Hashizume Osamu 橋爪脩

Researcher Number	50755692
Other IDs
Affiliation (Current)	2026: 京都大学, 工学研究科, 助教
Affiliation (based on the past Project Information) *help	2026: 京都大学, 工学研究科, 助教 2022 – 2024: 京都大学, 工学研究科, 助教 2021: 大阪大学, 微生物病研究所, 助教 2015 – 2020: 大阪大学, 微生物病研究所, 特任研究員(常勤)
Review Section/Research Field	Principal Investigator Basic Section 44010:Cell biology-related / General medical chemistry / Basic Section 48040:Medical biochemistry-related
Keywords	Principal Investigator マグネシウム / 活性酸素種 / ミトコンドリア / PRL / 酸化ストレス / 血圧調節 / 酸性環境 / TRPML / エキソサイトーシス / リソソーム … More / トランスポーター / 酸素消費 / NADH / 腸上皮細胞 / ROS / エネルギー代謝 / がん悪性化 / ATP / CNNM / Mg2+ / レドックス / マグネシウム再吸収 / 腎臓遠位尿細管 / 再吸収 / TRPM6 / CNNM2 / レニン / 血圧 / 腎臓 / トランポーター Less

Mg2+トランスポーターCNNM2異常による統合失調症発症メカニズムの解明Principal Investigator
- Principal Investigator
  
  橋爪脩
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kyoto University
ミトコンドリアからリソソームへの特異的な活性酸素シグナル伝達機構Principal Investigator
- Principal Investigator
  
  橋爪脩
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Kyoto University
Mitochondrial energy metabolism abnormalities and cancer malignancy induced by excess Mg ions.Principal Investigator
- Principal Investigator
  
  Hashizume Osamu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Kyoto University
  Osaka University
The mechanism of blood pressure regulation associated with magnesium reabsorptionPrincipal Investigator
- Principal Investigator
  
  Hashizume Osamu
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University
マグネシウム再吸収を介した新たな血圧調節機構の解明Principal Investigator
- Principal Investigator
  
  橋爪脩
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University

All 2024 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] 細胞工学 vol.34 No.112015
- Author(s)
  清水章文、橋爪脩、三藤崇之、林純一
- Total Pages
  86
- Publisher
  学研メディカル秀潤社
- Data Source
  KAKENHI-PROJECT-15H06367
[Journal Article] Intestinal Mg2+ accumulation induced by cnnm mutations decreases the body size by suppressing TORC2 signaling in Caenorhabditis elegans2024
- Author(s)
  Hashizume Osamu、Kawabe Tomofumi、Funato Yosuke、Miki Hiroaki
- Journal Title
  
  Developmental Biology
  
  Volume: 509 Pages: 59-69
- DOI
  10.1016/j.ydbio.2024.02.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07312, KAKENHI-PROJECT-21K19406, KAKENHI-PLANNED-20H05789, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05272, KAKENHI-PROJECT-23H00409, KAKENHI-PROJECT-24K02225, KAKENHI-PROJECT-22K06205
[Journal Article] Phosphatase‐independent role of phosphatase of regenerating liver in cancer progression2022
- Author(s)
  Funato Yosuke、Hashizume Osamu、Miki Hiroaki
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 1 Pages: 25-33
- DOI
  10.1111/cas.15625
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07312, KAKENHI-PROJECT-22K06205, KAKENHI-PROJECT-21K19406, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05272, KAKENHI-PROJECT-20H03515, KAKENHI-PROJECT-19K16125, KAKENHI-PLANNED-20H05789
[Journal Article] Role of adenomatous polyposis coli in proliferation and differentiation of colon epithelial cells in organoid culture2021
- Author(s)
  Yamazaki Daisuke、Hashizume Osamu、Taniguchi Shiho、Funato Yosuke、Miki Hiroaki
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 3980-3980
- DOI
  10.1038/s41598-021-83590-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07616, KAKENHI-PROJECT-19K16125, KAKENHI-PROJECT-17K08631, KAKENHI-PROJECT-20H03515
[Journal Article] The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis.2020
- Author(s)
  Yosuke Funato, Atsushi Yoshida, Yusuke Hirata, Osamu Hashizume, Daisuke Yamazaki, Hiroaki Miki
- Journal Title
  
  Developmental cell
  
  Volume: 55 Issue: 4 Pages: 387-397
- DOI
  10.1016/j.devcel.2020.08.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07011, KAKENHI-PROJECT-20K07312, KAKENHI-PROJECT-20K07616, KAKENHI-PROJECT-19K16125, KAKENHI-PUBLICLY-20H05508, KAKENHI-ORGANIZER-20H05787, KAKENHI-PLANNED-20H05789, KAKENHI-PROJECT-17K08631, KAKENHI-PROJECT-17K19396, KAKENHI-PROJECT-20H03515
[Journal Article] Excessive Mg2+ Impairs Intestinal Homeostasis by Enhanced Production of Adenosine Triphosphate and Reactive Oxygen Species.2020
- Author(s)
  Hashizume O, Funato Y, Yamazaki D, Miki H.
- Journal Title
  
  Antioxidant & Redox Signaling
  
  Volume: in press Issue: 4 Pages: L287-L297
- DOI
  10.1152/ajplung.00071.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19034
[Journal Article] Excessive Mg 2+ Impairs Intestinal Homeostasis by Enhanced Production of Adenosine Triphosphate and Reactive Oxygen Species2020
- Author(s)
  Osamu Hashizume , Yosuke Funato , Daisuke Yamazaki, Hiroaki Miki
- Journal Title
  
  Antioxid Redox Signal .
  
  Volume: - Issue: 1 Pages: 20-34
- DOI
  10.1089/ars.2019.7951
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08631, KAKENHI-PROJECT-19K16125, KAKENHI-PROJECT-16K14723, KAKENHI-PROJECT-20K07312, KAKENHI-PROJECT-20K07616, KAKENHI-PUBLICLY-20H05508, KAKENHI-PLANNED-20H05789, KAKENHI-PROJECT-17K19396, KAKENHI-PROJECT-20H03515
[Journal Article] Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal.2018
- Author(s)
  Tani H, Ohnishi S, Shitara H, Mito T, Yamaguchi M, Yonekawa H, Hashizume O, Ishikawa K, Nakada K, Hayashi JI.
- Journal Title
  
  Sci Rep.
  
  Volume: 8 Issue: 1 Pages: 425-425
- DOI
  10.1038/s41598-017-18828-3
- NAID
  120007134501
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18535, KAKENHI-PROJECT-16K19034, KAKENHI-PROJECT-16H04678, KAKENHI-PROJECT-16K14719, KAKENHI-PROJECT-18K06203, KAKENHI-PROJECT-16H02463, KAKENHI-PROJECT-16H04688, KAKENHI-PROJECT-18J20289
[Journal Article] Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage.2016
- Author(s)
  Suzuki T, Kanno SI, Abe T. et al
- Journal Title
  
  J Am Soc Nephrol.
  
  Volume: 27 Issue: 7 Pages: 1-8
- DOI
  10.1681/asn.2015060623
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26340020, KAKENHI-PROJECT-26460331, KAKENHI-PROJECT-26860094, KAKENHI-PROJECT-15H06367, KAKENHI-PROJECT-16H04678, KAKENHI-PROJECT-16H04710, KAKENHI-PROJECT-26282153, KAKENHI-PROJECT-15K17882, KAKENHI-PROJECT-16K12925, KAKENHI-PROJECT-16K14719, KAKENHI-PROJECT-16H02420, KAKENHI-PROJECT-26293031, KAKENHI-PROJECT-26305007
[Journal Article] Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans.2016
- Author(s)
  Ishii T, Funato Y, Hashizume O, Yamazaki D, Hirata Y, Nishiwaki K, Kono N, Arai H, Miki H.
- Journal Title
  
  PLoS Genet.
  
  Volume: 12 Issue: 8 Pages: e1006276-e1006276
- DOI
  10.1371/journal.pgen.1006276
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23227004, KAKENHI-PLANNED-26111007, KAKENHI-PROJECT-15H04379, KAKENHI-PROJECT-26291042, KAKENHI-PROJECT-26650086, KAKENHI-PROJECT-15K18856, KAKENHI-PROJECT-26430113, KAKENHI-PROJECT-26460364, KAKENHI-PROJECT-16K14723, KAKENHI-PROJECT-16K19034
[Journal Article] Mutations in mitochondrial DNA regulate mitochondrial diseases and metastasis but do not regulate aging.2016
- Author(s)
  Hayashi JI, Hashizume O, Ishikawa K, Shimizu A.
- Journal Title
  
  Curr Opin Genet Dev.
  
  Volume: 未定 Pages: 63-67
- DOI
  10.1016/j.gde.2016.03.004
- NAID
  120007135211
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25250011, KAKENHI-PROJECT-16H02463, KAKENHI-PROJECT-16K18535, KAKENHI-PROJECT-16K19034
[Journal Article] Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects2015
- Author(s)
  Hashizume O, Ohnishi S, Mito T, Shimizu A, Ishikawa K, Nakada K, Soda M, Mano H, Togayachi S, Miyoshi H, Okita K, Hayashi J
- Journal Title
  
  Sci Rep
  
  Volume: 5 Issue: 1 Pages: 10434-10434
- DOI
  10.1038/srep10434
- NAID
  120005819481
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461155, KAKENHI-PLANNED-23117005, KAKENHI-PROJECT-23240058, KAKENHI-PROJECT-25250011, KAKENHI-PROJECT-15H06367, KAKENHI-PROJECT-14J00467
[Presentation] Mg2+排出トランスポーターcnnm変異による線虫のボディサイズ縮小メカニズムの解明2024
- Author(s)
  橋爪脩、船戸洋佑、三木裕明
- Organizer
  第47回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K06205
[Presentation] CNNM変異により線虫のボディサイズが縮小する仕組みの解析2021
- Author(s)
  橋爪脩、川邊智史、船戸洋佑、三木裕明
- Organizer
  第44回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K16125
[Presentation] 細胞内でのマグネシウム蓄積が引き起こす過剰なROSとATP産生2019
- Author(s)
  橋爪脩
- Organizer
  ミトコンドリアサイエンスワークショップ2019
- Data Source
  KAKENHI-PROJECT-16K19034
[Presentation] 細胞内でのマグネシウム蓄積が引き起こす過剰なROSとATP産生2019
- Author(s)
  橋爪脩
- Organizer
  ミトコンドリアサイエンスワークショップ2019
- Data Source
  KAKENHI-PROJECT-19K16125
[Presentation] 細胞内Mg2+の過剰蓄積が活性酸素種（ROS）レベル上昇と線虫の寿命短縮を引き起こす2018
- Author(s)
  橋爪脩、船戸洋佑、三木裕明
- Organizer
  新学術領域　酸素生物学・ダイイングコード合同若手会議（2018）
- Data Source
  KAKENHI-PROJECT-16K19034
[Presentation] CNNM変異体のMg2+恒常性破綻が引き起こす各種異常とそのメカニズム2018
- Author(s)
  橋爪脩、船戸洋佑、三木裕明
- Organizer
  関西地区線虫勉強会(2018)
- Data Source
  KAKENHI-PROJECT-16K19034
[Presentation] 過剰なマグネシウムが引き起こすミトコンドリアでのATPとROSの過剰産生2018
- Author(s)
  橋爪脩、船戸洋佑、三木裕明
- Organizer
  第91回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K19034
[Presentation] Overproduction of ATP and Reactive Oxygen Species in Mitochondria by Excessive Magnesium2018
- Author(s)
  Osamu Hashizume, Yosuke Funato, Hiroaki Miki
- Organizer
  The 13th International Symposium of the Institute Network for Biomedical Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19034
[Presentation] 過剰なマグネシウムが引き起こすミトコンドリアでの活性酸素種とATPの過剰産生2018
- Author(s)
  橋爪脩、船戸洋佑、三木裕明
- Organizer
  第18回日本ミトコンドリア学会年会
- Data Source
  KAKENHI-PROJECT-16K19034
[Presentation] Mg2+トランスポーターCNNMは線虫でROSレベルと寿命を調節する2017
- Author(s)
  橋爪脩、船戸洋佑、三木裕明
- Organizer
  生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K19034

1. KANNO Shinichirou

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. YAMAZAKI Daisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. KONO Nozomu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 平田祐介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 曽田学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 石川香

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 船戸洋佑

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 新井洋由

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 林純一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hashizume Osamu 橋爪 脩

Research Projects

Research Products

Co-Researchers

Mg2+トランスポーターCNNM2異常による統合失調症発症メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ミトコンドリアからリソソームへの特異的な活性酸素シグナル伝達機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mitochondrial energy metabolism abnormalities and cancer malignancy induced by excess Mg ions.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanism of blood pressure regulation associated with magnesium reabsorptionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

マグネシウム再吸収を介した新たな血圧調節機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 細胞工学 vol.34 No.112015

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Intestinal Mg2+ accumulation induced by cnnm mutations decreases the body size by suppressing TORC2 signaling in Caenorhabditis elegans2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphatase‐independent role of phosphatase of regenerating liver in cancer progression2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of adenomatous polyposis coli in proliferation and differentiation of colon epithelial cells in organoid culture2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Excessive Mg2+ Impairs Intestinal Homeostasis by Enhanced Production of Adenosine Triphosphate and Reactive Oxygen Species.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Excessive Mg 2+ Impairs Intestinal Homeostasis by Enhanced Production of Adenosine Triphosphate and Reactive Oxygen Species2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage.2016

Author(s)

Journal Title

DOI

Data Source

Hashizume Osamu 橋爪脩