Shimbo Hiroko 新保裕子

… Alternative Names

SHIMBO Hiroko 新保裕子

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Researcher Number	50724663
Affiliation (Current)	2025: 地方独立行政法人神奈川県立病院機構神奈川県立こども医療センター(臨床研究所), 臨床研究所, 研究員
Affiliation (based on the past Project Information) *help	2016 – 2024: 地方独立行政法人神奈川県立病院機構神奈川県立こども医療センター(臨床研究所), 臨床研究所, 研究員 2015: 神奈川県立こども医療センター, 臨床研究所, 研究員 2014 – 2015: 地方独立行政法人神奈川県立病院機構神奈川県立こども医療センター(臨床研究所), その他部局等, その他
Review Section/Research Field	Principal Investigator Neurosurgery Except Principal Investigator Basic Section 46020:Anatomy and histopathology of nervous system-related / Medium-sized Section 46:Neuroscience and related fields / Orthodontics/Pediatric dentistry / Pediatrics
Keywords	Principal Investigator 遺伝子 / 脳神経疾患 / TWIST１ / 歯髄細胞 / RUNX2 / TWIST1 / FGFR3 / FGFR2 / 鎖骨頭蓋骨異形成症 / 頭蓋縫合早期癒合症 … More Except Principal Investigator … More RP58 / 転写抑制因子 / 認知機能 / 老化 / OSVZ / マウス / 進化 / 脳の進化 / 外側脳室下帯 / 細胞周期離脱 / アルツバイマー病 / Mossy細胞 / ssDNA / ミクログリア / MAP2 / ドーパミン受容体５ / アルツハイマー病 / RP58/zBTB18 / グルタミン酸ニューロン / 高次脳機能 / 認知機能異常 / DNA修復 / オステオネクチン / Ⅰ型コラーゲン / ｍＲＮＡ / 骨成長 / 発生・分化 / 骨芽細胞 / 顎顔面頭蓋 / mRNA / 骨芽細胞分化 / 歯髄幹細胞 / 上顎骨劣成長 / ダウン症 / 自閉症 / 精神遅滞 / グアニジノ酢酸 / クレアチニン / グアニジノ化合物 / iPS細胞 / 発達障害 / クレアチントランスポーター / 治療薬 / 脳クレアチン欠乏症候群 / 先天性代謝異常 / トランスポーター / クレアチン / 知的障害 Less

Evolution of the Cerebral Cortex by Experimental Manipulation Using Cell Cycle Withdrawal Delay
- Principal Investigator
  
  岡戸晴生
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 46:Neuroscience and related fields
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Transcriptional repressor RP58 and the mechanisms by which RP58 suppresses brain ageing
- Principal Investigator
  
  岡戸晴生
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Molecular mechanism for brain development and aging
- Principal Investigator
  
  OKADO Haruo
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Molecular genetic analysis of patients with craniosynostosis and the elucidation of mechanisms of osteoblast differentiation and bone formationPrincipal Investigator
- Principal Investigator
  
  Shimbo Hiroko
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Kanagawa Children's Medical Center (Clinical Research Institute)
Study for Pathogenesis of Cerebral Creatine Deficiency Syndromes
- Principal Investigator
  
  WADA Takahito
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University
Diagnosis of craniofacial disorders with dental pulp stem cells in Down syndrome
- Principal Investigator
  
  SASAKI YASUNORI
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  Kanagawa Children's Medical Center (Clinical Research Institute)

All 2024 2021 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Patent

[Journal Article] High-sucrose diets contribute to brain angiopathy with impaired glucose uptake and psychosis-related higher brain dysfunctions in mice2021
- Author(s)
  Hirai Shinobu, Toriumi Kazuya (4番目/24人中), et al.
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 46 Pages: 1-5
- DOI
  10.1126/sciadv.abl6077
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06977, KAKENHI-PROJECT-19K08033, KAKENHI-PROJECT-18K19383, KAKENHI-PROJECT-18K14832, KAKENHI-PROJECT-18H02542, KAKENHI-PUBLICLY-21H00180, KAKENHI-PUBLICLY-21H05694, KAKENHI-PROJECT-19H03589, KAKENHI-PROJECT-20H03608, KAKENHI-PROJECT-18K06496, KAKENHI-PROJECT-21K06403, KAKENHI-PROJECT-20K20392, KAKENHI-PROJECT-18KK0442, KAKENHI-PROJECT-18H02537, KAKENHI-PROJECT-23K21414
[Journal Article] A contiguous gene deletion neighboring TWIST1 identified in a patient with Saethre-Chotzen syndrome associated with neurodevelopmental delay: possible contribution of HDAC9.2017
- Author(s)
  Shimbo H, Oyoshi T, Kurosawa K.
- Journal Title
  
  Congenit Anom (Kyoto)
  
  Volume: 印刷中 Issue: 1 Pages: 33-35
- DOI
  10.1111/cga.12216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461538, KAKENHI-PROJECT-16K10805
[Journal Article] Haploinsufficiency of BCL11A associated with cerebellar abnormalities in 2p15p16.1 deletion syndrome2017
- Author(s)
  Shimbo Hiroko、Yokoi Takayuki、Aida Noriko、Mizuno Seiji、Suzumura Hiroshi、Nagai Junichi、Ida Kazumi、Enomoto Yumi、Hatano Chihiro、Kurosawa Kenji
- Journal Title
  
  Molecular Genetics & Genomic Medicine
  
  Volume: 5 Issue: 4 Pages: 429-437
- DOI
  10.1002/mgg3.289
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10805
[Journal Article] 頭蓋縫合早期癒合症における遺伝子異常の系統的スクリーニングの確立2017
- Author(s)
  伊藤進、新保裕子
- Journal Title
  
  こども医療センター医学誌
  
  Volume: 46 Pages: 168-169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10805
[Journal Article] Urine screening for patients with developmental disabilities detected a patient with creatine transporter deficiency due to a novel missense mutation in SLC6A8.2014
- Author(s)
  Kato H, Miyake F, Shimbo H, Ohya M, Sugawara H, Aida N, Anzai R, Takagi M, Okuda M, Takano K, Wada T*, Iai M, Yamashita S, Osaka H.
- Journal Title
  
  Brain Dev.
  
  Volume: 36 Issue: 7 Pages: 630-633
- DOI
  10.1016/j.braindev.2013.08.004
- Data Source
  KAKENHI-PROJECT-26461544
[Journal Article] A Japanese adult case of guanidinoacetate methyltransferase deficiency.2014
- Author(s)
  Akiyama T, Osaka H, Shimbo H, Nakajiri T, Kobayashi K, Oka M, Endoh F, Yoshinaga H.
- Journal Title
  
  JIMD Rep
  
  Volume: 12 Pages: 65-69
- DOI
  10.1007/8904_2013_245
- ISBN
  9783319034607, 9783319034614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461544
[Patent] 転写抑制因子RP58の発現制御可能なトランスジェニック非ヒト動物2019
- Inventor(s)
  岡戸晴生、新保裕子
- Industrial Property Rights Holder
  公益財団法人東京都医学総合研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18H02537
[Presentation] 成熟後のRP58/ZBTB18の発現制御は認知機能と歯状回の苔状細胞の健全性を規定する2024
- Author(s)
  新保裕子、平井志伸、田中謙二、岡戸晴生
- Organizer
  第１０１回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-23K23992
[Presentation] 成体でのRP58発現抑制は認知機能低下を惹起する2019
- Author(s)
  新保裕子、平井志伸、田中智子、田中謙二、岡戸晴生
- Organizer
  第４２回日本神経科学大会 July 25-28 Niigata
- Data Source
  KAKENHI-PROJECT-18H02537
[Presentation] TWIST1遺伝子に異常が認められたSaethre-Chotzen症候群の10症例2019
- Author(s)
  新保裕子
- Organizer
  第15回Craniosynostosis研究会
- Data Source
  KAKENHI-PROJECT-16K10805
[Presentation] 頭蓋縫合早期癒合症における系統的遺伝子検索2018
- Author(s)
  新保裕子
- Organizer
  第14回Craniosynostosis研究会
- Data Source
  KAKENHI-PROJECT-16K10805
[Presentation] Diagnosis of osteoblast differentiation with dental pulp stem cells in Down syndrome2016
- Author(s)
  Sasaki Y, Shimbo H, Taya Y
- Organizer
  10th Biennial Conference of the Pediatric Dentistry Association of Asia
- Place of Presentation
  Tokyo　Ｄｏｍｅ　Ｈｏｔｅｌ　（Ｂｕｎｋｙｏ－ｋｕ、Ｔｏｋｙｏ）
- Year and Date
  2016-05-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670891
[Presentation] Diagnosis of osteoblast differentiation in Down syndrome with the pulpal stem cell2016
- Author(s)
  Yasunori Sasaki, Hiroko Shimbo, Yuji Taya
- Organizer
  The 10th Biennial Conference of the Pediatric Dentistry Association of Asia(PDAA)
- Place of Presentation
  東京ドームホテル(東京都文京区)
- Year and Date
  2016-05-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10805
[Presentation] Saethre-Chotzen 症候群を呈する 7p21.1 欠失症例2016
- Author(s)
  新保裕子，大吉達樹，黒澤健司
- Organizer
  第58回日本小児神経学会学術集会
- Place of Presentation
  京王プラザホテル新宿(東京都新宿区)
- Year and Date
  2016-06-03
- Data Source
  KAKENHI-PROJECT-16K10805
[Presentation] 「脳クレアチン欠乏症候群の臨床研究班」の取り組み2015
- Author(s)
  和田敬仁，小坂仁，相田典子，後藤知英，露崎悠，新保裕子，加藤秀一，高野亨子，大槻純男，伊藤慎悟，立川正憲，黒澤裕子
- Organizer
  第57回日本小児神経学会
- Place of Presentation
  大阪
- Year and Date
  2015-05-27
- Data Source
  KAKENHI-PROJECT-26461544
[Presentation] Molecular genetic study and urine analysis of Japanese patients with cerebral creatine deficiency syndromes.2015
- Author(s)
  H. Shimbo, H. Osaka, M. Tachikawa, S. Ohtsuki, S. Ito, T. Goto, Y. Tsuyusaki, N. Aida, K. Kurosawa, Y. Kurosawa, H. Kato, K. Takano, T. Wada.
- Organizer
  65th American Society of Human Genetics
- Place of Presentation
  Baltimore
- Year and Date
  2015-10-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461544
[Presentation] Regulation of osteoblast derived from dental pulp cells of cleidocranial. .
- Author(s)
  Sasaki, Y, Shimbo,H, Osaka, H
- Organizer
  The9th Congress of Asian Association of Paediatric Dentistry
- Place of Presentation
  シンガポール
- Year and Date
  2014-08-22 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-26670891

1. OKADO Haruo (60221842)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. 平井志伸 (00625189)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. 三輪秀樹 (80468488)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. SASAKI YASUNORI (70332848)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. 田中智子 (40578986)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. WADA Takahito (70359727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. OHTSUKI Sumio (60323036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. TAYA Yuji (30197587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. SAKUMA Syuji (00535429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 立川正憲 (00401810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 伊藤慎悟 (20466535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 小坂仁 (90426320)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. 伊藤進 (50254181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. TORIUMI Kazuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 黒澤健司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimbo Hiroko 新保 裕子

SHIMBO Hiroko 新保 裕子

Research Projects

Research Products

Co-Researchers

Evolution of the Cerebral Cortex by Experimental Manipulation Using Cell Cycle Withdrawal Delay

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Transcriptional repressor RP58 and the mechanisms by which RP58 suppresses brain ageing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism for brain development and aging

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular genetic analysis of patients with craniosynostosis and the elucidation of mechanisms of osteoblast differentiation and bone formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for Pathogenesis of Cerebral Creatine Deficiency Syndromes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Diagnosis of craniofacial disorders with dental pulp stem cells in Down syndrome

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] High-sucrose diets contribute to brain angiopathy with impaired glucose uptake and psychosis-related higher brain dysfunctions in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A contiguous gene deletion neighboring TWIST1 identified in a patient with Saethre-Chotzen syndrome associated with neurodevelopmental delay: possible contribution of HDAC9.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Haploinsufficiency of BCL11A associated with cerebellar abnormalities in 2p15p16.1 deletion syndrome2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 頭蓋縫合早期癒合症における遺伝子異常の 系統的スクリーニングの確立2017

Author(s)

Journal Title

Data Source

[Journal Article] Urine screening for patients with developmental disabilities detected a patient with creatine transporter deficiency due to a novel missense mutation in SLC6A8.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Japanese adult case of guanidinoacetate methyltransferase deficiency.2014

Author(s)

Journal Title

DOI

ISBN

Data Source

[Patent] 転写抑制因子RP58の発現制御可能なトランスジェニック非ヒト動物2019

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] 成熟後のRP58/ZBTB18の発現制御は認知機能と歯状回の苔状細胞の健全性を規定する2024

Author(s)

Organizer

Shimbo Hiroko 新保裕子

SHIMBO Hiroko 新保裕子

[Journal Article] 頭蓋縫合早期癒合症における遺伝子異常の系統的スクリーニングの確立2017