MATSUO Akira 松尾顕

Researcher Number	50735074
Other IDs	https://orcid.org/0009-0002-2081-1954
Affiliation (based on the past Project Information) *help	2025: 熊本大学, 発生医学研究所, 学術研究員 2022 – 2023: 熊本大学, 発生医学研究所, 学術研究員 2021: 熊本大学, 大学院生命科学研究部(医), 特別研究員 2020 – 2021: 熊本大学, 大学院生命科学研究部(医), 学術研究員 2017 – 2019: 熊本大学, 大学院生命科学研究部(医), 研究員 2017: 熊本大学, 大学院生命科学研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine Except Principal Investigator Respiratory organ internal medicine
Keywords	Principal Investigator 運命転換 / 可塑性 / 脱分化 / 扁平上皮化生 / 基底細胞 / Club細胞 / 肺癌 / Notchシグナル / 細胞運命転換 / 前癌病変 … More / 発癌 / 損傷修復 / 器官形成 / 扁平上皮癌 / 呼吸器 / 扁平上皮細胞 / 単１細胞遺伝子発現解析 / 細胞系譜解析 / 細胞へ運命転換 / 肺腺癌 / 発生医学 / 直接運命転換 / 幹細胞 … More Except Principal Investigator 分子標的治療 / 神経ガイダンス分子 / 癌 / 受容体 / ガイダンス分子 / neogenin / neterin1 / draxin / DCC / Neogenin / Netrin1 / Draxin / 非小細胞肺癌 / 小細胞肺癌 Less

扁平上皮化生における脱分化した基底細胞の再生及び発癌の細胞運命決定機構の解明Principal Investigator
- Principal Investigator
  
  松尾顕
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kumamoto University
高解像細胞系譜解析を用いたclub細胞の恒常性維持及び疾患時の可塑性の解明Principal Investigator
- Principal Investigator
  
  松尾顕
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kumamoto University
Progenitor cells and initiation of squamous metaplasia focused on club cell fate conversionPrincipal Investigator
- Principal Investigator
  
  MATSUO Akira
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kumamoto University
Defining the mechanism underlying transformation from adenocarcinoma to small cell lung carcinoma focused on club cell fate conversionPrincipal Investigator
- Principal Investigator
  
  Matsuo Akira
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kumamoto University
Regulation of small cell lung carcinoma cells by interference between axon guidance molecules and their receptors
- Principal Investigator
  
  Ito Takaaki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kumamoto University

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] The role of YAP1 in small cell lung cancer2022
- Author(s)
  Saito Haruki、Tenjin Yuki、Yamada Tatsuya、Kudoh Shinji、Kudo Noritaka、Sanada Mune、Sato Younosuke、Matsuo Akira、Orita Yorihisa、Ito Takaaki
- Journal Title
  
  Human Cell
  
  Volume: 35 Issue: 2 Pages: 628-638
- DOI
  10.1007/s13577-022-00669-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08655, KAKENHI-PROJECT-20H03691, KAKENHI-PROJECT-21H04241
[Journal Article] Heterogeneous expression and role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in small cell lung cancer2022
- Author(s)
  Sanada Mune、Yamazaki Masaya、Yamada Tatsuya、Fujino Kosuke、Kudoh Shinji、Tenjin Yuki、Saito Haruki、Kudo Noritaka、Sato Younosuke、Matsuo Akira、Suzuki Makoto、Ito Takaaki
- Journal Title
  
  Human Cell
  
  Volume: 36 Issue: 1 Pages: 409-420
- DOI
  10.1007/s13577-022-00830-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08258, KAKENHI-PROJECT-20H03691
[Journal Article] ZMYM3 May Promote Cell Proliferation in Small Cell Lung Carcinoma2021
- Author(s)
  Kudo Noritaka、Kudoh Shinji、Matsuo Akira、Motooka Yamato、Ito Takaaki
- Journal Title
  
  ACTA HISTOCHEMICA ET CYTOCHEMICA
  
  Volume: 54 Issue: 5 Pages: 143-153
- DOI
  10.1267/ahc.21-00012
- NAID
  130008112276
- ISSN
  0044-5991, 1347-5800
- Year and Date
  2021-10-29
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08655, KAKENHI-PROJECT-20H03691
[Journal Article] Significance of achaete-scute complex homologue 1 (ASCL1) in pulmonary neuroendocrine carcinomas; RNA sequence analyses using small cell lung cancer cells and Ascl1-induced pulmonary neuroendocrine carcinoma cells2020
- Author(s)
  Kudoh Shinji、Tenjin Yuki、Kameyama Hiroki、Ichimura Takaya、Yamada Tatsuya、Matsuo Akira、Kudo Noritaka、Sato Younosuke、Ito Takaaki
- Journal Title
  
  Histochemistry and Cell Biology
  
  Volume: 153 Issue: 6 Pages: 443-456
- DOI
  10.1007/s00418-020-01863-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08655, KAKENHI-PROJECT-20H03691, KAKENHI-PROJECT-18K19480
[Journal Article] Ascl1-induced Wnt11 regulates neuroendocrine differentiation, cell proliferation, and E-cadherin expression in small-cell lung cancer and Wnt11 regulates small-cell lung cancer biology2019
- Author(s)
  Tenjin Yuki、Kudoh Shinji、Kubota Sho、Yamada Tatsuya、Matsuo Akira、Sato Younosuke、Ichimura Takaya、Kohrogi Hirotsugu、Sashida Goro、Sakagami Takuro、Ito Takaaki
- Journal Title
  
  Laboratory Investigation
  
  Volume: 99 Issue: 11 Pages: 1622-1635
- DOI
  10.1038/s41374-019-0277-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08655, KAKENHI-PROJECT-18K19480, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K16090, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-17J02389
[Journal Article] Significance of Tsukushi in lung cancer.2019
- Author(s)
  Yamada T, Ohta K, Motooka Y, Fujino K, Kudoh S, Tenjin Y, Sato Y, Matsuo A, Ikeda K, Suzuki M, Ito T.
- Journal Title
  
  Lung Cancer.
  
  Volume: 32(2) Pages: 103-113
- DOI
  10.1016/j.lungcan.2019.03.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16050
[Journal Article] Alveolus-like organoid from isolated tip epithelium of embryonic mouse lung.2019
- Author(s)
  Seiji Y, Ito T, Nakamura Y, Nakaishi-Fukuchi Y, Matsuo A, Sato N, Nogawa H
- Journal Title
  
  Human Cell
  
  Volume: 32 Issue: 2 Pages: 103-113
- DOI
  10.1007/s13577-019-00236-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19480, KAKENHI-PROJECT-17K16050
[Journal Article] Expression of Drain in Lung Carcinomas2018
- Author(s)
  Sato Y, Matsuo A, Kudoh S, Fang L, Hasegawa K, Shinmyo Y, Ito T
- Journal Title
  
  Acta Histochem Cytochem
  
  Volume: 51(1) Pages: 53-62
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16050
[Journal Article] Expression of Draxin in Lung Carcinomas2018
- Author(s)
  Sato Y, Matsuo A, Kudoh S, Liu F, Hasegawa K, Shinmyo Y, Ito T
- Journal Title
  
  ACTA HISTOCHEMICA ET CYTOCHEMICA
  
  Volume: 51 Issue: 1 Pages: 53-62
- DOI
  10.1267/ahc.17035
- NAID
  130006405032
- ISSN
  0044-5991, 1347-5800
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15459, KAKENHI-PROJECT-17K08749, KAKENHI-PROJECT-18K19376
[Presentation] Club細胞から基底細胞への運命転換2021
- Author(s)
  松尾　顕　伊藤隆明
- Organizer
  第110回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19K08655
[Presentation] Club 細胞から基底細胞への運命転換2021
- Author(s)
  松尾　顕、伊藤隆明
- Organizer
  第110回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19K08655
[Presentation] Club cell dedifferentiation induced by Notch inactivation2019
- Author(s)
  Akira Matsuo,Takaaki Ito
- Organizer
  第52回発生生物学会大会
- Data Source
  KAKENHI-PROJECT-19K08655
[Presentation] Defining the mechanism underlying dedifferentiation of committed secretory cells into basal stem cells.2018
- Author(s)
  Matsuo A, Ito T.
- Organizer
  第51回発生生物学会大会
- Data Source
  KAKENHI-PROJECT-17K16050
[Presentation] Club細胞から神経内分泌細胞への運命転換2018
- Author(s)
  松尾顕、伊藤隆明
- Organizer
  第107回病理学会総会
- Data Source
  KAKENHI-PROJECT-17K16050
[Presentation] Club cell から基底細胞への脱分化機構の解明2018
- Author(s)
  松尾顕、伊藤隆明
- Organizer
  第41回分子生物学会大会
- Data Source
  KAKENHI-PROJECT-17K16050
[Presentation] 肺発生及び恒常性維持におけるClub細胞の可塑性2017
- Author(s)
  松尾　顕
- Organizer
  第3回呼吸器基礎研究を加速するための若手研究会議、細胞・分子生物学学術部会、第５７回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K16050
[Presentation] Club細胞の可塑性を明らかにする2017
- Author(s)
  松尾　顕, 伊藤　隆明
- Organizer
  第４０回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-17K16050
[Presentation] Defining the mechanism of club cell plasticity in lung development, homeostasis and cancer2017
- Author(s)
  松尾　顕
- Organizer
  第1回若手呼吸器研究者による研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K16050

1. Ito Takaaki (70168392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. SHINMYO Yohei (00418831)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. HASEGAWA Koki (50525798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MATSUO Akira 松尾 顕

Research Projects

Research Products

Co-Researchers

扁平上皮化生における脱分化した基底細胞の再生及び発癌の細胞運命決定機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

高解像細胞系譜解析を用いたclub細胞の恒常性維持及び疾患時の可塑性の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Progenitor cells and initiation of squamous metaplasia focused on club cell fate conversionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Defining the mechanism underlying transformation from adenocarcinoma to small cell lung carcinoma focused on club cell fate conversionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of small cell lung carcinoma cells by interference between axon guidance molecules and their receptors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The role of YAP1 in small cell lung cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Heterogeneous expression and role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in small cell lung cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ZMYM3 May Promote Cell Proliferation in Small Cell Lung Carcinoma2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Significance of achaete-scute complex homologue 1 (ASCL1) in pulmonary neuroendocrine carcinomas; RNA sequence analyses using small cell lung cancer cells and Ascl1-induced pulmonary neuroendocrine carcinoma cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ascl1-induced Wnt11 regulates neuroendocrine differentiation, cell proliferation, and E-cadherin expression in small-cell lung cancer and Wnt11 regulates small-cell lung cancer biology2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Significance of Tsukushi in lung cancer.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Alveolus-like organoid from isolated tip epithelium of embryonic mouse lung.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of Drain in Lung Carcinomas2018

Author(s)

Journal Title

Data Source

[Journal Article] Expression of Draxin in Lung Carcinomas2018

Author(s)

Journal Title

MATSUO Akira 松尾顕