Yasujima Tomoya 保嶋智也

Researcher Number	50753555
Other IDs
Affiliation (Current)	2025: 名古屋市立大学, 医薬学総合研究院(薬学), 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 名古屋市立大学, 医薬学総合研究院(薬学), 准教授 2019 – 2022: 名古屋市立大学, 医薬学総合研究院(薬学), 講師 2017 – 2018: 名古屋市立大学, 大学院薬学研究科, 講師 2016 – 2017: 名古屋市立大学, 大学院薬学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy Except Principal Investigator Basic Section 47060:Clinical pharmacy-related
Keywords	Principal Investigator トランスポーター / リソソーム / ビタミンプール / チアミン / ピリドキシン / ビタミン / lysosome / 神経伝達 / シナプス小胞 / モノアミン … More / 高尿酸血症 / 痛風 / 尿酸結晶 / 尿酸 / 癌 / がん / 促進拡散 / エストロゲン硫酸 / 小胞体 / 乳がん / エストロゲン … More Except Principal Investigator トランスポーター / 創薬標的 / 薬物送達 / 薬物吸収 / ビタミン / 相互作用 / 基質認識機構 / 薬物間相互作用 / 迅速機能評価 / 蛍光 / コリン / 前立腺 / プトレシン / スペルミン / スペルミジン / ポリアミン Less

新規小胞膜局在型モノアミントランスポーターの機能解析と創薬標的としての有望性評価Principal Investigator
- Principal Investigator
  
  保嶋智也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Nagoya City University
新規コリントランスポーター類の分子機能と生理的及び薬物動態的役割
- Principal Investigator
  
  湯浅博昭
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Nagoya City University
Elucidation of substrate recognition mechanism of SLC19A3 to establish the molecular basis for medical applications
- Principal Investigator
  
  山城貴弘
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Nagoya City University
Elucidation of molecular mechanism that triggers onset of gout from hyperuricemiaPrincipal Investigator
- Principal Investigator
  
  Yasujima Tomoya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Nagoya City University
Elucidation of the Function and Physiological Role of a Novel Polyamine Transporter
- Principal Investigator
  
  Hiroaki Yuasa
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Nagoya City University
Relationship between novel thiamine pool mechanism and proliferative capacity in cancer cellsPrincipal Investigator
- Principal Investigator
  
  Tomoya Yasujima
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Nagoya City University
Elucidation of a novel pool mechanism of B vitamins through lysosome accumulationPrincipal Investigator
- Principal Investigator
  
  Yasujima Tomoya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Nagoya City University
Molecular mechanism of estrogen supply pathway in hormone-sensitive breast cancerPrincipal Investigator
- Principal Investigator
  
  Yasujima Tomoya
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagoya City University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Involvement of Proton-Coupled SLC49A4-Mediated Transport in the Export of Lysosomally Trapped Pyrilamine2024
- Author(s)
  Akino Shogo, Yasujima Tomoya, Shibutani Rei,Yamashiro Takahiro, Yuasa Hiroaki
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 52 Issue: 1 Pages: 19-25
- DOI
  10.1124/dmd.123.001354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21KK0280, KAKENHI-PROJECT-23K06283
[Journal Article] Disrupted in renal carcinoma 2 (DIRC2/SLC49A4) is an H<sup>+</sup>-driven lysosomal pyridoxine exporter2022
- Author(s)
  Akino Shogo, Yasujima Tomoya, Yamashiro Takahiro, Yuasa Hiroaki
- Journal Title
  
  Life Science Alliance
  
  Volume: 6 Issue: 2 Pages: e202201629-e202201629
- DOI
  10.26508/lsa.202201629
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21KK0280, KAKENHI-PROJECT-20K07135, KAKENHI-PROJECT-21K15318
[Journal Article] Functional characterization of human organic anion transporter 10 (OAT10/SLC22A13) as an orotate transporter2022
- Author(s)
  Shinoda Yutaro、Yamashiro Takahiro、Hosooka Akira、Yasujima Tomoya、Yuasa Hiroaki
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 43 Pages: 100443-100443
- DOI
  10.1016/j.dmpk.2021.100443
- NAID
  210000188785
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07159
[Journal Article] Proinflammatory cytokines inhibit thiamin uptake by human and mouse pancreatic acinar cells: involvement of transcriptional mechanism(s)2021
- Author(s)
  Anandam Kasin Yadunandam、Srinivasan Padmanabhan、Yasujima Tomoya、Al-Juburi Saleh、Said Hamid M.
- Journal Title
  
  American Journal of Physiology-Gastrointestinal and Liver Physiology
  
  Volume: 320 Issue: 1 Pages: G108-G116
- DOI
  10.1152/ajpgi.00361.2020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18KK0453, KAKENHI-PROJECT-20K07135
[Journal Article] Functional Analysis of the Role of Equilibrative Nucleobase Transporter 1 (ENBT1/SLC43A3) in Adenine Transport in HepG2?Cells2020
- Author(s)
  Takenaka Risa、Yasujima Tomoya、Furukawa Junji、Hishikawa Yosuke、Yamashiro Takahiro、Ohta Kinya、Inoue Katsuhisa、Yuasa Hiroaki
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 109 Issue: 8 Pages: 2622-2628
- DOI
  10.1016/j.xphs.2020.04.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07135
[Journal Article] pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: Implications for absorption in acidic microclimates2020
- Author(s)
  Yamashiro Takahiro、Yasujima Tomoya、Said Hamid M.、Yuasa Hiroaki
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 50 Pages: 16998-17008
- DOI
  10.1074/jbc.ra120.013610
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07135, KAKENHI-PROJECT-19K16416, KAKENHI-PROJECT-18KK0453
[Journal Article] Pharmacokinetic functions of human induced pluripotent stem cell-derived small intestinal epithelial cells2020
- Author(s)
  Kabeya Tomoki、Mima Shinji、Imakura Yuki、Miyashita Toshihide、Ogura Izumi、Yamada Tadanori、Yasujima Tomoya、Yuasa Hiroaki、Iwao Takahiro、Matsunaga Tamihide
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 35 Issue: 4 Pages: 374-382
- DOI
  10.1016/j.dmpk.2020.04.334
- NAID
  50014558611
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07135, KAKENHI-PROJECT-19H03391
[Journal Article] Posttranscriptional regulation of thiamin transporter-1 expression by microRNA-200a-3p in pancreatic acinar cells2020
- Author(s)
  Ramamoorthy Kalidas、Anandam Kasin Yadunandam、Yasujima Tomoya、Srinivasan Padmanabhan、Said Hamid M.
- Journal Title
  
  American Journal of Physiology-Gastrointestinal and Liver Physiology
  
  Volume: 319 Issue: 3 Pages: G323-G332
- DOI
  10.1152/ajpgi.00178.2020
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07135, KAKENHI-PROJECT-18KK0453
[Journal Article] Identification of the amino acid residue responsible for the myricetin sensitivity of human proton-coupled folate transporter2019
- Author(s)
  Yamashiro Takahiro、Yasujima Tomoya、Ohta Kinya、Inoue Katsuhisa、Yuasa Hiroaki
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 18105-18105
- DOI
  10.1038/s41598-019-54367-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0453, KAKENHI-PROJECT-18K14953
[Journal Article] 18β-glycyrrhetyl-3-O-sulfate would be a causative agent of licorice-induced pseudoaldosteronism2019
- Author(s)
  Ishiuchi Kan’ichiro、Morinaga Osamu、Ohkita Takeshi、Tian Chuanting、Hirasawa Asuka、Mitamura Miaki、Maki Yasuhito、Kondo Tsubasa、Yasujima Tomoya、Yuasa Hiroaki、Minamizawa Kiyoshi、Namiki Takao、Makino Toshiaki
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 1587-1587
- DOI
  10.1038/s41598-018-38182-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0453, KAKENHI-PROJECT-18K14953
[Journal Article] Specific inhibitory effects of myricetin on human proton-coupled folate transporter: Comparison with its effects on rat proton-coupled folate transporter and human riboflavin transporter 32017
- Author(s)
  Yamashiro Takahiro、Yasujima Tomoya、Ohta Kinya、Inoue Katsuhisa、Yuasa Hiroaki
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 32 Issue: 6 Pages: 311-314
- DOI
  10.1016/j.dmpk.2017.10.003
- NAID
  210000166654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18951
[Journal Article] Functional Identification of Plasma Membrane Monoamine Transporter (PMAT/SLC29A4) as an Atenolol Transporter Sensitive to Flavonoids Contained in Apple Juice2017
- Author(s)
  Mimura Yoshihisa、Yasujima Tomoya、Ohta Kinya、Inoue Katsuhisa、Yuasa Hiroaki
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 106 Issue: 9 Pages: 2592-2598
- DOI
  10.1016/j.xphs.2017.01.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18951
[Presentation] FLVCR1/2のコリン輸送機能解析：CHT1との比較2024
- Author(s)
  山﨑美音, 廣瀬　舞, 保嶋智也, 山城貴弘, 湯浅博昭
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06258
[Presentation] 各種細胞株でのコリン取込におけるFLVCR1/2の寄与の評価2024
- Author(s)
  保嶋智也, 川本彩果, 山城貴弘, 湯浅博昭
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06258
[Presentation] SLC19A2/3の蛍光性試験基質としてのamilorideの輸送特性の評価と利用2023
- Author(s)
  松井快人、山本道弘、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  日本薬剤学会第38年会
- Data Source
  KAKENHI-PROJECT-23K06283
[Presentation] OAT2/SLC22A7の尿酸輸送機能の動物種差に関わる分子機構2023
- Author(s)
  澁谷玲衣、谷内夏月、保嶋智也、山城貴弘、湯浅博昭
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] ENBT1/SLC43A3によるオロト酸輸送：HEK293細胞一過性発現系及びHepG2細胞での解析2023
- Author(s)
  森本遥香, 髙見華奈, 保嶋智也, 山城貴弘, 湯浅博昭
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07159
[Presentation] Analysis of the transport function of SLC19A2/3 for amiloride: utilization as a fluorescent probe substrate2023
- Author(s)
  Kaito Matsui, Michihiro Yamamoto, Takahiro Yamashiro, Tomoya Yasujima, Hiroaki Yuasa
- Organizer
  2023 International Joint Meeting of 23rd ICCP450/38th JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06283
[Presentation] Comparative evaluation of the choline transport functions of novel choline transporters and choline transporter 12023
- Author(s)
  Mai Hirose, Chitaka Namba, Yosuke Azuma, Tomoya Yasujima, Takahiro Yamashiro, Hiroaki Yuasa
- Organizer
  2023 International Joint Meeting of 23rd ICCP450/38th JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06258
[Presentation] SUBSTRATE-DEPENDENT CHARACTERISTICS IN THE TRANSPORT FUNCTION OF SLC19A3: EXAMINATION OF THE ASPECT OF ITS SENSITIVITY TO FLAVONOIDS2023
- Author(s)
  Hiroaki Yuasa, Saena Yamashita, Takahiro Yamashiro, Tomoya Yasujima
- Organizer
  25th North American ISSX Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06283
[Presentation] Functional characteristics and role of DIRC2/SLC49A4 as a novel lysosomal pyridoxine exporter2022
- Author(s)
  秋野翔伍、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] OAT2の尿酸輸送機能の動物種差2022
- Author(s)
  谷内夏月、保嶋智也、山城貴弘、湯浅博昭
- Organizer
  第43回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] OCT2阻害活性評価における基質依存的な差異：atenolol輸送阻害とMPP+輸送阻害との比較2022
- Author(s)
  細岡晶、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] ENT類による核酸塩基取込における核酸塩基代謝酵素類の基質特異的協働効果2022
- Author(s)
  小西拓実、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] ENBT1のオロト酸輸送機能2022
- Author(s)
  高見華奈, 保嶋智也, 山城貴弘, 湯浅博昭
- Organizer
  第43回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07159
[Presentation] fisetinに対するCNT2の感受性の動物種差に関わるアミノ酸残基2022
- Author(s)
  田中雄大、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] DIRC2のpyrilamine輸送機能及び薬物動態的役割2022
- Author(s)
  秋野翔伍、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  第43回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] 小腸に発現する新規コリントランスポーターの機能解析2022
- Author(s)
  東洋輔、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] オロト酸トランスポーターとしてのSMCT2の機能的同定2022
- Author(s)
  篠田裕太郎、細岡晶、保嶋智也、山城貴弘、湯浅博昭
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] SLC19A3のpyridoxine輸送機能の動物種差に関わるヒト特異的アミノ酸残基2022
- Author(s)
  三宅浩平、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] SLC19A3のpyridoxine輸送機能の動物種差に関わるアミノ酸残基2021
- Author(s)
  三宅浩平、高橋駿介、保嶋智也、山城貴弘、湯浅博昭
- Organizer
  第42回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] オロト酸トランスポーターとしてのヒトOAT10の機能的同定2021
- Author(s)
  篠田裕太郎, 細岡晶, 保嶋智也, 山城貴弘, 湯浅博昭
- Organizer
  第36回日本薬物動態学会年会
- Data Source
  KAKENHI-PROJECT-20K07159
[Presentation] OCT2における基質依存的な阻害活性差：atenolol輸送阻害試験とMPP+輸送阻害試験との比較2021
- Author(s)
  細岡晶、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  第42回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] リソソーム膜局在型の新規pyridoxineトランスポーターの機能解析2021
- Author(s)
  秋野翔伍、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] Functional identification of human OAT10 as an orotate transporter2021
- Author(s)
  篠田裕太郎、細岡晶、保嶋智也、山城貴弘、湯浅博昭
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] ENT2の尿酸輸送機能の解析2021
- Author(s)
  間竹勇、保嶋智也、山城貴弘、湯浅博昭
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] ENT2の尿酸輸送機能の解析：Caco-2細胞での検証2021
- Author(s)
  間竹勇、保嶋智也、山城貴弘、湯浅博昭
- Organizer
  第42回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] SLC19A2/3のpyridoxine/thiamine輸送機構：輸送特性の基質間比較解析2021
- Author(s)
  山城貴弘、保嶋智也、Hamid M. Said、湯浅博昭
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] Functional characterization of the carrier-mediated choline transport system in Caco-2 cells2021
- Author(s)
  難波知尭、保嶋智也、山城貴弘、湯浅博昭
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] Comparative assessment of the uptakes of pyridoxine and thiamine in the rat small intestine: absence of Slc19a3-dependent function of carrier-mediated pyridoxine uptake2021
- Author(s)
  山城貴弘、保嶋智也、湯浅博昭
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] BCRPの尿酸排出輸送活性の評価系としてのSNBT1/BCRP共発現細胞の利用：フラボノイド類の阻害効果2021
- Author(s)
  石牧礼子、奈良佳幸、保嶋智也、山城貴弘、太田欣哉、井上勝央、湯浅博昭
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] ヒトCNT2及びCNT3に対するフラボノイド類の阻害作用の速度論的解析2021
- Author(s)
  難波知尭、矢嶋陽菜、黒田大祐、保嶋智也、山城貴弘、湯浅博昭
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] fisetin及び類縁フラボノイドに対するCNT2の感受性の動物種差2021
- Author(s)
  田中雄大、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20K07135
[Presentation] SLC19A3の脳神経変性疾患関連遺伝子変異と輸送機能との関係2020
- Author(s)
  三宅浩平、小川有沙、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  薬学会，140年会
- Data Source
  KAKENHI-PROJECT-18KK0453
[Presentation] SLC19A3の脳神経変性疾患関連遺伝子変異と輸送機能との関係2020
- Author(s)
  三宅浩平、小川有沙、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  薬学会，140年会
- Data Source
  KAKENHI-PROJECT-18K14953
[Presentation] SLC19A3によるpyridoxine及びthiamineの輸送に対するフラボノイド類の阻害作用の解析2020
- Author(s)
  山下紗瑛奈、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  薬学会，140年会
- Data Source
  KAKENHI-PROJECT-18K14953
[Presentation] SLC19A3によるpyridoxine及びthiamineの輸送に対するフラボノイド類の阻害作用の解析2020
- Author(s)
  山下紗瑛奈、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  薬学会，140年会
- Data Source
  KAKENHI-PROJECT-18KK0453
[Presentation] SLC19A3に対するフラボノイド類の阻害作用2019
- Author(s)
  山下紗瑛奈、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  病院薬剤師会東海ブロック/薬学会東海支部合同学術大会
- Data Source
  KAKENHI-PROJECT-18K14953
[Presentation] Species differences in SLC19A3 for pyridoxine transport function2019
- Author(s)
  三宅浩平、高橋駿介、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  薬物動態学会，34回年会
- Data Source
  KAKENHI-PROJECT-18K14953
[Presentation] Functional identification of SLC19A2/3 as pyridoxine transporters2019
- Author(s)
  山城貴弘、保嶋智也、湯浅博昭
- Organizer
  薬物動態学会，34回年会
- Data Source
  KAKENHI-PROJECT-18KK0453
[Presentation] PCFTの葉酸輸送機能におけるmyricetin感受性に関与するアミノ酸残基の同定2019
- Author(s)
  山城貴弘、保嶋智也、太田欣哉、井上勝央、湯浅博昭
- Organizer
  生体膜と薬物の相互作用シンポジウム，41回
- Data Source
  KAKENHI-PROJECT-18K14953
[Presentation] pyridoxineの小腸上皮取込の解析：ヒトとラットとの種差2019
- Author(s)
  三宅浩平、高橋駿介、石川千尋、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  日本薬学会，139年会
- Data Source
  KAKENHI-PROJECT-18K14953
[Presentation] Functional identification of SLC19A2/3 as pyridoxine transporters2019
- Author(s)
  山城貴弘、保嶋智也、湯浅博昭
- Organizer
  薬物動態学会，34回年会
- Data Source
  KAKENHI-PROJECT-18K14953
[Presentation] SLC19A3に対するフラボノイド類の阻害作用2019
- Author(s)
  山下紗瑛奈、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  病院薬剤師会東海ブロック/薬学会東海支部合同学術大会
- Data Source
  KAKENHI-PROJECT-18KK0453
[Presentation] PCFTの葉酸輸送機能におけるmyricetin感受性に関与するアミノ酸残基の同定2019
- Author(s)
  山城貴弘、保嶋智也、太田欣哉、井上勝央、湯浅博昭
- Organizer
  生体膜と薬物の相互作用シンポジウム，41回
- Data Source
  KAKENHI-PROJECT-18KK0453
[Presentation] Functional characterization of the carrier-mediated nicotinamide transport system in HepG2 cells2019
- Author(s)
  難波莉子、保嶋智也、山城貴弘、湯浅博昭
- Organizer
  薬物動態学会，34回年会
- Data Source
  KAKENHI-PROJECT-18KK0453
[Presentation] Functional characterization of the carrier-mediated nicotinamide transport system in HepG2 cells2019
- Author(s)
  難波莉子、保嶋智也、山城貴弘、湯浅博昭
- Organizer
  薬物動態学会，34回年会
- Data Source
  KAKENHI-PROJECT-18K14953
[Presentation] Species differences in SLC19A3 for pyridoxine transport function2019
- Author(s)
  三宅浩平、高橋駿介、山城貴弘、保嶋智也、湯浅博昭
- Organizer
  薬物動態学会，34回年会
- Data Source
  KAKENHI-PROJECT-18KK0453
[Presentation] Caco-2細胞における担体介在性nicotinamide取込の解析2018
- Author(s)
  難波莉子、三村佳久、保嶋智也、山城貴弘、湯浅博昭
- Organizer
  日本薬剤学会，33年会
- Data Source
  KAKENHI-PROJECT-18K14953
[Presentation] Functional characteristics of human renal organic cation transporters for histamine transport2018
- Author(s)
  田嶋柊也、保嶋智也、山城貴弘、太田欣哉、湯浅博昭
- Organizer
  第8回南京/名古屋/瀋陽薬学学術シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14953
[Presentation] Functional characterization of the carrier-mediated nicotinamide transport system in Caco-2 cells2018
- Author(s)
  難波莉子、保嶋智也、山城貴弘、湯浅博昭
- Organizer
  日本薬物動態学会，33回年会
- Data Source
  KAKENHI-PROJECT-18K14953
[Presentation] 核酸塩基類縁医薬品の生体膜透過過程におけるENBT1の役割2017
- Author(s)
  保嶋智也
- Organizer
  生体膜と薬物の相互作用シンポジウム，39回
- Data Source
  KAKENHI-PROJECT-16K18951
[Presentation] 6-mercaptopurineのがん細胞取り込みにおけるENBT1の役割2017
- Author(s)
  保嶋智也
- Organizer
  薬剤学会，32年会
- Data Source
  KAKENHI-PROJECT-16K18951

1. Hiroaki Yuasa (20191471)

# of Collaborated Projects: 5 results

# of Collaborated Products: 35 results
2. 山城貴弘 (20826614)

# of Collaborated Projects: 5 results

# of Collaborated Products: 36 results
3. 大澤匡弘 (80369173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yasujima Tomoya 保嶋 智也

Research Projects

Research Products

Co-Researchers

新規小胞膜局在型モノアミントランスポーターの機能解析と創薬標的としての有望性評価Principal Investigator

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新規コリントランスポーター類の分子機能と生理的及び薬物動態的役割

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Elucidation of substrate recognition mechanism of SLC19A3 to establish the molecular basis for medical applications

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Elucidation of molecular mechanism that triggers onset of gout from hyperuricemiaPrincipal Investigator

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Elucidation of the Function and Physiological Role of a Novel Polyamine Transporter

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Relationship between novel thiamine pool mechanism and proliferative capacity in cancer cellsPrincipal Investigator

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Elucidation of a novel pool mechanism of B vitamins through lysosome accumulationPrincipal Investigator

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Molecular mechanism of estrogen supply pathway in hormone-sensitive breast cancerPrincipal Investigator

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[Journal Article] Involvement of Proton-Coupled SLC49A4-Mediated Transport in the Export of Lysosomally Trapped Pyrilamine2024

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[Journal Article] Disrupted in renal carcinoma 2 (DIRC2/SLC49A4) is an H<sup>+</sup>-driven lysosomal pyridoxine exporter2022

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[Journal Article] Functional characterization of human organic anion transporter 10 (OAT10/SLC22A13) as an orotate transporter2022

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NAID

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[Journal Article] Proinflammatory cytokines inhibit thiamin uptake by human and mouse pancreatic acinar cells: involvement of transcriptional mechanism(s)2021

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[Journal Article] Functional Analysis of the Role of Equilibrative Nucleobase Transporter 1 (ENBT1/SLC43A3) in Adenine Transport in HepG2?Cells2020

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[Journal Article] pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: Implications for absorption in acidic microclimates2020

Author(s)

Yasujima Tomoya 保嶋智也