Kawashima Atsunari 河嶋厚成

Researcher Number	50746568
Other IDs
Affiliation (Current)	2026: 大阪大学, 大学院医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2024 – 2026: 大阪大学, 大学院医学系研究科, 准教授 2022 – 2023: 大阪大学, 大学院医学系研究科, 講師 2017 – 2021: 大阪大学, 医学系研究科, 助教 2016: 大阪大学, 医学系研究科, 寄附講座助教 2015: 大阪大学, 医学(系)研究科(研究院), 特任助教〈常勤)
Review Section/Research Field	Principal Investigator Basic Section 56030:Urology-related / Urology / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields Except Principal Investigator Basic Section 56030:Urology-related
Keywords	Principal Investigator 尿路上皮癌 / 制御性T細胞 / 効果予測 / 腎細胞癌 / 膀胱癌 / 転移 / Gm / Am / Cm / 上部尿路上皮癌 … More / Dアミノ酸 / RNA修飾 / 血液 / 細菌叢 / Ｄアミノ酸 / CD31 / 血管新生 / Cutibacterium acnes / 癌免疫療法 / 細菌関連代謝物 / Firmicutes / Bacteroidia / 細胞外小胞 / エクソソーム / 免疫療法 / 血液内細菌叢 / ノックアウトマウス / CCR8 / シングルセルシークエンス / 新規治療標的 / 癌免疫 / 泌尿器科癌 / 疲弊化T細胞 / Tim-3 / 腫瘍悪性度 / 予後予測 / ニボルマブ / TIM-3 / PD-1 … More Except Principal Investigator 尿路上皮癌 / RNA修飾 / 腫瘍免疫 / Dアラニン / Dアミノ酸 / 細菌遺伝情報 / 細胞外小胞 / 空間的不均一性 / 腸内細菌叢 / 前立腺癌 / ショットガンメタゲノム解析 / 免疫チェックポイント阻害剤 / 上部尿路腫瘍 / 血液細菌叢 / 腫瘍微小環境 / 腫瘍代謝 / Dアスパラギン / 早期血液診断薬 / D-アスパラギン / D-アミノ酸 / スクリーニング / バイオマーカー / 膀胱癌 / 腎癌組織内免疫 / 血液内細菌情報 / 腎細胞癌 Less

尿路上皮癌に対するMHC class IIインバリアント鎖発現調節に基づく新規免疫療法の開発Principal Investigator
- Principal Investigator
  
  河嶋厚成
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  The University of Osaka
D-アラニンを用いた新規腫瘍免疫賦活薬の臨床応用へのトランスレーショナルリサーチ
- Principal Investigator
  
  山本顕生
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  The University of Osaka
Development of a novel treatment for urothelial carcinoma focusing on bacterial information in serum extracellular vesicles
- Principal Investigator
  
  植村俊彦
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  The University of Osaka
癌微小環境にも着目した尿路上皮癌への新規併用治療の最適化と逐次療法の探索
- Principal Investigator
  
  林拓自
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  The University of Osaka
Elucidation of the cancer local immune status constructed by the systemic circulating microbiome and bacterial-related metabolism in urogenital cancerPrincipal Investigator
- Principal Investigator
  
  Kawashima Atsunari
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Osaka University
前立腺癌における腸内細菌叢が制御する免疫療法関連RNA修飾の解明と治療標的の探索
- Principal Investigator
  
  松下慎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Osaka University
時空間的トランスクリプトーム解析による上部尿路上皮癌の進展・薬剤耐性機序の解明
- Principal Investigator
  
  石津谷祐
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Osaka University
尿路上皮癌のRNA修飾によるエピトランスクリプトムの解明と新規治療戦略創成
- Principal Investigator
  
  山本致之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Osaka University
Identification of blood microbiota that regulates the local immune status in renal cell carcinoma
- Principal Investigator
  
  Uemura Toshihiro
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Osaka University
Understanding the Significance of D-Amino Acid Expression in Patients with Urothelial Carcinoma
- Principal Investigator
  
  Yamamoto Akinaru
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Osaka University
Elucidation of RNA modification mechanisms involved in cancer metastasis and the development of novel therapeutic strategiesPrincipal Investigator
- Principal Investigator
  
  Kawashima Atsunari
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Osaka University
Development of cancer immunotherapy for urothelial carcinoma targeting tissue infiltrating regulatory T cellsPrincipal Investigator
- Principal Investigator
  
  KAWASHIMA ATSUNARI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Osaka University
Clarification of immune status in urological cancer tissues and identification for novel therapeutic targetsPrincipal Investigator
- Principal Investigator
  
  Kawashima Atsunari
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Osaka University
Identification of new therapeutic items for drug resistant metastatic urothelial carcinomaPrincipal Investigator
- Principal Investigator
  
  Kawashima Atsunari
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Osaka University

All 2025 2024 2023 2022 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] Serum D-asparagine concentration adjusted for eGFR could serve as a novel screening tool for urothelial carcinoma2024
- Author(s)
  Yamamoto Akinaru,Kawashima Atsunari,Sakai Shinsuke,Mita Masashi,Sassi Nesrine,Inoguchi Shunsuke,Horibe Yuki,Yoshimura Akihiro,Tani Masaru,Yutong Liu,Okuda Yohei,Oka Toshiki,Uemura Toshihiro,Yamamichi Gaku,Ishizuya Yu,Hayashi Takuji,Yamamoto Yoshiyuki, Imamura Ryoichi,Kimura Tomonori,Nonomura Norio etc.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 733 Pages: 150701-150701
- DOI
  10.1016/j.bbrc.2024.150701
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24472, KAKENHI-PROJECT-22K09523, KAKENHI-PROJECT-22K19414
[Journal Article] Cutibacterium acnes‐derived extracellular vesicles promote tumor growth in renal cell carcinoma2024
- Author(s)
  Jingushi Kentaro、Kawashima Atsunari、Tanikawa Sayaka、Saito Takuro、Yamamoto Akinaru、Uemura Toshihiro、Sassi Nesrine、Ishizuya Yu、Yamamoto Yoshiyuki、Kato Taigo、Hatano Koji、Hase Hiroaki、Nonomura Norio、Tsujikawa Kazutake
- Journal Title
  
  Cancer Science
  
  Volume: 1 Issue: 8 Pages: 1-1
- DOI
  10.1111/cas.16202
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24472
[Journal Article] Bacterial information in serum extracellular vesicles reflects the inflammation of adherent perinephric fat2024
- Author(s)
  Uemura Toshihiro,Kawashima Atsunari,Jingushi Kentaro,Motooka Daisuke,Saito Takuro,Sassi Nesrine,Horibe Yuki,Yamamoto Akinaru,Liu Yutong,Tani Masaru,Yoshimura Akihiro,Oka Toshiki,Okuda Yohei,Yamamichi Gaku,Ishizuya Yu,Yamamoto Yoshiyuki,Kato Taigo,Hatano Koji,Tsujikawa Kazutake,Wada Hisashi,Nonomura Norio
- Journal Title
  
  Cancer Science
  
  Volume: 116 Issue: 2 Pages: 338-349
- DOI
  10.1111/cas.16410
- Data Source
  KAKENHI-PROJECT-23K24472, KAKENHI-PROJECT-22K09469, KAKENHI-PROJECT-23K08194
[Journal Article] Bacteria-derived DNA in serum extracellular vesicles are biomarkers for renal cell carcinoma2023
- Author(s)
  Uemura Toshihiro、Kawashima Atsunari、Jingushi Kentaro、Motooka Daisuke、Saito Takuro、Nesrine Sassi、Oka Toshiki、Okuda Yohei、Yamamoto Akinaru、Yamamichi Gaku、Tomiyama Eisuke、Ishizuya Yu、Yamamoto Yoshiyuki、Kato Taigo、Hatano Koji、Tsujikawa Kazutake、Wada Hisashi、Nonomura Norio
- Journal Title
  
  Heliyon
  
  Volume: 9 Issue: 9 Pages: e19800-e19800
- DOI
  10.1016/j.heliyon.2023.e19800
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09469, KAKENHI-PROJECT-23K24472
[Journal Article] Circulating extracellular vesicles carrying Firmicutes reflective of the local immune status may predict clinical response to pembrolizumab in urothelial carcinoma patients2022
- Author(s)
  Jingushi Kentaro,Kawashima Atsunari、Saito Takuro、Kanazawa Takayuki、Motooka Daisuke、Kimura Tomonori、Mita Masashi、Yamamoto Akinaru、Uemura Toshihiro、Yamamichi Gaku、Okada Koichi、Tomiyama Eisuke、Koh Yoko、Matsushita Makoto、Kato Taigo、Hatano Koji、Uemura Motohide、Tsujikawa Kazutake、Wada Hisashi、Nonomura Norio
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 71 Issue: 12 Pages: 2999-3011
- DOI
  10.1007/s00262-022-03213-5
- Data Source
  KAKENHI-PROJECT-21K20968, KAKENHI-PROJECT-23K24472
[Journal Article] Phenotypic Analysis of Tumor Tissue?Infiltrating Lymphocytes in Tumor Microenvironment of Bladder Cancer and Upper Urinary Tract Carcinoma2019
- Author(s)
  Kawashima Atsunari、Kanazawa Takayuki、Jingushi Kentaro、Kato Taigo、Ujike Takeshi、Nagahara Akira、Fujita Kazutoshi、Morimoto-Okazawa Akiko、Iwahori Kota、Uemura Motohide、Imamura Ryoichi、Wada Hisashi、Nonomura Norio
- Journal Title
  
  Clinical Genitourinary Cancer
  
  Volume: 17 Issue: 2 Pages: 114-124
- DOI
  10.1016/j.clgc.2018.11.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16790, KAKENHI-PROJECT-19H03729
[Patent] 癌の種類についての情報を提供する方法2023
- Inventor(s)
  河嶋厚成、野々村祝夫、今村亮一、山本顕生、木村友則、三田真史
- Industrial Property Rights Holder
  河嶋厚成、野々村祝夫、今村亮一、山本顕生、木村友則、三田真史
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-036041
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K24472
[Presentation] eGFR補正した血清D-アスパラギンは尿路上皮癌に対する新規のスクリーニングツールとなりうる2025
- Author(s)
  井之口舜亮、山本顕生、河嶋厚成、Sassi Nesrine、堀部祐輝、植村俊彦、石津谷祐、林拓自、山本致之、加藤大悟、波多野浩士、角田洋一、野々村祝夫
- Organizer
  第112回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-22K09523
[Presentation] 血清D-アスパラギンは尿路上皮癌の新規診断バイオマーカーとなる2025
- Author(s)
  石津谷祐、河嶋厚成、山本顕生、木村友則、三田真史、Sassi Nesrine、林拓自、山本致之、加藤大悟、波多野浩士、野々村祝夫
- Organizer
  第9回Liquid Biopsy 研究会
- Data Source
  KAKENHI-PROJECT-22K09523
[Presentation] キラルアミノ酸であるDアミノ酸は尿路上皮癌の新規バイオマーカーとなる2024
- Author(s)
  山本顕生、河嶋厚成、木村友則、三田真史、Sassi Nesrine、堀部祐輝、植村俊彦、石津谷祐、林拓自、山本致之、加藤大悟、波多野浩士、野々村祝夫
- Organizer
  第83回日本癌学会
- Data Source
  KAKENHI-PROJECT-22K09523
[Presentation] Development of a novel blood marker panel including D-asparagine for urothelial carcinoma diagnosis2024
- Author(s)
  Atunari Kawashima et al.
- Organizer
  国際Dアミノ酸学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24472
[Presentation] 尿路上皮癌に対する免疫療法の個別化2024
- Author(s)
  河嶋厚成ら
- Organizer
  第10回日本泌尿器腫瘍学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24472
[Presentation] 上部尿路上皮癌におけるRNA修飾を用いた新規バイオマーカー開発2024
- Author(s)
  山本致之、河嶋厚成、長谷拓明、宮崎陽平、堀部祐輝、Nesrine Sassi、植村俊彦、山本顕生、山道岳、中野剛佑、石津谷祐、加藤大悟、波多野浩士、辻川和丈、野々村祝夫
- Organizer
  第62回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K08778
[Presentation] 尿路性器癌患者の血液由来細胞外小胞を用いた血液細菌叢評価の臨床的重要性2024
- Author(s)
  河嶋厚成ら
- Organizer
  第９７回日本細菌学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24472
[Presentation] 細菌特異的代謝産物であるD-アミノ酸は尿路上皮癌患者の血清で高値を示す2024
- Author(s)
  山本顕生、河嶋厚成、木村友則、三田真史、Sassi Nesrine、堀部祐輝、谷　優、植村俊彦、石津谷祐、山本致之、加藤大悟、波多野浩士、野々村祝夫
- Organizer
  第111回日本泌尿器科学会
- Data Source
  KAKENHI-PROJECT-22K09523
[Presentation] Clinical utility of the novel risk model using RNA modifications for upper tract urothelial cancer.2024
- Author(s)
  山本致之、河嶋厚成、長谷拓明、宮崎陽平、堀部祐輝、Nesrine Sassi、植村俊彦、山本顕生、山道岳、中野剛佑、石津谷祐、加藤大悟、波多野浩士、辻川和丈、野々村祝夫
- Organizer
  第83回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K08778
[Presentation] 尿路上皮癌におけるRNA修飾クラスターの生物学的意義解明2023
- Author(s)
  山本致之、河嶋厚成、長谷拓明、宮崎陽平、堀部祐輝、山道　岳、石津谷祐、加藤大悟、波多野浩士、野々村祝夫
- Organizer
  第33回泌尿器科分子・細胞研究会
- Data Source
  KAKENHI-PROJECT-23K08778
[Presentation] 20.尿路性器癌患者の血液内細菌遺伝情報を用いた予後予測リキッドバイオプシーの可能性2023
- Author(s)
  河嶋厚成ら
- Organizer
  第61回日本癌治療学会
- Data Source
  KAKENHI-PROJECT-23K24472
[Presentation] Establishment of Blood-based Diagnostic Markers of Urothelial Carcinoma Using Chiral Amino Acids2023
- Author(s)
  Atunari Kawashima et al.
- Organizer
  米国泌尿器科学会総会 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24472
[Presentation] D-asparagine could become a novel blood-based diagnostic marker for urothelial carcinoma patients.2023
- Author(s)
  Atunari Kawashima et al.
- Organizer
  EMUC 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24472
[Presentation] 4.Development of novel cancer immunotherapy based on the circulating microbiome2023
- Author(s)
  河嶋厚成ら
- Organizer
  第110回　日本泌尿器科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24472
[Presentation] Implications of RNA modification clusters in urothelial carcinoma2023
- Author(s)
  Yoshiyuki Yamamoto, Atsunari Kawashima, Hiroaki Hase, Yohei Miyazaki, Yuki Horibe, Masaru Tani, Nesrine Sassi, Toshihiro Uemura, Akinaru Yamamoto, Gaku Yamamichi, Kosuke Nakano, Yu Ishizuya, Taigo Kato, Koji Hatano, Norio Nonomura
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K08778
[Presentation] 16.血液内細菌遺伝情報・代謝情報に基づいた新規バイオマーカーの開発2023
- Author(s)
  河嶋厚成
- Organizer
  Urologist Forum in Osaka　2023
- Invited
- Data Source
  KAKENHI-PROJECT-23K24472
[Presentation] 血液内細菌叢の多様性は、癌免疫療法の治療効果を予測する2022
- Author(s)
  河嶋厚成
- Organizer
  日本泌尿器腫瘍学会
- Data Source
  KAKENHI-PROJECT-23K24472
[Presentation] 腎細胞癌の腫瘍悪性度は癌組織内T細胞の機能低下と有意な相関示す2018
- Author(s)
  河嶋厚成
- Organizer
  第68回日本泌尿器科学会中部総会
- Data Source
  KAKENHI-PROJECT-17K16790
[Presentation] 膀胱癌と上部尿路上皮癌における癌局所内免疫状態の比較2018
- Author(s)
  河嶋厚成
- Organizer
  第77回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-17K16790
[Presentation] Overall dysfunction of T cells was significantly correlated with tumor grade in Renal Cell Carcinoma patients2018
- Author(s)
  Atsunari Kawashima
- Organizer
  35th Korea-Japan Urological Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16790
[Presentation] The significance as a prognostic predictor of immunological phenotype in urothelial carcinoma varies depending on the tumor sites2018
- Author(s)
  Atsunari Kawashima
- Organizer
  Asia Urological Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16790
[Presentation] 尿路上皮癌における腫瘍浸潤T細胞サブセット解析2017
- Author(s)
  河嶋　厚成
- Organizer
  泌尿器分子細胞研究会
- Place of Presentation
  大分
- Year and Date
  2017-03-10
- Data Source
  KAKENHI-PROJECT-15K20085

1. 野々村祝夫 (30263263)

# of Collaborated Projects: 8 results

# of Collaborated Products: 12 results
2. 神宮司健太郎 (80707571)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
3. 木村友則 (00631300)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. Uemura Toshihiro (60905941)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. Yamamoto Akinaru (50909653)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. 和田尚 (70243459)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 長谷拓明 (80779926)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
8. 山本致之 (90759557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. 元岡大祐 (10636830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 西塔拓郎 (20646468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 林拓自 (50747079)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 松下慎 (40824785)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 石津谷祐 (00783854)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kawashima Atsunari 河嶋 厚成

Research Projects

Research Products

Co-Researchers

尿路上皮癌に対するMHC class IIインバリアント鎖発現調節に基づく新規免疫療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Principal Investigator

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Review Section

Research Institution

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Elucidation of the cancer local immune status constructed by the systemic circulating microbiome and bacterial-related metabolism in urogenital cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

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Elucidation of RNA modification mechanisms involved in cancer metastasis and the development of novel therapeutic strategiesPrincipal Investigator

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Development of cancer immunotherapy for urothelial carcinoma targeting tissue infiltrating regulatory T cellsPrincipal Investigator

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Clarification of immune status in urological cancer tissues and identification for novel therapeutic targetsPrincipal Investigator

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Identification of new therapeutic items for drug resistant metastatic urothelial carcinomaPrincipal Investigator

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Kawashima Atsunari 河嶋厚成

[Presentation] 血清D-アスパラギンは尿路上皮癌の新規診断バイオマーカーとなる2025