Kato Hiroki 加藤浩貴

Researcher Number	50801677
Other IDs
Affiliation (Current)	2025: 東北大学, 大学病院, 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 東北大学, 大学病院, 講師 2022 – 2023: 東北大学, 医学系研究科, 助教 2021 – 2022: 東北大学, 大学病院, 助教 2018: 東北大学, 医学系研究科, 大学院非常勤講師 2017 – 2018: 東北大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / 0803:Pathology, infection/immunology, and related fields / Hematology Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Medium-sized Section 48:Biomedical structure and function and related fields / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Keywords	Principal Investigator エピゲノム / SAM / S-アデノシルメチオニン / MAT2A / 造血 / B細胞造血 / メチオニン代謝 / 造血幹細胞分化 / メチオニン / 遺伝子発現調節 … More / Sアデノシルメチオニン / Bリンパ球造血 / ＭＡＴ / ＳＡＭ / 難治性貧血 / 赤血球造血 … More Except Principal Investigator 造血 / GATA2 / CAR-T細胞療法 / 同種造血幹細胞移植 / サイトカイン放出症候群 / 移植片対宿主病 / 造血幹細胞移植 / 免疫細胞療法 / RNA修飾 / 液性免疫 / メチル化 / S-アデノシルメチオニン / 代謝 / エピゲノム / 肺血管内皮 / ミトコンドリア / ヘム / BACH1 / 鉄 / 上皮間葉転換 / 転移 / 膵臓癌 / 獲得免疫 / T細胞分化 / T細胞初期分化 Less

ヘム合成に着目した免疫細胞分化制御機構の解明とその破綻に伴う疾患の克服
- Principal Investigator
  
  張替秀郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tohoku University
SアデノシルメチオニンのBリンパ球初期分化での役割の解明Principal Investigator
- Principal Investigator
  
  加藤浩貴
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tohoku University
転写因子GATA2に着目した造血と肺血管内皮の連関解析
- Principal Investigator
  
  張替秀郎
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Tohoku University
Regulation of acquired immune cell responses by S-adenosylmethionine metabolism and its subcellular localization
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Tohoku University
Molecular basis of RNA modification in immune response after transplantation and cell therapy and novel biomarkers
- Principal Investigator
  
  大西康
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tohoku University
The Roles of Transcription Factor GATA2 in T Cell Development by Epigenetic Memory
- Principal Investigator
  
  Harigae Hideo
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Tohoku University
Elucidation of mechanisms in iron-driven pancreatic cancer cell metastasis
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Tohoku University
Role of S-adenosylmethionine in the Maintenance of Hematopoietic Stem and Progenitor CellsPrincipal Investigator
- Principal Investigator
  
  Kato Hiroki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tohoku University
Roles for S-adenosylmethionine in B cell differentiation and activationPrincipal Investigator
- Principal Investigator
  
  Kato Hiroki
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0803:Pathology, infection/immunology, and related fields
- Research Institution
  Tohoku University
Identification of the mechanism by which SAM synthesis inhibition induces erythroblast maturationPrincipal Investigator
- Principal Investigator
  
  Kato Hiroki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Hematology
- Research Institution
  Tohoku University

All 2023 2022 2021

All Journal Article Presentation

[Journal Article] Heme-dependent induction of mitophagy program during differentiation of murine erythroid cells2023
- Author(s)
  Ikeda Masatoshi、Kato Hiroki、Shima Hiroki、Matsumoto Mitsuyo、Furukawa Eijiro、Yan Yan、Liao Ruiqi、Xu Jian、Muto Akihiko、Fujiwara Tohru、Harigae Hideo、Bresnick Emery H.、Igarashi Kazuhiko
- Journal Title
  
  Experimental Hematology
  
  Volume: 118 Pages: 21-30
- DOI
  10.1016/j.exphem.2022.11.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07129, KAKENHI-PROJECT-22H00443, KAKENHI-PROJECT-20K07321, KAKENHI-PROJECT-21K20770, KAKENHI-PROJECT-21K08385, KAKENHI-PROJECT-22K16295, KAKENHI-PROJECT-23K24156
[Journal Article] Congenital sideroblastic anemia model due to ALAS2 mutation is susceptible to ferroptosis2022
- Author(s)
  Ono Koya、Fujiwara Tohru、Saito Kei、Nishizawa Hironari、Takahashi Noriyuki、Suzuki Chie、Ochi Tetsuro、Kato Hiroki、Ishii Yusho、Onodera Koichi、Ichikawa Satoshi、Fukuhara Noriko、Onishi Yasushi、Yokoyama Hisayuki、Yamada Rie、Nakamura Yukio、Igarashi Kazuhiko、Harigae Hideo
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 9024-9024
- DOI
  10.1038/s41598-022-12940-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08385, KAKENHI-PROJECT-22K16294, KAKENHI-PROJECT-22H00443, KAKENHI-PROJECT-21K20770, KAKENHI-PROJECT-22K16295
[Journal Article] TM5614, an Inhibitor of Plasminogen Activator Inhibitor-1, Exerts an Antitumor Effect on Chronic Myeloid Leukemia2022
- Author(s)
  Sasaki Katsuyuki、Fujiwara Tohru、Ochi Tetsuro、Ono Koya、Kato Hiroki、Onodera Koichi、Ichikawa Satoshi、Fukuhara Noriko、Onishi Yasushi、Yokoyama Hisayuki、Miyata Toshio、Harigae Hideo
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 257 Issue: 3 Pages: 211-224
- DOI
  10.1620/tjem.2022.J036
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16294, KAKENHI-PROJECT-21K20770, KAKENHI-PROJECT-22K16295
[Journal Article] Elucidation of the Role of FAM210B in Mitochondrial Metabolism and Erythropoiesis2022
- Author(s)
  Suzuki Chie、Fujiwara Tohru、Shima Hiroki、Ono Koya、Saito Kei、Kato Hiroki、Onodera Koichi、Ichikawa Satoshi、Fukuhara Noriko、Onishi Yasushi、Yokoyama Hisayuki、Nakamura Yukio、Igarashi Kazuhiko、Harigae Hideo
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 42 Issue: 12
- DOI
  10.1128/mcb.00143-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08385, KAKENHI-PROJECT-22K16294, KAKENHI-PROJECT-22H00443, KAKENHI-PROJECT-20K07321, KAKENHI-PROJECT-21K20770, KAKENHI-PROJECT-22K16295
[Journal Article] Exploring the mechanistic link between SF3B1 mutation and ring sideroblast formation in myelodysplastic syndrome2022
- Author(s)
  Ochi Tetsuro、Fujiwara Tohru、Ono Koya、Suzuki Chie、Nikaido Maika、Inoue Daichi、Kato Hiroki、Onodera Koichi、Ichikawa Satoshi、Fukuhara Noriko、Onishi Yasushi、Yokoyama Hisayuki、Nakamura Yukio、Harigae Hideo
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 14562-14562
- DOI
  10.1038/s41598-022-18921-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08385, KAKENHI-PROJECT-22K16294, KAKENHI-PROJECT-21K20770, KAKENHI-PROJECT-20H03717, KAKENHI-PROJECT-22K16295
[Presentation] Metabolic Regulation of Erythropoiesis2023
- Author(s)
  Kazuhiko Igarashi, Hiroki Kato
- Organizer
  8th Meeting of the Asian Forum for Chromosome and Chromatin Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00443
[Presentation] HEMATOPOIETIC STEM AND PROGENITOR CELL INTRINSIC SAM SYNTHESIS IS REQUIRED TO PREVENT P53 PATHWAY ACTIVATION BY MAINTAINING DNA STABILITY2023
- Author(s)
  Eijiro Furukawa, Hiroki Kato, Sayaka Sano, Yan Yan, Daigo Michimata, Yuya Tanaka, Kazuki Sakurai, Koichi Onodera, Satoshi Ichikawa, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Daisuke Saigusa, Tohru Fujiwara, Kazuhiko Igarashi, Hideo Harigae
- Organizer
  第65回米国血液学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16295
[Presentation] Transcription Factor GATA2 Is Inevitable for the Survival and Proper Differentiation of Thymic Multipotent Progenitor Cells By Gene Expression Orchestration2023
- Author(s)
  Sayaka Sano, Hiroki Kato, Yan Yan, Eijiro Furukawa, Daigo Michimata, Yuya Tanaka, Kazuki Sakurai, Koichi Onodera, Satoshi Ichikawa, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Tohru Fujiwara, Hideo Harigae.
- Organizer
  第65回米国血液学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19537
[Presentation] Integration of erythroid differentiation and autophagy by iron-heme metabolism2022
- Author(s)
  Igarashi K, Kato H, Ikeda M, Fujiwara T, Harigae H
- Organizer
  第84回日本血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22H00443
[Presentation] メチオニン代謝によるエピゲノム調節をかいした赤血球造血制御2021
- Author(s)
  加藤浩貴
- Organizer
  日本血液学会 (第83回日本血液学会学術集会）
- Invited
- Data Source
  KAKENHI-PROJECT-21K20770
[Presentation] Inhibition of S-Adenosylmethionine Synthesis Promotes Erythropoiesis via Epigenetic Modifications2021
- Author(s)
  Hiroki Kato et. al.
- Organizer
  American Society of Hematology (63rd ASH Annual Meeting)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20770

1. Harigae Hideo (50302146)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. 五十嵐和彦 (00250738)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. 西澤弘成 (30846655)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 大西康 (10509574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 小川亜希子 (00868565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 魏范研 (90555773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Matsumoto Mitsuyo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 藤原亨

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
9. 武藤哲彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kato Hiroki 加藤 浩貴

Research Projects

Research Products

Co-Researchers

ヘム合成に着目した免疫細胞分化制御機構の解明とその破綻に伴う疾患の克服

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

SアデノシルメチオニンのBリンパ球初期分化での役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

転写因子GATA2に着目した造血と肺血管内皮の連関解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of acquired immune cell responses by S-adenosylmethionine metabolism and its subcellular localization

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular basis of RNA modification in immune response after transplantation and cell therapy and novel biomarkers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The Roles of Transcription Factor GATA2 in T Cell Development by Epigenetic Memory

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mechanisms in iron-driven pancreatic cancer cell metastasis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of S-adenosylmethionine in the Maintenance of Hematopoietic Stem and Progenitor CellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles for S-adenosylmethionine in B cell differentiation and activationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of the mechanism by which SAM synthesis inhibition induces erythroblast maturationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Heme-dependent induction of mitophagy program during differentiation of murine erythroid cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Congenital sideroblastic anemia model due to ALAS2 mutation is susceptible to ferroptosis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TM5614, an Inhibitor of Plasminogen Activator Inhibitor-1, Exerts an Antitumor Effect on Chronic Myeloid Leukemia2022

Author(s)

Journal Title

DOI

ISSN

Language

Kato Hiroki 加藤浩貴