Kanemura Shingo 金村進吾

Researcher Number	50803178
Other IDs
Affiliation (Current)	2025: 東北大学, 学際科学フロンティア研究所, 助教
Affiliation (based on the past Project Information) *help	2021 – 2022: 関西学院大学, 理学部, 助教 2018 – 2020: 関西学院大学, 理工学部, 助教 2017: 東北大学, 学際科学フロンティア研究所, 教育研究支援者
Review Section/Research Field	Principal Investigator Basic Section 43040:Biophysics-related / Biophysics Except Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Keywords	Principal Investigator 新生鎖 / ジスルフィド結合 / PDIファミリー / 二次構造 / 酸化的フォールディング / 小胞体 / セミインタクト細胞 / 無細胞タンパク質合成系 Except Principal Investigator NMR / 常磁性タグ … More / フォールディング中間体 / フォールディング / 小胞体 / シャペロン / タンパク質フォールディング Less

Structural basis for recognition and regulation of protein folding intermediate by molecular chaperones in the endoplasmic reticulum
- Principal Investigator
  
  SAIO Tomohide
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokushima
Understanding the molecular mechanism by which PDI family catalyze oxidative protein folding of nascent chainsPrincipal Investigator
- Principal Investigator
  
  Kanemura Shingo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Kwansei Gakuin University
Understanding the molecular mechanism of co-translational oxidative folding in the ERPrincipal Investigator
- Principal Investigator
  
  Kanemura Shingo
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biophysics
- Research Institution
  Kwansei Gakuin University
  Tohoku University

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] A unique leucine-valine adhesive motif supports structure and function of protein disulfide isomerase P5 via dimerization2021
- Author(s)
  Okumura M, Kanemura S., Matsusaki M., Kinoshita M., Saio T., Ito D., Hirayama C., Kumeta H., Watabe M., Amagai Y., Lee Y. H., Akiyama S. and Inaba K.
- Journal Title
  
  Structure
  
  Volume: 29 Issue: 12 Pages: 1-14
- DOI
  10.1016/j.str.2021.03.016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16092, KAKENHI-PROJECT-20K15969, KAKENHI-PROJECT-18H03978, KAKENHI-PROJECT-19J00893, KAKENHI-PROJECT-20J11932, KAKENHI-PROJECT-19K06520, KAKENHI-PUBLICLY-20H04688, KAKENHI-PLANNED-21H05095, KAKENHI-PROJECT-21H04758, KAKENHI-PUBLICLY-19H04945, KAKENHI-PLANNED-21H05253
[Journal Article] Functional Interplay between P5 and PDI/ERp72 to Drive Protein Folding.2021
- Author(s)
  Matsusaki M, Okada R, Tanikawa Y, Kanemura S, Ito D, Lin Y, Watabe M, Yamaguchi H, Saio T, Lee YH, Inaba K, and *Okumura M.
- Journal Title
  
  Biology
  
  Volume: 10 Issue: 11 Pages: 1112-1112
- DOI
  10.3390/biology10111112
- NAID
  120007168792
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06520, KAKENHI-PROJECT-19K16092, KAKENHI-PROJECT-20K15969, KAKENHI-PUBLICLY-20H04688, KAKENHI-PLANNED-21H05095, KAKENHI-PROJECT-21H04758, KAKENHI-PLANNED-21H05253
[Journal Article] Ca2+ Regulates ERp57-Calnexin Complex Formation.2021
- Author(s)
  Tanikawa Y,# Kanemura S,# Ito D, Lin Y, Matsusaki M, Kuroki K, Yamaguchi H, Maenaka K, Lee YH, Inaba K, and *Okumura M.
- Journal Title
  
  Molecules
  
  Volume: 26 Issue: 10 Pages: 2853-2853
- DOI
  10.3390/molecules26102853
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06520, KAKENHI-PROJECT-19K16092, KAKENHI-PROJECT-20K15969, KAKENHI-PUBLICLY-20H04688, KAKENHI-PLANNED-21H05095, KAKENHI-PROJECT-21H04758, KAKENHI-PLANNED-21H05253
[Journal Article] PDI Family Members as Guides for Client Folding and Assembly2020
- Author(s)
  Kanemura S., Matsusaki M., Inaba K. and Okumura M.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 21 Issue: 24 Pages: 9351-9351
- DOI
  10.3390/ijms21249351
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16092, KAKENHI-PROJECT-20K15969, KAKENHI-PROJECT-18H03978, KAKENHI-PROJECT-19J00893
[Journal Article] Protein secondary structure determines the temporal relationship between folding and disulfide formation2020
- Author(s)
  Robinson Philip J.、Kanemura Shingo、Cao Xiaofei、Bulleid Neil J.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 8 Pages: 2438-2448
- DOI
  10.1074/jbc.ra119.011983
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16092
[Journal Article] 小胞体内におけるMHCの品質管理2020
- Author(s)
  金村進吾、松崎元紀、前仲勝実、稲葉謙次、奥村正樹
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 74 Pages: 419-426
- Data Source
  KAKENHI-PROJECT-19K16092
[Journal Article] Antipsychotic olanzapine-induced misfolding of proinsulin in the endoplasmic reticulum accounts for atypical development of diabetes2020
- Author(s)
  Ninagawa Satoshi、Tada Seiichiro、Okumura Masaki、Inoguchi Kenta、Kinoshita Misaki、Kanemura Shingo、Imami Koshi、Umezawa Hajime、Ishikawa Tokiro、Mackin Robert B、Torii Seiji、Ishihama Yasushi、Inaba Kenji、Anazawa Takayuki、Nagamine Takahiko、Mori Kazutoshi
- Journal Title
  
  eLife
  
  Volume: 9 Pages: 23-31
- DOI
  10.7554/elife.60970
- NAID
  120006898101
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06658, KAKENHI-PROJECT-19K16092, KAKENHI-PLANNED-17H06419, KAKENHI-PUBLICLY-20H05310, KAKENHI-PROJECT-18H03978, KAKENHI-PROJECT-20H03241, KAKENHI-PROJECT-17K08528, KAKENHI-PROJECT-18K06216, KAKENHI-ORGANIZER-17H06413
[Journal Article] Characterization of the endoplasmic reticulum-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding2020
- Author(s)
  Kanemura S., Sofia E. F., Hirai N., Okumura M., Kadokura H. and Inaba K.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 295 Issue: 36 Pages: 12772-12785
- DOI
  10.1074/jbc.ra120.013607
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16092, KAKENHI-PROJECT-18H03978, KAKENHI-PROJECT-19H02881
[Journal Article] Dynamic assembly of protein disulfide isomerase in catalysis of oxidative folding2019
- Author(s)
  Okumura Masaki、Noi Kentaro、Kanemura Shingo、Kinoshita Misaki、Saio Tomohide、Inoue Yuichi、Hikima Takaaki、Akiyama Shuji、Ogura Teru、Inaba Kenji
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 15 Issue: 5 Pages: 499-509
- DOI
  10.1038/s41589-019-0268-8
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05657, KAKENHI-PUBLICLY-17H05868, KAKENHI-PROJECT-17H06521, KAKENHI-PROJECT-17K15098, KAKENHI-PROJECT-19K06520, KAKENHI-PROJECT-17H06165, KAKENHI-PROJECT-18H03978, KAKENHI-PLANNED-26116005, KAKENHI-PUBLICLY-17H05867, KAKENHI-PUBLICLY-19H04945
[Journal Article] Protein Disulfide Isomerase family: from Proteostasis to Pathogenesis2019
- Author(s)
  Matsusaki M.#, Kanemura S.#, Kinoshita M.#, Lee Y.H., Inaba K.*, and Okumura M.* (#equal contribution *corresponding authors)
- Journal Title
  
  Biochim Biophys Acta-general subjects
  
  Volume: in press Issue: 2 Pages: 30080-30087
- DOI
  10.1016/j.bbagen.2019.04.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05868, KAKENHI-PROJECT-18H03978, KAKENHI-PROJECT-17H06521, KAKENHI-PROJECT-17K15098, KAKENHI-PROJECT-19K06520, KAKENHI-PROJECT-19K16092, KAKENHI-PROJECT-19J00893
[Journal Article] Ero1-mediated reoxidation of PDI accelerates the folding of cone-snail toxins2018
- Author(s)
  O'Brien H., Kanemura S., Okumura M., Baskin P., Bandyopadhyay P., Ellgaard L., Inaba K., and Safavi-Hemami H.*
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 11 Issue: 11 Pages: 3418-3418
- DOI
  10.3390/ijms19113418
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05868, KAKENHI-PROJECT-18H03978, KAKENHI-PROJECT-17H06521, KAKENHI-PROJECT-17K15098, KAKENHI-PLANNED-26116005
[Patent] 液滴及びその製造方法2021
- Inventor(s)
  奥村正樹、松﨑元紀、金村進吾、齋尾智英、稲葉謙次
- Industrial Property Rights Holder
  学校法人関西学院
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-19K16092
[Patent] 液滴及びその製造方法2020
- Inventor(s)
  奥村正樹、松﨑元紀、金村進吾、齋尾智英、稲葉謙次
- Industrial Property Rights Holder
  学校法人関西学院
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K16092
[Presentation] 小胞体ストレスセンサーの会合状態分布を介した応答制御機構の研究2022
- Author(s)
  松崎元紀、横山武司、次田篤史、金村進吾、田尻道子、明石知子、齋尾智英、稲葉謙次、奥村正樹
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-19K16092
[Presentation] Structural basis for redox-regulated galectin1 function2021
- Author(s)
  岡田莉奈、金村進吾、黒井邦巧、松崎元紀、山口宏、中林孝和、稲葉謙次、奥村正樹
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19K16092
[Presentation] インスリン分解酵素による基質分解メカニズムの解明2021
- Author(s)
  古川蘭、金村進吾、山口宏、李映昊、奥村正樹
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16092
[Presentation] Elucidating the degradation mechanism of substrates by IDE2021
- Author(s)
  古川蘭、金村進吾、山口宏、Lee Young-Ho、奥村正樹
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19K16092
[Presentation] PDIファミリー酵素による前駆体タンパク質の酸化的フォールディング触媒機構の解明2021
- Author(s)
  新納翔悟、金村進吾、山口宏、日高雄二、稲葉謙次、奥村正樹
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16092
[Presentation] Impact of Ca2+ on the function interplay between ERp57 and Calnexin2021
- Author(s)
  谷川雄哉、金村進吾、伊藤大、Lin Yuxi、松崎元紀、山口宏、黒木喜美子、前仲勝実、Lee Young-Ho、稲葉謙次、奥村正樹
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19K16092
[Presentation] プロインスリンのフォールディング中間体の理解2021
- Author(s)
  関凪沙、金村進吾、荒井堅太、山口宏、稲葉謙次、奥村正樹
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16092
[Presentation] Elucidating the in vivo oxidative folding mechanism2021
- Author(s)
  金村進吾、奥村正樹、稲葉謙次
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19K16092
[Presentation] 酸化還元制御によるヒトガレクチン1の構造機能調節の理解2021
- Author(s)
  岡田莉奈、金村進吾、黒井邦巧、松崎元紀、齋尾智英、山口宏、伊藤大、李映昊、中林孝和、稲葉謙次、奥村正樹
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16092
[Presentation] Ca2+によるERp57-CNX複合体の構造機能調節メカニズムの解明2021
- Author(s)
  金村進吾、谷川雄哉、伊藤大、林雨曦、松崎元紀、黒木喜美子、山口宏、前仲勝実、李映昊、稲葉謙次、奥村正樹
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16092
[Presentation] Understanding the folding pathways of proinsulin2021
- Author(s)
  関凪沙、金村進吾、荒井堅太、山口宏、Lee Young-Ho、稲葉謙次、奥村正樹
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19K16092
[Presentation] Biochemical characterizations of ER-resident peroxidases, GPx7 and GPx8, reveal their distinct oxidative activities2020
- Author(s)
  Kanemura S., Sofia E. F., Hirai N., Okumura M., Kadokura H. and Inaba K.
- Organizer
  第20回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19K16092
[Presentation] 小胞体内における新生鎖のジスルフィド結合形成機構の解明2019
- Author(s)
  金村進吾、奥村正樹、Neil Bulleid、稲葉謙次
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19K16092
[Presentation] Mechanisms of disulfide bond formation of newly synthesized polypeptide chains in the endoplasmic reticulum2019
- Author(s)
  Kanemura S., Okumura M., Robinson P. J., Bulleid N. J. and Inaba K.
- Organizer
  International Symposium on Disordered Proteins, Protein Folding, and Disease-causing Aggregation
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16092
[Presentation] 小胞体内における新生鎖のジスルフィド結合形成機構の解明2019
- Author(s)
  金村進吾
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17H06521
[Presentation] 小胞体内腔における新生鎖のジスルフィド結合形成反応の解析2018
- Author(s)
  金村進吾
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17H06521
[Presentation] 小胞体内腔における新生ポリペプチド鎖のジスルフィド結合形成をモニタリングするシステムの開発2017
- Author(s)
  金村進吾
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17H06521

1. SAIO Tomohide (80740802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 奥村正樹 (50635810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. 石川時郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kanemura Shingo 金村 進吾

Research Projects

Research Products

Co-Researchers

Structural basis for recognition and regulation of protein folding intermediate by molecular chaperones in the endoplasmic reticulum

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding the molecular mechanism by which PDI family catalyze oxidative protein folding of nascent chainsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding the molecular mechanism of co-translational oxidative folding in the ERPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A unique leucine-valine adhesive motif supports structure and function of protein disulfide isomerase P5 via dimerization2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional Interplay between P5 and PDI/ERp72 to Drive Protein Folding.2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Ca2+ Regulates ERp57-Calnexin Complex Formation.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PDI Family Members as Guides for Client Folding and Assembly2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protein secondary structure determines the temporal relationship between folding and disulfide formation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 小胞体内におけるMHCの品質管理2020

Author(s)

Journal Title

Data Source

[Journal Article] Antipsychotic olanzapine-induced misfolding of proinsulin in the endoplasmic reticulum accounts for atypical development of diabetes2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Characterization of the endoplasmic reticulum-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dynamic assembly of protein disulfide isomerase in catalysis of oxidative folding2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protein Disulfide Isomerase family: from Proteostasis to Pathogenesis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ero1-mediated reoxidation of PDI accelerates the folding of cone-snail toxins2018

Author(s)

Journal Title

DOI

Data Source

[Patent] 液滴及びその製造方法2021

Inventor(s)

Kanemura Shingo 金村進吾