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Takagi Yuko  高木 悠友子

Researcher Number 50783669
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-4567-0986
Affiliation (Current) 2026: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員
Affiliation (based on the past Project Information) *help 2017 – 2024: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員
2016: 国立研究開発法人産業技術総合研究所, バイオメディカル研究部門, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 49040:Parasitology-related / Parasitology (including sanitary zoology)
Except Principal Investigator
Basic Section 49040:Parasitology-related
Keywords
Principal Investigator
原虫 / 培養 / 微生物 / 遺伝子 / 創薬標的 / 感染症 / ドロップレット / 分化 / 感染 / 遺伝子組換え / ゲノム編集 / 熱帯病 … More
Except Principal Investigator
… More 病理学 / 寄生虫学 / mRNA キャッピング / RNA methylation / Trypanosoma / Recapping / mRNA processing / トリパのソーマ / RNA capping / RNA modification / Trypansome / 寄生虫 / RNA プロセッシング / トリパノソーマ / RNA キャッピング Less
  • Research Projects

    (4 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (1 People)
  •  トリパノソーマ原虫の感染ステージ分化を誘導する必須要件の解明Principal Investigator

    • Principal Investigator
      高木 悠友子
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49040:Parasitology-related
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Structure and biological targets of Trypanosome mRNA recapping enzyme

    • Principal Investigator
      Ho Kiong
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49040:Parasitology-related
    • Research Institution
      University of Tsukuba
  •  Development of gene modification method that contributes to drug target search for Chagas DiseasePrincipal Investigator

    • Principal Investigator
      Takagi Yuko
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 49040:Parasitology-related
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Searching for a drug target against parasitic protozoa, TrypanosomaPrincipal Investigator

    • Principal Investigator
      Takagi Yuko
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Parasitology (including sanitary zoology)
    • Research Institution
      National Institute of Advanced Industrial Science and Technology

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] Nanoscale Surface Metal-Coating Method without Pretreatment for High-Magnification Biological Observation and Applications2024

    • Author(s)
      Takemura Kenshin、Motomura Taisei、Takagi Yuko
    • Journal Title

      Biomimetics

      Volume: 9 Issue: 10 Pages: 588-588

    • DOI

      10.3390/biomimetics9100588

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K06524, KAKENHI-PROJECT-23K13566
  • [Journal Article] Differentiating Trypanosoma cruzi in a Host Mammalian Cell Imaged in Aqueous Liquid by Atmospheric Scanning Electron Microscopy2022

    • Author(s)
      Takagi Yuko、Sato Mari、Naya Masami、Sato Chikara
    • Journal Title

      Microbiology Spectrum

      Volume: 10(1) Issue: 1

    • DOI

      10.1128/spectrum.01413-21

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15141
  • [Journal Article] Crystal structures of the RNA triphosphatase from Trypanosoma cruzi provide insights into how it recognizes the 5′-end of the RNA substrate2020

    • Author(s)
      Takagi Yuko、Kuwabara Naoyuki、Dang Truong Tat、Furukawa Koji、Ho C. Kiong
    • Journal Title

      Journal of Biological Chemistry

      Volume: 295 Issue: 27 Pages: 9076-9086

    • DOI

      10.1074/jbc.ra119.011811

    • NAID

      120007127729

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15141, KAKENHI-PROJECT-16H05180
  • [Journal Article] Introducing a Gene Knockout Directly Into the Amastigote Stage of <em>Trypanosoma cruzi</em> Using the CRISPR/Cas9 System2019

    • Author(s)
      Akutsu Yukie、Doi Motomichi、Furukawa Koji、Takagi Yuko
    • Journal Title

      Journal of Visualized Experiments

      Volume: 149 Issue: 149

    • DOI

      10.3791/59962

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K15141
  • [Journal Article] Utilization of proliferable extracellular amastigotes for transient gene expression, drug sensitivity assay, and CRISPR/Cas9-mediated gene knockout in Trypanosoma cruzi2019

    • Author(s)
      Takagi Yuko、Akutsu Yukie、Doi Motomichi、Furukawa Koji
    • Journal Title

      PLOS Neglected Tropical Diseases

      Volume: 13 Issue: 1 Pages: e0007088-e0007088

    • DOI

      10.1371/journal.pntd.0007088

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15141
  • [Journal Article] Development of a motion-based cell-counting system for Trypanosoma parasite using a pattern recognition approach2019

    • Author(s)
      Takagi Yuko、Nosato Hirokazu、Doi Motomichi、Furukawa Koji、Sakanashi Hidenori
    • Journal Title

      BioTechniques

      Volume: 66 Issue: 4 Pages: 179-185

    • DOI

      10.2144/btn-2018-0163

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15141
  • [Presentation] Identification of Biological Targets of the Cytoplasmic Capping Enzyme Trypanosoma Parasites2024

    • Author(s)
      Kieu DM Nguyen, Yuko Takagi, C Kiong Ho
    • Organizer
      Biomolecular Horizons 2024
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K06524
  • [Presentation] Cap-dependent m6A RNA methyltransferase in Trypanosoma brucei2024

    • Author(s)
      Anna Ignatochkina, Shinichiro Akichika, Yuko Takagi, Kieu DM Nguyen, Tsutomu Suzuki, C Kiong Ho
    • Organizer
      第94回日本寄生虫学会大会
    • Data Source
      KAKENHI-PROJECT-23K06524
  • [Presentation] The Analysis of Uncapped mRNA Transcriptome in Trypanosoma Parasites2024

    • Author(s)
      Kieu DM Nguyen, Yuko Takagi, C Kiong Ho
    • Organizer
      第25回日本RNA学会年会
    • Data Source
      KAKENHI-PROJECT-23K06524
  • [Presentation] Identification of Cytoplasmic mRNA Capping Targets in Trypanosoma cruzi2023

    • Author(s)
      Kieu Duong My Nguyen, Yuko Takagi, and Kiong Ho
    • Organizer
      第93回日本寄生虫学会大会
    • Data Source
      KAKENHI-PROJECT-21K06984
  • [Presentation] Transcriptosome Analysis of mRNA Recapping Pathway2023

    • Author(s)
      Kieu Duong My Nguyen, Yuko Takagi, and Kiong Ho
    • Organizer
      第24回日本RNA学会
    • Data Source
      KAKENHI-PROJECT-21K06984
  • [Presentation] 大気圧走査型電子顕微鏡を使用したTrypanosoma cruziの溶液中観察2022

    • Author(s)
      高木悠友子、佐藤真理、納谷昌実、佐藤 主税
    • Organizer
      第91回 日本寄生虫学会大会
    • Data Source
      KAKENHI-PROJECT-18K15141
  • [Presentation] Circularization of C/D Box sRNA by Archaeal ATP-Dependent RNA Ligase.2022

    • Author(s)
      Liu, Yancheng, Yuko Takagi, Milyadi Sugijanto, Kieu Duong My Nguyen, Akira Hirata, Hiroyuki Hori, and C. Kiong Ho.
    • Organizer
      第23回日本RNA学会
    • Data Source
      KAKENHI-PROJECT-21K06984
  • [Presentation] The Identification and Characterization of RNA Recapping Targets in Trypanosomes.2022

    • Author(s)
      Kieu Duong My Nguyen, Yuko Takagi, and Kiong Ho
    • Organizer
      The 3rd University of Science- University of Tsukuba Joint Symposium in Biomedical Science
    • Data Source
      KAKENHI-PROJECT-21K06984
  • [Presentation] Development of a Tet-inducible CRISPR-Cas9 system to elucidate the role of cap 4 methylation in Trypanosoma cruzi2021

    • Author(s)
      Anna Ignatochkina, Yuko Takagi, Kiong Ho
    • Organizer
      日本寄生虫学会 日本臨床寄生虫学会 合同大会
    • Data Source
      KAKENHI-PROJECT-18K15141
  • [Presentation] Water-in-oilドロップレットを用いたTrypanosoma cruziの新規増殖評価手法2021

    • Author(s)
      高木 悠友子、大田 悠里、森田 雅宗、野田 尚宏
    • Organizer
      日本寄生虫学会 日本臨床寄生虫学会 合同大会
    • Data Source
      KAKENHI-PROJECT-18K15141
  • [Presentation] Characterization of Trypanosome cap-dependent RNA methyltransferase2021

    • Author(s)
      Anna Ignatochkina, Yuko Takagi, Kiong Ho
    • Organizer
      第22回 日本RNA学会年会
    • Data Source
      KAKENHI-PROJECT-18K15141
  • [Presentation] Trypanosoma cruziの成長を阻害する低分子化合物の特定2020

    • Author(s)
      高木悠友子、Kiong Ho
    • Organizer
      第89回 日本寄生虫学会大会
    • Data Source
      KAKENHI-PROJECT-18K15141
  • [Presentation] トリパノソーマRNA triphosphataseの結晶構造解析による三リン酸ならびに核酸認識機構の解明2019

    • Author(s)
      Kiong Ho, 高木 悠友子, 桑原 直之, Dang Truong, 古川 功治, 阪下 日登志
    • Organizer
      第42回 日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K15141
  • [Presentation] Potential usage of extracellular amastigotes of Trypanosoma cruzi as a temporal axenic culture for transient gene expression, drug sensitivity assay, and CRISPR/Cas9-mediated gene knockout2019

    • Author(s)
      Yuko Takagi, Yukie Akutsu, Motomichi Doi, Koji Furukawa
    • Organizer
      Kinetoplastid Molecular Cell Biology Meeting VIII
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15141
  • [Presentation] Trypanosoma cruzi宿主外アマスティゴートにおけるCRISPR/Cas9を利用した遺伝子ノックアウト2018

    • Author(s)
      圷 ゆき枝、戸井 基道、古川 功治、高木 悠友子
    • Organizer
      第88回日本寄生虫学会大会
    • Data Source
      KAKENHI-PROJECT-18K15141
  • [Presentation] Structural and functional analysis of protozoan mRNA capping enzyme2018

    • Author(s)
      高木 悠友子、桑原 直之、Truong Dang、古川 功治、阪下 日登志、Kiong Ho
    • Organizer
      第20回日本RNA学会年会
    • Data Source
      KAKENHI-PROJECT-18K15141
  • [Presentation] トリパノソムmRNAキャッピング酵素の結晶構造と機能解析2018

    • Author(s)
      高木 悠友子、桑原 直之、Truong Dang、古川 功治、阪下 日登志、Kiong Ho
    • Organizer
      第88回日本寄生虫学会大会
    • Data Source
      KAKENHI-PROJECT-18K15141
  • [Presentation] Target-directed drug discovery: exploring parasite genes toward targeted antiprotozoal2017

    • Author(s)
      Yuko Takagi
    • Organizer
      NSTDA-AIST Joint Symposium on Bio-Innovations
    • Place of Presentation
      Pathumwan Princess Hotel, Bangkok, Thailand
    • Year and Date
      2017-03-14
    • Data Source
      KAKENHI-PROJECT-16H07474
  • [Presentation] Inhibitor Screening against Trypanosoma cruzi RNA Triphosphatase2017

    • Author(s)
      Yuko Takagi, Naoyuki Kuwabara, Kiong Ho, Hitoshi Sakashita, Koji Furukawa
    • Organizer
      Kinetoplastid Molecular Cell Biology Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H07474
  • 1.  Ho Kiong (20598502)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results

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