• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Hayashizaki Koji  林崎 浩史

ORCIDConnect your ORCID iD *help
Researcher Number 50779907
Other IDs
Affiliation (Current) 2025: 東京慈恵会医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2019 – 2024: 東京慈恵会医科大学, 医学部, 助教
2018: 国立感染症研究所, 真菌部, 研究員
2017: 千葉大学, 大学院医学研究院, 特任助教
Review Section/Research Field
Principal Investigator
Basic Section 49070:Immunology-related / Immunology
Except Principal Investigator
Basic Section 54030:Infectious disease medicine-related / Basic Section 90110:Biomedical engineering-related
Keywords
Principal Investigator
肺炎球菌ワクチン / NKT細胞 / 肺炎球菌 / 糖脂質 / ミトコンドリア代謝 / Gr-1+細胞 / IL-27 / NKTFH細胞 / ワクチン / 細菌感染 … More / 未分化NKT細胞 / 感染免疫 / 未分化 / 骨髄 / 気道炎症 / CD69リガンド / DSS誘導性大腸炎モデル / 抗原提示細胞 / 血管内腔 / 感染 / 血栓様構造体 / MHCクラスⅡ発現細胞 / Myl9 nets / T細胞 / アレルギー性気道炎症 / 慢性炎症 / CD69-Myl9システム … More
Except Principal Investigator
NKT細胞 / 糖脂質 / 抗体 / ワクチン / 肺炎 / 肺炎球菌 / osseointegration / 皮質骨多孔化 / 中間水コンセプト / NKT / 肺炎球菌感染症 Less
  • Research Projects

    (6 results)
  • Research Products

    (22 results)
  • Co-Researchers

    (9 People)
  •  新規インプラント開発に向けた中間水制御技術による骨吸収抑制機序の解明

    • Principal Investigator
      牛久 智加良
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 90110:Biomedical engineering-related
    • Research Institution
      Jikei University School of Medicine
  •  高親和性抗体の産生及び持続をもたらす免疫応答の解明とワクチンへの応用

    • Principal Investigator
      金城 雄樹
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54030:Infectious disease medicine-related
    • Research Institution
      Jikei University School of Medicine
  •  The differentiation mechanism of functional NKT cells that induce long-term antibody productionPrincipal Investigator

    • Principal Investigator
      Hayashizaki Koji
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Jikei University School of Medicine
  •  A role of bone marrow resident-uncommitted NKT cells under the infectious immune responsesPrincipal Investigator

    • Principal Investigator
      Hayashizaki Koji
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Jikei University School of Medicine
  •  The mechanism of NKT cell-mediated persistent antibody production and host protection by a new pneumococcal vaccine

    • Principal Investigator
      Kinjo Yuki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54030:Infectious disease medicine-related
    • Research Institution
      Jikei University School of Medicine
  •  Molecular mechanisms of the CD69-Myl9 system in the chronic inflammationPrincipal Investigator

    • Principal Investigator
      Hayashizaki Koji
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Immunology
    • Research Institution
      National Institute of Infectious Diseases
      Chiba University

All 2024 2023 2022 2021 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria2024

    • Author(s)
      Kamii Yasuhiro、Hayashizaki Koji、Kanno Toshio、Chiba Akio、Ikegami Taku、Saito Mitsuru、Akeda Yukihiro、Ohteki Toshiaki、Kubo Masato、Yoshida Kiyotsugu、Kawakami Kazuyoshi、Oishi Kazunori、Araya Jun、Kuwano Kazuyoshi、Kronenberg Mitchell、Endo Yusuke、Kinjo Yuki
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 121 Issue: 9

    • DOI

      10.1073/pnas.2313964121

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K14552, KAKENHI-PROJECT-21K07085, KAKENHI-PUBLICLY-23H04794, KAKENHI-PROJECT-20H03455, KAKENHI-PROJECT-23K24382
  • [Journal Article] Myosin Light Chain 9/12 Regulates the Pathogenesis of Inflammatory Bowel Disease2021

    • Author(s)
      Yokoyama Masaya、Kimura Motoko Y.、Ito Toshihiro、Hayashizaki Koji、Endo Yukihiro、Wang Yangsong、Yagi Ryoji、Nakagawa Tomoo、Kato Naoya、Matsubara Hisahiro、Nakayama Toshinori
    • Journal Title

      Frontiers in Immunology

      Volume: 11

    • DOI

      10.3389/fimmu.2020.594297

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K20383, KAKENHI-PUBLICLY-19H04800, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03464, KAKENHI-PROJECT-20K21537, KAKENHI-PROJECT-19K16704, KAKENHI-PROJECT-21K07085
  • [Journal Article] Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue Treg cell homeostasis2021

    • Author(s)
      Kanno Toshio、Nakajima Takahiro、Kawashima Yusuke、Yokoyama Satoru、Asou Hikari K.、Sasamoto Shigemi、Hayashizaki Koji、Kinjo Yuki、Ohara Osamu、Nakayama Toshinori、Endo Yusuke
    • Journal Title

      Cell Reports

      Volume: 37(6) Issue: 6 Pages: 109921-109921

    • DOI

      10.1016/j.celrep.2021.109921

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-20K21618, KAKENHI-PROJECT-19K16704, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03455, KAKENHI-PROJECT-21K07085, KAKENHI-PROJECT-21K20766, KAKENHI-PROJECT-19H03705
  • [Journal Article] SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells2021

    • Author(s)
      Kanno Toshio、Nakajima Takahiro、Yokoyama Satoru、Asou Hikari K.、Sasamoto Shigemi、Kamii Yasuhiro、Hayashizaki Koji、Ouchi Yasuo、Onodera Taishi、Takahashi Yoshimasa、Ikeda Kazutaka、Hasegawa Yoshinori、Kinjo Yuki、Ohara Osamu、Nakayama Toshinori、Endo Yusuke
    • Journal Title

      Communications Biology

      Volume: 4(1) Issue: 1 Pages: 820-820

    • DOI

      10.1038/s42003-021-02310-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-20K21618, KAKENHI-PROJECT-19K16704, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03455, KAKENHI-PROJECT-21K07085, KAKENHI-PROJECT-21K15476, KAKENHI-PROJECT-19H03705, KAKENHI-PROJECT-17KK0189, KAKENHI-PROJECT-20K07651
  • [Journal Article] Crucial role for CD69 in allergic inflammatory responses: CD69-Myl9 system in the pathogenesis of airway inflammation2017

    • Author(s)
      Kimura Motoko Y.、Hayashizaki Koji、Tokoyoda Koji、Takamura Shiki、Motohashi Shinichiro、Nakayama Toshinori
    • Journal Title

      Immunol. Rev.

      Volume: 278 Issue: 1 Pages: 87-100

    • DOI

      10.1111/imr.12559

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15715, KAKENHI-PUBLICLY-17H05787, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-15K08524
  • [Presentation] The metabolic adaptation is necessary for iNKT cells to differentiate into the follicular subset, which is regulated by Gr-1+ cells.2024

    • Author(s)
      Hayashizaki K, Kamii Y, Kanno T, Kubo M, Ohteki T, Kawakami K, Endo Y, Kinjo Y.
    • Organizer
      第52回 日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K07085
  • [Presentation] The metabolic adaptation is necessary for iNKT cells to differentiate into the follicular subset, which is regulated by Gr-1+ cells2024

    • Author(s)
      Hayashizaki K, Kamii Y, Kanno T, Kubo M, Ohteki T, Kawakami K, Endo Y, Kinjo Y
    • Organizer
      第52回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K24382
  • [Presentation] 2価PspA 融合タンパク質ワクチンによる肺炎球菌感染防御効果の解析2023

    • Author(s)
      金城雄樹,中山大輝,古泉ゆか,黒田英介,常彬,林崎浩史,竹河志郎,明田幸宏,大石和徳
    • Organizer
      第96回日本細菌学会総会
    • Data Source
      KAKENHI-PROJECT-23K24382
  • [Presentation] 肺炎球菌蛋白・糖脂質ワクチンによる濾胞性ヘルパーNKT 細胞の誘導機構の解析2022

    • Author(s)
      林崎 浩史
    • Organizer
      第33回日本生体防御学会
    • Data Source
      KAKENHI-PROJECT-21K07085
  • [Presentation] Interleukin-27 supports metabolic adaptation of Natural killer T cells and effector responses2022

    • Author(s)
      Yasuhiro Kamii, Koji Hayashizaki, Toshio Kanno, Yoshimasa Takahashi, Toshiaki Ohteki, Yusuke Endo, Yuki Kinjo
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K24382
  • [Presentation] NKT-mediated vaccine induces affinity maturation of BCR and supply antibody dependent protection against Streptococcus pneumoniae2021

    • Author(s)
      Koji Hayashizaki
    • Organizer
      第50回日本免疫学会
    • Data Source
      KAKENHI-PROJECT-19K16704
  • [Presentation] Pneumococcal surface protein A and glycolipid vaccine augments generation of long-lived plasma cells that produce antigen-specific IgG2021

    • Author(s)
      Koji Hayashizaki
    • Organizer
      第3回アジア肺炎球菌シンポジウム
    • Data Source
      KAKENHI-PROJECT-21K07085
  • [Presentation] NKT-mediated vaccine induces affinity maturation of BCR and supply antibody dependent protection against Streptococcus pneumoniae2021

    • Author(s)
      Koji Hayashizaki
    • Organizer
      第50回日本免疫学会
    • Data Source
      KAKENHI-PROJECT-21K07085
  • [Presentation] NKT-mediated vaccine induces affinity maturation of BCR and supply antibody dependent protection against Streptococcus pneumoniae2021

    • Author(s)
      Hayashizaki K, Takatsuka S, Kamii Y, Tsuiji M, Kubo M, Takahashi Y, Kinjo Y
    • Organizer
      第50回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-19H03705
  • [Presentation] Gr-1+ cells influence on the differentiation of follicular helper Natural killer T cells2021

    • Author(s)
      Kamii Y, Hayashizaki K, Kanno T, Endo Y, Takahashi Y, Kinjo Y
    • Organizer
      第50回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-19H03705
  • [Presentation] Pneumococcal surface protein A and glycolipid vaccine augments generation of long-lived plasma cells that produce antigen-specific IgG2021

    • Author(s)
      Hayashizaki K, Akeda Y, Chang B, Kawakami K, Oishi K, Kinjo Y
    • Organizer
      The third Asian pneumococcal symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03705
  • [Presentation] Pneumococcal surface protein A and glycolipid vaccine augments generation of long-lived plasma cells that produce antigen-specific IgG2021

    • Author(s)
      Koji Hayashizaki
    • Organizer
      第3回アジア肺炎球菌シンポジウム
    • Data Source
      KAKENHI-PROJECT-19K16704
  • [Presentation] The protein and glycolipid vaccine induce long-term protection against pneumococcal infection through differentiation of follicular helper NKT cells.2019

    • Author(s)
      Hayashizaki K, Takatsuka S, Kawakubo S, Kamii Y, Takahashi Y, Kawakami K, Kubo M, Kinjo Y.
    • Organizer
      The 48th Annual Meeting of The Japanese Society for Immunology
    • Data Source
      KAKENHI-PROJECT-19K16704
  • [Presentation] Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation.2018

    • Author(s)
      Hayashizaki K., Kimura M.Y., Tokoyoda K. and Nakayama T.
    • Organizer
      The 2nd Chiba University-UC San Diego Symposium "Mucosal Immunology, Allergy and Vaccine"
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15715
  • [Presentation] CD69-Myl9 system regulates pathogenesis of inflammatory disorders.2018

    • Author(s)
      Kimura M.Y., Hayashizaki K. and Nakayama T.
    • Organizer
      The 2nd Chiba University-UC San Diego Symposium "Mucosal Immunology, Allergy and Vaccine"
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15715
  • [Presentation] Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation.2017

    • Author(s)
      Kimura M.Y., Hayashizaki K. and Nakayama T.
    • Organizer
      The 5th Annual Meeting of the International Cytokine and Interferon Society 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15715
  • [Presentation] Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation.2017

    • Author(s)
      Hayashizaki K., Kimura M.Y., Mita Y., Yagi R. and Nakayama T.
    • Organizer
      The 46th Annual Meeting of The Japanese Society for Immunology
    • Data Source
      KAKENHI-PROJECT-17K15715
  • 1.  Kinjo Yuki (20570831)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 2.  高橋 宜聖 (60311403)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 3.  高塚 翔吾 (90609398)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 4.  牛久 智加良 (10338874)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  田中 賢 (00322850)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  穴田 貴久 (30398466)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  常 彬 (50370961)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  中山 俊憲
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 9.  菅野 敏生
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi