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Tetsuro Tago  多胡 哲郎

… Alternative Names

Tago Tetsuro  多胡 哲郎

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Researcher Number 50780649
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-9545-0922
Affiliation (Current) 2025: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員
Affiliation (based on the past Project Information) *help 2025: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員
2016 – 2023: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 52040:Radiological sciences-related / Radiation science
Keywords
Principal Investigator
放射性医薬品 / 核医学 / HDAC6 / PET / 分子イメージング / ユビキチン / イメージング / プロテイノパチー
  • Research Projects

    (5 results)
  • Research Products

    (39 results)
  • Co-Researchers

    (7 People)
  •  脳内PETイメージングに適した細胞膜透過性ペプチドからなるBBB輸送体の開発Principal Investigator

    • Principal Investigator
      多胡 哲郎
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Tokyo Metropolitan Institute for Geriatrics and Gerontology
  •  Structural optimization of PET imaging probes for HDAC6 in the brainPrincipal Investigator

    • Principal Investigator
      多胡 哲郎
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
  •  Development of 18F-labeled tetrahydroquinoline derivatives for HDAC6 PET imagingPrincipal Investigator

    • Principal Investigator
      Tago Tetsuro
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
  •  Development of PET probes for HDAC6 imagingPrincipal Investigator

    • Principal Investigator
      Tago Tetsuro
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
  •  Development of HDAC6 PET imaging probes for proteinopathiesPrincipal Investigator

    • Principal Investigator
      Tago Tetsuro
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Radiation science
    • Research Institution
      Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Preclinical validation of a novel brain-penetrant PET ligand for visualization of histone deacetylase 6: a potential imaging target for neurodegenerative diseases2024

    • Author(s)
      Tago Tetsuro、Sakata Muneyuki、Kanazawa Masakatsu、Yamamoto Shigeyuki、Ishii Kenji、Toyohara Jun
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: - Issue: 8 Pages: 2193-2203

    • DOI

      10.1007/s00259-024-06666-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K07682, KAKENHI-PROJECT-21K07663
  • [Journal Article] Preclinical Evaluation of an 18F-Labeled SW-100 Derivative for PET Imaging of Histone Deacetylase 6 in the Brain2021

    • Author(s)
      Tago Tetsuro、Toyohara Jun、Ishii Kenji
    • Journal Title

      ACS Chemical Neuroscience

      Volume: 12 Issue: 4 Pages: 746-755

    • DOI

      10.1021/acschemneuro.0c00774

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K16778, KAKENHI-PROJECT-18K07658
  • [Journal Article] Metabolic network topology of Alzheimer’s disease and dementia with Lewy bodies generated using fluorodeoxyglucose positron emission tomography.2020

    • Author(s)
      Imai M, Tanaka M, SakataM, Wagatsuma K, Tago T, Toyohara J, Sengoku R, Nishina Y, Kanemaru K, Ishibashi K, Murayama S, Ishii K.
    • Journal Title

      J Alzheimers Dis

      Volume: 73 Issue: 1 Pages: 197-207

    • DOI

      10.3233/jad-190843

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09736, KAKENHI-PROJECT-18K07658, KAKENHI-PROJECT-17K09813, KAKENHI-PROJECT-18K15655
  • [Journal Article] Mechanical regulation underlies effects of exercise on serotonin-induced signaling in the prefrontal cortex neurons.2020

    • Author(s)
      Ryu Y, Maekawa T, Yoshino D, Sakitani N, Takashima A, Inoue T, Suzurikawa J, Toyohara J, Tago T, Fujita N, Sawada K, Murase S, Watanave M, Sakai T, Yoshikawa Y, Ogata T, Shinohara M, Nagao M, Sawada Y
    • Journal Title

      iScience

      Volume: 23 Issue: 2 Pages: 100874-100874

    • DOI

      10.1016/j.isci.2020.100874

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18KT0018, KAKENHI-PROJECT-18K07658, KAKENHI-PLANNED-17H06380, KAKENHI-PROJECT-18H04088, KAKENHI-PROJECT-18H02027, KAKENHI-PROJECT-19H03124, KAKENHI-PROJECT-18K15655
  • [Journal Article] Radiosynthesis and preliminary evaluation of an 18F-labeled tubastatin A analog for PET imaging of histone deacetylase 62020

    • Author(s)
      Tago Tetsuro、Toyohara Jun、Ishii Kenji
    • Journal Title

      Journal of Labelled Compounds and Radiopharmaceuticals

      Volume: 63 Issue: 2 Pages: 85-95

    • DOI

      10.1002/jlcr.3823

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07658, KAKENHI-PROJECT-18K15655
  • [Journal Article] Radiosynthesis of 18F-labeled d-allose2019

    • Author(s)
      Yamamoto Hiroyuki、Wada Kenji、Toyohara Jun、Tago Tetsuro、Ibaraki Masanobu、Kinoshita Toshibumi、Yamamoto Yuka、Nishiyama Yoshihiro、Kudomi Nobuyuki
    • Journal Title

      Carbohydrate Research

      Volume: 486 Pages: 107827-107827

    • DOI

      10.1016/j.carres.2019.107827

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07658, KAKENHI-PROJECT-18K15655
  • [Journal Article] Characterization of the binding of tau imaging ligands to melanin-containing cells: putative off-target-binding site2019

    • Author(s)
      Tago Tetsuro、Toyohara Jun、Harada Ryuichi、Furumoto Shozo、Okamura Nubuyuki、Kudo Yukitsuka、Takahashi-Fujigasaki Junko、Murayama Shigeo、Ishii Kenji
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 33 Issue: 6 Pages: 1-8

    • DOI

      10.1007/s12149-019-01344-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09813, KAKENHI-PROJECT-18K15655, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K07658, KAKENHI-PROJECT-18K15538, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-18H02771
  • [Journal Article] Monoamine Oxidase B Binding of 18F-THK5351 to Visualize Glioblastoma and Associated Gliosis2019

    • Author(s)
      Tago Tetsuro、Toyohara Jun、Sengoku Renpei、Murayama Shigeo、Ishii Kenji
    • Journal Title

      Clinical Nuclear Medicine

      Volume: 44 Issue: 6 Pages: 507-509

    • DOI

      10.1097/rlu.0000000000002564

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09813, KAKENHI-PROJECT-18K15655, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16K09736, KAKENHI-PROJECT-18K07658
  • [Journal Article] Searching for diagnostic properties of novel fluorine-18-labeled d-allose2019

    • Author(s)
      Toyohara Jun、Yamamoto Hiroyuki、Tago Tetsuro
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 33 Issue: 11 Pages: 855-865

    • DOI

      10.1007/s12149-019-01398-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07658, KAKENHI-PROJECT-18K15655
  • [Journal Article] Correlations of (18)F-THK5351 PET with Postmortem Burden of Tau and Astrogliosis in Alzheimer Disease.2018

    • Author(s)
      Harada R, Furukawa K, et al.
    • Journal Title

      J Nucl Med

      Volume: 59 Issue: 4 Pages: 671-674

    • DOI

      10.2967/jnumed.117.197426

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09318, KAKENHI-PROJECT-16K15570, KAKENHI-PROJECT-17K20083, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-16H05383, KAKENHI-PROJECT-16H05385, KAKENHI-PROJECT-16H06621, KAKENHI-PROJECT-16H07486, KAKENHI-PROJECT-15K08127
  • [Journal Article] Advances in the Development of PET Ligands Targeting Histone Deacetylases for the Assessment of Neurodegenerative Diseases2018

    • Author(s)
      Tago Tetsuro、Toyohara Jun
    • Journal Title

      Molecules

      Volume: 23 Issue: 2 Pages: 300-300

    • DOI

      10.3390/molecules23020300

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H07486
  • [Journal Article] Response of cerebral blood flow and blood pressure to dynamic exercise: A study using PET2018

    • Author(s)
      Hiura, M., Nariai, T. Muta, A., Sakata, M., Ishibashi, K. Toyohara, J. Wagatsuma, K. Tago, T., Ishii, K. Maehara, T.
    • Journal Title

      International Journal of Sports Medicine

      Volume: 39 Issue: 03 Pages: 181-188

    • DOI

      10.1055/s-0043-123647

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K01841, KAKENHI-PROJECT-16H07486
  • [Journal Article] Potential Use of 18F-THK5351 PET to Identify Wallerian Degeneration of the Pyramidal Tract Caused by Cerebral Infarction2017

    • Author(s)
      Ishibashi Kenji、Kameyama Masashi、Tago Tetsuro、Toyohara Jun、Ishii Kenji
    • Journal Title

      Clinical Nuclear Medicine

      Volume: 42 Issue: 12 Pages: e523-e524

    • DOI

      10.1097/rlu.0000000000001868

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09813, KAKENHI-PROJECT-16H07486
  • [Journal Article] ヒストンデアセチラーゼ6のイメージングを目的としたPETプローブの開発2017

    • Author(s)
      多胡哲郎、豊原潤、酒井昌成、林薫平、石井賢二
    • Journal Title

      JSMI Report

      Volume: 11 Pages: 25-28

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H07486
  • [Presentation] Visualization of histone deacetylase 6 expression in the conscious monkey brain: preliminary PET study with [18F]FSW-1002024

    • Author(s)
      Tetsuro Tago, Muneyuki Sakata, Masakatsu Kanazawa, Shigeyuki Yamamoto, Jun Toyohara
    • Organizer
      19th European Molecular Imaging Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07682
  • [Presentation] Optimization of the automated radiosynthesis of an 18F-labeled tetrahydroquinoline derivative for brain HDAC6 imaging.2023

    • Author(s)
      Tetsuro Tago, Jun Toyohara, Kenji Ishii
    • Organizer
      The 25th International Symposium on Radiopharmaceutical Sciences
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07682
  • [Presentation] PET用HDAC6イメージングプローブ[18F]FSW-100の自動合成最適化2023

    • Author(s)
      多胡哲郎、豊原潤、石井賢二
    • Organizer
      日本薬学会第143年会
    • Data Source
      KAKENHI-PROJECT-22K07682
  • [Presentation] PET用HDAC6プローブ[11C]Bavarostatの標識合成2023

    • Author(s)
      多胡哲郎、豊原潤、石井賢二
    • Organizer
      第17回日本分子イメージング学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-22K07682
  • [Presentation] PET用HDAC6プローブ[18F]FSW-100の被ばく線量推定と毒性試験2023

    • Author(s)
      多胡哲郎,坂田宗之,豊原潤
    • Organizer
      第63回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-22K07682
  • [Presentation] 神経変性疾患を標的としたPET用薬剤開発2023

    • Author(s)
      多胡哲郎
    • Organizer
      第192回東京医科大学医学会総会
    • Data Source
      KAKENHI-PROJECT-22K07682
  • [Presentation] [18F]F-の活性化法2022

    • Author(s)
      多胡哲郎
    • Organizer
      PET化学ワークショップ2022
    • Data Source
      KAKENHI-PROJECT-20K16778
  • [Presentation] Radiosynthesis and biological evaluation of a nicotinic acid hydroxamate derivative as a radioligand for HDAC6 PET imaging2022

    • Author(s)
      Tetsuro Tago, Jun Toyohara, Kenji Ishii
    • Organizer
      International Symposium on Radiopharmaceutical Sciences
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07682
  • [Presentation] 新規脳内HDAC6 PETイメージングプローブの開発2022

    • Author(s)
      多胡哲郎、豊原潤、石井賢二
    • Organizer
      第62回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-22K07682
  • [Presentation] Development of a PET probe for histone deacetylase 6 in the brain2021

    • Author(s)
      Tetsuro Tago, Jun Toyohara, Kenji Ishii
    • Organizer
      第61回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K16778
  • [Presentation] Radiosynthesis and preliminary evaluation of a novel 18F-labeled probe for PET imaging of HDAC6 in the brain2021

    • Author(s)
      Tetsuro Tago, Jun Toyohara, Kenji Ishii
    • Organizer
      The 11th China-Japan-Korea Symposium on Radiopharmaceutical Sciences
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K16778
  • [Presentation] 脳内HDAC6 PETイメージングのための18F-標識テトラヒドロキノリン誘導体の開発2020

    • Author(s)
      多胡哲郎、豊原潤、石井賢二
    • Organizer
      第60回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K16778
  • [Presentation] F-182020

    • Author(s)
      多胡哲郎
    • Organizer
      PET化学ワークショップ
    • Data Source
      KAKENHI-PROJECT-18K15655
  • [Presentation] A simple SPE purification method for 18F-radiolabeleing: Proof-of-concept study in stilbene amyloid-β ligands with a neopentyl labeling group2019

    • Author(s)
      Tago T, Toyohara J, Fujimaki R, Hirano K, Iwai K, Ishibashi K, Tanaka H
    • Organizer
      The 23rd International Symposium on Radiopharmaceutical Sciences
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15655
  • [Presentation] HDAC6イメージングを目的とした18F-標識ツバスタチンA類縁体の標識合成と生物学的評価2019

    • Author(s)
      多胡哲郎,豊原潤,石井賢二
    • Organizer
      第14回日本分子イメージング学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-18K15655
  • [Presentation] F-18化学2019

    • Author(s)
      多胡哲郎
    • Organizer
      PET化学ワークショップ2019
    • Data Source
      KAKENHI-PROJECT-18K15655
  • [Presentation] アルツハイマー病イメージングのためのPETプローブ開発2019

    • Author(s)
      多胡哲郎
    • Organizer
      第35回都市高齢者の健康長寿医療研究会
    • Data Source
      KAKENHI-PROJECT-18K15655
  • [Presentation] Preliminary biological evaluation of radioligands for PET imaging of histone deacetylase 62018

    • Author(s)
      Tago, T., Toyohara, J., Ishii, K
    • Organizer
      EANM'18
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15655
  • [Presentation] Radiosynthesis and preliminary biological evaluation of a 18F-labeled probe for histone deacetylase 6 PET imaging2018

    • Author(s)
      Tago, T., Toyohara, J., Ishii, K
    • Organizer
      The 10th China-Japan-Korea Symposium on Radiopharmaceutical Sciences
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15655
  • [Presentation] Development of PET probes for imaging of histone deacetylase 62017

    • Author(s)
      Tetsuro Tago、Kunpei Hayashi、Masanari Sakai、Kenji Ishii、Jun Toyohara
    • Organizer
      FASMI 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H07486
  • [Presentation] Radiosynthesis of carbon-11- and fluorine-18-labeled Tubastatin A derivatives for PET imaging of histone deacetylase 62017

    • Author(s)
      Tetsuro Tago、Kunpei Hayashi、Masanari Sakai、Kenji Ishii、Jun Toyohara
    • Organizer
      22nd International Symposium on Radiopharmaceutical Sciences
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H07486
  • [Presentation] Development of PET probes for imaging of histone deacetylase 62017

    • Author(s)
      多胡哲郎、林薫平、酒井昌成、石井賢二、豊原潤
    • Organizer
      第12回日本分子イメージング学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H07486
  • [Presentation] ヒストンデアセチラーゼ6のPETイメージングを目的とした放射性標識ツバスタチンA誘導体の開発2017

    • Author(s)
      多胡哲郎、豊原潤、酒井昌成、林薫平、石井賢二
    • Organizer
      第57回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H07486
  • [Presentation] コンフォメーション病のイメージングを目的としたPETプローブ開発2016

    • Author(s)
      多胡哲郎
    • Organizer
      首都大バイオコンファレンス2016
    • Place of Presentation
      首都大学東京(東京・八王子)
    • Year and Date
      2016-11-18
    • Data Source
      KAKENHI-PROJECT-16H07486
  • [Presentation] 臨床応用を目指したPET薬剤の次世代化2016

    • Author(s)
      豊原潤、多胡哲郎、坂田宗之、石橋賢士、我妻慧、石渡喜一、石井賢二
    • Organizer
      第56回日本核医学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知・名古屋)
    • Year and Date
      2016-11-03
    • Data Source
      KAKENHI-PROJECT-16H07486
  • 1.  TOYOHARA Jun
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 2.  仙石 錬平
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  篠原 正浩
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  古川 勝敏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  日浦 幹夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  石井 賢二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 7.  成相 直
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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