Inoue Akitoshi 井上明俊

… Alternative Names

INOUE Akitoshi 井上明俊

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Researcher Number	50709152
Other IDs
Affiliation (Current)	2025: 関西医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2014 – 2023: 関西医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Pain science / Basic Section 43020:Structural biochemistry-related / Basic Section 48040:Medical biochemistry-related Except Principal Investigator Pain science / Medium-sized Section 48:Biomedical structure and function and related fields / Basic Section 51010:Basic brain sciences-related
Keywords	Principal Investigator 痒み / GRPR / がん / 構造解析 / GluN2B / 脊髄 / NR2B / c-fos / NMDA受容体 / クライオ電子顕微鏡 … More / 抗体医薬 / 結晶構造解析 / 機能性抗体作製 / クライオ電顕 / GPCR / NMBR / Cryo EM SPA / 脳 / 全脳イメージング / NMDAR / 三叉神経 / 大槽内投与 / GRP … More Except Principal Investigator セロトニン / クロロキン / c-fos / シグナル伝達 / ヘテロ二量体 / オピオイド受容体 / 副作用 / オピオイド / 場所細胞 / 神経回路 / FLP リコンビナーゼ / Cre リコンビナーゼ / ウイルス / 遺伝子導入技術 / シナプス / 神経活動 / 細胞競合 / Cre / 神経細胞 / 遺伝子導入 / 海馬 / 遺伝子の戦い / 多光子励起顕微鏡 / 脊髄後角 / 痒みの神経機構 / 慢性掻痒モデル / in situハイブリダイゼーション / 蛍光タンパク / 三叉神経脊髄路核 / 起痒物質 / 痒みの伝達経路 / 末梢神経再生モデル / ビタミンD3アナログ / 神経障害性掻痒 / ビタミンD / ジニトロフルオロベンゼン / 発現解析 / 脳部位 / 伝達経路 / 慢性掻痒 / 痒み / 遺伝子改変マウス / 脊髄と延髄 / c-fosの発現 / NMDA受容体 / ガストリン放出ペプチド / 痒みの動物モデル / 大槽内投与 / 一次求心性線維 / arc / 三叉神経節 / 慢性掻痒動物モデル / 急性掻痒動物モデル / ガストリン遊離ペプチド / グルタミン酸受容体 / 痛覚 / 掻痒 / 動物モデル Less

慢性掻痒の創薬に向けた中枢痒み受容体GRPR、NMBRの構造基盤の解明Principal Investigator
- Principal Investigator
  
  井上明俊
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Kansai Medical University
Clarification of the signal transduction mechanism of hetero-dimerized opioid receptors that cause side effects of opioids
- Principal Investigator
  
  KOBAYASHI Takuya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Kansai Medical University
Structure-based analysis of the central itch receptors aiming at development of new medicine for chronic itch and cancerPrincipal Investigator
- Principal Investigator
  
  INOUE Akitoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kansai Medical University
Development of new gene transfer technology using novel strategy and verification of cellular competition hypothesis in adult hippocampus
- Principal Investigator
  
  KOHARA Keigo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51010:Basic brain sciences-related
- Research Institution
  Kansai Medical University
Studies on central mechanisms of acute and chronic itch and its network in the spinal cord
- Principal Investigator
  
  Ito Seiji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pain science
- Research Institution
  Osaka Medical College
  Kansai Medical University
Analysis of the brain circuit and mechanism for itch processingPrincipal Investigator
- Principal Investigator
  
  INOUE Akitoshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pain science
- Research Institution
  Kansai Medical University
Elucidation of itch mechanism by in vivo imaging of spinal dorsal horn with two-photon microscopy
- Principal Investigator
  
  ITO SEIJI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pain science
- Research Institution
  Kansai Medical University
Analysis of the molecular and neuronal mechanisms for chronic itch in the central nervous systemPrincipal Investigator
- Principal Investigator
  
  INOUE Akitoshi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pain science
- Research Institution
  Kansai Medical University

All 2024 2022 2021 2020 2017 2016

All Journal Article Presentation

[Journal Article] Interaction modes of human orexin 2 receptor with selective and nonselective antagonists studied by NMR spectroscopy2024
- Author(s)
  Imamura Kayo、Akagi Ken-Ichi、Miyanoiri Yohei、Tsujimoto Hirokazu、Hirokawa Takatsugu、Ashida Hideo、Murakami Kaori、Inoue Asuka、Suno Ryoji、Ikegami Takahisa、Sekiyama Naotaka、Iwata So、Kobayashi Takuya、Tochio Hidehito
- Journal Title
  
  Structure
  
  Volume: 32 Issue: 3 Pages: 352-361
- DOI
  10.1016/j.str.2023.12.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K05653, KAKENHI-PROJECT-23K05667, KAKENHI-PROJECT-20K06509, KAKENHI-PROJECT-21K19360, KAKENHI-PLANNED-19H05777, KAKENHI-PLANNED-21H05112, KAKENHI-PLANNED-21H05113, KAKENHI-PLANNED-22H05090, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-19H03428
[Journal Article] Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex2022
- Author(s)
  Ryoji Suno, Yukihiko Sugita, Kazushi Morimoto, Hiroko Takazaki, Hirokazu Tsujimoto, Mika Hirose, Chiyo Suno-Ikeda, Norimichi Nomura, Tomoya Hino, Asuka Inoue, Kenji Iwasaki, Takayuki Kato, So Iwata, Takuya Kobayashi
- Journal Title
  
  Cell Rep.
  
  Volume: 40(11) Issue: 11 Pages: 111323-111323
- DOI
  10.1016/j.celrep.2022.111323
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19360, KAKENHI-PLANNED-21H05112, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-19H03428, KAKENHI-PUBLICLY-22H04753, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-20H03434
[Journal Article] Cryo-EM structure of the human MT1-Gi signaling complex.2021
- Author(s)
  Okamoto, H. H., Miyauchi, H., Inoue, A., Raimondi, F., Tsujimoto, H., Kusakizako, T., Shihoya, W., Yamashita, K., Suno, R., Nomura, N., Kobayashi, T., Iwata, S., Nishizawa, T. and Nureki, O.
- Journal Title
  
  Nat. Struct. Mol. Biol.
  
  Volume: 28 Issue: 8 Pages: 694-701
- DOI
  10.1038/s41594-021-00634-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06294, KAKENHI-PLANNED-21H05112, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-19H03428, KAKENHI-PROJECT-21K19360, KAKENHI-PROJECT-20K15754, KAKENHI-PROJECT-22KJ0604, KAKENHI-PROJECT-21H05037, KAKENHI-PLANNED-19H05777
[Journal Article] Vibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R)2021
- Author(s)
  Katayama Kota、Suzuki Kohei、Suno Ryoji、Kise Ryoji、Tsujimoto Hirokazu、Iwata So、Inoue Asuka、Kobayashi Takuya、Kandori Hideki
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 1-10
- DOI
  10.1038/s42003-021-02836-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05440, KAKENHI-ORGANIZER-21H05111, KAKENHI-PLANNED-21H05112, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-19H03428, KAKENHI-PROJECT-21K19360, KAKENHI-PROJECT-21H04969, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-23K21097
[Journal Article] BATTLE: Genetically Engineered Strategies for Split-Tunable Allocation of Multiple Transgenes in the Nervous System2020
- Author(s)
  Kohara Keigo、Inoue Akitoshi、Nakano Yousuke、Hirai Hirokazu、Kobayashi Takuya、Maruyama Masato、Baba Ryosuke、Kawashima Chiho
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 6 Pages: 101248-101248
- DOI
  10.1016/j.isci.2020.101248
- NAID
  120006884902
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02521, KAKENHI-PROJECT-19K22583, KAKENHI-PROJECT-19H03534
[Journal Article] Protocol for BATTLE-1EX: A High-Resolution Imaging Method to Visualize Whole Synaptic Structures and their Components in the Nervous System2020
- Author(s)
  Inoue Akitoshi、Kobayashi Takuya、Hirai Hirokazu、Kanaya Noriko、Kohara Keigo
- Journal Title
  
  STAR Protocols
  
  Volume: 1 Issue: 3 Pages: 100166-100166
- DOI
  10.1016/j.xpro.2020.100166
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02521, KAKENHI-PROJECT-19K22583, KAKENHI-PROJECT-19H03534
[Journal Article] Multiple Signaling Pathways Coordinately Regulate Forgetting of Olfactory Adaptation through Control of Sensory Responses in Caenorhabditis elegans2017
- Author(s)
  Kitazono T, Hara-Kuge S, Matsuda O, Inoue A, Fujiwara M, Ishihara T
- Journal Title
  
  J Neurosci
  
  Volume: 37(42) Issue: 42 Pages: 10240-10251
- DOI
  10.1523/jneurosci.0031-17.2017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07503, KAKENHI-PLANNED-25115009, KAKENHI-PROJECT-16K19219, KAKENHI-PROJECT-17H06113
[Journal Article] Phosphorylation of NMDA receptor GluN2B subunit at Tyr1472 is important for trigeminal processing of itch.2016
- Author(s)
  Inoue A, Uchida H, Nakazawa T, Yamamoto T, Ito S.
- Journal Title
  
  Eur J Neurosci.
  
  Volume: 44 Issue: 7 Pages: 2474-2482
- DOI
  10.1111/ejn.13337
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01286, KAKENHI-PROJECT-16H05233, KAKENHI-PROJECT-26670291, KAKENHI-PROJECT-16K19219
[Presentation] 「遺伝子組換え酵素の戦い」と反発分離調節的な遺伝子発現を実現する新規の実験戦略2020
- Author(s)
  小原圭吾、井上昭俊、中野洋輔、平井宏和、小林拓也、丸山正人、雲財知、馬場亮輔、川島千穂
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19H03534
[Presentation] 痒みの神経伝達において NMDA 受容体 GluN2B サブユニットの Tyr1472 のリン酸化は重要である2017
- Author(s)
  井上明俊、中澤敬信、伊藤誠二
- Organizer
  第110回近畿生理学談話会
- Data Source
  KAKENHI-PROJECT-16K19219
[Presentation] 痒みの神経伝達においてNMDA受容体GluN2BサブユニットのTyr1472のリン酸化は重要である2017
- Author(s)
  井上明俊、中澤敬信、伊藤誠二
- Organizer
  第110回近畿生理学談話会
- Data Source
  KAKENHI-PROJECT-16H05233

1. 寿野良二 (60447521)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. ITO SEIJI (80201325)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 松村伸治 (70276393)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 西田和彦 (80448026)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KOHARA Keigo (60740917)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. KOBAYASHI Takuya (20311730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. Pham Minh・Vuong (50828853)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NGUYEN Huu Tu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. PHAM Minh Vuong

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. UCHIDA Hitoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NAKAZAWA Takanobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 今村香代

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 濡木理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 藤原学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 平井宏和

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 片山耕大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Inoue Akitoshi 井上 明俊

INOUE Akitoshi 井上 明俊

Research Projects

Research Products

Co-Researchers

慢性掻痒の創薬に向けた中枢痒み受容体GRPR、NMBRの構造基盤の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of the signal transduction mechanism of hetero-dimerized opioid receptors that cause side effects of opioids

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structure-based analysis of the central itch receptors aiming at development of new medicine for chronic itch and cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new gene transfer technology using novel strategy and verification of cellular competition hypothesis in adult hippocampus

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on central mechanisms of acute and chronic itch and its network in the spinal cord

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the brain circuit and mechanism for itch processingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of itch mechanism by in vivo imaging of spinal dorsal horn with two-photon microscopy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the molecular and neuronal mechanisms for chronic itch in the central nervous systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Interaction modes of human orexin 2 receptor with selective and nonselective antagonists studied by NMR spectroscopy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cryo-EM structure of the human MT1-Gi signaling complex.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R)2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BATTLE: Genetically Engineered Strategies for Split-Tunable Allocation of Multiple Transgenes in the Nervous System2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Protocol for BATTLE-1EX: A High-Resolution Imaging Method to Visualize Whole Synaptic Structures and their Components in the Nervous System2020

Inoue Akitoshi 井上明俊

INOUE Akitoshi 井上明俊