohnishi
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 未定 Issue: 7 Pages: 776-782
- DOI
  10.1038/s41589-020-0530-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02144
[Journal Article] Involvement of β‐Alkylation Machinery and Two Sets of Ketosynthase‐Chain‐Length Factors in the Biosynthesis of Fogacin Polyketides in Actinoplanes missouriensis2019
- Author(s)
  Sato Kei、Katsuyama Yohei、Yokota Kousuke、Awakawa Takayoshi、Tezuka Takeaki、Ohnishi Yasuo
- Journal Title
  
  ChemBioChem
  
  Volume: 20 Issue: 8 Pages: 1039-1050
- DOI
  10.1002/cbic.201800640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17KT0095, KAKENHI-PROJECT-18H02144, KAKENHI-PROJECT-17H04763
[Journal Article] Biosynthesis of the 4-methyloxazoline-containing nonribosomal peptides, JBIR-34 and -35, in Streptomyces sp. Sp080513GE-23.2014
- Author(s)
  Adeline Muliandi, Yohei Katsuyama, Kaoru Sone, Miho Izumikawa, Tomohiro Moriya, Junko Hashimoto, Ikuko Kozone, Motoki Takagi, Kazuo Shin-ya, Yasuo Ohnishi.
- Journal Title
  
  Chemistry and Biology
  
  Volume: 21 Issue: 8 Pages: 923-934
- DOI
  10.1016/j.chembiol.2014.06.004
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25108706
[Presentation] 放線菌における亜硝酸を用いた芳香環アミノ化機構に関する研究2023
- Author(s)
  桑原康、勝山陽平、大西康夫
- Organizer
  2022年度 (第36回) 日本放線菌学会（福井県福井市）
- Data Source
  KAKENHI-PROJECT-23K23459
[Presentation] Streptomyces fragilis が生産するジアゾ基含有アミノ酸azaserineの生合成機構解析2023
- Author(s)
  四海佑亮、川合誠司、勝山陽平、大西康夫
- Organizer
  2022年度 (第36回) 日本放線菌学会（福井県福井市）
- Data Source
  KAKENHI-PROJECT-23K23459
[Presentation] 芳香族ポリケタイドyoropyrazone のスピロ環形成機構のin vitro 解析2022
- Author(s)
  清藤鈴奈、勝山陽平、大西康夫
- Organizer
  日本農芸化学会2022年度　京都大会
- Data Source
  KAKENHI-PROJECT-18H02144
[Presentation] 放線菌の持つ窒素酸化物を利用した二次代謝の多様性2022
- Author(s)
  勝山陽平
- Organizer
  第95回日本細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02144
[Presentation] In vitro解析とX線結晶構造解析による２種のII型PKSとFASにおけるACP-KS間特異性制御機構の解明2021
- Author(s)
  堀内真展, 杜丹ヤオ, DAVIS Tony D., BURKART Michael D., 勝山陽平, 大西康夫
- Organizer
  日本農芸化学会2021年度　仙台大会
- Data Source
  KAKENHI-PUBLICLY-19H04645
[Presentation] JBIR-34,35の生合成に関わるNRPSのクライオ電子顕微鏡による解析2020
- Author(s)
  浦野直樹、勝山陽平、安達成彦、川崎政人、千田俊哉、大西康夫
- Organizer
  日本農芸化学会2020年度　福岡大会
- Data Source
  KAKENHI-PUBLICLY-19H04645
[Presentation] Structural and biochemical analyses of methyloxazoline-forming tridomain-nonribosomal peptide synthetase2020
- Author(s)
  Yohei Katsuyama
- Organizer
  The 5th A3 foresight symposium on Chemical & Synthetic Biology of Natural Products
- Data Source
  KAKENHI-PUBLICLY-19H04645
[Presentation] 2つのII型PKSとFAS間におけるACPのクロストークに関するin vitro解析2020
- Author(s)
  ○堀内真展、杜丹ヤオ、勝山陽平、Burkart, Michael D.、大西康夫
- Organizer
  日本農芸化学会2020年度　福岡大会
- Data Source
  KAKENHI-PROJECT-18H02144
[Presentation] 放線菌が生産するジアゾ基含有トリペプチドalazopeptinの全生合成経路の解明2020
- Author(s)
  川合誠司、勝山陽平、菅谷優子、冨田宏矢、大西康夫
- Organizer
  日本農芸化学会関東支部2020年度大会
- Data Source
  KAKENHI-PUBLICLY-19H04645
[Presentation] 非リボソームペプチドcirratiomycinの生合成研究2020
- Author(s)
  ○李佳鳳、曽根薫、新家一男、勝山陽平、大西康夫
- Organizer
  日本農芸化学会2020年度　福岡大会
- Data Source
  KAKENHI-PUBLICLY-19H04645
[Presentation] ベンザスタチン生合成においてニトレン中間体を介した環化反応を触媒するP450のX線結晶構造解析2020
- Author(s)
  堤隼馬、浦野直樹、勝山陽平、大西康夫
- Organizer
  日本農芸化学会2020年度　福岡大会
- Data Source
  KAKENHI-PUBLICLY-19H04645
[Presentation] 高還元型II型PKS由来KS-CLFヘテロダイマー及びACP-KS-CLF三者複合体のX線結晶構造解析2019
- Author(s)
  杜丹ヤオ、勝山陽平、伏信進矢、Chen Aochiu、Davis Tony D、Burkart Michael、大西康夫
- Organizer
  日本農芸化学会2019年度　東京大会
- Data Source
  KAKENHI-PROJECT-18H02144
[Presentation] 放線菌の持つ二次代謝経路の探索と機能解析2019
- Author(s)
  勝山　陽平
- Organizer
  第18回微生物研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02144
[Presentation] JBIR-34, -35とJBIR-126の生合成に関わるNRPSのモジュール間相互作用2019
- Author(s)
  角田毅、勝山陽平、新家一男、大西康夫
- Organizer
  日本農芸化学会2019年度　東京大会
- Data Source
  KAKENHI-PUBLICLY-17H05432
[Presentation] Modification of Ligand Specificity of XylS through Directed Evolution.2018
- Author(s)
  Yohei Katsuyama, ○Yuki Ogawa, Kento Ueno and Yasuo Ohnishi
- Organizer
  18th International Symposium on the Biology of Actinomycetes (International Convention Center JEJU)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14880
[Presentation] 放線菌のもつ多様な二次代謝産物生合成機構の解析2018
- Author(s)
  勝山　陽平
- Organizer
  第3回関東支部例会　東京大学農学部弥生講堂一条ホール日本農芸化学会奨励賞受賞講演
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05432
[Presentation] Streptomyces sp. IFM11307 由来芳香族ポリケタイド yoropyrazone 生合成に関する研究2018
- Author(s)
  藤田夏澄, 勝山陽平, 當銘一文, 石橋正己, 大西康夫
- Organizer
  第３３回 (2018年度) 日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-18H02144
[Presentation] JBIR-34, -35の生合成を担う非リボソームペプチド合成酵素FmoA3のX線結晶構造解析2018
- Author(s)
  曽根薫、原田彩佳、勝山陽平、千田美紀、新家一男、千田俊哉、大西康夫
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PUBLICLY-17H05432
[Presentation] 放線菌の持つ多様な二次代謝産物の生合成機構2018
- Author(s)
  勝山　陽平
- Organizer
  第五回天然物化学研究会東京農業大学世田谷キャンパス
- Invited
- Data Source
  KAKENHI-PROJECT-18H02144
[Presentation] 放線菌のもつ多様な二次代謝産物生合成機構の解析2018
- Author(s)
  勝山　陽平
- Organizer
  第3回関東支部例会　東京大学農学部弥生講堂一条ホール日本農芸化学会奨励賞受賞講演
- Invited
- Data Source
  KAKENHI-PROJECT-18H02144
[Presentation] Reconstitution of a Type II Polyketide Synthase Catalyzing Polyene Formation2018
- Author(s)
  Danyao Du, Yohei Katsuyama, Kazuo Shin-ya, Yasuo Ohnishi
- Organizer
  3rd European Conference on Natural Products
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02144
[Presentation] 放線菌の持つ多様な二次代謝産物の生合成機構2018
- Author(s)
  勝山　陽平
- Organizer
  第五回天然物化学研究会東京農業大学世田谷キャンパス
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05432
[Presentation] In vitro analysis of the biosynthesis of 4-methyloxazoline-containing nonribosomal peptides, JBIR-34 and -352017
- Author(s)
  Kaoru Sone, Ayaka Harada, Miki Senda, Toshiya Senda, Kazuo Shin-ya, Yohei Katsuyama and Yasuo Ohnishi
- Organizer
  SIMB Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05432
[Presentation] 指向性進化による転写因子XylSのリガンド認識能の改変2017
- Author(s)
  勝山陽平、○小川友希、上野堅登、大西康夫
- Organizer
  日本農芸化学会
- Place of Presentation
  京都女子大学 (京都)
- Data Source
  KAKENHI-PROJECT-16K14880
[Presentation] Biosynthesis of JBIR-76 and -77, aromatic polyketides with isofuranonaphthoquinone scaffold2015
- Author(s)
  Yohei Katsuyama, Kaoru Sone, Ryutaro Satou, Miho Izumikawa, Motoki Takagi, Kazuo Shin-ya, Yasuo Ohnishi
- Organizer
  Natural Product - Discovery & Development in the Post Genomic Era
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-01-12
- Data Source
  KAKENHI-PUBLICLY-25108706
[Presentation] Streptomyces sp. JE-08由来シクロペンタ[b]ピリジン環構造を有するポリケタイドJBIR-70の生合成2015
- Author(s)
  太島有香、勝山陽平、泉川美穂、大野翔登、荒川孝俊、伏信進矢、新家一男、大西康夫
- Organizer
  日本農芸化学会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PUBLICLY-25108706
[Presentation] Streptomyces cremeusにおけるcremeomycin生合成に関与する新規亜硝酸脱離酵素CreGのX線結晶構造解析2015
- Author(s)
  勝山陽平、東山洋輔、佐藤優花里、菅井佳宣、千田美紀、千田俊哉、大西康夫
- Organizer
  日本農芸化学会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25850048
[Presentation] Cremeomycinのジアゾ基形成に関与する新規亜硝酸生合成経路2015
- Author(s)
  菅井佳宣、勝山陽平、大西康夫
- Organizer
  日本農芸化学会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25850048
[Presentation] 特異なヘテロ環を持つペプチドの生合成2014
- Author(s)
  勝山陽平、大西康夫
- Organizer
  日本農芸化学会関東支部2014年度第1回例会
- Place of Presentation
  東京大学
- Year and Date
  2014-05-24
- Invited
- Data Source
  KAKENHI-PUBLICLY-25108706
[Presentation] Cremeomycin生合成経路の解析2014
- Author(s)
  菅井佳宣、勝山陽平、大西康夫
- Organizer
  日本放線菌学会
- Place of Presentation
  筑波
- Year and Date
  2014-06-19
- Data Source
  KAKENHI-PROJECT-25850048
[Presentation] 放線菌由来4-メチルオキサゾリン環を有する非リボソームペプチドJBIR-34, 35の生合成経路のin vitro解析2014
- Author(s)
  曽根薫、勝山陽平、新家一男、大西康夫
- Organizer
  日本放線菌学会
- Place of Presentation
  つくばカピオ
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PUBLICLY-25108706
[Presentation] ジアゾ基含有化合物cremeomycinの生合成研究2013
- Author(s)
  菅井佳宣、勝山陽平、大西康夫
- Organizer
  放線菌学会
- Place of Presentation
  メルパルク広島
- Data Source
  KAKENHI-PROJECT-25850048
[Presentation] Biosynthesis of JBIR-34,35, nonribosomal peptides containing unusual methyloxazoline group2013
- Author(s)
  Yohei Katsuyama, Adeline Muliandi, Miho Izumikawa, Tomohiro Moriya, Ikuko Kozone, Junko Hashimoto, Motoki Takagi, Kazuo Shin-ya, Yasuo Ohnishi
- Organizer
  1st European Conference on Natural Products
- Place of Presentation
  DECHEMA-HAUS, FRANKFURT AM MAIN
- Data Source
  KAKENHI-PUBLICLY-25108706
[Presentation] 非リボソームペプチドJBIR-34, JBIR-35の生合成2013
- Author(s)
  勝山陽平, アデリンムリアンディ, 曽根薫, 泉川美穂, 守屋智博, 小曽根郁子, 橋本絢子, 高木基樹, 新家一男, 大西康夫
- Organizer
  放線菌学会
- Place of Presentation
  メルパルク広島
- Data Source
  KAKENHI-PUBLICLY-25108706

1. 小笠原泰志 (20732986)

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2. 葛山智久 (30280952)

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KATSUYAMA YOHEI 勝山 陽平

Katsuyama Yohei 勝山 陽平

KATSUYAMA Yohei 勝山 陽平

Research Projects

Research Products

Co-Researchers

Enhancing the diversity of peptides by amino acids with reactive functional groupsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

予知生合成科学・研究総括班

Principal Investigator

Project Period (FY)

Research Category

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Study on the biosynthesis of secondary metabolites with unique nitrogen-containing functional group produced by actinobacteriaPrincipal Investigator

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Study on biosynthesis of thiotemplate enzymesPrincipal Investigator

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Study on biosynthetic machinery of type II polyketide synthasePrincipal Investigator

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Analysis of reaction mechanism of nonribosomal peptide synthetase.Principal Investigator

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Development of method using synthetic biology to design artificial biosynthetic pathway.Principal Investigator

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ユニークな骨格を持つ放線菌由来二次代謝産物の生合成経路の解明Principal Investigator

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Study on biosynthesis of natural products with diazo groupPrincipal Investigator

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[Journal Article] Structural and functional analyses of the tridomain‐nonribosomal peptide synthetase FmoA3 for 4‐methyloxazoline ring formation2021

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[Journal Article] Complete Biosynthetic Pathway of Alazopeptin, a Tripeptide Consisting of Two Molecules of 6‐Diazo‐5‐oxo‐ l ‐norleucine and One Molecule of Alanine2021

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[Journal Article] Recent Advance in the Biosynthesis of Nitrogen-Nitrogen Bond-Containing Natural Products2020

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[Journal Article] Structural basis for selectivity in a highly reducing type II polyketide synthase.2020

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KATSUYAMA YOHEI 勝山陽平

Katsuyama Yohei 勝山陽平

KATSUYAMA Yohei 勝山陽平