Takahashi Hideaki 高橋秀聡

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TAKAHASHI Hideaki 高橋秀聡

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Researcher Number	50727196
Other IDs	https://orcid.org/0000-0003-3783-9961
Affiliation (Current)	2024: 横浜市立大学, 医学研究科, 客員教授
Affiliation (based on the past Project Information) *help	2024: 横浜市立大学, 医学研究科, 客員教授 2019 – 2023: 横浜市立大学, 附属病院, 助教 2016 – 2018: 横浜市立大学, 医学研究科, 客員研究員 2015: 横浜市立大学, 附属病院, 助教 2014: 横浜市立大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology
Keywords	Principal Investigator 頭頸部癌 / 分子標的治療 / 神経 / がん微小環境 / 唾液腺癌 / 腫瘍神経学 / 分化転換 / 神経新生 / 癌関連神経 / 癌微小環境 … More / 癌オルガノイド / 唾液腺腺様嚢胞癌 / 腺様嚢胞癌 / HPV関連中咽頭癌 / マイクロバイオーム / ディスバイオーシス / 発癌 / 口腔内マイクロバイオーム / ヒト乳頭腫ウイルス / 中咽頭癌 / 遠隔転移 / 頭頸部扁平上皮癌 / インターフェロン調節因子 / IRF / 肺転移 … More Except Principal Investigator 頭頸部癌 / 癌微小環境 / ヒト乳頭腫ウイルス関連中咽頭癌 / ヒト唾液腺がん / ヒトパピローマウイルス関連中咽頭癌 / マイクロRNA / HPV / 腫瘍関連神経 / がん幹細胞 / シングルセル解析 / オルガノイド / 唾液腺癌 / 血清鉄 / シスプラチン / 遅発性嘔吐 / VAChT発現 / TH発現 / ノルアドレナリン / 副交感神経 / 交感神経 / 自律神経 / 唾液腺導管癌 / 放射線感受性 / ヒト乳頭腫ウイルス / 中咽頭癌 Less

単一細胞RNAシーケンスによる唾液腺幹細胞の同定と各組織型への分化機構の解明
- Principal Investigator
  
  折舘伸彦
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Yokohama City University
唾液腺癌オルガノイドを用いた単一細胞解析による唾液腺癌がん細胞同定と新規治療開発
- Principal Investigator
  
  佐野大佑
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Yokohama City University
癌関連神経を介したHPV関連中咽頭癌の薬剤耐性・治療抵抗性機構の解明
- Principal Investigator
  
  波多野孝
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Yokohama City University
神経を中心としたがん微小環境ネットワークの解明から拓く新規治療法の開発Principal Investigator
- Principal Investigator
  
  高橋秀聡
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Yokohama City University
唾液腺導管癌の癌微小環境における自律神経相互作用の臨床的・分子病理学的意義
- Principal Investigator
  
  多田雄一郎
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  International University of Health and Welfare
シスプラチンによる遅発性悪心・嘔吐の原因と新しい治療法の検討；血清鉄過剰の解消
- Principal Investigator
  
  木谷洋輔
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Yokohama City University
Eradication of the interaction of adenoid cystic carcinoma of the salivary gland and cancer-associated neurons in the tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Hideaki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Yokohama City University
Explaining the mechanism of high sensitivity for radiotherapy in human papilloma related oropharyngeal cancer.
- Principal Investigator
  
  Nishimura Goshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Yokohama City University
The Role of Oral Microbiome in Human Oropharyngeal CancerPrincipal Investigator
- Principal Investigator
  
  Takahashi Hideaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Yokohama City University
Role of Interferon reguratory factor for distal metastasis in head and neck cancerPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Hideaki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Yokohama City University

All 2023 2022 2021 2020 2018

All Journal Article Presentation

[Journal Article] Effect of HER2-targeted therapy on PDX and PDX-derived organoids generated from HER2-positive salivary duct carcinoma2023
- Author(s)
  Aoyama Jun、Nojima Yusuke、Sano Daisuke、Hirai Yuri、Kijima Natsumi、Aizawa Yoshihiro、Takada Kentaro、Hatano Takashi、Takahashi Hideaki、Nishimura Goshi、Oridate Nobuhiko
- Journal Title
  
  Head & Neck
  
  Volume: online ahead of print Issue: 7 Pages: 1801-1811
- DOI
  10.1002/hed.27395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09873
[Journal Article] Real-world Therapeutic Outcomes of the Pembrolizumab Regimen as First-line Therapy for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: A Single-center Retrospective Cohort Study in Japan2022
- Author(s)
  SANO DAISUKE、TOKUHISA MOTOHIKO、TAKAHASHI HIDEAKI、HATANO TAKASHI、NISHIMURA GOSHI、ICHIKAWA YASUSHI、ORIDATE NOBUHIKO
- Journal Title
  
  Anticancer Research
  
  Volume: 42 Issue: 9 Pages: 4477-4484
- DOI
  10.21873/anticanres.15948
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09612, KAKENHI-PROJECT-22K09746, KAKENHI-PROJECT-19K09895, KAKENHI-PROJECT-20K18259
[Journal Article] Survival benefit of HER2-targeted or androgen deprivation therapy in salivary duct carcinoma2022
- Author(s)
  Kawakita Daisuke、Nagao Toshitaka、Takahashi Hideaki、Kano Satoshi、Honma Yoshitaka、Hirai Hideaki、Saigusa Natsuki、Akazawa Kohei、Tani Kaori、Ojiri Hiroya、Tsukahara Kiyoaki、Ozawa Hiroyuki、Okami Kenji、Kondo Takahito、Togashi Takafumi、Fushimi Chihiro、Shimura Tomotaka、Matsuki Takashi、Tada Yuichiro
- Journal Title
  
  Therapeutic Advances in Medical Oncology
  
  Volume: 14 Pages: 175883592211195-175883592211195
- DOI
  10.1177/17588359221119538
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07597, KAKENHI-PROJECT-20K09763, KAKENHI-PROJECT-21K09616, KAKENHI-PROJECT-22K06939, KAKENHI-PROJECT-21K16835, KAKENHI-PROJECT-21K16861, KAKENHI-PROJECT-22K16896, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-17K08753, KAKENHI-PROJECT-18K09340, KAKENHI-PROJECT-20K07417, KAKENHI-PROJECT-20K10508
[Journal Article] Establishment of experimental salivary gland cancer models using organoid culture and patient-derived xenografting2022
- Author(s)
  Aizawa Yoshihiro、Takada Kentaro、Aoyama Jun、Sano Daisuke、Taniguchi Hideki、Oridate Nobuhiko
- Journal Title
  
  Cellular Oncology
  
  Volume: 46 Issue: 2 Pages: 409-421
- DOI
  10.1007/s13402-022-00758-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09612, KAKENHI-PROJECT-22K09746, KAKENHI-PROJECT-19K09873, KAKENHI-PROJECT-20K08952, KAKENHI-PROJECT-20K18259
[Journal Article] Head and Neck Tumor　頭頸部腫瘍　診断・治療に向けた新技術の展開　p53変異による癌関連神経の再プログラミング2021
- Author(s)
  高橋秀聡，佐野大佑，折舘伸彦
- Journal Title
  
  癌と化学療法
  
  Volume: 48 Pages: 900-902
- Data Source
  KAKENHI-PROJECT-19K09873
[Journal Article] A risk factor for newly diagnosed secondary cancer in patients with early-stage laryngeal, oropharyngeal, or hypopharyngeal cancer: sub-analysis of a prospective observation study2021
- Author(s)
  Nishimura Goshi、Sano Daisuke、Arai Yasuhiro、Takahashi Hideaki、Hatano Takashi、Kitani Yosuke、Takada Kentaro、Wada Takashi、Hiiragi Yohei、Oridate Nobuhiko
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 27 Issue: 3 Pages: 488-494
- DOI
  10.1007/s10147-021-02080-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09895, KAKENHI-PROJECT-21K09636, KAKENHI-PROJECT-22K09746, KAKENHI-PROJECT-20K18259
[Journal Article] 【口腔癌診療の最前線】口腔癌とその周辺　口腔癌と神経2021
- Author(s)
  高橋秀聡，佐野大佑，折舘伸彦
- Journal Title
  
  JOHNS
  
  Volume: 37 Pages: 529-532
- Data Source
  KAKENHI-PROJECT-19K09873
[Journal Article] Predictive and Prognostic Biomarker Identification in a Large Cohort of Androgen Receptor-Positive Salivary Duct Carcinoma Patients Scheduled for Combined Androgen Blockade2021
- Author(s)
  Lassche Gerben、Tada Yuichiro、van Herpen Carla M. L.、Jonker Marianne A.、Nagao Toshitaka、Saotome Takashi、Hirai Hideaki、Saigusa Natsuki、Takahashi Hideaki、Ojiri Hiroya、van Engen-Van Grunsven Adriana C. H.、Schalken Jack A.、Fushimi Chihiro、Verhaegh Gerald W.
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 14 Pages: 3527-3527
- DOI
  10.3390/cancers13143527
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07417, KAKENHI-PROJECT-21K09616, KAKENHI-PROJECT-21K16835, KAKENHI-PROJECT-19K16568
[Journal Article] 【がん微小環境に1細胞レベルで挑む　技術革新で見えてきた腫瘍内の細胞と免疫応答の多様性、がん悪性化・治療抵抗性の鍵】(第1章)がん幹細胞を支えるがん微小環境の多様性　神経によるがんの進展2021
- Author(s)
  高橋秀聡，佐野大佑，折舘伸彦
- Journal Title
  
  実験医学
  
  Volume: 39 Pages: 1881-1886
- Data Source
  KAKENHI-PROJECT-19K09873
[Journal Article] Establishment of PDX‐derived salivary adenoid cystic carcinoma cell lines using organoid culture method2020
- Author(s)
  Takada Kentaro、Aizawa Yoshihiro、Sano Daisuke、Okuda Ryo、Sekine Keisuke、Ueno Yasuharu、Yamanaka Shoji、Aoyama Jun、Sato Kaname、Kuwahara Tatsu、Hatano Takashi、Takahashi Hideaki、Arai Yasuhiro、Nishimura Goshi、Taniguchi Hideki、Oridate Nobuhiko
- Journal Title
  
  International Journal of Cancer
  
  Volume: 148 Issue: 1 Pages: 193-202
- DOI
  10.1002/ijc.33315
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09873, KAKENHI-PROJECT-19K09895, KAKENHI-PROJECT-20K08952, KAKENHI-PROJECT-19H03718, KAKENHI-PROJECT-17K10057, KAKENHI-PROJECT-18K09382, KAKENHI-PROJECT-20K18259
[Journal Article] Loss of p53 drives neuron reprogramming in head and neck cancer2020
- Author(s)
  Amit Moran、Takahashi Hideaki、Calin George A.、Myers Jeffrey N, et al.
- Journal Title
  
  Nature
  
  Volume: 578 Issue: 7795 Pages: 449-454
- DOI
  10.1038/s41586-020-1996-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09873
[Journal Article] Sano D, Yabuki K, Arai Y, Tanabe T, Chiba Y, Nishimura G, Takahashi H, Yamanaka S, Oridate N. The applicability of new TNM classification for humanpapilloma virus-related oropharyngeal cancer in the 8th edition of the AJCC/UICC TNM staging system in Japan: A single-centre study2018
- Author(s)
  Sano D, Yabuki K, Arai Y, Tanabe T, Chiba Y, Nishimura G, Takahashi H, Yamanaka S, Oridate N
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: 45 Issue: 3 Pages: 558-565
- DOI
  10.1016/j.anl.2017.07.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11240, KAKENHI-PROJECT-16K11242
[Presentation] 腫瘍神経学2023
- Author(s)
  高橋秀聡
- Organizer
  第32回日本頭頸部外科学会総会ならびに学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09873
[Presentation] 唾液腺癌に対する標的治療の進歩2022
- Author(s)
  高橋秀聡
- Organizer
  第35回日本口腔・咽頭科学会　総会ならびに学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09873
[Presentation] オルガノイド培養技術とPatient-derived xenograftモデルを用いた唾液腺癌モデル作製2022
- Author(s)
  佐野大佑 , 相澤圭洋 , 青山準 , 野島雄介 , 高田顕太郎 , 高橋秀聡 , 折舘伸彦
- Organizer
  第 66 回日本唾液腺学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09873
[Presentation] ヒトHER2陽性唾液腺導管癌由来オルガノイドによるin vitro/in vivoでの薬効評価2022
- Author(s)
  青山準 , 野島雄介 , 相澤圭洋 , 高田顕太郎 , 鬼島菜摘 , 平井友梨 , 波多野孝 , 高橋秀聡 , 佐野大佑 , 藤井誠志 , 折舘伸彦
- Organizer
  第81回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09873
[Presentation] ヒトHER2陽性唾液腺導管癌由来オルガノイドによるin vitro/in vivoでの薬効評価(Drug evaluation using patient-derived organoid of HER2-positive salivary duct carcinoma in vitro and in vivo)2022
- Author(s)
  青山準, 野島雄介, 相澤圭洋, 高田顕太郎, 鬼島菜摘, 平井友梨, 波多野孝, 高橋秀聡, 佐野大佑, 藤井誠志, 折舘伸彦
- Organizer
  日本癌学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09746
[Presentation] μオピオイド受容体を標的とした治療の開発2022
- Author(s)
  高橋秀聡, 佐野大佑, 波多野孝, 木谷洋輔, 柊陽平, 大平彩菜, 折舘伸彦
- Organizer
  日本頭頸部癌学会
- Data Source
  KAKENHI-PROJECT-22K09746
[Presentation] 唾液腺導管癌における自律神経(交感神経・副交感神経)の臨床・分子病理学的意義2022
- Author(s)
  梶原真奈美, 高橋秀聡, 川北大介, 平井秀明, 内海由貴, 浦野誠, 中黒匡人, 佐藤由紀子, 塚原清彰, 加納里志, 大上研二, 小澤宏之, 富樫孝文, 岡田拓朗, 多田雄一郎, 長尾俊孝
- Organizer
  第66回日本唾液腺学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K09616
[Presentation] 唾液腺導管癌における自律神経(交感神経・副交感神経)の臨床・分子病理学的意義2022
- Author(s)
  梶原真奈美 , 高橋秀聡 , 川北大介 , 平井秀明 , 内海由貴 , 浦野誠 , 中黒匡人 , 佐藤由紀子 , 塚原清彰 , 加納里志 , 大上研二 , 小澤宏之 , 富樫孝文 , 岡田拓朗 , 多田雄一郎 , 長尾俊孝
- Organizer
  第 66 回日本唾液腺学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09873
[Presentation] 唾液腺導管癌における自律神経(交感神経・副交感神経)の臨床・分子病理学的意義2021
- Author(s)
  多田雄一郎，長尾俊孝，梶原真奈美，川北大介，高橋秀聡
- Organizer
  第11回国際医療福祉大学学会学術大会
- Data Source
  KAKENHI-PROJECT-19K09873
[Presentation] 癌と神経　そしてアメリカ留学で学んだメンタリティー2021
- Author(s)
  高橋秀聡
- Organizer
  第83回耳鼻咽喉科臨床学会総会・学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09873
[Presentation] 頭頸部癌研究のニューパラダイム　p53が癌微小環境に及ぼす影響2021
- Author(s)
  高橋秀聡
- Organizer
  第45回日本頭頸部癌学会
- Data Source
  KAKENHI-PROJECT-19K09873
[Presentation] Cancer takes a nerve: Loss of p53 drives neuron reprogramming in head and neck cancer2021
- Author(s)
  Amit M, Takahashi H, Dragomir MP, Anfossi S, Lindemann A, Netto-Glebber F, Tam S, Osman A, Kuntsen E, Pickering CR, Zhao M, Rao X, Wang J, Silverman DA, Caulin C, Zinger A, Tasciotti E, Dougherty P, El-Nagger A, Calin GA, Myers JN
- Organizer
  American Association for Cancer Research Annual Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09873
[Presentation] がん・緩和医療における神経可塑性・オピオイド受容体　がんと神経リプログラミング2021
- Author(s)
  高橋秀聡
- Organizer
  第43回日本疼痛学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09873
[Presentation] 頭頸部扁平上皮癌の癌微小環境における神経の役割2020
- Author(s)
  高橋秀聡，西村剛志，佐野大佑，荒井康裕，波多野孝，折舘伸彦
- Organizer
  第121回日本耳鼻咽喉科学会
- Data Source
  KAKENHI-PROJECT-19K09873

1. 佐野大佑 (10620990)

# of Collaborated Projects: 7 results

# of Collaborated Products: 12 results
2. 折舘伸彦 (90312355)

# of Collaborated Projects: 6 results

# of Collaborated Products: 14 results
3. Nishimura Goshi (30381510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 多田雄一郎 (70292430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 長尾俊孝 (90276709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 赤澤宏平 (10175771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 川北大介 (70584506)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 伏見千宙 (20623531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 平井秀明 (00770744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 木谷洋輔 (50783784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 藤井誠志 (30314743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 波多野孝 (40807583)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. 相澤圭洋 (50990082)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Takahashi Hideaki 高橋 秀聡

TAKAHASHI Hideaki 高橋 秀聡

Research Projects

Research Products

Co-Researchers

単一細胞RNAシーケンスによる唾液腺幹細胞の同定と各組織型への分化機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

唾液腺癌オルガノイドを用いた単一細胞解析による唾液腺癌がん細胞同定と新規治療開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

癌関連神経を介したHPV関連中咽頭癌の薬剤耐性・治療抵抗性機構の解明

Principal Investigator

Project Period (FY)

Research Category

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神経を中心としたがん微小環境ネットワークの解明から拓く新規治療法の開発Principal Investigator

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唾液腺導管癌の癌微小環境における自律神経相互作用の臨床的・分子病理学的意義

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シスプラチンによる遅発性悪心・嘔吐の原因と新しい治療法の検討；血清鉄過剰の解消

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Eradication of the interaction of adenoid cystic carcinoma of the salivary gland and cancer-associated neurons in the tumor microenvironmentPrincipal Investigator

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Explaining the mechanism of high sensitivity for radiotherapy in human papilloma related oropharyngeal cancer.

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The Role of Oral Microbiome in Human Oropharyngeal CancerPrincipal Investigator

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Role of Interferon reguratory factor for distal metastasis in head and neck cancerPrincipal Investigator

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[Journal Article] Effect of HER2-targeted therapy on PDX and PDX-derived organoids generated from HER2-positive salivary duct carcinoma2023

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[Journal Article] Real-world Therapeutic Outcomes of the Pembrolizumab Regimen as First-line Therapy for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: A Single-center Retrospective Cohort Study in Japan2022

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[Journal Article] Survival benefit of HER2-targeted or androgen deprivation therapy in salivary duct carcinoma2022

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Takahashi Hideaki 高橋秀聡

TAKAHASHI Hideaki 高橋秀聡

[Journal Article] Head and Neck Tumor　頭頸部腫瘍　診断・治療に向けた新技術の展開　p53変異による癌関連神経の再プログラミング2021

[Journal Article] 【口腔癌診療の最前線】口腔癌とその周辺　口腔癌と神経2021

[Journal Article] 【がん微小環境に1細胞レベルで挑む　技術革新で見えてきた腫瘍内の細胞と免疫応答の多様性、がん悪性化・治療抵抗性の鍵】(第1章)がん幹細胞を支えるがん微小環境の多様性　神経によるがんの進展2021