Ishida Saeko 石田紗恵子

Researcher Number	50777927
Other IDs	https://orcid.org/0000-0001-6005-7533
Affiliation (Current)	2026: 東京大学, 医科学研究所, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2025: 東京大学, 医科学研究所, 助教 2016 – 2019: 東京医科歯科大学, 難治疾患研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 42040:Laboratory animal science-related / Laboratory animal science Except Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Keywords	Principal Investigator 遺伝子 / てんかん / 疾患モデル動物 / ヒト化ラット / 肝臓 / ヒト化 / 免疫不全 / in vivoゲノム編集 / ラット / エピゲノム編集 … More / ゲノム編集 / 実験動物 / 体細胞変異 / 遺伝子変異 / 実験動物学 / 神経疾患 / 動物 / 脳神経疾患 / 自閉症 … More Except Principal Investigator マウス / in vivoゲノム編集 / 診断薬 / 脂質ナノ粒子 / 遺伝子改変マウス / コラテラル切断 / 原子間力顕微鏡 / モデル動物 / 核酸検出法 / in vivoゲノム編 / in vitroゲノム編集 / CRISPR診断 / 受精卵 / LNP-ｍRNA / CRISPR-Cas3 / ゲノム編集 Less

Establishment and Implementation of a Rapid Novel Rat Model Generation Method Using In Vivo Genome Editing TechniquesPrincipal Investigator
- Principal Investigator
  
  石田紗恵子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  The University of Tokyo
Development of novel gene editing methods based on the elucidation of the Type I CRISPR genome editing mechanisms
- Principal Investigator
  
  真下知士
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
Elucidation of the Mechanisms Underlying Focal Epilepsy via In Vivo Epigenome Editing in MicePrincipal Investigator
- Principal Investigator
  
  Ishida Saeko
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  The University of Tokyo
Elucidation of the pathogenic mechanism of epilepsy caused by somatic mutations of GATOR1 genesPrincipal Investigator
- Principal Investigator
  
  Ishida Saeko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  The University of Tokyo
  Tokyo Medical and Dental University
Deciphering the pathogenesis of neuropsychiatric disease using Depdc5 conditional KO micePrincipal Investigator
- Principal Investigator
  
  Ishida Saeko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokyo Medical and Dental University

All 2025 2024 2023 2022 2021 2018 2017

All Journal Article Presentation Book Patent

[Book] 週刊医学のあゆみゲノム編集医療2025
- Author(s)
  石田紗恵子
- Total Pages
  6
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-24K09295
[Journal Article] 第1土曜特集ゲノム編集医療--最先端ツールからモデル,創薬,遺伝子治療へゲノム編集治療 Ex vivo,in vivoゲノム編集治療法開発の動向2025
- Author(s)
  石田紗恵子
- Journal Title
  
  医学のあゆみ
  
  Volume: 292 Issue: 5 Pages: 445-450
- DOI
  10.32118/ayu292050445
- ISSN
  0039-2359
- Year and Date
  2025-02-01
- Data Source
  KAKENHI-PROJECT-23H00367
[Journal Article] Diverse Cre recombinase expression pattern in Albumin-Cre driver rats2025
- Author(s)
  ISHIDA Saeko、TAGUCHI Keiko、IIDA Ryuya、HATTORI Kosuke、TAKETSURU Hiroaki、YOSHIMI Kazuto、YAMAMOTO Masayuki、MASHIMO Tomoji
- Journal Title
  
  Exp. Anim.
  
  Volume: 74 Issue: 3 Pages: 328-334
- DOI
  10.1538/expanim.24-0174
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H00367, KAKENHI-PROJECT-22K19238, KAKENHI-PROJECT-19KK0401, KAKENHI-PROJECT-24K02010, KAKENHI-PROJECT-24K09295
[Journal Article] CRISPR Diagnostics for Quantification and Rapid Diagnosis of Myotonic Dystrophy Type 1 Repeat Expansion Disorders2024
- Author(s)
  Asano Koji、Yoshimi Kazuto、Takeshita Kohei、Mitsuhashi Satomi、Kochi Yuta、Hirano Rika、Tingyu Zong、Ishida Saeko、Mashimo Tomoji
- Journal Title
  
  ACS Synthetic Biology
  
  Volume: 13 Issue: 12 Pages: 3926-3935
- DOI
  10.1021/acssynbio.4c00265
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H00367, KAKENHI-PROJECT-23K23533, KAKENHI-PROJECT-22K19238, KAKENHI-PROJECT-19KK0401, KAKENHI-PROJECT-24K02010, KAKENHI-PROJECT-23KJ0356
[Journal Article] A novel Kit mutant rat enables hematopoietic stem cell engraftment without irradiation2024
- Author(s)
  Iida Ryuya、Ishida Saeko、Wang Jinxi、Hattori Kosuke、Yoshimi Kazuto、Yamazaki Satoshi、Mashimo Tomoji
- Journal Title
  
  Experimental Hematology
  
  Volume: 132 Pages: 104174-104174
- DOI
  10.1016/j.exphem.2024.104174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19238, KAKENHI-PROJECT-19KK0401, KAKENHI-PROJECT-21K05987, KAKENHI-PROJECT-23H00367, KAKENHI-PROJECT-24K02478
[Journal Article] Genome editing using type I-E CRISPR-Cas3 in mice and rat zygotes2024
- Author(s)
  Yoshimi K.; Kuno A.; Yamauchi Y.; Hattori K.; Taniguchi H.; Mikamo K.; Iida R.; Ishida S.; Goto M.; Takeshita K.; Ito R.; Takahashi R.; Takahashi S.; Mashimo T
- Journal Title
  
  Cell Reports Methods
  
  Volume: 4(8) Issue: 8 Pages: 100833-100833
- DOI
  10.1016/j.crmeth.2024.100833
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-23H00367, KAKENHI-PROJECT-23K23533, KAKENHI-PROJECT-22K19238, KAKENHI-PROJECT-19KK0401, KAKENHI-PROJECT-24K02010, KAKENHI-PROJECT-23K05608, KAKENHI-PROJECT-24K18045
[Journal Article] ゲノム編集技術の応用2023
- Author(s)
  石田紗恵子、真下　知士
- Journal Title
  
  医学のあゆみ「mRNAワクチンやゲノム編集で注目が集まる遺伝子治療」
  
  Volume: Vol.285(5) Pages: 328-333
- Data Source
  KAKENHI-PROJECT-23H00367
[Journal Article] Dorsal telencephalon-specific Nprl2- and Nprl3-knockout mice: novel mouse models for GATORopathy2021
- Author(s)
  Ishida Saeko、Zhao Di、Sawada Yuta、Hiraoka Yuichi、Mashimo Tomoji、Tanaka Kohichi
- Journal Title
  
  Human Molecular Genetics
  
  Volume: - Issue: 9 Pages: 1519-1530
- DOI
  10.1093/hmg/ddab337
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05987, KAKENHI-PROJECT-21K19425
[Journal Article] Depdc5 knockdown causes mTOR-dependent motor hyperactivity in zebrafish2018
- Author(s)
  de Calbiac H, Dabacan A, Marsan E, Tostivint H, Devienne G, Ishida S, Leguern E, Baulac S, Muresan RC, Kabashi E, Ciura S.
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: - Issue: 5 Pages: 510-523
- DOI
  10.1002/acn3.542
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06765, KAKENHI-PROJECT-18K14608
[Journal Article] DEPDC5, a new key to understand various epilepsies2018
- Author(s)
  Ishida Saeko
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 152 Issue: 6 Pages: 281-285
- DOI
  10.1254/fpj.152.281
- NAID
  130007528445
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-18K14608
[Patent] 修飾されたｃｒＲＮＡを含むＣＲＩＳＰＲーＣａｓ３系2024
- Inventor(s)
  真下知士、石田紗恵子、吉見一人
- Industrial Property Rights Holder
  真下知士、石田紗恵子、吉見一人
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2024-101553
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-23H00367
[Patent] 修飾されたcrRNAを含むCRISPR-Cas3系2024
- Inventor(s)
  真下知士、吉見一人、石田紗恵子
- Industrial Property Rights Holder
  真下知士、吉見一人、石田紗恵子
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-24K09295
[Presentation] 東大医科研におけるラットリソース2024
- Author(s)
  石田紗恵子, 吉見一人, 竹鶴裕亮, 服部晃佑, 山内祐子, 飯田龍哉, 小林俊寛, 真下知士
- Organizer
  第71回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-24K09295
[Presentation] ゲノム編集技術CRISPR/Cas3による遺伝子治療への挑戦2024
- Author(s)
  石田紗恵子
- Organizer
  第47回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-24K09295
[Presentation] Different rapamycin susceptibility among epileptic animal models of GATORopathy2022
- Author(s)
  Di ZHAO, Yuta SAWADA, Yuichi HIRAOKA, Tomoji MASHIMO, Kohichi TANAKA, Saeko ISHIDA
- Organizer
  第45回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-21K05987
[Presentation] 異なる薬剤感受性を示す新規GATORopathyてんかんモデルマウス2022
- Author(s)
  Di ZHAO, Yuta SAWADA, Yuichi HIRAOKA, Tomoji MASHIMO, Kohichi TANAKA, Saeko ISHIDA
- Organizer
  第69回　日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-21K05987
[Presentation] 小脳特異的GLT1欠損マウスは自閉症様行動を示す2018
- Author(s)
  石田　紗恵子, 小川　恕, 田中　光一
- Organizer
  第41回　日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K14608
[Presentation] 小脳でのグルタミン酸輸送体GLT1の欠損が誘発する表現型の解析2018
- Author(s)
  石田　紗恵子, 小川　恕, 田中　光一
- Organizer
  第65回　日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-18K14608
[Presentation] 焦点性てんかん原因遺伝子DEPDC52017
- Author(s)
  石田　紗恵子
- Organizer
  日本薬理学会
- Place of Presentation
  長崎
- Year and Date
  2017-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-16H06765
[Presentation] 焦点性てんかん原因遺伝子、DEPDC5 KOラットの解析2017
- Author(s)
  石田　紗恵子
- Organizer
  関西実験動物研究会
- Place of Presentation
  京都
- Year and Date
  2017-03-03
- Invited
- Data Source
  KAKENHI-PROJECT-16H06765
[Presentation] てんかんと遺伝子2017
- Author(s)
  石田　紗恵子
- Organizer
  日本てんかん学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H06765

1. 佐久間哲史 (90711143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 真下知士 (80397554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 吉見一人 (50709813)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 竹下浩平 (80346808)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 佐藤守俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 高橋智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishida Saeko 石田 紗恵子

Research Projects

Research Products

Co-Researchers

Establishment and Implementation of a Rapid Novel Rat Model Generation Method Using In Vivo Genome Editing TechniquesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel gene editing methods based on the elucidation of the Type I CRISPR genome editing mechanisms

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the Mechanisms Underlying Focal Epilepsy via In Vivo Epigenome Editing in MicePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the pathogenic mechanism of epilepsy caused by somatic mutations of GATOR1 genesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Deciphering the pathogenesis of neuropsychiatric disease using Depdc5 conditional KO micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 週刊 医学のあゆみ ゲノム編集医療2025

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] 第1土曜特集 ゲノム編集医療--最先端ツールからモデル,創薬,遺伝子治療へ ゲノム編集治療 Ex vivo,in vivoゲノム編集治療法開発の動向2025

Author(s)

Journal Title

DOI

ISSN

Year and Date

Data Source

[Journal Article] Diverse Cre recombinase expression pattern in Albumin-Cre driver rats2025

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] CRISPR Diagnostics for Quantification and Rapid Diagnosis of Myotonic Dystrophy Type 1 Repeat Expansion Disorders2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel Kit mutant rat enables hematopoietic stem cell engraftment without irradiation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome editing using type I-E CRISPR-Cas3 in mice and rat zygotes2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ゲノム編集技術の応用2023

Author(s)

Journal Title

Data Source

[Journal Article] Dorsal telencephalon-specific Nprl2- and Nprl3-knockout mice: novel mouse models for GATORopathy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Depdc5 knockdown causes mTOR-dependent motor hyperactivity in zebrafish2018

Author(s)

Journal Title

Ishida Saeko 石田紗恵子

[Book] 週刊医学のあゆみゲノム編集医療2025

[Journal Article] 第1土曜特集ゲノム編集医療--最先端ツールからモデル,創薬,遺伝子治療へゲノム編集治療 Ex vivo,in vivoゲノム編集治療法開発の動向2025