ARAKI KEIGO 荒木啓吾

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Araki Keigo 荒木啓吾

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Researcher Number	50756674
Other IDs
Affiliation (Current)	2026: 奥羽大学, 歯学部, 准教授 2026: 東京科学大学, その他の部局等, 非常勤講師
Affiliation (based on the past Project Information) *help	2025: 奥羽大学, 歯学部, 准教授 2022 – 2024: 奥羽大学, 歯学部, 講師 2020: 奥羽大学, 歯学部, 講師 2019: 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 2015 – 2018: 関西学院大学, 理工学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 57020:Oral pathobiological science-related / Tumor biology
Keywords	Principal Investigator 抗ガン剤耐性 / 多核巨大ガン細胞 / 悪性進行ガン / がん / 転写因子E2F3 / 癌 / DNA修復機構 / がん治療 / がん細胞 / PKA … More / アポトーシス / 悪性がん / 嗅覚受容体 / 嗅覚シグナル経路 / ガンの再発 / シンシチン / Furin / 匂いシグナル / 細胞融合 / E2F3 / リン酸化 / シグナル伝達 / マイトファジー / 細胞死 / 悪性がん細胞 / オートファジー / E2Fファミリー / ミトコンドリア / マイトファジー受容体 / E2F3d / 発現制御 / グアニン四重鎖構造 / グアニン四重鎖 / 転写 / 発現制御機構 Less

Molecular mechanisms regulating drug resistance of multinucleated cancer cellsPrincipal Investigator
- Principal Investigator
  
  荒木啓吾
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Ohu University
Mechanism of cell fusion in malignant cancer cells induced by olfactory signalingPrincipal Investigator
- Principal Investigator
  
  Araki Keigo
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Ohu University
Development of new therapies for malignant cancers through disruption of quality control machinery of mitochondriaPrincipal Investigator
- Principal Investigator
  
  ARAKI KEIGO
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Ohu University
  Tokyo Medical and Dental University
  Kwansei Gakuin University
Inhibition of G-quadruplex formation of E2F3 mRNA enhances its expression in cancer cellsPrincipal Investigator
- Principal Investigator
  
  Araki Keigo
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Tumor biology
- Research Institution
  Kwansei Gakuin University

All 2024 2023 2022 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] Distinct E2F-Mediated Transcriptional Mechanisms in Cell Proliferation, Endoreplication and Apoptosis2019
- Author(s)
  Hideyuki Komori, Ritsuko Iwanaga, Andrew P. Bradford, Keigo Araki and Kiyoshi Ohtani
- Total Pages
  18
- Publisher
  InTech Open Access Publisher
- ISBN
  9781789856842
- Data Source
  KAKENHI-PROJECT-17K07185
[Journal Article] The N-Terminal Region of the Transcription Factor E2F1 Contains a Novel Transactivation Domain and Recruits General Transcription Factor GTF2H22024
- Author(s)
  Zhao Lin、Nakajima Rinka、Zhou Yaxuan、Shirasawa Mashiro、Fikriyanti Mariana、Kamiya Yuki、Toh Hiroyuki、Komori Hideyuki、Iwanaga Ritsuko、Bradford Andrew P.、Nishitani Hideo、Kurayoshi Kenta、Araki Keigo、Ohtani Kiyoshi
- Journal Title
  
  Biomolecules
  
  Volume: 14 Issue: 11 Pages: 1357-1357
- DOI
  10.3390/biom14111357
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09946
[Journal Article] DEAD/H Box 5 (DDX5) Augments E2F1-Induced Cell Death Independent of the Tumor Suppressor p532024
- Author(s)
  Nakajima Rinka、Zhou Yaxuan、Shirasawa Mashiro、Nishimura Naoyasu、Zhao Lin、Fikriyanti Mariana、Kamiya Yuki、Iwanaga Ritsuko、Bradford Andrew P.、Shinmyozu Kaori、Nishibuchi Gohei、Nakayama Jun-ichi、Kurayoshi Kenta、Araki Keigo、Ohtani Kiyoshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 24 Pages: 13251-13251
- DOI
  10.3390/ijms252413251
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09946
[Journal Article] Trans-Activation of the Coactivator-Associated Arginine Methyltransferase 1 (Carm1) Gene by the Oncogene Product Tax of Human T-Cell Leukemia Virus Type 12024
- Author(s)
  Hayati Rahma F.、Nakajima Rinka、Zhou Yaxuan、Shirasawa Mashiro、Zhao Lin、Fikriyanti Mariana、Iwanaga Ritsuko、Bradford Andrew P.、Kurayoshi Kenta、Araki Keigo、Ohtani Kiyoshi
- Journal Title
  
  Genes
  
  Volume: 15 Issue: 6 Pages: 698-698
- DOI
  10.3390/genes15060698
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09946, KAKENHI-PROJECT-23K07855
[Journal Article] Activation of the CDK7 Gene, Coding for the Catalytic Subunit of the Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) and General Transcription Factor II H, by the Trans-Activator Protein Tax of Human T-Cell Leukemia Virus Type-12024
- Author(s)
  Shirasawa Mashiro、Nakajima Rinka、Zhou Yaxuan、Zhao Lin、Fikriyanti Mariana、Iwanaga Ritsuko、Bradford Andrew P.、Kurayoshi Kenta、Araki Keigo、Ohtani Kiyoshi
- Journal Title
  
  Genes
  
  Volume: 15 Issue: 8 Pages: 1080-1080
- DOI
  10.3390/genes15081080
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09946
[Journal Article] Non-canonical olfactory pathway activation induces cell fusion of cervical cancer cells2024
- Author(s)
  Araki Keigo、Torii Takeru、Takeuchi Kohei、Kinoshita Natsuki、Urano Ryoto、Nakajima Rinka、Zhou Yaxuan、Kobayashi Tokuo、Hanyu Tadayoshi、Ohtani Kiyoshi、Ambe Kimiharu、Kawauchi Keiko
- Journal Title
  
  Neoplasia
  
  Volume: 57 Pages: 101044-101044
- DOI
  10.1016/j.neo.2024.101044
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09946
[Journal Article] Deregulated E2F activity as a cancer-cell specific therapeutic tool2023
- Author(s)
  Rinka Nakajima, Lin Zhao, Yaxuan Zhou, Mashiro Shirasawa, Ayato Uchida, Hikaru Murakawa, Mariana Fikriyanti, Ritsuko Iwanaga, Andrew P. Bradford, Keigo Araki, Tomoko Warita and Kiyoshi Ohtani
- Journal Title
  
  Genes
  
  Volume: 14 Issue: 2 Pages: 393-393
- DOI
  10.3390/genes14020393
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07136, KAKENHI-PROJECT-22K09946
[Journal Article] Expanding Roles of the E2F-RB-p53 Pathway in Tumor Suppression.2023
- Author(s)
  Zhou Y, Nakajima R, Shirasawa M, Fikriyanti M, Zhao L, Iwanaga R, Bradford AP, Kurayoshi K, Araki K, Ohtani K.
- Journal Title
  
  Biology (Basel)
  
  Volume: 12(12) Issue: 12 Pages: 1-49
- DOI
  10.3390/biology12121511
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09946, KAKENHI-PROJECT-21K07136
[Journal Article] The TFDP1 gene coding for DP1, the heterodimeric partner of the transcription factor E2F, is a target of deregulated E2F2023
- Author(s)
  Nakajima R, Deguchi R, Komori H, Zhao L, Zhou Y, Shirasawa M, Angelina A, Goto Y, Tohjo F, Nakahashi K, Nakata K, Iwanaga R, Bradford AP, Araki K, Warita T, Ohtani K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 663 Pages: 154-162
- DOI
  10.1016/j.bbrc.2023.04.092
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09946, KAKENHI-PROJECT-21K07136
[Journal Article] Mitochondrial protein E2F3d, a distinctive E2F3 product, mediates hypoxia-induced mitophagy in cancer cells.2019
- Author(s)
  Araki K, Kawauchi K, Sugimoto W, Tsuda D, Oda H, Yoshida R, Ohtani K.
- Journal Title
  
  Communications Biology
  
  Volume: 2 Issue: 1 Pages: 550-561
- DOI
  10.1038/s42003-018-0246-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07185, KAKENHI-PROJECT-18K06231
[Journal Article] Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity.2019
- Author(s)
  Miyazaki T, Zhao Z, Ichihara Y, Yoshino D, Imamura T, Sawada K, Hayano S, Kamioka H, Mori S, Hirata H, Araki K, Kawauchi K, Shigemoto K, Tanaka S, Bonewald LF, Honda H, Shinohara M, Nagao M, Ogata T, Harada I, Sawada Y
- Journal Title
  
  Sci Adv
  
  Volume: 5 Issue: 9 Pages: 7802-7802
- DOI
  10.1126/sciadv.aau7802
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KT0018, KAKENHI-PROJECT-17K07185, KAKENHI-PROJECT-19K10381, KAKENHI-PROJECT-19K11660, KAKENHI-PUBLICLY-18H04970, KAKENHI-PROJECT-18H04088, KAKENHI-PROJECT-19H03991, KAKENHI-PROJECT-19H04064, KAKENHI-PROJECT-17K09151
[Journal Article] E2F3d, a novel E2F family member, contributes to mitochondrial quality control in cancer2019
- Author(s)
  荒木啓吾、大谷清
- Journal Title
  
  生化学
  
  Volume: 91 Issue: 6 Pages: 781-784
- DOI
  10.14952/SEIKAGAKU.2019.910781
- ISSN
  0037-1017
- Year and Date
  2019-12-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-17K07185
[Journal Article] Differential requirement for dimerization partner DP between E2F-dependent activation of tumor suppressor and growth-related genes.2018
- Author(s)
  Komori H, Goto Y, Kurayoshi K, Ozono E, Iwanaga R, Bradford AP, Araki K, Ohtani K.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1
- DOI
  10.1038/s41598-018-26860-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07185
[Journal Article] The phosphatidyl inositol 3 kinase pathway does not suppress activation of the ARF and BIM genes by deregulated E2F1 activity2017
- Author(s)
  Kenta Kurayoshi, Junko Okuno, Eiko Ozono, Ritsuko Iwanaga, Andrew P. Bradford, Kazuyuki Kugawa, Keigo Araki, Kiyoshi Ohtani
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 482(4) Issue: 4 Pages: 784-790
- DOI
  10.1016/j.bbrc.2016.11.111
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06770, KAKENHI-PROJECT-15K06957
[Journal Article] Ectopic expression of the CDK inhibitor p21Cip1 enhances deregulated E2F activity and increases cancer cell-specific cytotoxic gene expression mediated by the ARF tumor suppressor promoter2017
- Author(s)
  Kenta Kurayoshi, Ayumi Shiromoto, Eiko Ozono, Ritsuko Iwanaga, Andrew P. Bradford, Keigo Araki, Kiyoshi Ohtani
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 483(1) Issue: 1 Pages: 107-114
- DOI
  10.1016/j.bbrc.2016.12.185
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06770, KAKENHI-PROJECT-15K06957
[Journal Article] The Interaction Mode of the Acidic Region of the Cell Cycle Transcription Factor DP1 with TFIIH2016
- Author(s)
  Masahiko Okuda, Keigo Araki, Kiyoshi Ohtani, Yoshifumi Nishimura
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 428(24) Issue: 24 Pages: 4993-5006
- DOI
  10.1016/j.jmb.2016.11.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06770, KAKENHI-PROJECT-15K06957
[Journal Article] Association between tensin 1 and p130Cas at focal adhesions links actin inward flux to cell migration2016
- Author(s)
  Zhao Z, Tan SH, Machiyama H, Kawauchi K, Araki K, Hirata H, Sawada Y
- Journal Title
  
  Biology Open
  
  Volume: 5 Issue: 4 Pages: 1-8
- DOI
  10.1242/bio.016428
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01820, KAKENHI-PROJECT-15H04966, KAKENHI-PROJECT-26560410, KAKENHI-PROJECT-15H06770
[Presentation] 子宮頸がんにおける細胞融合メカニズムの解析2023
- Author(s)
  竹内浩平、川内敬子、取井猛流、浦野諒人、荒木啓吾
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K09946
[Presentation] 子宮頸がん細胞の細胞融合機構の解析2022
- Author(s)
  竹内浩平、川内敬子、取井猛流、浦野諒人、荒木啓吾
- Organizer
  第45回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-22K09946
[Presentation] 恒常的に融合するがん細胞の特性の解析2020
- Author(s)
  浦野諒人、取井猛流、杉本渉、荒木啓吾、川内敬子
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K07185
[Presentation] DEAD/H box 5はp53依存的にE2F1によるアポトーシス誘導を増強する2019
- Author(s)
  崎浜優士、荒木啓吾、大谷清
- Organizer
  第42回日本分子生物学会年、福岡
- Data Source
  KAKENHI-PROJECT-17K07185
[Presentation] WDR1は転写因子E2F1によるがん抑制遺伝子の活性化に貢献している2019
- Author(s)
  藤原悠人、荒木啓吾、大谷清
- Organizer
  第42回日本分子生物学会年、福岡
- Data Source
  KAKENHI-PROJECT-17K07185
[Presentation] 新しいE2FファミリーメンバーであるE2F3dはミトコンドリアに局在し、マイトファジーを誘導する2017
- Author(s)
  荒木啓吾、　尾田衡弥、　大谷清
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K07185
[Presentation] 転写因子E2Fの新たなメンバーであるE2F3dはミトコンドリアに局在する2016
- Author(s)
  荒木啓吾、芳田亮輔、大谷清
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-15H06770
[Presentation] アデノウィルスE1aによる転写因子E2F3の新たな発現調節機構2015
- Author(s)
  荒木啓吾、服部拓、行本愛、川内敬子、大谷清
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-15H06770

1. 川内敬子 (40434138)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. TATEISHI HISAE

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 大谷清

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 篠原正浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 澤田泰宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ARAKI KEIGO 荒木 啓吾

Araki Keigo 荒木 啓吾

Research Projects

Research Products

Co-Researchers

Molecular mechanisms regulating drug resistance of multinucleated cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of cell fusion in malignant cancer cells induced by olfactory signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new therapies for malignant cancers through disruption of quality control machinery of mitochondriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inhibition of G-quadruplex formation of E2F3 mRNA enhances its expression in cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Distinct E2F-Mediated Transcriptional Mechanisms in Cell Proliferation, Endoreplication and Apoptosis2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] The N-Terminal Region of the Transcription Factor E2F1 Contains a Novel Transactivation Domain and Recruits General Transcription Factor GTF2H22024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DEAD/H Box 5 (DDX5) Augments E2F1-Induced Cell Death Independent of the Tumor Suppressor p532024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Trans-Activation of the Coactivator-Associated Arginine Methyltransferase 1 (Carm1) Gene by the Oncogene Product Tax of Human T-Cell Leukemia Virus Type 12024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of the CDK7 Gene, Coding for the Catalytic Subunit of the Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) and General Transcription Factor II H, by the Trans-Activator Protein Tax of Human T-Cell Leukemia Virus Type-12024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Non-canonical olfactory pathway activation induces cell fusion of cervical cancer cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deregulated E2F activity as a cancer-cell specific therapeutic tool2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expanding Roles of the E2F-RB-p53 Pathway in Tumor Suppression.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The TFDP1 gene coding for DP1, the heterodimeric partner of the transcription factor E2F, is a target of deregulated E2F2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mitochondrial protein E2F3d, a distinctive E2F3 product, mediates hypoxia-induced mitophagy in cancer cells.2019

Author(s)

Journal Title

DOI

Data Source

ARAKI KEIGO 荒木啓吾

Araki Keigo 荒木啓吾