Takashima Ippei 高嶋一平

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高嶋一平タカシマイッペイ

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Researcher Number	50769742
Other IDs	https://orcid.org/0000-0002-0749-2349
Affiliation (Current)	2026: 函館工業高等専門学校, 一般系, 准教授 2026: 東北大学, 多元物質科学研究所, 助教
Affiliation (based on the past Project Information) *help	2026: 函館工業高等専門学校, 一般系, 准教授 2022 – 2024: 東北大学, 多元物質科学研究所, 助教 2019 – 2021: 神戸薬科大学, 薬学部, 特任助教 2017: 京都大学, 化学研究所, 研究員 2016: 京都大学, 物質－細胞統合システム拠点, 研究員
Review Section/Research Field	Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Basic Section 38040:Bioorganic chemistry-related / 0801:Pharmaceutical sciences and related fields / Chemical biology
Keywords	Principal Investigator シグナル増強 / 蛍光プローブ / IEDDA反応 / 蛍光イメージング / 液滴オートファジー / 逆電子需要型ディールズアルダー反応 / 発蛍光性クリック反応 / オートファジー / タンパク質液滴 / マンガン … More / 酵素-基質ペア / タンパク質工学 / Cancer therapy / Enzyme prodrug / AND logic gate / HYPOXIA / Fluorescent probe / ANDロジックゲート / ドラッグデリバリー / AＮＤロジック / がん微小環境 / 低酸素環境 / 微量元素 / アンドロジック / 合成化学 / 生理活性 / 細胞・組織 / 再生医学 / 分子認識 / 再生医療 / クラスタリング / シンデカン / 細胞接着 / 自己集合 / MMP2 / アドヘサミン / 細胞浸潤 / 細胞死抑制 / 生着効率 / 細胞移植 / 細胞治療 / 自己集合性分子 Less

細胞内組織間接触を精密に制御する化学的アプローチによる細胞機能操作Principal Investigator
- Principal Investigator
  
  高嶋一平
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Hakodate National College of Technology
Development of fluorescent tools imaging the initial process of protein-droplet autophagyPrincipal Investigator
- Principal Investigator
  
  高嶋一平
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Tohoku University
Signal amplification system to detect divalent manganese with a unique pair of enzyme variant and the fluorescent substratePrincipal Investigator
- Principal Investigator
  
  Takashima Ippei
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Tohoku University
  Kobe Pharmaceutical University
Development of fluorescent probes with AND-logic gate response for HYPOXIAPrincipal Investigator
- Principal Investigator
  
  Takashima Ippei
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  Kobe Pharmaceutical University
移植細胞の生着効率を高める合成化合物の創製Principal Investigator
- Principal Investigator
  
  高嶋一平
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  Kyoto University

All 2025 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Book Patent

[Book] CSJカレントレビュー2020
- Author(s)
  高嶋一平、上杉志成
- Total Pages
  212
- Publisher
  化学同人
- ISBN
  9784759813968
- Data Source
  KAKENHI-PROJECT-19K23816
[Book] カレントレビュー36：生体分子反応を制御する、14章 (p128-134)2020
- Author(s)
  高嶋一平、上杉志成
- Total Pages
  7
- Publisher
  化学同人
- ISBN
  9784759813968
- Data Source
  KAKENHI-PROJECT-19K23816
[Journal Article] A turn-on fluorescent probe containing a β-ketoester moiety for the selective detection of intracellular hydrazine2025
- Author(s)
  Takagi Akira、Takashima Ippei、Okuda Kensuke
- Journal Title
  
  RSC Advances
  
  Volume: 15 Issue: 1 Pages: 428-434
- DOI
  10.1039/d4ra06525e
- Data Source
  KAKENHI-PROJECT-23K06066
[Journal Article] Total Synthesis of Antiausterity Agent Callistrilone O Reveals Promising Antitumor Activity in a Melanoma Homograft Mouse Model2025
- Author(s)
  Okuda Kensuke、Takagi Akira、Shimizu Ryohei、Nishi Kensuke、Hayano Narumi、Takashima Ippei、Konishi Morichika
- Journal Title
  
  ChemMedChem
  
  Volume: 20 Issue: 7
- DOI
  10.1002/cmdc.202400818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06570, KAKENHI-PROJECT-23K06066
[Journal Article] Advances in reaction-based synthetic fluorescent probes for studying the role of zinc and copper ions in living systems2023
- Author(s)
  Okuda Kensuke、Takashima Ippei、Takagi Akira
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 72 Issue: 1 Pages: 1-12
- DOI
  10.3164/jcbn.22-92
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06525, KAKENHI-PROJECT-22K06570, KAKENHI-PROJECT-21K15246
[Journal Article] Non-genetic cell-surface modification with a self-assembling molecular glue2021
- Author(s)
  Hakariya, H., Takashima, I., Takemoto, M., Noda, N., Sato, S., Uesugi, M.
- Journal Title
  
  Chem Commun.
  
  Volume: 57 Issue: 12 Pages: 1470-1473
- DOI
  10.1039/d0cc07171d
- NAID
  120007002689
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06408, KAKENHI-PROJECT-19H00922, KAKENHI-PROJECT-19K23816
[Journal Article] Total Synthesis of Antiausterity Agent (±)-Uvaridacol L by Regioselective Axial Diacylation of a myo-Inositol Orthoester2021
- Author(s)
  Takagi Akira、Usuguchi Kazuki、Takashima Ippei、Okuda Kensuke
- Journal Title
  
  Organic Letters
  
  Volume: - Issue: 11 Pages: 4083-4087
- DOI
  10.1021/acs.orglett.1c00079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16341, KAKENHI-PROJECT-19K23816
[Journal Article] Discovery of Self‐Assembling Small Molecules as Vaccine Adjuvants2020
- Author(s)
  Jin Shuyu、Vu Hue Thi、Hioki Kou、Noda Naotaka、Yoshida Hiroki、Shimane Toru、Ishizuka Shigenari、Takashima Ippei、Mizuhata Yoshiyuki、Beverly Pe Kathleen、Ogawa Tetsuya、Nishimura Naoya、Packwood Daniel、Tokitoh Norihiro、Kurata Hiroki、Yamasaki Sho、Ishii Ken J.、Uesugi Motonari
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 60 Issue: 2 Pages: 961-969
- DOI
  10.1002/anie.202011604
- NAID
  120006958092
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20447, KAKENHI-PROJECT-20H00505, KAKENHI-PROJECT-18H01963, KAKENHI-PLANNED-17H06408, KAKENHI-PROJECT-19H05635, KAKENHI-PROJECT-19H00922, KAKENHI-PROJECT-19K23816
[Journal Article] Engineering of an archaeal phosphodiesterase to trigger aggregation-induced emission (AIE) of synthetic substrates2020
- Author(s)
  Zhang Yunlong、Wu Zhiyuan、Takashima Ippei、Nguyen Kathy-Uyen、Matsumoto Nobuyuki、Lindsey Jonathan S.
- Journal Title
  
  New Journal of Chemistry
  
  Volume: 44 Issue: 33 Pages: 14266-14277
- DOI
  10.1039/d0nj03208e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K23816
[Journal Article] A fluorogenic probe using a catalytic reaction for the detection of trace intracellular zinc2020
- Author(s)
  Takashima Ippei、Inoue Yohei、Matsumoto Nobuyuki、Takagi Akira、Okuda Kensuke
- Journal Title
  
  Chemical Communications
  
  Volume: 56 Issue: 87 Pages: 13327-13330
- DOI
  10.1039/d0cc05315e
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16341, KAKENHI-PROJECT-19K07035, KAKENHI-PROJECT-19K23816
[Journal Article] Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment2019
- Author(s)
  Takashima Ippei、Kusamori Kosuke、Hakariya Hayase、Takashima Megumi、Vu Thi Hue、Mizukami Yuya、Noda Naotaka、Takayama Yukiya、Katsuda Yousuke、Sato Shin-ichi、Takakura Yoshinobu、Nishikawa Makiya、Uesugi Motonari
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 14 Issue: 4 Pages: 775-783
- DOI
  10.1021/acschembio.9b00109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19200, KAKENHI-PLANNED-17H06408, KAKENHI-PROJECT-26220206, KAKENHI-PROJECT-19K23816
[Patent] 新規化合物及び該化合物を含有する亜鉛検出用蛍光プローブ2020
- Inventor(s)
  奥田健介、高嶋一平
- Industrial Property Rights Holder
  神戸薬科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-135407
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K23816
[Patent] 細胞移植を効率化する化合物2019
- Inventor(s)
  上杉志成、高嶋一平、西川元也
- Industrial Property Rights Holder
  上杉志成、高嶋一平、西川元也
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-19K23816
[Presentation] AFM/EM imaging of intracellular metals with nanostructures constructed via signal amplification systems2023
- Author(s)
  Ippei Takashima, Chihiro Ikenaga, Zhimin Yang, Eiji Nakata, Kensuke Okuda, Shin Mizukami
- Organizer
  第14回エネルギー理工学研究所国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15246
[Presentation] 亜鉛触媒反応を応用した亜鉛イオンの19F-MRIプローブ分子の開発研究2023
- Author(s)
  池永千裕、高木晃、高嶋一平、奥田健介
- Organizer
  日本薬学会第１４３年会（北海道）
- Data Source
  KAKENHI-PROJECT-21K15246
[Presentation] β-ケトエステル型ヒドラジン検出蛍光プローブの創製2022
- Author(s)
  高木晃、重松春花、高嶋一平、奥田健介
- Organizer
  日本薬学会第１４２年会（名古屋）
- Data Source
  KAKENHI-PROJECT-21K15246
[Presentation] がん微小環境を標的とする4-フェニル酪酸バイオアイソスターの創薬化学研究2022
- Author(s)
  北西悟司、高木晃、高嶋一平、大橋憲太郎、奥田健介
- Organizer
  日本薬学会第１４２年会（名古屋）
- Data Source
  KAKENHI-PROJECT-21K15246
[Presentation] Fluorescent analyses of biomolecules and metals through signal amplification system2022
- Author(s)
  Ippei Takashima, Yusuke Miura, Chinami Morita, Sakino Yata, Akira Takagi, Eiji Nakata, Kensuke Okuda
- Organizer
  The 13th International Symposium of Advanced Energy Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15246
[Presentation] がんの栄養飢餓耐性解除に着目したグルコース誘導体の構造活性相関研究2021
- Author(s)
  高木晃、田坂今日子、津田智英美、高嶋一平、奥田健介
- Organizer
  日本薬学会第141年会（広島）（オンライン）
- Data Source
  KAKENHI-PROJECT-19K23816
[Presentation] Fluorescent analyses of metals using cephem compound2021
- Author(s)
  Ippei Takashima, Yusuke Miura, Eiji Nakata, Akira Takagi, Kensuke Okuda
- Organizer
  第12回エネルギー理工学研究所国際シンポジウム、Institute of Advanced Energy, Kyoto University / The Joint Usage/Research Center for Zero Emission Energy Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15246
[Presentation] 亜鉛触媒反応を応用した細胞内亜鉛イオンの高感度検出プローブの開発2021
- Author(s)
  高嶋　一平、井上　陽平、松本　信之、髙木　晃、奥田　健介
- Organizer
  第22回日本亜鉛栄養治療研究会学術集会
- Data Source
  KAKENHI-PROJECT-21K15246
[Presentation] 位置選択的ジベンゾイル化による(±)-uvaridacol Lの効率的合成2021
- Author(s)
  臼口和希、高木晃、高嶋一平、奥田健介
- Organizer
  日本薬学会第141年会（広島）（オンライン）
- Data Source
  KAKENHI-PROJECT-19K23816
[Presentation] 細胞内亜鉛イオンの高感度検出プローブの開発2020
- Author(s)
  高嶋　一平，井上　陽平，松本　信之，高木　晃，奥田　健介
- Organizer
  生命金属に関する合同年会 (Conmetal2020)（オンライン）
- Data Source
  KAKENHI-PROJECT-19K23816
[Presentation] 亜鉛触媒反応を応用した細胞内亜鉛イオンの高感度検出プローブの開発2020
- Author(s)
  井上　陽平，高嶋　一平、松本　信之，奥田　健介
- Organizer
  第70回日本薬学会関西支部大会（オンライン）
- Data Source
  KAKENHI-PROJECT-19K23816
[Presentation] Signal amplification method for the detection of intracellular zinc2020
- Author(s)
  Ippei Takashima, Yohei Inoue, Nobuyuki Matsumoto, Akira Takagi, Eiji Nakata, and Kensuke Okuda
- Organizer
  第11回エネルギー理工学研究所国際シンポジウム（オンライン）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23816
[Presentation] 自己集合性分子による移植細胞の機能化2018
- Author(s)
  高嶋一平, 草森浩輔, Thi Hue VU, 水上優哉, 西川元也, 上杉志成
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K16641
[Presentation] Self-assembling molecules functionalize transplanted cells2018
- Author(s)
  TAKASHIMA, Ippei; KUSAMORI, Kosuke; VU, Thi Hue; MIZUKAMI, Yuya; KATSUDA, Yosuke; SATO, Shin-ichi; NISHIKAWA, Makiya; UESUGI, Motonari
- Organizer
  日本化学会第98春季年会 (2018)
- Data Source
  KAKENHI-PROJECT-16K16641

1. SATO Shinichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 上杉志成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 竹本靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 時任宣博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 奥田健介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 高木晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Takashima Ippei 高嶋 一平

高嶋 一平 タカシマ イッペイ

Research Projects

Research Products

Co-Researchers

細胞内組織間接触を精密に制御する化学的アプローチによる細胞機能操作Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of fluorescent tools imaging the initial process of protein-droplet autophagyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Signal amplification system to detect divalent manganese with a unique pair of enzyme variant and the fluorescent substratePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of fluorescent probes with AND-logic gate response for HYPOXIAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

移植細胞の生着効率を高める合成化合物の創製Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] CSJカレントレビュー2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] カレントレビュー36：生体分子反応を制御する、14章 (p128-134)2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] A turn-on fluorescent probe containing a β-ketoester moiety for the selective detection of intracellular hydrazine2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Total Synthesis of Antiausterity Agent Callistrilone O Reveals Promising Antitumor Activity in a Melanoma Homograft Mouse Model2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Advances in reaction-based synthetic fluorescent probes for studying the role of zinc and copper ions in living systems2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Non-genetic cell-surface modification with a self-assembling molecular glue2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Total Synthesis of Antiausterity Agent (±)-Uvaridacol L by Regioselective Axial Diacylation of a myo-Inositol Orthoester2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of Self‐Assembling Small Molecules as Vaccine Adjuvants2020

Author(s)

Journal Title

DOI

NAID

Takashima Ippei 高嶋一平

高嶋一平タカシマイッペイ

[Presentation] 亜鉛触媒反応を応用した細胞内亜鉛イオンの高感度検出プローブの開発2020