Isogawa Masanori 五十川正記

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ISOGAWA Masanori 五十川正記

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Researcher Number	50723201
Other IDs	https://orcid.org/0000-0001-8730-4303
Affiliation (Current)	2026: 国立健康危機管理研究機構, 国立感染症研究所ウイルス第二部, 部長
Affiliation (based on the past Project Information) *help	2025: 国立健康危機管理研究機構, ウイルス第二部, 部長 2023 – 2024: 国立感染症研究所, ウイルス第二部, 部長 2020 – 2023: 国立感染症研究所, 治療薬・ワクチン開発研究センター, 室長 2019: 名古屋市立大学, 医薬学総合研究院(医学), 講師 2016 – 2018: 名古屋市立大学, 大学院医学研究科, 助教 2014 – 2015: 名古屋市立大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Basic Section 49060:Virology-related
Keywords	Principal Investigator B型肝炎ウイルス / T細胞 / CD8+T細胞 / IFN / HBV / HBV特異的CD8+T細胞 / 獲得免疫 / A型肝炎ウイルス / I型IFN / 免疫寛容 … More / CD8+ T細胞 / hepatitis B virus / B型肝炎 / T細胞応答 / インターフェロン / 自然免疫 / CD8＋T細胞 / 活性化樹状細胞 / 抗原提示 … More Except Principal Investigator 慢性肝炎 / ジェノタイプ / ウイルス複製 / 肝細胞がん / B型肝炎ウイルス / 肝細胞癌 / 発癌 / chronic infection / HCC / Hepatitis B virus / 発ガン / 遺伝子型 / 動物モデル / マウスモデル / 慢性感染 / ウイルス発癌 / B型肝炎 / ウイルス Less

A型肝炎ウイルス(HAV)排除メカニズムの解明Principal Investigator
- Principal Investigator
  
  五十川正記
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Japan Institute for Health Security
Why genotype C HBV causes liver cancer more rapidly than other genotypes?
- Principal Investigator
  
  村松正道
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
  National Institute of Infectious Diseases
Analysis of the Significance and Mechanism of Type I Interferon Signaling Suppression in HBV-Specific CD8⁺ T CellsPrincipal Investigator
- Principal Investigator
  
  Isogawa Masanori
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  National Institute of Infectious Diseases
Regulation of Hepatitis B Virus-Specific T Cell Responses by Innate Immune ResponsePrincipal Investigator
- Principal Investigator
  
  Isogawa Masanori
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University
Induction of hepatitis B virus specific T cell responses by activating innate immune responsePrincipal Investigator
- Principal Investigator
  
  ISOGAWA Masanori
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University

All 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Differential regulation of calcium-NFAT signaling pathway by Akt isoforms: unraveling effector dynamics and exhaustion of cytotoxic T lymphocytes in tumor microenvironment2025
- Author(s)
  Chen Wen-Ling、Chang Yong-Lin、Lin Su-Fang、Protzer Ulrike、Isogawa Masanori、Yang Hung-Chih、Huang Li-Rung
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 13 Issue: 3 Pages: e009827-e009827
- DOI
  10.1136/jitc-2024-009827
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08313
[Journal Article] Exploring the tolerable region for HiBiT tag insertion in the hepatitis B virus genome2024
- Author(s)
  Murayama Asako、Igarashi Hitomi、Yamada Norie、Aly Hussein Hassan、Toyama Masaaki、Isogawa Masanori、Shimakami Tetsuro、Kato Takanobu
- Journal Title
  
  mSphere
  
  Volume: 9 Issue: 10 Pages: 00518-24
- DOI
  10.1128/msphere.00518-24
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08313, KAKENHI-PROJECT-20KK0178, KAKENHI-PROJECT-23K27581, KAKENHI-PROJECT-23K06575
[Journal Article] Highlights from the 2023 International Meeting on the Molecular Biology of Hepatitis B virus2024
- Author(s)
  HBV2023、Allweiss Lena、Isogawa Masanori、et. al.
- Journal Title
  
  Journal of General Virology
  
  Volume: 105 Issue: 5
- DOI
  10.1099/jgv.0.001978
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08313
[Journal Article] Therapeutic potential of co-signaling receptor modulation in hepatitis B2024
- Author(s)
  Andreata Francesco、Isogawa Masanori、et. al.
- Journal Title
  
  Cell
  
  Volume: 187 Issue: 15 Pages: 4078-4094.e21
- DOI
  10.1016/j.cell.2024.05.038
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08313, KAKENHI-PROJECT-20K17028
[Journal Article] HBV感染に対する免疫応答機構　ウイルス性肝炎学―最新の病態・診断・治療情報2023
- Author(s)
  4.五十川正記
- Journal Title
  
  日本臨牀
  
  Volume: 81巻増刊号 Pages: 271-275
- Data Source
  KAKENHI-PROJECT-20K08313
[Journal Article] SARS-CoV-2 Omicron-neutralizing memory B-cells are elicited by two doses of BNT162b2 mRNA vaccine.2022
- Author(s)
  Kotaki R, Adachi Y, Moriyama S, Onodera T, Fukushi S, Nagakura T, Tonouchi K, Terahara K, Sun L, Takano T, Nishiyama A, Shinkai M, Oba K, Nakamura-Uchiyama F, Shimizu H, Suzuki T, Matsumura T, Isogawa M, Takahashi Y.
- Journal Title
  
  Sci Immunol.
  
  Volume: - Issue: 70
- DOI
  10.1126/sciimmunol.abn8590
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07520, KAKENHI-PROJECT-20K08313
[Journal Article] Droplet digital PCR assay provides intrahepatic HBV?cccDNA quantification tool for clinical application2022
- Author(s)
  Hayashi Sanae、Isogawa Masanori、Kawashima Keigo、Ito Kyoko、Chuaypen Natthaya、Morine Yuji、Shimada Mitsuo、Higashi-Kuwata Nobuyo、Watanabe Takehisa、Tangkijvanich Pisit、Mitsuya Hiroaki、Tanaka Yasuhito
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 2133-2133
- DOI
  10.1038/s41598-022-05882-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08313, KAKENHI-PROJECT-20K16996, KAKENHI-PROJECT-21K07904
[Journal Article] Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variants2021
- Author(s)
  Moriyama Saya、Adachi Yu、Sato Takashi、Fujimoto Tsuguto、Maeda Ken、Ohnishi Makoto、Wakita Takaji、Suzuki Tadaki、Takahashi Yoshimasa
- Journal Title
  
  Immunity
  
  Volume: 54 Issue: 8 Pages: 1841-1852
- DOI
  10.1016/j.immuni.2021.06.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08175, KAKENHI-PROJECT-20K08313
[Journal Article] HBV-Specific CD8+ T-Cell Tolerance in the Liver2021
- Author(s)
  Baudi Ian、Kawashima Keigo、Isogawa Masanori
- Journal Title
  
  Frontiers in immunology
  
  Volume: 12 Pages: 721975-721975
- DOI
  10.3389/fimmu.2021.721975
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17028, KAKENHI-PROJECT-20K08313
[Journal Article] Restoration of type I interferon signaling in intrahepatically primed CD8+ T cells promotes functional differentiation2021
- Author(s)
  Kawashima Keigo、Isogawa Masanori、Onishi Masaya、Baudi Ian、Saito Satoru、Nakajima Atsushi、Fujita Takashi、Tanaka Yasuhito
- Journal Title
  
  JCI Insight
  
  Volume: 6 Issue: 3
- DOI
  10.1172/jci.insight.145761
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08313, KAKENHI-PROJECT-20K17028
[Journal Article] Interferon signaling suppresses the unfolded protein response and induces cell death in hepatocytes accumulating hepatitis B surface antigen2021
- Author(s)
  Baudi Ian、Isogawa Masanori、Moalli Federica、Onishi Masaya、Kawashima Keigo、Ishida Yuji、Tateno Chise、Sato Yusuke、Harashima Hideyoshi、Ito Hiroyasu、Ishikawa Tetsuya、Wakita Takaji、Iannacone Matteo、Tanaka Yasuhito
- Journal Title
  
  PLOS Pathogens
  
  Volume: 17 Issue: 5 Pages: e1009228-e1009228
- DOI
  10.1371/journal.ppat.1009228
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17028, KAKENHI-PROJECT-20K08313
[Journal Article] HBVに対する宿主免疫応答2020
- Author(s)
  五十川正記
- Journal Title
  
  Farumashia
  
  Volume: 56 Issue: 12 Pages: 1089-1093
- DOI
  10.14894/faruawpsj.56.12_1089
- NAID
  130007948619
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-20K08313
[Journal Article] Inhibitory Effect of a Human MicroRNA, miR-6133-5p, on the Fibrotic Activity of Hepatic Stellate Cells in Culture2020
- Author(s)
  Hamada-Tsutsumi Susumu、Onishi Masaya、Matsuura Kentaro、Isogawa Masanori、Kawashima Keigo、Sato Yusuke、Tanaka Yasuhito
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 19 Pages: 7251-7251
- DOI
  10.3390/ijms21197251
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09435, KAKENHI-PROJECT-20K08313, KAKENHI-PROJECT-20K08314, KAKENHI-PROJECT-20K17028, KAKENHI-PROJECT-19H03640
[Journal Article] Mechanisms of HBV immune evasion2020
- Author(s)
  Kuipery Adrian、Gehring Adam J.、Isogawa Masanori
- Journal Title
  
  Antiviral Research
  
  Volume: 179 Pages: 104816-104816
- DOI
  10.1016/j.antiviral.2020.104816
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08313
[Journal Article] 7-Deaza-7-fluoro modification confers on 4′-cyano-nucleosides potent activity against entecavir/adefovir-resistant HBV variants and favorable safety2020
- Author(s)
  Hayashi Sanae、Higashi-Kuwata Nobuyo、Das Debananda、Tomaya Kota、Yamada Kohei、Murakami Shuko、Venzon David J.、Hattori Shin-ichiro、Isogawa Masanori、Sarafianos Stefan G.、Mitsuya Hiroaki、Tanaka Yasuhito
- Journal Title
  
  Antiviral Research
  
  Volume: 176 Pages: 104744-104744
- DOI
  10.1016/j.antiviral.2020.104744
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08313
[Journal Article] The antiviral effects of human microRNA miR-302c-3p against hepatitis B virus infection2019
- Author(s)
  Hamada-Tsutsumi Susumu、Naito Yutaka、Sato Seiichi、Takaoka Akinori、Kawashima Keigo、Isogawa Masanori、Ochiya Takahiro、Tanaka Yasuhito
- Journal Title
  
  Alimentary Pharmacology & Therapeutics
  
  Volume: 49 Issue: 8 Pages: 1060-1070
- DOI
  10.1111/apt.15197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09436
[Journal Article] Designing a therapeutic hepatitis B vaccine to circumvent immune tolerance2019
- Author(s)
  Whitacre DC、Peters CJ、Sureau C、Nio K、Li F、Su L、Jones JE、Isogawa M、Sallberg M、Frelin L、Peterson DL、Milich DR
- Journal Title
  
  Human Vaccines & Immunotherapeutics
  
  Volume: 16 Issue: 2 Pages: 251-268
- DOI
  10.1080/21645515.2019.1689745
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09436
[Journal Article] Small Interfering RNA Screening for the Small GTPase Rab Proteins Identifies Rab5B as a Major Regulator of Hepatitis B Virus Production2019
- Author(s)
  Inoue Jun、Ninomiya Masashi、Umetsu Teruyuki、Nakamura Takuya、Kogure Takayuki、Kakazu Eiji、Iwata Tomoaki、Takai Satoshi、Sano Akitoshi、Fukuda Mitsunori、Watashi Koichi、Isogawa Masanori、Tanaka Yasuhito、Shimosegawa Tooru、McNiven Mark A.、Masamune Atsushi
- Journal Title
  
  Journal of Virology
  
  Volume: 93 Issue: 15
- DOI
  10.1128/jvi.00621-19
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08385, KAKENHI-PROJECT-17K09436, KAKENHI-PROJECT-17H04085
[Journal Article] Functional cureをめざすB型肝炎治療の近未来2019
- Author(s)
  五十川正記, 田中靖人
- Journal Title
  
  医学のあゆみ
  
  Volume: 268(4) Pages: 282-3
- Data Source
  KAKENHI-PROJECT-17K09436
[Journal Article] なぜHBV排除は困難なのか2018
- Author(s)
  五十川正記, 田中靖人
- Journal Title
  
  Mebio
  
  Volume: 35 Pages: 4-13
- Data Source
  KAKENHI-PROJECT-17K09436
[Journal Article] Type I Interferon Signaling Prevents Hepatitis B Virus-Specific T Cell Responses by Reducing Antigen Expression2018
- Author(s)
  Kawashima Keigo, Isogawa Masanori, Hamada-Tsutsumi Susumu, Baudi Ian, Saito Satoru, Nakajima Atsushi, Tanaka Yasuhito
- Journal Title
  
  Journal of Virology
  
  Volume: 92 (23) Issue: 23 Pages: 01099-18
- DOI
  10.1128/jvi.01099-18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09436, KAKENHI-PROJECT-16H05288
[Journal Article] An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People2018
- Author(s)
  Hayashi Sanae, Khan Anis, Simons Brenna C., Homan Chriss, Matsui Takeshi, Ogawa Kenji, Kawashima Keigo, Murakami Shuko, Takahashi Satoru, Isogawa Masanori, Ikeo Kazuho, Mizokami Masashi, McMahon Brian J., Tanaka Yasuhito
- Journal Title
  
  Hepatology
  
  Volume: 69 (1) Issue: 1 Pages: 19-33
- DOI
  10.1002/hep.30111
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436
[Journal Article] B型肝炎に対する免疫治療の展望2018
- Author(s)
  五十川正記, 田中靖人
- Journal Title
  
  Medical Science Digest
  
  Volume: 44(7) Pages: 344-49
- Data Source
  KAKENHI-PROJECT-17K09436
[Journal Article] Intrahepatic Cross-Presentation and Hepatocellular Antigen Presentation Play Distinct Roles in the Induction of HBV-Specific CD8+ T Cell Responses2018
- Author(s)
  Murata Yasuhiro, Kawashima Keigo, Sheikh Knvul, Tanaka Yasuhito, Isogawa Masanori
- Journal Title
  
  Journal of Virology
  
  Volume: 92 (21) Issue: 21 Pages: 00920-18
- DOI
  10.1128/jvi.00920-18
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436, KAKENHI-PROJECT-16H05288
[Journal Article] A new class of hepatitis B and D virus entry inhibitors, proanthocyanidin and its analogs, that directly act on the viral large surface proteins.2017
- Author(s)
  Tsukuda S, Watashi K, Hojima T, Isogawa M, Iwamoto M, Omagari K, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Sureau C, Wakita T
- Journal Title
  
  Hepatology
  
  Volume: 65 Issue: 4 Pages: 1104-1116
- DOI
  10.1002/hep.28952
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J03185, KAKENHI-PROJECT-26461015, KAKENHI-PROJECT-16K19145, KAKENHI-PROJECT-26460565
[Journal Article] Molecular epidemiology of co-infection with hepatitis B virus and human immunodeficiency virus (HIV) among adult patients in Harare, Zimbabwe2017
- Author(s)
  Baudi I, Iijima S, Chin'ombe N, Mtapuri-Zinyowera S, Murakami S, Isogawa M, Hachiya A, Iwatani Y, and Tanaka Y
- Journal Title
  
  Journal of Medical Virology
  
  Volume: 89 Issue: 2 Pages: 257-266
- DOI
  10.1002/jmv.24641
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04740, KAKENHI-PROJECT-16H05288, KAKENHI-PROJECT-26461015, KAKENHI-PROJECT-16K09366
[Journal Article] 新規核酸アナログ4'-C-cyano-2-amino-2'-deoxyadenosine、4'-C-cyano-2'-deoxyguanosineは薬剤耐性B型肝炎ウイルス変異株に対して有効である.2016
- Author(s)
  林佐奈衣, 高松悠樹, 前田賢次, 村上周子, 尾曲克己, 松居剛志, 五十川正記, 渡邊綱正, 狩野吉康, 向後悟, 満屋裕明, 田中靖人.
- Journal Title
  
  肝臓
  
  Volume: 57(6) Pages: 299-301
- NAID
  130005160949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461015
[Journal Article] Host genetic variants influencing the clinical course of Hepatitis B virus infection.2016
- Author(s)
  Matsuura K, Isogawa M, Tanaka Y.
- Journal Title
  
  J Med Virol.
  
  Volume: 88(3) Issue: 3 Pages: 371-9
- DOI
  10.1002/jmv.24350
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461015
[Journal Article] Ｂ型肝炎治療不応例における新規Entecavir耐性変異（rtA186T）の同定.2016
- Author(s)
  林佐奈衣, 村上周子, 尾曲克己, 松居剛志, 飯尾悦子, 五十川正記, 渡邊綱正, 狩野吉康, 田中靖人.
- Journal Title
  
  NAGOYA MEDICAL JOURNAL（名古屋市立大学医学会雑誌）
  
  Volume: 55(1) Pages: 35-42
- Data Source
  KAKENHI-PROJECT-26461015
[Journal Article] Host-virus interactions in hepatitis B virus infection.2015
- Author(s)
  Guidotti LG, Isogawa M, Chisari FV.
- Journal Title
  
  Curr Opin Immunol.
  
  Volume: 36 Pages: 61-6
- DOI
  10.1016/j.coi.2015.06.016
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461015
[Journal Article] Immunosurveillance of the liver by intravascular effector CD8(+) T cells.2015
- Author(s)
  Guidotti LG, Inverso D, Sironi L, Di Lucia P, Fioravanti J, Ganzer L, Fiocchi A, Vacca M, Aiolfi R, Sammicheli S, Mainetti M, Cataudella T, Raimondi A, Gonzalez-Aseguinolaza G, Protzer U, Ruggeri ZM, Chisari FV, Isogawa M, Sitia G, Iannacone M.
- Journal Title
  
  Cell
  
  Volume: 161(3) Issue: 3 Pages: 486-500
- DOI
  10.1016/j.cell.2015.03.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461015
[Journal Article] Immunobiology of hepatitis B virus infection.2015
- Author(s)
  Isogawa M, Tanaka Y.
- Journal Title
  
  Hepatology Research
  
  Volume: 45 Issue: 2 Pages: 179-189
- DOI
  10.1111/hepr.12439
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461015
[Journal Article] Characterization of novel entecavir resistance mutations.2015
- Author(s)
  Hayashi S, Murakami S, Omagari K, Matsui T, Iio E, Isogawa M, Watanabe T, Karino Y, Tanaka Y.
- Journal Title
  
  J Hepatol.
  
  Volume: 63(3) Issue: 3 Pages: 546-53
- DOI
  10.1016/j.jhep.2015.03.020
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461015, KAKENHI-PROJECT-25293176
[Presentation] Distinct Localization of Cytotoxic and Cytokine-producing CD8+ T Cells in the Liver during OX40-mediated Virus Inactivation.2025
- Author(s)
  Masanori Isogawa
- Organizer
  U.S.-Japan Cooperative Medical Sciences Program (USJCMSP) 25th International Conference on Emerging Infectious Diseases (EID) in the Pacific Rim. March 11-15, 2025
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08313
[Presentation] Cathepsin F is required for HBV/HDV entry2024
- Author(s)
  Mahmoud A.A, Hussein S.A, Gad S.A,Kamal E, Kato T, Murayama A, Shoji I, Isogawa M, Wakita T, Moi M.L, Aly H.H
- Organizer
  Japanese Society of Virology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08313
[Presentation] Profiling viral integration in HBV-HCC by RAISING-sequencing2024
- Author(s)
  Fukano K, Wakae K, Nao N, Tsubota A, Saito M, Toyoshima T, Kudo H, Aizaki H, Hosomichi K, Matsudaira T, Kimura M, Watashi K, Isogawa M, Sugiura W, Muramatsu M
- Organizer
  2024 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24142
[Presentation] Role of lipid droplet accumulation in HBV-HCC development.2024
- Author(s)
  Ryuta Ueda, Kosho Wakae, Haruyo Aoyagi, Kento Fukano, Masaya Sugiyama, Tsunekazu Oikawa, Naganori Nao, Noritomo Shimada, Keizo Kato, Kazuyoshi Hosomichi, Toru Ikegami, Akihito Tsubota, Hiroko Iijima, Masamichi Muramatsu, Masanori Isogawa, Hiroshi Yotsuyanagi, Takaji Wakita, Hideki Aizaki
- Organizer
  日台韓 HBV Research Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08313
[Presentation] The permissible region for HiBiT tag Insertion in HBV genome.2024
- Author(s)
  Asako Murayama, Hitomi Igarashi,Norie Yamada, Hussein H. Aly, Masaaki Toyama, Masanori Isogawa, Tetsuro Shimakami, Takanobu Kato
- Organizer
  2024 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08313
[Presentation] Profiling viral integration in HBV-HCC by RAISING-sequencing2024
- Author(s)
  Kento Fukano, Kousho Wakae, Naganori Nao, Akihito Tsubota, Masumichi Saito, Takae Toyoshima, Haruka Kudo,Hideki Aizaki, Kazuyoshi Hosomichi, Takahiro Matsudaira, Moto Kimura, Koichi Watashi, Masanori Isogawa, Wataru Sugiura1, Masamichi Muramatsu
- Organizer
  2024 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08313
[Presentation] Role of lipid droplet accumulation in HBV-HCC development2024
- Author(s)
  Ryuta Ueda, Kosho Wakae, Haruyo Aoyagi, Kento Fukano, Masaya Sugiyama, Tsunekazu Oikawa, Naganori Nao, Noritomo Shimada, Keizo Kato, Kazuyoshi Hosomichi, Toru Ikegami, Akihito Tsubota, Hiroko Iijima, Masamichi Muramatsu, Masanori Isogawa, Hiroshi Yotsuyanagi, Takaji Wakita, Hideki Aizaki
- Organizer
  10th JAPAN-TAIWAN-KOREA HBV Research Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24142
[Presentation] Mechanisms of HBV immune evasion,2023
- Author(s)
  Masanori Isogawa
- Organizer
  The 32nd Conference of the Asian Pacific Association for the Study of the Liver (APASL 2023)
- Data Source
  KAKENHI-PROJECT-20K08313
[Presentation] Spatial transcriptomic atlas of cytokine-producing and cytolytic HBV-specific CD8+ T cells in the liver after OX40 stimulation.2023
- Author(s)
  7.Kawashima K, Onishi M,Iannacone M, Suzuki Y, Tanaka Y, Isogawa M
- Organizer
  2023 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08313
[Presentation] OX40 stimulation of HBV-specific CD8+ T cells achieves long-term HBV suppression in a transgenic mouse model2022
- Author(s)
  Keigo Kawashima, Masanori Isogawa, Masaya Onishi, Matteo Iannacone, Yasuhito Tanaka
- Organizer
  2022 International HBV Meeting (Paris, France)
- Data Source
  KAKENHI-PROJECT-20K08313
[Presentation] T cell responses against HBV2022
- Author(s)
  Isogawa M
- Organizer
  The 31st Conference of the Asian Pacific Association for the Study of the Liver
- Invited
- Data Source
  KAKENHI-PROJECT-20K08313
[Presentation] The impact of antigen recognition in the liver on hepatitis B virus-specific CD8+ T cells2022
- Author(s)
  Masanori Isogawa
- Organizer
  Westin Immunogenicity Seminar 2022
- Data Source
  KAKENHI-PROJECT-20K08313
[Presentation] B型肝炎と免疫2021
- Author(s)
  五十川正記
- Organizer
  School of Hepatology 2021 in Awaji Island
- Invited
- Data Source
  KAKENHI-PROJECT-20K08313
[Presentation] Functional cure を目指したOX40刺激によるHBV特異的CD8+T細胞の賦活化2021
- Author(s)
  五十川正記, 河島圭吾 ,田中靖人
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-20K08313
[Presentation] Hypernutrition Exacerbates Chronic Hepatitis B and Facilitates HCC Development in Association with Type I Interferon Signaling Activation2021
- Author(s)
  Isogawa M, Onishi M, Kawashima K, Baudi I, Tanaka Y
- Organizer
  Global Hepatitis Summit
- Data Source
  KAKENHI-PROJECT-20K08313
[Presentation] OX40 stimulation of HBV-specific CD8+ T cells achieves long-term HBs suppression2021
- Author(s)
  Isogawa M, Kawashima K, Tanaka Y
- Organizer
  Japan Digestive Diseases Week 2021
- Data Source
  KAKENHI-PROJECT-20K08313
[Presentation] IFNαはHBs抗原を蓄積する肝細胞内の小胞体ストレス反応を減弱させ細胞死を誘導する2020
- Author(s)
  五十川正記, 田中靖人
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-20K08313
[Presentation] HBV特異的CD8+T細胞のOX40シグナル刺激による持続的なHBs抗原抑制2020
- Author(s)
  五十川正記, 河島圭吾, 田中靖人
- Organizer
  第28回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-20K08313
[Presentation] Suppression of intrahepatic hepatitis B surface antigen (HBsAg) prevents interferon mediated liver injury2020
- Author(s)
  Baudi I, Isogawa M, Kawashima K, Tanaka Y
- Organizer
  The Liver Meeting Digital Experience, American Association for the Study of Liver Diseases
- Data Source
  KAKENHI-PROJECT-20K08313
[Presentation] Type 1 IFN signaling suppresses the unfolded protein response and induces ER stress-associated cell death2020
- Author(s)
  Isogawa M
- Organizer
  U.S.-Japan Cooperative Medical Sciences Program (USJCMSP) Hepatitis Panel Mini-symposium on Animal Models for Hepatitis Virus Infections
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08313
[Presentation] IFNα directly induces apoptosis in hepatocytes that accumulate hepatitis B large S proteins2019
- Author(s)
  Baudi I, Isogawa M, Kawashima K, Tanaka Y
- Organizer
  APASL Single Topic Conference in Tokyo “Liver Immunology and Genetics”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] OX40 signaling activation selectively differentiates CD8 T cells recognizing HBV antigens in the liver2019
- Author(s)
  Kawashima K，Isogawa M，Onishi M，Tanaka Y
- Organizer
  2019 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] OX40シグナル刺激によるHBV排除の試み～HBV特異的CD8+T細胞の選択的活性化～2019
- Author(s)
  河島圭吾, 五十川正記, 田中靖人
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] 肝臓内インターフェロンシグナル活性化によるHBV排除の試み2019
- Author(s)
  河島圭吾, 五十川正記, 大西雅也, 田中靖人
- Organizer
  第29回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] The role of intrahepatic type I interferon signaling in HBV-specific T cell responses2019
- Author(s)
  Isogawa M
- Organizer
  APASL Single Topic Conference in Tokyo “Liver Immunology and Genetics”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] The role of intrahepatic type I interferon signaling in HBV-specific T cell responses2019
- Author(s)
  Kawashima K, Isogawa M, Saito S, Nakajima A, Tanaka Y
- Organizer
  APASL Single Topic Conference in Tokyo “Liver Immunology and Genetics”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] 14.Potential role of unfolded protein responses in IFN-mediated liver injury during HBV infection2019
- Author(s)
  Baudi I, Isogawa M, Kawashima K, Tanaka Y
- Organizer
  The 70th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] HBV排除における肝臓内インターフェロンシグナル誘導の重要性2018
- Author(s)
  河島圭吾, 五十川正記, 田中靖人
- Organizer
  第54回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] A Novel Association Between Core Mutations in Hepatitis B Virus Genotype F1b and HCC in Alaskan Native People2018
- Author(s)
  Hayashi S, Khan A, Simons BC, Homan C, Matsui T, Ogawa K, Kawashima K, Murakami S, Takahashi S, Isogawa M, Ikeo K, Mizokami M, McMahon BJ, Tanaka Y
- Organizer
  APASL Single Topic Conference on HCC
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] Akt signaling triggers expansion of intrahepatic effector CD8+ T cells and drives protective immunity against persistent HBV infection2018
- Author(s)
  Huang LR, Chen YJ, Hsu SC, Hsu DW, Pong CY, Su YC, Knolle P, Isogawa M
- Organizer
  The 2018 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] Activation of type I interferon signaling is required for the induction of functional HBV-specific CD8 T cells2018
- Author(s)
  Kawashima K，Isogawa M，Saito S，Nakajima A，Tanaka Y
- Organizer
  The 2018 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] Highly accurate quantification of intrahepatic Hepatitis B virus cccDNA by droplet digital PCR2018
- Author(s)
  Hayashi S，Ito K，Isogawa M，Tanaka Y，Kawashima K
- Organizer
  The 2018 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] Type I interferon signaling prevents hepatitis B virus-specific T cell responses by reducing antigen expression2018
- Author(s)
  Kawashima K, Isogawa M, Tsutsumi S, Saito S, Nakajima A, Tanaka Y
- Organizer
  Taiwan-Japan-Korea HBV Research Symposium 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] ヒト肝細胞キメラマウスを用いた長期CFCP投与による抗HBV効果～cccDNAは低下するか？～2018
- Author(s)
  林佐奈衣, 鍬田伸好, 熊本浩樹, 村上周子, 尾曲克己, 五十川正記, 前田賢次, 満屋裕明, 田中靖人
- Organizer
  第28回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] Critical role of hepatic antigen presentation in the expansion of hepatitis B virus-specific CD8+ T cells2018
- Author(s)
  Isogawa M
- Organizer
  2018 US-Japan Hepatitis Panel Meeting,
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] HBV特異的CD8+T細胞応答誘導における肝細胞の役割2018
- Author(s)
  五十川正記, 村田泰洋, 田中靖人
- Organizer
  第32回肝類洞壁細胞研究会学術集会
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] Intrahepatic Stimulation of RIG-I Like Receptors (RLR) Induces HBV-Specific Cytotoxic T Cell Responses and Suppresses HBV Gene Expression2017
- Author(s)
  Isogawa M, Kawashima K, Tanaka Y
- Organizer
  5th JAPAN-TAIWAN-KOREA HBV Research Symposium 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] I型インターフェロンはHBV Large S 抗原を蓄積した肝細胞の細胞死を誘導する2017
- Author(s)
  五十川正記, 河島圭吾, 田中靖人
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] Accumulation of the Large Hepatitis B Surface Antigen Predisposes Hepatocytes to IFNα Mediated Cell Death2017
- Author(s)
  Baudi I, Isogawa M, Kawashima K, Tanaka Y
- Organizer
  The 68th Annual Meeting of the American Association for the Study of Liver Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] 肝臓内HBV特異的CD8+T細胞応答はI型インターフェロンシグナルにより制御される2017
- Author(s)
  河島圭吾, 五十川正記, 田中靖人
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] Type 1 Interferon Signaling Induces Cell Death in Hepatocytes That Accumulate the Large Hepatitis B Surface Antigen2017
- Author(s)
  Baudi I, Isogawa M, Kawashima K, Tanaka Y
- Organizer
  The 2017 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] Reduction of Hepatitis B Virus (HBV) Gene Expression in the Liver Induces Functional HBV-specific CD8 T Cell Responses without Liver Disease2017
- Author(s)
  Kawashima K, Isogawa M, Tanaka Y
- Organizer
  5th JAPAN-TAIWAN-KOREA HBV Research Symposium 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] I型インターフェロンシグナルは肝臓内HBV特異的CD8+T細胞応答を阻害する2017
- Author(s)
  河島圭吾, 五十川正記, 田中靖人
- Organizer
  第103回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] 肝臓内RIG-I Like Receptors（RLR）刺激によるB型肝炎ウイルス（HBV）特異的CD8+T細胞応答の誘導,2017
- Author(s)
  五十川正記, 河島圭吾, 田中靖人
- Organizer
  第42回日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] Entecavirよりも持続的かつ強力に抗HBV活性を有する新規核酸アナログCFCPの同定2017
- Author(s)
  林佐奈衣, 鍬田伸好, 熊本浩樹, 村上周子, 尾曲克己, 五十川正記, 前田賢次, 満屋裕明, 田中靖人
- Organizer
  第27回抗ウイルス療法学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] Type I interferon signaling prevents hepatitis B virus-specific T cell responses2017
- Author(s)
  Kawashima K, Isogawa M, Tsutsumi S, Saito S, Nakajima A, Tanaka Y
- Organizer
  The 2017 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] 肝臓内RIG-I Like Receptors (RLR)刺激による効率的なHBV抑制2017
- Author(s)
  河島圭吾, 五十川正記, 田中靖人
- Organizer
  第27回抗ウイルス療法学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] Hepatitis B Virus-specific T Cell Responses Are Regulated by Type I Interferon Signaling and Correlated with Intrahepatic Antigen Expression2017
- Author(s)
  Kawashima K, Isogawa M, Hamada-Tsutsumi S, Saito S, Tanaka Y
- Organizer
  The 68th Annual Meeting of the American Association for the Study of Liver Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] Hepatocytes Retaining the Large Hepatitis B Surface Antigen (LHBs) are Susceptible to the Cytotoxic Effect of Type I Interferons2017
- Author(s)
  Isogawa M，Baudi I，Kawashima K，Tanaka Y
- Organizer
  第65回日本ウイルス学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09436
[Presentation] Proanthocyanidin and its analogs are new class of HBV and HDV entry inhibitors that target the viral preS1 region2016
- Author(s)
  Tsukuda S, Watashi K, Hojima T, Isogawa M, Iwamoto M, Suzki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Wakita T
- Organizer
  2016 International HBV Meeting on the Molecular Biology of Hepatitis B Viruses
- Place of Presentation
  Centennial Concert Hall, Yonsei University, Korea, Seoul
- Year and Date
  2016-09-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] Hepatitis B virus (HBV) antigen suppression prevents HBV-specific CD8 T cell exhaustion2016
- Author(s)
  Kawashima K, Isogawa M, Saito S, Nakajima A, Tanaka Y
- Organizer
  Asian Pacific Digestive Week 2016 (APDW 2016)
- Place of Presentation
  Kobe Convention Center (International Exhibition Center), Hyogo, Kobe
- Year and Date
  2016-11-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] Host and viral determinants for differential hepatitis B virus clearance between genotypes2016
- Author(s)
  Kawashima K, Isogawa M, Tsutsumi S, Murakami S, Saito S, Nakajima A, Tanaka Y. 25th Conference of the Asian Pasific Association for the Study of the Liver (APASL2016), 2016/2/
- Organizer
  25th Conference of the Asian Pasific Association for the Study of the Liver (APASL2016)
- Place of Presentation
  International Convention Center Pamir, Tokyo, Japan
- Year and Date
  2016-02-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] Endogenous antigen presentation by hepatocytes plays an essential role in the induction of HBV-specific CD8+ T cell responses2016
- Author(s)
  Isogawa M, Murata Y, Kawashima K, Tanaka Y
- Organizer
  4th Taiwan-Korea-Japan Research Symposium on Hepatitis B Virus
- Place of Presentation
  Academia Sinica, Taiwan, Taipei
- Year and Date
  2016-04-09
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] Hepatocellular carcinoma-associated core N51H mutation with BCP PC mutations in HBV genotype F1b enhances infectivity and up-regulates C-Myc and GAB22016
- Author(s)
  Hayashi S, Khan AA, Ogawa K, Kawashima K, Simons-Petrusa B, Homan CE, McMahon BJ, Murakami S, Iijima S, Isogawa M, Watanabe T, Tanaka Y
- Organizer
  The 67th Annual Meeting of the American Association for the Study of Liver Diseases(AASLD2016)
- Place of Presentation
  John B. Hynes Veterans Memorial Convention Center, The United States of America, Boston,
- Year and Date
  2016-11-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] 異なるHBV遺伝子型によるHBV抗原遷延化率の違い～肝臓内CD8+T細胞応答およびコア抗原発現量の相関性2016
- Author(s)
  河島圭吾, 五十川正記, 堤進, 村上周子, 斉藤聡, 中島淳, 田中靖人
- Organizer
  第52回日本肝臓学会総会
- Place of Presentation
  東京ベイ幕張ホール, 千葉,千葉
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] Suppression of the hepatitis B virus (HBV) antigen expression in the liver prevents HBV-specific CD8 T cell exhaustion2016
- Author(s)
  Kawashima K, Isogawa M, Saito S, Nakajima A, Tanaka Y
- Organizer
  2016 International HBV Meeting on the Molecular Biology of Hepatitis B Viruses
- Place of Presentation
  Centennial Concert Hall, Yonsei University, Korea, Seoul
- Year and Date
  2016-09-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] The hepatitis B virus (HBV) core antigen expression level determines the rate of CD8 T cell mediated viral clearance2016
- Author(s)
  Isogawa M, Kawashima K, Tsutsumi S, Tanaka Y
- Organizer
  The 67th Annual Meeting of the American Association for the Study of Liver Diseases(AASLD2016)
- Place of Presentation
  John B. Hynes Veterans Memorial Convention Center, The United States of America, Boston,
- Year and Date
  2016-11-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] Novel 4'-modified nucleoside analogs,CAdA and CdG，strongly suppress the replication of wild-type hepatitis B virus and drug-resistant mutants2016
- Author(s)
  Hayashi S, Takamatsu Y, Maeda K, Murakami S, Omagari K, Matsui T, Isogawa M, Watanabe T, Karino Y, Kohgo S, Mitsuya H, Tanaka Y
- Organizer
  2016 International HBV Meeting on the Molecular Biology of Hepatitis B Viruses
- Place of Presentation
  Centennial Concert Hall, Yonsei University, Korea, Seoul
- Year and Date
  2016-09-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] Novel 4'-modified nucleoside analogs exert antiviral replication against hepatitis B virus with drug resistance mutations2016
- Author(s)
  Hayashi S, Takamatsu Y, Maeda K, Murakami S, Omagari K, Matsui T, Isogawa M, Watanabe T, Karino Y, Kohgo S, Mitsuya H, Tanaka Y
- Organizer
  25th Conference of the Asian Pasific Association for the Study of the Liver (APASL2016)
- Place of Presentation
  International Convention Center Pamir, Tokyo, Japan
- Year and Date
  2016-02-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] 肝臓内HBV抗原抑制によるHBV特異的エフェクターCD8＋T細胞応答の誘導2016
- Author(s)
  河島圭吾, 五十川正記, 田中靖人
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル, 東京, 新宿
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] Retinoic acid inducible gene-I like receptors (RLRs) stimulation suppresses hepatitis B virusn (HBV) replication and induces cytotolytic ability of HBV-specific CD8 T cells more efficiently than Toll like receptor 3 stimulation2016
- Author(s)
  Kawashima K, Isogawa M, Tanaka Y
- Organizer
  2016 International HBV Meeting on the Molecular Biology of Hepatitis B Viruses
- Place of Presentation
  Centennial Concert Hall, Yonsei University, Korea, Seoul
- Year and Date
  2016-09-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] B型肝炎ウイルス（HBV）抗原抑制による機能的なHBV特異的CD8+T細胞応答の誘導2016
- Author(s)
  五十川正記, 河島圭吾, 田中靖人
- Organizer
  第52回日本肝臓学会総会
- Place of Presentation
  ホテルニューオータニ幕張, 千葉,千葉
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] Silencing hepatitis B virus (HBV) gene expression in the liver by RNAi prevents HBV-specific CD8 T cell exhaustion2016
- Author(s)
  Kawashima K, Isogawa M, Saito S, Tanaka Y
- Organizer
  The 67th Annual Meeting of the American Association for the Study of Liver Diseases(AASLD2016)
- Place of Presentation
  John B. Hynes Veterans Memorial Convention Center, The United States of America, Boston,
- Year and Date
  2016-11-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] Hepatocellular carcinoma-associated core N51H mutation enhances infectivity of hepatitis B virus genotype F1b by facilitating dimerization of the core protein2015
- Author(s)
  Hayashi S, Khan A, Ogawa K, Kawashima K, Simons B, Jones C, Homan C, McMahon B, Murakami S, Iijima S, Isogawa M, Watanabe T, Tanaka Y
- Organizer
  2015 International Meeting on the Molecular Biology of Hepatitis B Viruses
- Place of Presentation
  Dolce Bad Nauheim, Germany
- Year and Date
  2015-10-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] 新規エンテカビル耐性株の同定とその特徴2015
- Author(s)
  林佐奈衣, 村上周子, 尾曲克己, 松居剛志, 飯尾悦子, 五十川正記, 渡邊綱正, 狩野吉康, 田中靖人
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  ホテル日航熊本、熊本県
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] 異なるHBV遺伝子型間で認められるHBV抗原遷延化率の違いと肝臓内CD8＋T細胞応答の相関性2015
- Author(s)
  河島圭吾, 五十川正記, 松波加代子, 堤進, 村上周子, 渡邊綱正, 斉藤聡, 中島淳, 田中靖人
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  ホテル日航熊本、熊本県
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] Endogenous antigen presentation by hepatocytes plays an essential role in the induction of HBV-specific CD8+ T cell responses2015
- Author(s)
  Isogawa M, Murata Y, Kawashima K, Tanaka Y
- Organizer
  The 66th Annual Meeting of the American Association for the Study of Liver Diseases(AASLD2015)
- Place of Presentation
  Moscone West Convention Center, San Francisco, USA
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] Identification of a flavonoid derivative that directly acts on hepatitis B virus surface protein and inhibits viral entry.2015
- Author(s)
  Tsukuda S, Watashi K, Hamada Y, Isogawa M, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Wakita T
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場、福岡
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] 肝細胞による内因性抗原提示と樹状細胞による外因性抗原提示がHBV特異的CD8＋T細胞応答に及ぼす相対的役割2015
- Author(s)
  五十川正記, 村田泰洋, 田中靖人
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  ホテル日航熊本、熊本県
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] Check Point Inhibitors and Therapy for HBV Infection.2015
- Author(s)
  Isogawa M.
- Organizer
  17th International Conference on Emerging Infectious Diseases
- Place of Presentation
  Taipei (Taiwan)
- Year and Date
  2015-01-25
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] Comparison of cytopathic and non-cytopathic antiviral effects of interferon alpha and lambda against hepatitis B virus infection.2015
- Author(s)
  Tsutsumi S, Watanabe T, Kawashima K, Murakami S, Isogawa M, Tanaka Y
- Organizer
  2015 International Meeting on the Molecular Biology of Hepatitis B Viruses
- Place of Presentation
  Dolce Bad Nauheim, Germany
- Year and Date
  2015-10-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] Clearance rate of hepatitis B virus differs between genotypes in association with CD8+ T cell activation in the liver.2015
- Author(s)
  Isogawa M, Kawashima K, Tsutsumi S, Murakami S, Tanaka Y
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場、福岡
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] Differential hepatitis B virus clearance between genotypes is correlated with HBV-specific CD8+T cell responses in the liver2015
- Author(s)
  Kawashima K, Isogawa M, Tsutsumi S, Murakami S, Saito S, Nakajima A, Tanaka Y
- Organizer
  2015 International Meeting on the Molecular Biology of Hepatitis B Viruses
- Place of Presentation
  Dolce Bad Nauheim, Germany
- Year and Date
  2015-10-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] Endogenous Antigen Presentation By Hepatocytes Plays and Essential Role in the Induction of HBV-Specific CD8+ T cell responses.
- Author(s)
  Isogawa M, Murata Y, Sheikh K, Tanaka Y, Chisari FV.
- Organizer
  2014 International Meeting on Molecular Biology of Hepatitis B Viruses
- Place of Presentation
  Los Angeles (USA)
- Year and Date
  2014-09-03 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] A VLP Based Therapeutic HBV Vaccine Designed to Inhibit Viral Spread.
- Author(s)
  Whitacre D, Peterson D, Sureau C, Milich D, Isogawa M.
- Organizer
  International Meeting on Molecular Biology of Hepatitis B Viruses
- Place of Presentation
  Los Angeles (USA)
- Year and Date
  2014-09-03 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-26461015
[Presentation] HBV 特異的 CD8+T 細胞の増殖と細胞傷害能は肝細胞による内因性抗原提示に依存する
- Author(s)
  五十川正記、村田泰洋、田中靖人
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜会議センター（神奈川県・横浜市）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-26461015

1. Tanaka Yasuhito (90336694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 30 results
2. 村松正道 (20359813)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 加藤孝宣 (20333370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 塩田智之 (80616144)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. JUN Inoue

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. KAKAZU Eiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. MATSUURA Kentarou

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. IWATANI Yasumasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 中村ふくみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 藤本嗣人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 二宮匡史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 岩田朋晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 河島圭吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Isogawa Masanori 五十川 正記

ISOGAWA Masanori 五十川 正記

Research Projects

Research Products

Co-Researchers

A型肝炎ウイルス(HAV)排除メカニズムの解明Principal Investigator

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Why genotype C HBV causes liver cancer more rapidly than other genotypes?

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Analysis of the Significance and Mechanism of Type I Interferon Signaling Suppression in HBV-Specific CD8&#8314; T CellsPrincipal Investigator

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Regulation of Hepatitis B Virus-Specific T Cell Responses by Innate Immune ResponsePrincipal Investigator

Principal Investigator

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Induction of hepatitis B virus specific T cell responses by activating innate immune responsePrincipal Investigator

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[Journal Article] Differential regulation of calcium-NFAT signaling pathway by Akt isoforms: unraveling effector dynamics and exhaustion of cytotoxic T lymphocytes in tumor microenvironment2025

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[Journal Article] Exploring the tolerable region for HiBiT tag insertion in the hepatitis B virus genome2024

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[Journal Article] Highlights from the 2023 International Meeting on the Molecular Biology of Hepatitis B virus2024

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[Journal Article] Therapeutic potential of co-signaling receptor modulation in hepatitis B2024

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[Journal Article] HBV感染に対する免疫応答機構 ウイルス性肝炎学―最新の病態・診断・治療情報2023

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[Journal Article] SARS-CoV-2 Omicron-neutralizing memory B-cells are elicited by two doses of BNT162b2 mRNA vaccine.2022

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[Journal Article] Droplet digital PCR assay provides intrahepatic HBV?cccDNA quantification tool for clinical application2022

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[Journal Article] Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variants2021

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[Journal Article] HBV-Specific CD8+ T-Cell Tolerance in the Liver2021

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[Journal Article] Restoration of type I interferon signaling in intrahepatically primed CD8+ T cells promotes functional differentiation2021

Isogawa Masanori 五十川正記

ISOGAWA Masanori 五十川正記

Analysis of the Significance and Mechanism of Type I Interferon Signaling Suppression in HBV-Specific CD8⁺ T CellsPrincipal Investigator

[Journal Article] HBV感染に対する免疫応答機構　ウイルス性肝炎学―最新の病態・診断・治療情報2023