Takagi Yuko 高木悠友子

Researcher Number	50783669
Other IDs	https://orcid.org/0000-0002-4567-0986
Affiliation (Current)	2026: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員
Affiliation (based on the past Project Information) *help	2017 – 2024: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 2016: 国立研究開発法人産業技術総合研究所, バイオメディカル研究部門, 研究員
Review Section/Research Field	Principal Investigator Basic Section 49040:Parasitology-related / Parasitology (including sanitary zoology) Except Principal Investigator Basic Section 49040:Parasitology-related
Keywords	Principal Investigator 原虫 / 培養 / 微生物 / 遺伝子 / 創薬標的 / 感染症 / ドロップレット / 分化 / 感染 / 遺伝子組換え / ゲノム編集 / 熱帯病 … More Except Principal Investigator … More 病理学 / 寄生虫学 / mRNA キャッピング / RNA methylation / Trypanosoma / Recapping / mRNA processing / トリパのソーマ / RNA capping / RNA modification / Trypansome / 寄生虫 / RNA プロセッシング / トリパノソーマ / RNA キャッピング Less

トリパノソーマ原虫の感染ステージ分化を誘導する必須要件の解明Principal Investigator
- Principal Investigator
  
  高木悠友子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49040:Parasitology-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Structure and biological targets of Trypanosome mRNA recapping enzyme
- Principal Investigator
  
  Ho Kiong
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49040:Parasitology-related
- Research Institution
  University of Tsukuba
Development of gene modification method that contributes to drug target search for Chagas DiseasePrincipal Investigator
- Principal Investigator
  
  Takagi Yuko
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49040:Parasitology-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Searching for a drug target against parasitic protozoa, TrypanosomaPrincipal Investigator
- Principal Investigator
  
  Takagi Yuko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Parasitology (including sanitary zoology)
- Research Institution
  National Institute of Advanced Industrial Science and Technology

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Nanoscale Surface Metal-Coating Method without Pretreatment for High-Magnification Biological Observation and Applications2024
- Author(s)
  Takemura Kenshin、Motomura Taisei、Takagi Yuko
- Journal Title
  
  Biomimetics
  
  Volume: 9 Issue: 10 Pages: 588-588
- DOI
  10.3390/biomimetics9100588
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06524, KAKENHI-PROJECT-23K13566
[Journal Article] Differentiating Trypanosoma cruzi in a Host Mammalian Cell Imaged in Aqueous Liquid by Atmospheric Scanning Electron Microscopy2022
- Author(s)
  Takagi Yuko、Sato Mari、Naya Masami、Sato Chikara
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 10(1) Issue: 1
- DOI
  10.1128/spectrum.01413-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15141
[Journal Article] Crystal structures of the RNA triphosphatase from Trypanosoma cruzi provide insights into how it recognizes the 5′-end of the RNA substrate2020
- Author(s)
  Takagi Yuko、Kuwabara Naoyuki、Dang Truong Tat、Furukawa Koji、Ho C. Kiong
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 27 Pages: 9076-9086
- DOI
  10.1074/jbc.ra119.011811
- NAID
  120007127729
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15141, KAKENHI-PROJECT-16H05180
[Journal Article] Introducing a Gene Knockout Directly Into the Amastigote Stage of <em>Trypanosoma cruzi</em> Using the CRISPR/Cas9 System2019
- Author(s)
  Akutsu Yukie、Doi Motomichi、Furukawa Koji、Takagi Yuko
- Journal Title
  
  Journal of Visualized Experiments
  
  Volume: 149 Issue: 149
- DOI
  10.3791/59962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15141
[Journal Article] Utilization of proliferable extracellular amastigotes for transient gene expression, drug sensitivity assay, and CRISPR/Cas9-mediated gene knockout in Trypanosoma cruzi2019
- Author(s)
  Takagi Yuko、Akutsu Yukie、Doi Motomichi、Furukawa Koji
- Journal Title
  
  PLOS Neglected Tropical Diseases
  
  Volume: 13 Issue: 1 Pages: e0007088-e0007088
- DOI
  10.1371/journal.pntd.0007088
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15141
[Journal Article] Development of a motion-based cell-counting system for Trypanosoma parasite using a pattern recognition approach2019
- Author(s)
  Takagi Yuko、Nosato Hirokazu、Doi Motomichi、Furukawa Koji、Sakanashi Hidenori
- Journal Title
  
  BioTechniques
  
  Volume: 66 Issue: 4 Pages: 179-185
- DOI
  10.2144/btn-2018-0163
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15141
[Presentation] Identification of Biological Targets of the Cytoplasmic Capping Enzyme Trypanosoma Parasites2024
- Author(s)
  Kieu DM Nguyen, Yuko Takagi, C Kiong Ho
- Organizer
  Biomolecular Horizons 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06524
[Presentation] Cap-dependent m6A RNA methyltransferase in Trypanosoma brucei2024
- Author(s)
  Anna Ignatochkina, Shinichiro Akichika, Yuko Takagi, Kieu DM Nguyen, Tsutomu Suzuki, C Kiong Ho
- Organizer
  第94回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-23K06524
[Presentation] The Analysis of Uncapped mRNA Transcriptome in Trypanosoma Parasites2024
- Author(s)
  Kieu DM Nguyen, Yuko Takagi, C Kiong Ho
- Organizer
  第25回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-23K06524
[Presentation] Identification of Cytoplasmic mRNA Capping Targets in Trypanosoma cruzi2023
- Author(s)
  Kieu Duong My Nguyen, Yuko Takagi, and Kiong Ho
- Organizer
  第93回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-21K06984
[Presentation] Transcriptosome Analysis of mRNA Recapping Pathway2023
- Author(s)
  Kieu Duong My Nguyen, Yuko Takagi, and Kiong Ho
- Organizer
  第24回日本RNA学会
- Data Source
  KAKENHI-PROJECT-21K06984
[Presentation] 大気圧走査型電子顕微鏡を使用したTrypanosoma cruziの溶液中観察2022
- Author(s)
  高木悠友子、佐藤真理、納谷昌実、佐藤主税
- Organizer
  第91回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-18K15141
[Presentation] Circularization of C/D Box sRNA by Archaeal ATP-Dependent RNA Ligase.2022
- Author(s)
  Liu, Yancheng, Yuko Takagi, Milyadi Sugijanto, Kieu Duong My Nguyen, Akira Hirata, Hiroyuki Hori, and C. Kiong Ho.
- Organizer
  第23回日本RNA学会
- Data Source
  KAKENHI-PROJECT-21K06984
[Presentation] The Identification and Characterization of RNA Recapping Targets in Trypanosomes.2022
- Author(s)
  Kieu Duong My Nguyen, Yuko Takagi, and Kiong Ho
- Organizer
  The 3rd University of Science- University of Tsukuba Joint Symposium in Biomedical Science
- Data Source
  KAKENHI-PROJECT-21K06984
[Presentation] Development of a Tet-inducible CRISPR-Cas9 system to elucidate the role of cap 4 methylation in Trypanosoma cruzi2021
- Author(s)
  Anna Ignatochkina, Yuko Takagi, Kiong Ho
- Organizer
  日本寄生虫学会日本臨床寄生虫学会合同大会
- Data Source
  KAKENHI-PROJECT-18K15141
[Presentation] Water-in-oilドロップレットを用いたTrypanosoma cruziの新規増殖評価手法2021
- Author(s)
  高木悠友子、大田悠里、森田雅宗、野田尚宏
- Organizer
  日本寄生虫学会日本臨床寄生虫学会合同大会
- Data Source
  KAKENHI-PROJECT-18K15141
[Presentation] Characterization of Trypanosome cap-dependent RNA methyltransferase2021
- Author(s)
  Anna Ignatochkina, Yuko Takagi, Kiong Ho
- Organizer
  第22回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-18K15141
[Presentation] Trypanosoma cruziの成長を阻害する低分子化合物の特定2020
- Author(s)
  高木悠友子、Kiong Ho
- Organizer
  第89回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-18K15141
[Presentation] トリパノソーマRNA triphosphataseの結晶構造解析による三リン酸ならびに核酸認識機構の解明2019
- Author(s)
  Kiong Ho, 高木悠友子, 桑原　直之, Dang Truong, 古川功治, 阪下日登志
- Organizer
  第42回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K15141
[Presentation] Potential usage of extracellular amastigotes of Trypanosoma cruzi as a temporal axenic culture for transient gene expression, drug sensitivity assay, and CRISPR/Cas9-mediated gene knockout2019
- Author(s)
  Yuko Takagi, Yukie Akutsu, Motomichi Doi, Koji Furukawa
- Organizer
  Kinetoplastid Molecular Cell Biology Meeting VIII
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15141
[Presentation] Trypanosoma cruzi宿主外アマスティゴートにおけるCRISPR/Cas9を利用した遺伝子ノックアウト2018
- Author(s)
  圷ゆき枝、戸井基道、古川功治、高木悠友子
- Organizer
  第88回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-18K15141
[Presentation] Structural and functional analysis of protozoan mRNA capping enzyme2018
- Author(s)
  高木悠友子、桑原直之、Truong Dang、古川功治、阪下日登志、Kiong Ho
- Organizer
  第20回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-18K15141
[Presentation] トリパノソムmRNAキャッピング酵素の結晶構造と機能解析2018
- Author(s)
  高木悠友子、桑原直之、Truong Dang、古川功治、阪下日登志、Kiong Ho
- Organizer
  第88回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-18K15141
[Presentation] Target-directed drug discovery: exploring parasite genes toward targeted antiprotozoal2017
- Author(s)
  Yuko Takagi
- Organizer
  NSTDA-AIST Joint Symposium on Bio-Innovations
- Place of Presentation
  Pathumwan Princess Hotel, Bangkok, Thailand
- Year and Date
  2017-03-14
- Data Source
  KAKENHI-PROJECT-16H07474
[Presentation] Inhibitor Screening against Trypanosoma cruzi RNA Triphosphatase2017
- Author(s)
  Yuko Takagi, Naoyuki Kuwabara, Kiong Ho, Hitoshi Sakashita, Koji Furukawa
- Organizer
  Kinetoplastid Molecular Cell Biology Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H07474

1. Ho Kiong (20598502)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Takagi Yuko 高木 悠友子

Research Projects

Research Products

Co-Researchers

トリパノソーマ原虫の感染ステージ分化を誘導する必須要件の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structure and biological targets of Trypanosome mRNA recapping enzyme

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of gene modification method that contributes to drug target search for Chagas DiseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Searching for a drug target against parasitic protozoa, TrypanosomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Nanoscale Surface Metal-Coating Method without Pretreatment for High-Magnification Biological Observation and Applications2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differentiating Trypanosoma cruzi in a Host Mammalian Cell Imaged in Aqueous Liquid by Atmospheric Scanning Electron Microscopy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystal structures of the RNA triphosphatase from Trypanosoma cruzi provide insights into how it recognizes the 5′-end of the RNA substrate2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Introducing a Gene Knockout Directly Into the Amastigote Stage of <em>Trypanosoma cruzi</em> Using the CRISPR/Cas9 System2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Utilization of proliferable extracellular amastigotes for transient gene expression, drug sensitivity assay, and CRISPR/Cas9-mediated gene knockout in Trypanosoma cruzi2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a motion-based cell-counting system for Trypanosoma parasite using a pattern recognition approach2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Identification of Biological Targets of the Cytoplasmic Capping Enzyme Trypanosoma Parasites2024

Author(s)

Organizer

Data Source

[Presentation] Cap-dependent m6A RNA methyltransferase in Trypanosoma brucei2024

Author(s)

Organizer

Data Source

[Presentation] The Analysis of Uncapped mRNA Transcriptome in Trypanosoma Parasites2024

Author(s)

Organizer

Data Source

[Presentation] Identification of Cytoplasmic mRNA Capping Targets in Trypanosoma cruzi2023

Author(s)

Organizer

Data Source

[Presentation] Transcriptosome Analysis of mRNA Recapping Pathway2023

Author(s)

Organizer

Data Source

[Presentation] 大気圧走査型電子顕微鏡を使用したTrypanosoma cruziの溶液中観察2022

Takagi Yuko 高木悠友子