FUJIWARA Yasuhiro 藤原靖浩

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Fujiwara Yasuhiro 藤原靖浩

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Researcher Number	50793064
Other IDs	https://orcid.org/0000-0002-6416-9679
Affiliation (Current)	2025: 東京大学, 定量生命科学研究所, 助教
Affiliation (based on the past Project Information) *help	2020 – 2023: 東京大学, 定量生命科学研究所, 助教 2019: 東京大学, 定量生命科学研究所, 特任研究員 2018: 東京大学, 定量生命科学研究所, 特別研究員 2017: 東京大学, 分子細胞生物学研究所, 特別研究員
Review Section/Research Field	Principal Investigator Basic Section 42040:Laboratory animal science-related / Integrative animal science Except Principal Investigator Medium-sized Section 42:Veterinary medical science, animal science, and related fields
Keywords	Principal Investigator 減数分裂 / R-loop / SETX / 遺伝学 / 細胞・組織 / HORMAD1相互作用因子 Except Principal Investigator 繁殖障害 / 日本在来馬 / PRDM9 / 在来馬 / 黒毛和種 / 近交退化

第一減数分裂前期のR-loop形成制御に見る転写制御機構の雌雄差の解明Principal Investigator
- Principal Investigator
  
  藤原靖浩
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  The University of Tokyo
動物集団における近交退化の分子メカニズムの解明
- Principal Investigator
  
  国枝哲夫
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Okayama University of Science
Study on the mechanism for homologous chromosome pairing by HORMAD1Principal Investigator
- Principal Investigator
  
  Fujiwara Yasuhiro
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Integrative animal science
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] A novel mouse allele of the DNA/RNA helicase senataxin (Setxspcar3) causing meiotic arrest of spermatocytes and male infertility2023
- Author(s)
  4.Yasuhiro Fujiwara, Kouhei Saito, Fengyun Sun, Sabrina Petri, Erina Inoue, JohnSchimenti, Yuki Okada, Mary Ann Handel
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2023.04.12.536672
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15005
[Journal Article] New allele of mouse DNA/RNA helicase senataxin causes meiotic arrest and infertility2023
- Author(s)
  Fujiwara Yasuhiro、Saito Kouhei、Sun Fengyun、Petri Sabrina、Inoue Erina、Schimenti John、Okada Yuki、Handel Mary Ann
- Journal Title
  
  Reproduction
  
  Volume: 166 Issue: 6 Pages: 437-450
- DOI
  10.1530/rep-23-0166
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15005
[Journal Article] Isolation of stage‐specific spermatogenic cells by dynamic histone incorporation and removal in spermatogenesis2023
- Author(s)
  Fujiwara Yasuhiro、Hada Masashi、Fukuda Yuko、Koga Chizuko、Inoue Erina、Okada Yuki
- Journal Title
  
  Cytometry Part A
  
  Volume: 105 Issue: 4 Pages: 297-307
- DOI
  10.1002/cyto.a.24812
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15005, KAKENHI-PROJECT-23K14191, KAKENHI-PLANNED-20H05939
[Journal Article] CUT&Tag Using "Stress-Free" Con A-Conjugated Dynabeads2023
- Author(s)
  Fujiwara, Y , Okada, Y
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 2519 Pages: 141-153
- DOI
  10.1007/978-1-0716-2433-3_16
- ISBN
  9781071624326, 9781071624333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00446
[Journal Article] Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity,2023
- Author(s)
  Shuwen He, John P Gillies, Juliana L Zang, Carmen M Cordoba-Beldad, Io Yamamoto, Yasuhiro Fujiwara, Julie Grantham, Morgan E DeSantis, Hiroki Shibuya
- Journal Title
  
  Nature Communications
  
  Volume: 14(1) Issue: 1 Pages: 1715-1715
- DOI
  10.1038/s41467-023-37370-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15005
[Journal Article] Birth of mice from meiotically arrested spermatocytes following biparental meiosis in halved oocytes2022
- Author(s)
  Narumi Ogonuki, Hirohisa Kyogoku, Toshiaki Hino, Yuki Osawa, Yasuhiro Fujiwara, Kimiko Inoue, Tetsuo Kunieda, Seiya Mizuno, Hiroyuki Tateno, Fumihiro Sugiyama, Tomoya S. Kitajima, Atsuo Ogura
- Journal Title
  
  EMBO Rep
  
  Volume: 5;23(7) Issue: 7
- DOI
  10.15252/embr.202254992
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15005, KAKENHI-PROJECT-21H02407, KAKENHI-PLANNED-18H05549, KAKENHI-ORGANIZER-19H05749, KAKENHI-PLANNED-19H05758
[Journal Article] R-loop Formation in Meiosis: Roles in Meiotic Transcription-Associated DNA Damage2022
- Author(s)
  Yasuhiro Fujiwara, Mary Ann Handel, Yuki Okada
- Journal Title
  
  Epigenomes
  
  Volume: 6(3) Issue: 3 Pages: 26-26
- DOI
  10.3390/epigenomes6030026
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15005
[Journal Article] Solubilization of Mouse Sperm Chromatin for Sequencing Analyses Using a Chaperon Protein2022
- Author(s)
  Yuko Fukuda, Keishi Shintomi, Kosuke Yamaguchi, Yasuhiro Fujiwara, Yuki Okada
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2577 Pages: 161-173
- DOI
  10.1007/978-1-0716-2724-2_11
- ISBN
  9781071627235, 9781071627242
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15005, KAKENHI-PLANNED-20H05939, KAKENHI-PLANNED-19H05755, KAKENHI-PROJECT-23K23815
[Journal Article] Preparation of optimized concanavalin A-conjugated Dynabeads magnetic beads for CUT&Tag2021
- Author(s)
  Yasuhiro Fujiwara, Yuji Tanno, Hiroki Sugishita, Yusuke Kishi, Yoshinori Makino, and Yuki Okada*
- Journal Title
  
  PLoS One
  
  Volume: 16 Issue: 11 Pages: e0259846-e0259846
- DOI
  10.1371/journal.pone.0259846
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05383, KAKENHI-PUBLICLY-21H00242, KAKENHI-PROJECT-20H03179, KAKENHI-PROJECT-21K15005, KAKENHI-PROJECT-16H06279
[Journal Article] The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 axis2020
- Author(s)
  Jingjing Zhang, Manickam Gurusaran, Yasuhiro Fujiwara, Manickam Gurusaran, Kexin Zhang, Meriem Echbarthi, Egor Vorontsov, Rui Guo, Devon F. Pendlebury, Intekhab Alam, Gabriel Livera, Martini Emmanuelle, P. Jeremy Wang, Jayakrishnan Nandakumar, Owen R. Davies, and Hiroki Shibuya
- Journal Title
  
  Nature Communications
  
  Volume: 11(1) Issue: 1 Pages: 2055-2055
- DOI
  10.1038/s41467-020-15954-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15392
[Journal Article] Meiotic cohesins mediate initial loading of HORMAD1 to the chromosomes and coordinate SC formation during meiotic prophase2020
- Author(s)
  Fujiwara Yasuhiro、Horisawa-Takada Yuki、Inoue Erina、Tani Naoki、Shibuya Hiroki、Fujimura Sayoko、Kariyazono Ryo、Sakata Toyonori、Ohta Kunihiro、Araki Kimi、Okada Yuki、Ishiguro Kei-ichiro
- Journal Title
  
  PLOS Genetics
  
  Volume: 16 Issue: 9 Pages: e1009048-e1009048
- DOI
  10.1371/journal.pgen.1009048
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06642, KAKENHI-PROJECT-20K21504, KAKENHI-PLANNED-19H05743, KAKENHI-PROJECT-20H03265, KAKENHI-PROJECT-17K15392, KAKENHI-PROJECT-16H06276
[Journal Article] Uncoupling of transcriptomic and cytological differentiation in mouse spermatocytes with impaired meiosis2019
- Author(s)
  Fine Alexander D.、Ball Robyn L.、Fujiwara Yasuhiro、Handel Mary Ann、Carter Gregory W.
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 30 Issue: 5 Pages: 717-728
- DOI
  10.1091/mbc.e18-10-0681
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16J03195, KAKENHI-PROJECT-17K15392
[Journal Article] Hybrid sterility with meiotic metaphase arrest in intersubspecific mouse crosses.2019
- Author(s)
  Nishino R, Petri S, Handel MA, Kunieda T, Fujiwara Y.
- Journal Title
  
  J Hered.
  
  Volume: 110 Issue: 2 Pages: 183-193
- DOI
  10.1093/jhered/esy060
- NAID
  130007485879
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04636, KAKENHI-PROJECT-16J03195, KAKENHI-PROJECT-17K15392, KAKENHI-PROJECT-16H05016
[Journal Article] A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination2019
- Author(s)
  Zhang Jingjing、Fujiwara Yasuhiro、Yamamoto Shohei、Shibuya Hiroki
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 722-722
- DOI
  10.1038/s41467-019-08676-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16J03195, KAKENHI-PROJECT-17K15392
[Journal Article] Dissecting the telomere-inner nuclear membrane interface formed in meiosis2017
- Author(s)
  Pendlebury Devon F、Fujiwara Yasuhiro、Tesmer Valerie M、Smith Eric M、Shibuya Hiroki、Watanabe Yoshinori、Nandakumar Jayakrishnan
- Journal Title
  
  Nat Struct Mol Biol
  
  Volume: 24 Issue: 12 Pages: 1064-1072
- DOI
  10.1038/nsmb.3493
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16J03195, KAKENHI-PROJECT-17K15392
[Presentation] マウス減数分裂前期における転写制御と転写共役損傷の影響2024
- Author(s)
  藤原靖浩
- Organizer
  第４回有性生殖研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15005
[Presentation] マウスSETX は精子形成過程において転写共役DNA損傷からゲノムを保護する2023
- Author(s)
  藤原靖浩、Mary Ann Handel、岡田由紀
- Organizer
  第116回日本繁殖生物学会
- Data Source
  KAKENHI-PROJECT-21K15005
[Presentation] Transcriptional maintenance through the regulation of R-loop formation during meiosis in mouse2023
- Author(s)
  藤原靖浩
- Organizer
  第31回遺伝研バイオロジカルウェビナー
- Invited
- Data Source
  KAKENHI-PROJECT-21K15005
[Presentation] マウスSETX は精子形成過程において転写共役DNA損傷からゲノムを保護する2023
- Author(s)
  藤原靖浩，Mary Ann Handel、岡田由紀
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K15005
[Presentation] マウス雄性生殖細胞における転写共役損傷の影響2023
- Author(s)
  藤原靖浩
- Organizer
  基礎生物学研究所部門セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-21K15005
[Presentation] 蛍光標識ヒストンH３・H４発現Tgマウスを用いた雄性生殖細胞分画法の開発2022
- Author(s)
  藤原靖浩，羽田政司，福田裕子，古賀千津子，井上絵里奈，岡田由紀
- Organizer
  繁殖生物学会
- Data Source
  KAKENHI-PROJECT-21K15005
[Presentation] Preparation of optimized concanavalin A-conjugated Dynabeads magnetic beads for CUT&Tag、CUT&Tag法に最適化されたconcanavalin A結合Dynabeadsの利用2022
- Author(s)
  藤原靖浩
- Organizer
  第15回日本エピジェネティクス研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15005
[Presentation] 分化段階特異的レポーターマウスを用いた雄性生殖細胞分画とエピゲノム解析2022
- Author(s)
  藤原靖浩，羽田政司，福田裕子，古賀千津子，井上絵里奈，岡田由紀
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K15005
[Presentation] 細胞外マトリックスの構成因子であるAdamtsl2は幼若期マウスの精巣で発現しテストステロン合成に関与する2022
- Author(s)
  岩永有可、藤原靖浩、辻岳人
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K15005
[Presentation] 精子核凝縮過程におけるクロマチンの動体解析2022
- Author(s)
  羽田政司、福田裕子，古賀千津子，井上絵里奈，藤原靖浩、岡田由紀
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K15005
[Presentation] R-loop因子SETXは転写因子MYBL1(A-MYB)のリクルートを介して減数分裂前期パキテン期の転写を促進する2021
- Author(s)
  藤原靖浩, 山口幸佑, 齋藤康平, 福田裕子, 井上絵里奈, Mary Ann Handel, 岡田由紀
- Organizer
  日本繁殖生物学会
- Data Source
  KAKENHI-PROJECT-21K15005
[Presentation] R-loop因子SETXは転写因子MYBL1(A-MYB)のリクルートを介して減数分裂前期パキテン期の転写を促進する2021
- Author(s)
  藤原靖浩, 山口幸佑, 齋藤康平, 福田裕子, 井上絵里奈, 古賀千津子、Fengyun Sun, Mary Ann Handel, 岡田由紀
- Organizer
  第39回染色体ワークショップ
- Data Source
  KAKENHI-PROJECT-21K15005
[Presentation] Meiotic cohesins mediate initial chromatin loading of HORMAD1 and coordinate SC formation during meiotic prophase in mouse2020
- Author(s)
  Yasuhiro Fujiwara, Yuki Horisawa-Takada, Naoki Tani, Hiroki Shibuya, Erina Inoue, Kimi Araki, Yuki Okada and Kei-ichiro Ishiguro
- Organizer
  Cold Spring Harbor Laboratory Meeting Germ Cell
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15392
[Presentation] 減数分裂前期でのHORMAD１とコヒーシンによるクロマチンの制御2019
- Author(s)
  藤原靖浩
- Organizer
  2019遺伝研研究会　有性生殖に関わる染色体・核動態に関する研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K15392
[Presentation] A HORMAD1-RAD21L complex is required for initial homolog recognition and pairing in mouse spermatocytes2018
- Author(s)
  藤原靖浩, 澁谷大輝, 岡田由紀, 渡邊嘉典, 石黒啓一郎
- Organizer
  第41回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-17K15392
[Presentation] Hybrid sterility with meiotic metaphase arrest in intersubspecific mouse crosses2018
- Author(s)
  Yasuhiro Fujiwara, Risako Nishino, Sabrina Petri, Mary Ann Handel, Tetsuo Kunieda
- Organizer
  第111回　日本繁殖生物学会大会
- Data Source
  KAKENHI-PROJECT-17K15392

1. 国枝哲夫 (80178011)

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2. 大月純子 (00573031)

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3. 佐々木慎二 (10365439)

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4. 渋谷周作 (20534473)

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5. 桃沢幸秀 (40708583)

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6. 揖斐隆之 (70335305)

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7. 辻岳人 (90314682)

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8. 北川均 (70144003)

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9. 高田幸

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10. 岸雄介

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FUJIWARA Yasuhiro 藤原 靖浩

Fujiwara Yasuhiro 藤原 靖浩

Research Projects

Research Products

Co-Researchers

第一減数分裂前期のR-loop形成制御に見る転写制御機構の雌雄差の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

動物集団における近交退化の分子メカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the mechanism for homologous chromosome pairing by HORMAD1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A novel mouse allele of the DNA/RNA helicase senataxin (Setxspcar3) causing meiotic arrest of spermatocytes and male infertility2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New allele of mouse DNA/RNA helicase senataxin causes meiotic arrest and infertility2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isolation of stage‐specific spermatogenic cells by dynamic histone incorporation and removal in spermatogenesis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CUT&Tag Using "Stress-Free" Con A-Conjugated Dynabeads2023

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity,2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Birth of mice from meiotically arrested spermatocytes following biparental meiosis in halved oocytes2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] R-loop Formation in Meiosis: Roles in Meiotic Transcription-Associated DNA Damage2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Solubilization of Mouse Sperm Chromatin for Sequencing Analyses Using a Chaperon Protein2022

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Preparation of optimized concanavalin A-conjugated Dynabeads magnetic beads for CUT&Tag2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 axis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Meiotic cohesins mediate initial loading of HORMAD1 to the chromosomes and coordinate SC formation during meiotic prophase2020

Author(s)

Journal Title

DOI

Data Source

FUJIWARA Yasuhiro 藤原靖浩

Fujiwara Yasuhiro 藤原靖浩