Hoshino Atsushi 星野温

Researcher Number	50737210
Other IDs
Affiliation (Current)	2025: 京都府立医科大学, 医学(系)研究科(研究院), 講師
Affiliation (based on the past Project Information) *help	2022 – 2025: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2018 – 2021: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Medium-sized Section 52:General internal medicine and related fields / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords	Principal Investigator スクリーニング / deep mutational scanning / AAV / base editor / CRISPR / セクレトーム / 線維化 / 凝集抵抗性変異 / ゲノム編集 / 凝集抵抗性 … More / αシヌクレイン / パーキンソン病 / シグナルネットワーク / 心不全 / エピゲノム / シングルセル解析 / ミトコンドリア / マイトファジー / ミトコンドリア生合成 / 遺伝子治療 / アミロイドβ / 合成アミロイドβ受容体 / バイオエンジニアリング / 合成受容体 / アルツハイマー病 … More Except Principal Investigator 病態解析 / 液・液相分離 / タンパク質凝集体形成 / 神経変性疾患 / mRNA / Electroporation / ライソゾーム病 / 中和抗体 / CAR T Less

トランスサイレチン構造安定化保護バリアントの網羅的同定とゲノム編集による疾患克服Principal Investigator
- Principal Investigator
  
  星野温
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Analysis of protein aggregation in pathological droplet by liquid-liquid phase separation and neurodegenerative diseases.
- Principal Investigator
  
  渡邊義久
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kyoto Prefectural University of Medicine
Development of an AAV-deliverable compact and enhanced base editorPrincipal Investigator
- Principal Investigator
  
  星野温
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Kyoto Prefectural University of Medicine
Elucidating the transcriptional network for profibrotic secretome and its application for heart failure therapyPrincipal Investigator
- Principal Investigator
  
  星野温
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Comprehensive analysis of aggregate-resistant structure and its application for disease preventionPrincipal Investigator
- Principal Investigator
  
  Hoshino Atsushi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Kyoto Prefectural University of Medicine
Neutralizing antibody producing B cell deletion by CAR technology in Lysosomal diseases
- Principal Investigator
  
  Gojo Satoshi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Kyoto Prefectural University of Medicine
Comprehensive analysis to uncover molecular network between mitochondria and nucleus underlying mitochondrial homeostasisPrincipal Investigator
- Principal Investigator
  
  Hoshino Atsushi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Development of synthetic Amyloid beta receptor for Alzheimer's disease therapyPrincipal Investigator
- Principal Investigator
  
  Hoshino Atsushi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Kyoto Prefectural University of Medicine

All 2024 2023 2021 2020 2019

All Journal Article Presentation

[Journal Article] Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion2023
- Author(s)
  Minami Yoshito、Hoshino Atsushi、Higuchi Yusuke、Hamaguchi Masahide、Kaneko Yusaku、Kirita Yuhei、Taminishi Shunta、Nishiji Toshiyuki、Taruno Akiyuki、Fukui Michiaki、Arany Zoltan、Matoba Satoaki
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1
- DOI
  10.1038/s41467-023-39404-6
- Data Source
  KAKENHI-PROJECT-23K24332
[Journal Article] Fibroblast Nrf2 inhibits profibrotic transcription with Ddx54 and mitigates pathological fibrosis in the mouse heart and kidney2023
- Author(s)
  Nishiji Toshiyuki、Hoshino Atsushi、IKemura Nariko、Alcantara Mellissa C、Higuchi Yusuke、Uchio Yuki、Kirita Yuhei、Taminishi Shunta、Ozaki Yuki、Motooka Daisuke、Kobayashi Ryosuke、Horii Takuro、Hatada Izuho、Matoba Satoaki
- Journal Title
  
  bioRxiv
  
  Volume: N/A
- DOI
  10.1101/2023.11.09.566496
- Open Access
- Data Source
  KAKENHI-PROJECT-23K24332
[Journal Article] An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis2023
- Author(s)
  Hino Tomohiro、Omura Satoshi N.、Nakagawa Ryoya、Togashi Tomoki、Takeda Satoru N.、Hiramoto Takafumi、Tasaka Satoshi、Hirano Hisato、Tokuyama Takeshi、Uosaki Hideki、Ishiguro Soh、Kagieva Madina、Yamano Hiroyuki、Ozaki Yuki、Motooka Daisuke、Mori Hideto、Kirita Yuhei、Kise Yoshiaki et al.
- Journal Title
  
  Cell
  
  Volume: 186 Issue: 22 Pages: 4920-4935
- DOI
  10.1016/j.cell.2023.08.031
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19263, KAKENHI-PROJECT-19KK0219, KAKENHI-PROJECT-22K15397, KAKENHI-PROJECT-22KJ0608, KAKENHI-PROJECT-23K23819, KAKENHI-PROJECT-23K24332
[Journal Article] Generation of inducible mitophagy mice2023
- Author(s)
  Nishiji Toshiyuki、Hoshino Atsushi、Uchio Yuki、Matoba Satoaki
- Journal Title
  
  Genes to Cells
  
  Volume: 29 Issue: 2 Pages: 159-168
- DOI
  10.1111/gtc.13091
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24332
[Journal Article] The ADP/ATP translocase drives mitophagy independent of nucleotide exchange2019
- Author(s)
  Hoshino Atsushi、Wang Wei-jia、Wada Shogo、McDermott-Roe Chris、Evans Chantell S.、Gosis Bridget、Morley Michael P.、Rathi Komal S.、Li Jian、Li Kristina、Yang Steven、McManus Meagan J.、Bowman Caitlyn、Potluri Prasanth、Levin Michael、Damrauer Scott、Wallace Douglas C.、Holzbaur Erika L. F.、Arany Zoltan
- Journal Title
  
  Nature
  
  Volume: 575 Issue: 7782 Pages: 375-379
- DOI
  10.1038/s41586-019-1667-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03658
[Presentation] An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis2024
- Author(s)
  Tomohiro Hino, Atsushi Hoshino, Satoaki Matoba
- Organizer
  第88回日本循環器学会総会
- Data Source
  KAKENHI-PROJECT-23K24332
[Presentation] N-terminal acetyltransferase C as a new treatment option target for skeletal muscle atrophy in cancer cachexia.2023
- Author(s)
  Yusaku Kaneko, Atsushi Hoshino, Satoaki Matoba
- Organizer
  CVMW2023
- Data Source
  KAKENHI-PROJECT-23K24332
[Presentation] カスタムゲノム編集ツールによる精密化ゲノム編集医療2023
- Author(s)
  星野温
- Organizer
  ゲノム編集学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24332
[Presentation] オートファジーによるミトコンドリア品質管理と創薬応用2021
- Author(s)
  星野　温
- Organizer
  第31回日本循環薬理学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03658
[Presentation] Mitochondrial biogenesis coupled with mitophagy-mediated mitochondrial degradation2021
- Author(s)
  星野温
- Organizer
  第37回国際心臓研究学会日本部会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03658
[Presentation] 多層性CRISPRスクリーニングによるマイトファジー制御因子の網羅的同定2020
- Author(s)
  星野温
- Organizer
  高血圧関連疾患モデル学会
- Data Source
  KAKENHI-PROJECT-19H03658

1. 渡邊義久 (50363990)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Gojo Satoshi (90316745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 伊東恭子 (80243301)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 上大介 (80415588)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 野村征太郎 (10722118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 木瀬孔明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hoshino Atsushi 星野 温

Research Projects

Research Products

Co-Researchers

トランスサイレチン構造安定化保護バリアントの網羅的同定とゲノム編集による疾患克服Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of protein aggregation in pathological droplet by liquid-liquid phase separation and neurodegenerative diseases.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of an AAV-deliverable compact and enhanced base editorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the transcriptional network for profibrotic secretome and its application for heart failure therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive analysis of aggregate-resistant structure and its application for disease preventionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Neutralizing antibody producing B cell deletion by CAR technology in Lysosomal diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive analysis to uncover molecular network between mitochondria and nucleus underlying mitochondrial homeostasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of synthetic Amyloid beta receptor for Alzheimer's disease therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fibroblast Nrf2 inhibits profibrotic transcription with Ddx54 and mitigates pathological fibrosis in the mouse heart and kidney2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of inducible mitophagy mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The ADP/ATP translocase drives mitophagy independent of nucleotide exchange2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis2024

Author(s)

Organizer

Hoshino Atsushi 星野温