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Hoshino Atsushi  星野 温

ORCIDConnect your ORCID iD *help
Researcher Number 50737210
Other IDs
Affiliation (Current) 2025: 京都府立医科大学, 医学(系)研究科(研究院), 講師
Affiliation (based on the past Project Information) *help 2022 – 2025: 京都府立医科大学, 医学(系)研究科(研究院), 講師
2018 – 2021: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field
Principal Investigator
Basic Section 53020:Cardiology-related / Medium-sized Section 52:General internal medicine and related fields / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Except Principal Investigator
Basic Section 51030:Pathophysiologic neuroscience-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords
Principal Investigator
スクリーニング / deep mutational scanning / AAV / base editor / CRISPR / セクレトーム / 線維化 / 凝集抵抗性変異 / ゲノム編集 / 凝集抵抗性 … More / αシヌクレイン / パーキンソン病 / シグナルネットワーク / 心不全 / エピゲノム / シングルセル解析 / ミトコンドリア / マイトファジー / ミトコンドリア生合成 / 遺伝子治療 / アミロイドβ / 合成アミロイドβ受容体 / バイオエンジニアリング / 合成受容体 / アルツハイマー病 … More
Except Principal Investigator
病態解析 / 液・液相分離 / タンパク質凝集体形成 / 神経変性疾患 / mRNA / Electroporation / ライソゾーム病 / 中和抗体 / CAR T Less
  • Research Projects

    (8 results)
  • Research Products

    (11 results)
  • Co-Researchers

    (6 People)
  •  トランスサイレチン構造安定化保護バリアントの網羅的同定とゲノム編集による疾患克服Principal Investigator

    • Principal Investigator
      星野 温
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Analysis of protein aggregation in pathological droplet by liquid-liquid phase separation and neurodegenerative diseases.

    • Principal Investigator
      渡邊 義久
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Development of an AAV-deliverable compact and enhanced base editorPrincipal Investigator

    • Principal Investigator
      星野 温
    • Project Period (FY)
      2024 – 2025
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Elucidating the transcriptional network for profibrotic secretome and its application for heart failure therapyPrincipal Investigator

    • Principal Investigator
      星野 温
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Comprehensive analysis of aggregate-resistant structure and its application for disease preventionPrincipal Investigator

    • Principal Investigator
      Hoshino Atsushi
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Neutralizing antibody producing B cell deletion by CAR technology in Lysosomal diseases

    • Principal Investigator
      Gojo Satoshi
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 49:Pathology, infection/immunology, and related fields
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Comprehensive analysis to uncover molecular network between mitochondria and nucleus underlying mitochondrial homeostasisPrincipal Investigator

    • Principal Investigator
      Hoshino Atsushi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Development of synthetic Amyloid beta receptor for Alzheimer's disease therapyPrincipal Investigator

    • Principal Investigator
      Hoshino Atsushi
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Kyoto Prefectural University of Medicine

All 2024 2023 2021 2020 2019

All Journal Article Presentation

  • [Journal Article] Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion2023

    • Author(s)
      Minami Yoshito、Hoshino Atsushi、Higuchi Yusuke、Hamaguchi Masahide、Kaneko Yusaku、Kirita Yuhei、Taminishi Shunta、Nishiji Toshiyuki、Taruno Akiyuki、Fukui Michiaki、Arany Zoltan、Matoba Satoaki
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1

    • DOI

      10.1038/s41467-023-39404-6

    • Data Source
      KAKENHI-PROJECT-23K24332
  • [Journal Article] Fibroblast Nrf2 inhibits profibrotic transcription with Ddx54 and mitigates pathological fibrosis in the mouse heart and kidney2023

    • Author(s)
      Nishiji Toshiyuki、Hoshino Atsushi、IKemura Nariko、Alcantara Mellissa C、Higuchi Yusuke、Uchio Yuki、Kirita Yuhei、Taminishi Shunta、Ozaki Yuki、Motooka Daisuke、Kobayashi Ryosuke、Horii Takuro、Hatada Izuho、Matoba Satoaki
    • Journal Title

      bioRxiv

      Volume: N/A

    • DOI

      10.1101/2023.11.09.566496

    • Open Access
    • Data Source
      KAKENHI-PROJECT-23K24332
  • [Journal Article] An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis2023

    • Author(s)
      Hino Tomohiro、Omura Satoshi N.、Nakagawa Ryoya、Togashi Tomoki、Takeda Satoru N.、Hiramoto Takafumi、Tasaka Satoshi、Hirano Hisato、Tokuyama Takeshi、Uosaki Hideki、Ishiguro Soh、Kagieva Madina、Yamano Hiroyuki、Ozaki Yuki、Motooka Daisuke、Mori Hideto、Kirita Yuhei、Kise Yoshiaki et al.
    • Journal Title

      Cell

      Volume: 186 Issue: 22 Pages: 4920-4935

    • DOI

      10.1016/j.cell.2023.08.031

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19263, KAKENHI-PROJECT-19KK0219, KAKENHI-PROJECT-22K15397, KAKENHI-PROJECT-22KJ0608, KAKENHI-PROJECT-23K23819, KAKENHI-PROJECT-23K24332
  • [Journal Article] Generation of inducible mitophagy mice2023

    • Author(s)
      Nishiji Toshiyuki、Hoshino Atsushi、Uchio Yuki、Matoba Satoaki
    • Journal Title

      Genes to Cells

      Volume: 29 Issue: 2 Pages: 159-168

    • DOI

      10.1111/gtc.13091

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K24332
  • [Journal Article] The ADP/ATP translocase drives mitophagy independent of nucleotide exchange2019

    • Author(s)
      Hoshino Atsushi、Wang Wei-jia、Wada Shogo、McDermott-Roe Chris、Evans Chantell S.、Gosis Bridget、Morley Michael P.、Rathi Komal S.、Li Jian、Li Kristina、Yang Steven、McManus Meagan J.、Bowman Caitlyn、Potluri Prasanth、Levin Michael、Damrauer Scott、Wallace Douglas C.、Holzbaur Erika L. F.、Arany Zoltan
    • Journal Title

      Nature

      Volume: 575 Issue: 7782 Pages: 375-379

    • DOI

      10.1038/s41586-019-1667-4

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03658
  • [Presentation] An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis2024

    • Author(s)
      Tomohiro Hino, Atsushi Hoshino, Satoaki Matoba
    • Organizer
      第88回日本循環器学会総会
    • Data Source
      KAKENHI-PROJECT-23K24332
  • [Presentation] N-terminal acetyltransferase C as a new treatment option target for skeletal muscle atrophy in cancer cachexia.2023

    • Author(s)
      Yusaku Kaneko, Atsushi Hoshino, Satoaki Matoba
    • Organizer
      CVMW2023
    • Data Source
      KAKENHI-PROJECT-23K24332
  • [Presentation] カスタムゲノム編集ツールによる精密化ゲノム編集医療2023

    • Author(s)
      星野温
    • Organizer
      ゲノム編集学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K24332
  • [Presentation] オートファジーによるミトコンドリア品質管理と創薬応用2021

    • Author(s)
      星野 温
    • Organizer
      第31回 日本循環薬理学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03658
  • [Presentation] Mitochondrial biogenesis coupled with mitophagy-mediated mitochondrial degradation2021

    • Author(s)
      星野温
    • Organizer
      第37回国際心臓研究学会日本部会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03658
  • [Presentation] 多層性CRISPRスクリーニングによるマイトファジー制御因子の網羅的同定2020

    • Author(s)
      星野温
    • Organizer
      高血圧関連疾患モデル学会
    • Data Source
      KAKENHI-PROJECT-19H03658
  • 1.  渡邊 義久 (50363990)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  Gojo Satoshi (90316745)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  伊東 恭子 (80243301)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  上 大介 (80415588)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  野村 征太郎 (10722118)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  木瀬 孔明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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