TANAKA HIROKI 田中宏樹

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Hiroki Tanaka 田中宏樹

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Researcher Number	50747920
Other IDs
Affiliation (Current)	2025: 北海道大学, 遺伝子病制御研究所, 特任講師
Affiliation (based on the past Project Information) *help	2025: 北海道大学, 遺伝子病制御研究所, 特任講師 2020 – 2022: 大阪大学, 免疫学フロンティア研究センター, 特任講師(常勤) 2018 – 2020: 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) 2019: 大阪大学, 免疫学フロンティア研究センター, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related Except Principal Investigator Broad Section H / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Biological Sciences
Keywords	Principal Investigator RNA安定性 / 炎症 / mRNA安定性 / 炎症性 / 炎症応答 / 細胞分化 / RNA分解酵素 / 免疫応答 / 蛋白質分解 / 蛋白質リン酸化 … More / 自己免疫疾患 / TH17細胞 / 炎症反応制御 / 小胞体 / IL17 / 細胞内局在 / リン酸化 / IL-17 / 炎症反応 / Regnase-1 / mRNA分解酵素 … More Except Principal Investigator 組織恒常性 / 代謝調節 / mRNA産生制御 / Regnase-1 / mRNA安定性 / mRNA安定 / 炎症 / M2マクロファージ / mRNA安定性制御 / 自然免疫 Less

迷走神経刺激による新規抗炎症応答の作用機序の解明Principal Investigator
- Principal Investigator
  
  田中宏樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Hokkaido University
Integrated understanding of functional features of Regnase -1
- Principal Investigator
  
  審良静男
- Project Period (FY)
  2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Osaka University
A novel mechanism for regulation of mRNA stability through functional inactivation of Regnase-1.Principal Investigator
- Principal Investigator
  
  Hiroki Tanaka
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Osaka University
Comprehensive understanding of Regnase-1-mediated mRNA surveillance system
- Principal Investigator
  
  審良静男
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section H
- Research Institution
  Osaka University
Reguratory role of RNase Reganse-1 in inflammatory response through its phosphorylationPrincipal Investigator
- Principal Investigator
  
  Hiroki Tanaka
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Osaka University
Comprehensive analysis of innate immunity
- Principal Investigator
  
  AKIRA Shizuo
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University

All 2023 2020 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] Breaking self‐regulation of Regnase‐1 promotes its own protein expression2023
- Author(s)
  Piboonprai Kitiya、Millius Arthur、Shimoda Mayuko、Tanaka Hiroki、Akira Shizuo、Maeda Kazuhiko
- Journal Title
  
  Genes to Cells
  
  Volume: - Issue: 5 Pages: 383-389
- DOI
  10.1111/gtc.13018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03502, KAKENHI-PROJECT-23K06597, KAKENHI-PROJECT-20H05693
[Journal Article] Regnase-1 degradation is crucial for IL-33- and IL-25-mediated ILC2 activation2020
- Author(s)
  Matsushita Kazufumi、Tanaka Hiroki、Yasuda Koubun、Adachi Takumi、Fukuoka Ayumi、Akasaki Shoko、Koida Atsuhide、Kuroda Etsushi、Akira Shizuo、Yoshimoto Tomohiro
- Journal Title
  
  JCI Insight
  
  Volume: 5 Issue: 4
- DOI
  10.1172/jci.insight.131480
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08813, KAKENHI-PROJECT-18K15189, KAKENHI-PROJECT-15H05704
[Journal Article] Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response.2019
- Author(s)
  7.Tanaka, H., Y. Arima, D. Kamimura, Y. Tanaka, N. Takahashi, T. Uehata, K. Maeda, T. Satoh, M. Murakami, and S. Akira.
- Journal Title
  
  J Exp Med.
  
  Volume: 216 Issue: 6 Pages: 1431-1449
- DOI
  10.1084/jem.20181078
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22522, KAKENHI-PROJECT-18K15189, KAKENHI-PROJECT-15H05704
[Journal Article] mRNA安定化、不安定化を介したサイトカイン産生制御機構2019
- Author(s)
  田中宏樹、審良静男
- Journal Title
  
  医学のあゆみ
  
  Volume: 271 Pages: 478-483
- Data Source
  KAKENHI-PROJECT-18K15189
[Journal Article] Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism2018
- Author(s)
  Nagahama, Y. Shimoda, M. Mao, G. Singh, S. K. Kozakai, Y. Sun, X. Motooka, D. Nakamura, S. Tanaka, H. Satoh, T. Maeda, K. Akira, S.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 115 Issue: 43 Pages: 11036-11041
- DOI
  10.1073/pnas.1809575115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07173, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-15H05704
[Journal Article] BATF2 activates DUSP2 gene expression and up-regulates NF-κB activity via phospho-STAT3 dephosphorylation2018
- Author(s)
  Hisashi Kanemaru, Fumihiro Yamane, Hiroki Tanaka, Kazuhiko Maeda, Takashi Satoh, Shizuo Akira
- Journal Title
  
  International immunology
  
  Volume: dxy023 Issue: 6 Pages: 255-265
- DOI
  10.1093/intimm/dxy023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15J07065, KAKENHI-PROJECT-15H05704, KAKENHI-ORGANIZER-17H06391
[Journal Article] Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages.2017
- Author(s)
  Kanemaru H, Yamane F, Fukushima K, Matsuki T, Kawasaki T, Ebina I, Kuniyoshi K, Tanaka H, Maruyama K, Maeda K, Satoh T, Akira S.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 114 Issue: 35
- DOI
  10.1073/pnas.1708598114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15724, KAKENHI-PROJECT-15H05686, KAKENHI-PROJECT-15J07065, KAKENHI-PROJECT-16K15665, KAKENHI-PROJECT-15H05704
[Patent] 出願2018
- Inventor(s)
  田中宏樹、審良静男、佐藤荘
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-15H05704
[Patent] 出願2018
- Inventor(s)
  佐藤荘、審良静男、田中宏樹、糟谷恵子
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-229845
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-15H05704
[Patent] 出願2018
- Inventor(s)
  田中宏樹、審良静男、佐藤荘
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-15H05704
[Patent] Regnase-1が関与する疾患の治療および／または予防法2018
- Inventor(s)
  田中　宏樹
- Industrial Property Rights Holder
  田中　宏樹
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-229845
- Filing Date
  2018
- Acquisition Date
  2018
- Data Source
  KAKENHI-PROJECT-18K15189
[Presentation] Subcellular translocation of phosphorylated Regnase-1 is critical in controlling target mRNA2019
- Author(s)
  田中宏樹
- Organizer
  第48回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05704
[Presentation] Regnase-1: A key regulator of the mRNA stabilization during Interleukin-17-induced inflammation.2019
- Author(s)
  Hiroki Tanaka
- Organizer
  MMCB, 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15189
[Presentation] Sucellular translocation of phosphorylated Regnase-1 is critical in controlling target mRNA stability in IL-17 signaling.2019
- Author(s)
  Tanaka H, Arima Y, Kamimura D, Tanaka Y, Takahashi N, Uehata T, Maeda K, Satoh T, Murakami M and Akira S.
- Organizer
  第４８回日本免疫学会
- Data Source
  KAKENHI-PROJECT-18K15189
[Presentation] The role of endoribonulease Regnase-1 in inflammation and immune responses/Regnase-1, a key endoribonuclease responsible for the inflammatory and immune responses2019
- Author(s)
  田中宏樹
- Organizer
  MMCB2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05704
[Presentation] Phosphorylation and functional inactivation of Regnase-1 enhance target mRNA stability during IL-17-mediated inflammatory response2018
- Author(s)
  田中　宏樹
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-18K15189
[Presentation] Regnase-1 phosphorylation induced by proinflammatory cytokines controls stability of its target mRNAs.2017
- Author(s)
  Hiroki Tanaka
- Organizer
  第46回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05704

1. AKIRA Shizuo (50192919)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. KUNIYOSHI Kanako (70747881)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. MAEDA Kazuhiko (20332869)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. SATOH Takashi (60619716)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. シンシャイレンドラ・クマール (10792187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YASUDA Koubun

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 村上正晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TANAKA HIROKI 田中 宏樹

Hiroki Tanaka 田中 宏樹

Research Projects

Research Products

Co-Researchers

迷走神経刺激による新規抗炎症応答の作用機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Integrated understanding of functional features of Regnase -1

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel mechanism for regulation of mRNA stability through functional inactivation of Regnase-1.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive understanding of Regnase-1-mediated mRNA surveillance system

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Reguratory role of RNase Reganse-1 in inflammatory response through its phosphorylationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive analysis of innate immunity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Breaking self‐regulation of Regnase‐1 promotes its own protein expression2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regnase-1 degradation is crucial for IL-33- and IL-25-mediated ILC2 activation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] mRNA安定化、不安定化を介したサイトカイン産生制御機構2019

Author(s)

Journal Title

Data Source

[Journal Article] Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BATF2 activates DUSP2 gene expression and up-regulates NF-κB activity via phospho-STAT3 dephosphorylation2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages.2017

Author(s)

Journal Title

DOI

Data Source

[Patent] 出願2018

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

TANAKA HIROKI 田中宏樹

Hiroki Tanaka 田中宏樹