Hayashizaki Koji 林崎浩史

Researcher Number	50779907
Other IDs
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2019 – 2024: 東京慈恵会医科大学, 医学部, 助教 2018: 国立感染症研究所, 真菌部, 研究員 2017: 千葉大学, 大学院医学研究院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / Immunology Except Principal Investigator Basic Section 54030:Infectious disease medicine-related / Basic Section 90110:Biomedical engineering-related
Keywords	Principal Investigator 肺炎球菌ワクチン / NKT細胞 / 肺炎球菌 / 糖脂質 / ミトコンドリア代謝 / Gr-1+細胞 / IL-27 / NKTFH細胞 / ワクチン / 細菌感染 … More / 未分化NKT細胞 / 感染免疫 / 未分化 / 骨髄 / 気道炎症 / CD69リガンド / DSS誘導性大腸炎モデル / 抗原提示細胞 / 血管内腔 / 感染 / 血栓様構造体 / MHCクラスⅡ発現細胞 / Myl9 nets / T細胞 / アレルギー性気道炎症 / 慢性炎症 / CD69-Myl9システム … More Except Principal Investigator NKT細胞 / 糖脂質 / 抗体 / ワクチン / 肺炎 / 肺炎球菌 / osseointegration / 皮質骨多孔化 / 中間水コンセプト / NKT / 肺炎球菌感染症 Less

新規インプラント開発に向けた中間水制御技術による骨吸収抑制機序の解明
- Principal Investigator
  
  牛久智加良
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Jikei University School of Medicine
高親和性抗体の産生及び持続をもたらす免疫応答の解明とワクチンへの応用
- Principal Investigator
  
  金城雄樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Jikei University School of Medicine
The differentiation mechanism of functional NKT cells that induce long-term antibody productionPrincipal Investigator
- Principal Investigator
  
  Hayashizaki Koji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Jikei University School of Medicine
A role of bone marrow resident-uncommitted NKT cells under the infectious immune responsesPrincipal Investigator
- Principal Investigator
  
  Hayashizaki Koji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Jikei University School of Medicine
The mechanism of NKT cell-mediated persistent antibody production and host protection by a new pneumococcal vaccine
- Principal Investigator
  
  Kinjo Yuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Jikei University School of Medicine
Molecular mechanisms of the CD69-Myl9 system in the chronic inflammationPrincipal Investigator
- Principal Investigator
  
  Hayashizaki Koji
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  National Institute of Infectious Diseases
  Chiba University

All 2024 2023 2022 2021 2019 2018 2017

All Journal Article Presentation

[Journal Article] IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria2024
- Author(s)
  Kamii Yasuhiro、Hayashizaki Koji、Kanno Toshio、Chiba Akio、Ikegami Taku、Saito Mitsuru、Akeda Yukihiro、Ohteki Toshiaki、Kubo Masato、Yoshida Kiyotsugu、Kawakami Kazuyoshi、Oishi Kazunori、Araya Jun、Kuwano Kazuyoshi、Kronenberg Mitchell、Endo Yusuke、Kinjo Yuki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 121 Issue: 9
- DOI
  10.1073/pnas.2313964121
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14552, KAKENHI-PROJECT-21K07085, KAKENHI-PUBLICLY-23H04794, KAKENHI-PROJECT-20H03455, KAKENHI-PROJECT-23K24382
[Journal Article] Myosin Light Chain 9/12 Regulates the Pathogenesis of Inflammatory Bowel Disease2021
- Author(s)
  Yokoyama Masaya、Kimura Motoko Y.、Ito Toshihiro、Hayashizaki Koji、Endo Yukihiro、Wang Yangsong、Yagi Ryoji、Nakagawa Tomoo、Kato Naoya、Matsubara Hisahiro、Nakayama Toshinori
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 11
- DOI
  10.3389/fimmu.2020.594297
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PUBLICLY-19H04800, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03464, KAKENHI-PROJECT-20K21537, KAKENHI-PROJECT-19K16704, KAKENHI-PROJECT-21K07085
[Journal Article] Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue Treg cell homeostasis2021
- Author(s)
  Kanno Toshio、Nakajima Takahiro、Kawashima Yusuke、Yokoyama Satoru、Asou Hikari K.、Sasamoto Shigemi、Hayashizaki Koji、Kinjo Yuki、Ohara Osamu、Nakayama Toshinori、Endo Yusuke
- Journal Title
  
  Cell Reports
  
  Volume: 37(6) Issue: 6 Pages: 109921-109921
- DOI
  10.1016/j.celrep.2021.109921
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-20K21618, KAKENHI-PROJECT-19K16704, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03455, KAKENHI-PROJECT-21K07085, KAKENHI-PROJECT-21K20766, KAKENHI-PROJECT-19H03705
[Journal Article] SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells2021
- Author(s)
  Kanno Toshio、Nakajima Takahiro、Yokoyama Satoru、Asou Hikari K.、Sasamoto Shigemi、Kamii Yasuhiro、Hayashizaki Koji、Ouchi Yasuo、Onodera Taishi、Takahashi Yoshimasa、Ikeda Kazutaka、Hasegawa Yoshinori、Kinjo Yuki、Ohara Osamu、Nakayama Toshinori、Endo Yusuke
- Journal Title
  
  Communications Biology
  
  Volume: 4(1) Issue: 1 Pages: 820-820
- DOI
  10.1038/s42003-021-02310-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-20K21618, KAKENHI-PROJECT-19K16704, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03455, KAKENHI-PROJECT-21K07085, KAKENHI-PROJECT-21K15476, KAKENHI-PROJECT-19H03705, KAKENHI-PROJECT-17KK0189, KAKENHI-PROJECT-20K07651
[Journal Article] Crucial role for CD69 in allergic inflammatory responses: CD69-Myl9 system in the pathogenesis of airway inflammation2017
- Author(s)
  Kimura Motoko Y.、Hayashizaki Koji、Tokoyoda Koji、Takamura Shiki、Motohashi Shinichiro、Nakayama Toshinori
- Journal Title
  
  Immunol. Rev.
  
  Volume: 278 Issue: 1 Pages: 87-100
- DOI
  10.1111/imr.12559
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15715, KAKENHI-PUBLICLY-17H05787, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-15K08524
[Presentation] The metabolic adaptation is necessary for iNKT cells to differentiate into the follicular subset, which is regulated by Gr-1+ cells.2024
- Author(s)
  Hayashizaki K, Kamii Y, Kanno T, Kubo M, Ohteki T, Kawakami K, Endo Y, Kinjo Y.
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07085
[Presentation] The metabolic adaptation is necessary for iNKT cells to differentiate into the follicular subset, which is regulated by Gr-1+ cells2024
- Author(s)
  Hayashizaki K, Kamii Y, Kanno T, Kubo M, Ohteki T, Kawakami K, Endo Y, Kinjo Y
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24382
[Presentation] 2価PspA 融合タンパク質ワクチンによる肺炎球菌感染防御効果の解析2023
- Author(s)
  金城雄樹，中山大輝，古泉ゆか，黒田英介，常彬，林崎浩史，竹河志郎，明田幸宏，大石和徳
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-23K24382
[Presentation] 肺炎球菌蛋白・糖脂質ワクチンによる濾胞性ヘルパーNKT 細胞の誘導機構の解析2022
- Author(s)
  林崎浩史
- Organizer
  第33回日本生体防御学会
- Data Source
  KAKENHI-PROJECT-21K07085
[Presentation] Interleukin-27 supports metabolic adaptation of Natural killer T cells and effector responses2022
- Author(s)
  Yasuhiro Kamii, Koji Hayashizaki, Toshio Kanno, Yoshimasa Takahashi, Toshiaki Ohteki, Yusuke Endo, Yuki Kinjo
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24382
[Presentation] NKT-mediated vaccine induces affinity maturation of BCR and supply antibody dependent protection against Streptococcus pneumoniae2021
- Author(s)
  Koji Hayashizaki
- Organizer
  第50回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K16704
[Presentation] Pneumococcal surface protein A and glycolipid vaccine augments generation of long-lived plasma cells that produce antigen-specific IgG2021
- Author(s)
  Koji Hayashizaki
- Organizer
  第3回アジア肺炎球菌シンポジウム
- Data Source
  KAKENHI-PROJECT-21K07085
[Presentation] NKT-mediated vaccine induces affinity maturation of BCR and supply antibody dependent protection against Streptococcus pneumoniae2021
- Author(s)
  Koji Hayashizaki
- Organizer
  第50回日本免疫学会
- Data Source
  KAKENHI-PROJECT-21K07085
[Presentation] NKT-mediated vaccine induces affinity maturation of BCR and supply antibody dependent protection against Streptococcus pneumoniae2021
- Author(s)
  Hayashizaki K, Takatsuka S, Kamii Y, Tsuiji M, Kubo M, Takahashi Y, Kinjo Y
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03705
[Presentation] Gr-1+ cells influence on the differentiation of follicular helper Natural killer T cells2021
- Author(s)
  Kamii Y, Hayashizaki K, Kanno T, Endo Y, Takahashi Y, Kinjo Y
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03705
[Presentation] Pneumococcal surface protein A and glycolipid vaccine augments generation of long-lived plasma cells that produce antigen-specific IgG2021
- Author(s)
  Hayashizaki K, Akeda Y, Chang B, Kawakami K, Oishi K, Kinjo Y
- Organizer
  The third Asian pneumococcal symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03705
[Presentation] Pneumococcal surface protein A and glycolipid vaccine augments generation of long-lived plasma cells that produce antigen-specific IgG2021
- Author(s)
  Koji Hayashizaki
- Organizer
  第3回アジア肺炎球菌シンポジウム
- Data Source
  KAKENHI-PROJECT-19K16704
[Presentation] The protein and glycolipid vaccine induce long-term protection against pneumococcal infection through differentiation of follicular helper NKT cells.2019
- Author(s)
  Hayashizaki K, Takatsuka S, Kawakubo S, Kamii Y, Takahashi Y, Kawakami K, Kubo M, Kinjo Y.
- Organizer
  The 48th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-19K16704
[Presentation] Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation.2018
- Author(s)
  Hayashizaki K., Kimura M.Y., Tokoyoda K. and Nakayama T.
- Organizer
  The 2nd Chiba University-UC San Diego Symposium "Mucosal Immunology, Allergy and Vaccine"
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15715
[Presentation] CD69-Myl9 system regulates pathogenesis of inflammatory disorders.2018
- Author(s)
  Kimura M.Y., Hayashizaki K. and Nakayama T.
- Organizer
  The 2nd Chiba University-UC San Diego Symposium "Mucosal Immunology, Allergy and Vaccine"
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15715
[Presentation] Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation.2017
- Author(s)
  Kimura M.Y., Hayashizaki K. and Nakayama T.
- Organizer
  The 5th Annual Meeting of the International Cytokine and Interferon Society 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15715
[Presentation] Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation.2017
- Author(s)
  Hayashizaki K., Kimura M.Y., Mita Y., Yagi R. and Nakayama T.
- Organizer
  The 46th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-17K15715

1. Kinjo Yuki (20570831)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. 高橋宜聖 (60311403)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 高塚翔吾 (90609398)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 牛久智加良 (10338874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 田中賢 (00322850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 穴田貴久 (30398466)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 常彬 (50370961)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 中山俊憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
9. 菅野敏生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayashizaki Koji 林崎 浩史

Research Projects

Research Products

Co-Researchers

新規インプラント開発に向けた中間水制御技術による骨吸収抑制機序の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

高親和性抗体の産生及び持続をもたらす免疫応答の解明とワクチンへの応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The differentiation mechanism of functional NKT cells that induce long-term antibody productionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A role of bone marrow resident-uncommitted NKT cells under the infectious immune responsesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanism of NKT cell-mediated persistent antibody production and host protection by a new pneumococcal vaccine

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms of the CD69-Myl9 system in the chronic inflammationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Myosin Light Chain 9/12 Regulates the Pathogenesis of Inflammatory Bowel Disease2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue Treg cell homeostasis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crucial role for CD69 in allergic inflammatory responses: CD69-Myl9 system in the pathogenesis of airway inflammation2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] The metabolic adaptation is necessary for iNKT cells to differentiate into the follicular subset, which is regulated by Gr-1+ cells.2024

Author(s)

Organizer

Data Source

[Presentation] The metabolic adaptation is necessary for iNKT cells to differentiate into the follicular subset, which is regulated by Gr-1+ cells2024

Author(s)

Organizer

Data Source

[Presentation] 2価PspA 融合タンパク質ワクチンによる肺炎球菌感染防御効果の解析2023

Author(s)

Organizer

Data Source

[Presentation] 肺炎球菌蛋白・糖脂質ワクチンによる濾胞性ヘルパーNKT 細胞の誘導機構の解析2022

Author(s)

Organizer

Hayashizaki Koji 林崎浩史