Shizu Ryota 志津怜太

Researcher Number	50803912
Other IDs
Affiliation (Current)	2025: 静岡県立大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2024: 静岡県立大学, 薬学部, 講師 2017 – 2022: 静岡県立大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Environmental and hygienic pharmacy Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy
Keywords	Principal Investigator 肝がん / PXR / 核内受容体 / 肝星細胞 / 上皮間葉転換 / CAR / 化学物質 / 肝発がん / YAP / 肝細胞増殖 … More / 種差 / 化学発がん / 結晶構造 / 蛋白質 / 転写因子 / 結晶化 / in vitro評価系 / 蛍光偏光解消法 / 組換えタンパク質 / インビトロ評価系 … More Except Principal Investigator 肝臓 / 核内受容体 / 薬物代謝酵素 / 化学物質 / CAR / PXR / 次世代影響 / 発達毒性 / 新生仔 / 遺伝子発現 / 成長障害 / 甲状腺ホルモン / ヒト腸管 / PPARγ / CYP3A4 / 臓器差 / 酵素誘導 / 腸管 / 個人差 / 分子記述子 / P450 / DILI評価系 / cytochrome P450 / インビトロDILI 評価系 / Cytochrome P450 / インビトロ評価系 / DILI / 薬剤性肝障害 / 種差 / 肝再生 / 肝細胞 / 肝 / 細胞増殖 / 転写調節 / 分子間相互作用 / 抗炎症 / 医薬品副作用 / 肝がん / 化学発がん / 肝細胞増殖 / 肝毒性 Less

Development of a Treatment Strategy for Hepatocellular CarcinomaThorough Nuclear Receptor PXR-Mediated Inhibition of Epithelial-Mesenchymal TransitionPrincipal Investigator
- Principal Investigator
  
  志津怜太
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Shizuoka
Understanding the influence of PXR activation on the epithelial mesenchymal transition of liver cancer cellsPrincipal Investigator
- Principal Investigator
  
  Shizu Royta
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Shizuoka
Investigation of the next-generation and late-onset effects of drugs focusing on liver maturation and liver function regulated by the nuclear receptors PXR and CAR
- Principal Investigator
  
  Yoshinari Kouichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Shizuoka
Elucidation of the molecular mechanism of CYP3A4 induction in the human intestine and its differences from the liver
- Principal Investigator
  
  Hosaka Takuomi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Shizuoka
Identification of the molecular mechanism of nuclear receptor CAR-mediated liver carcinogenesis and its species differences.Principal Investigator
- Principal Investigator
  
  Shizu Ryota
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  University of Shizuoka
Nuclear receptor PXR-mediated hepatocyte proliferation: understanding of its mechanism and human relevance
- Principal Investigator
  
  Yoshinari Kouichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Shizuoka
Development of evaluation methods for drug-induced liver injury based on both chemical structure/biological reactivity of drugs and individual factors
- Principal Investigator
  
  Sasaki Takamitsu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Shizuoka
Establishment of in vitro evaluation system for the activation of nuclear receptor CAR and PXRPrincipal Investigator
- Principal Investigator
  
  Shizu Ryota
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  University of Shizuoka

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] PPARα Induces the Expression of CAR That Works as a Negative Regulator of PPARα Functions in Mouse Livers2023
- Author(s)
  Ryota Shizu, Yuta Otsuka, Chizuru Ishii, Kanako Ezaki, Kouichi Yoshinari
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 4 Pages: 3953-3953
- DOI
  10.3390/ijms24043953
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07202, KAKENHI-PROJECT-21K15317
[Journal Article] Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development2022
- Author(s)
  Kouichi Yoshinari, Ryota Shizu
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 50 Issue: 7 Pages: 1019-1026
- DOI
  10.1124/dmd.121.000481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07202
[Journal Article] Development of a strategy to identify and evaluate direct and indirect activators of constitutive androstane receptor in rats2022
- Author(s)
  Sato Takumi、Shizu Ryota、Miura Yoshie、Hosaka Takuomi、Kanno Yuichiro、Sasaki Takamitsu、Yoshinari Kouichi
- Journal Title
  
  Food and Chemical Toxicology
  
  Volume: 170 Pages: 113510-113510
- DOI
  10.1016/j.fct.2022.113510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15317
[Journal Article] The influence of the long‐term chemical activation of the nuclear receptor pregnane X receptor (PXR) on liver carcinogenesis in mice2021
- Author(s)
  Ryota Shizu, Mai Ishimura, Sumihito Nobusawa, Takuomi Hosaka, Takamitsu Sasaki, Satoru Kakizaki, Kouichi Yoshinari
- Journal Title
  
  Archives of Toxicology
  
  Volume: 95 Issue: 3 Pages: 1089-1102
- DOI
  10.1007/s00204-020-02955-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07202, KAKENHI-PROJECT-17K08387, KAKENHI-PROJECT-19K16352
[Journal Article] Glucocorticoid receptor dimerization in the cytoplasm might be essential for nuclear localization2021
- Author(s)
  Lee Su-Jun、Shizu Ryota、Negishi Masahiko
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 553 Pages: 154-159
- DOI
  10.1016/j.bbrc.2021.03.071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15317
[Journal Article] PXR suppresses PPARα-dependent HMGCS2 gene transcription by inhibiting the interaction between PPARα and PGC1α2021
- Author(s)
  R. Shizu, K. Ezaki, T. Sato, A. Sugawara, T. Hosaka, T. Sasaki, K. Yoshinari
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 12 Pages: 3550-3550
- DOI
  10.3390/cells10123550
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07202, KAKENHI-PROJECT-21K15317
[Journal Article] Helix 12 stabilization contributes to basal transcriptional activity of PXR2021
- Author(s)
  Shizu Ryota、Nishiguchi Hikaru、Tashiro Sarii、Sato Takumi、Sugawara Ayaka、Kanno Yuichiro、Hosaka Takuomi、Sasaki Takamitsu、Yoshinari Kouichi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 297 Issue: 3 Pages: 100978-100978
- DOI
  10.1016/j.jbc.2021.100978
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15317
[Journal Article] Antiepileptic Drug?Activated Constitutive Androstane Receptor Inhibits Peroxisome Proliferator?Activated Receptorαand Peroxisome Proliferator?Activated ReceptorγCoactivator 1α?Dependent Gene Expression to Increase Blood Triglyceride Levels2020
- Author(s)
  Shizu Ryota、Otsuka Yuta、Ezaki Kanako、Ishii Chizuru、Arakawa Shingo、Amaike Yuto、Abe Taiki、Hosaka Takuomi、Sasaki Takamitsu、Kanno Yuichiro、Miyata Masaaki、Yamazoe Yasushi、Yoshinari Kouichi
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 98 Issue: 5 Pages: 634-647
- DOI
  10.1124/molpharm.120.000103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07090, KAKENHI-PROJECT-20K07202
[Journal Article] Nuclear receptor CAR-mediated liver cancer and its species differences2020
- Author(s)
  Shizu Ryota、Yoshinari Kouichi
- Journal Title
  
  Expert Opinion on Drug Metabolism & Toxicology
  
  Volume: 16 Issue: 4 Pages: 343-351
- DOI
  10.1080/17425255.2020.1746268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08418, KAKENHI-PROJECT-20K07202, KAKENHI-PROJECT-19K16352
[Journal Article] PXR functionally interacts with NF-κB and AP-1 to downregulate the inflammation-induced expression of chemokine CXCL2 in mice.2020
- Author(s)
  Maya Okamura, Ryota Shizu, Taiki Abe, Susumu Kodama, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Journal Title
  
  Cells
  
  Volume: 9 Issue: 10 Pages: 2520-2520
- DOI
  10.3390/cells9102296
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07202
[Journal Article] Functional interaction between PXR and YAP in xenobiotic-dependent liver hypertrophy and drug metabolism.2019
- Author(s)
  Abe, T., Shizu, R., Sasaki, T., Shimizu, Y., Hosaka, T., Kodama, S., Matsuzawa, A., Yoshinari, K.
- Journal Title
  
  J. Pharmacol. Exp. Ther.
  
  Volume: 371 Issue: 3 Pages: 590-601
- DOI
  10.1124/jpet.119.258632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02567, KAKENHI-PROJECT-17K08418
[Journal Article] Possible involvement of the competition for the transcriptional coactivator glucocorticoid receptor-interacting protein 1 in the inflammatory signal-dependent suppression of PXR-mediated CYP3A induction in?vitro2019
- Author(s)
  Okamura Maya、Shizu Ryota、Hosaka Takuomi、Sasaki Takamitsu、Yoshinari Kouichi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 34 Issue: 4 Pages: 272-279
- DOI
  10.1016/j.dmpk.2019.04.005
- NAID
  50014558515
- Data Source
  KAKENHI-PROJECT-17K08418
[Journal Article] Screening of Industrial and Agricultural Chemicals for Searching a Mouse PXR Activator Using Cell-Based Reporter Gene Assays2018
- Author(s)
  Ryota Shizu, Makoto Kano, Taiki Abe, Saki Tsuchiya, Yuki Shimizu, Michiko Watanabe, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Journal Title
  
  BPB Reports
  
  Volume: 1 Pages: 11-19
- NAID
  130007938427
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08418
[Journal Article] Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR2018
- Author(s)
  Shohei Yoshimaru, Ryota Shizu, Satoshi Tsuruta, Yuto Amaike, Makoto Kano, Takuomi Hosaka, Takamitsu Sasak, Kouichi Yoshinari
- Journal Title
  
  J Toxicol Sci
  
  Volume: 印刷中
- NAID
  50014469406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08418
[Journal Article] Interaction of the phosphorylated DNA-binding domain in nuclear receptor CAR with its ligand-binding domain regulates CAR activation2018
- Author(s)
  Shizu Ryota、Min Jungki、Sobhany Mack、Pedersen Lars C.、Mutoh Shingo、Negishi Masahiko
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293 Issue: 1 Pages: 333-344
- DOI
  10.1074/jbc.m117.806604
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H07004
[Journal Article] Phosphorylated Nuclear Receptor CAR Forms a Homodimer To Repress Its Constitutive Activity for Ligand Activation2017
- Author(s)
  Shizu Ryota、Osabe Makoto、Perera Lalith、Moore Rick、Sueyoshi Tatsuya、Negishi Masahiko
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 37 Issue: 10
- DOI
  10.1128/mcb.00649-16
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H07004
[Presentation] :核内受容体PXRによる肝星細胞形質転換抑制機序の解析2023
- Author(s)
  佐藤拓海、志津怜太、保坂卓臣、佐々木崇光、菅野裕一朗、吉成浩一
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] ヒトVIMENTIN遺伝子プロモーターを用いた肝がん細胞の上皮間葉転換評価系の構築と核内受容体PXR活性化の上皮間葉転換に対する影響評価2022
- Author(s)
  馬場遼之介、志津怜太、佐藤拓海、保坂卓臣、佐々木崇光、菅野裕一朗、吉成浩一
- Organizer
  フォーラム2022衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] 化学物質曝露による核内受容体CAR活性化が乳幼児の発達に及ぼす影響2022
- Author(s)
  田代紗莉依、志津怜太、保坂卓臣、菅野裕一朗、吉成浩一
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20K07202
[Presentation] 乳幼児期における化学物質曝露はCAR活性化を介して成長遅延を引き起こす2022
- Author(s)
  田代紗莉依、志津怜太、保坂卓臣、菅野裕一朗、吉成浩一
- Organizer
  第68回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-20K07202
[Presentation] 異物応答性核内受容体PXRによるタンパク質間相互作用を介した炎症・免疫調節2022
- Author(s)
  志津怜太、吉成浩一
- Organizer
  第49回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] Structural characterization of constitutive transcriptional activity of the nuclear receptor PXR and the generation of ligand-sensitive PXR mutants2022
- Author(s)
  Ryota Shizu, Hikaru Nishiguchi, Sarii Tashiro, Takumi Sato, Ayaka Sugawara, Takuomi Hosaka, Yuichiro Kanno, Takamitsu Sasaki, Kouichi Yoshinari
- Organizer
  13th ISSX and 24th MDO meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] Development of a strategy to identify and evaluate ligand and indirect activators of rat CAR2022
- Author(s)
  Takumi Sato, Ryota Shizu, Yoshie Miura, Takuomi Hosaka, Takamitsu Sasaki, Yuichiro Kanno, Kouichi Yoshinari
- Organizer
  13th ISSX and 24th MDO meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] 化学物質による肝化学発がんの種差解析～発がん性試験結果のヒト外挿性の理解～2022
- Author(s)
  志津怜太、吉成浩一
- Organizer
  日本薬学会第142年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] 核内受容体を介した肝化学発がん：リスク評価に向けた機序と種差の理解2021
- Author(s)
  志津怜太、吉成浩一
- Organizer
  第48回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] 乳幼児期マウスにおける核内受容体CARの活性化が甲状腺ホルモンシグナルに及ぼす影響2021
- Author(s)
  田代紗莉依、志津怜太、保坂卓臣、菅野裕一朗、吉成浩一
- Organizer
  第4回医薬品毒性機序研究会
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] ヒト型変異導入マウスを用いた核内受容体CARによる肝発がんプロモーションの種差解析2021
- Author(s)
  牧田夏希、志津怜太、曽部圭一郎、保坂卓臣、菅野裕一朗、佐々木崇光、吉成浩一
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2021
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] 核内受容体CARのヒト型変異導入マウスを用いたCARによる肝発がんプロモーション作用の種差解析2021
- Author(s)
  牧田夏希、志津怜太、曽部圭一郎、保坂卓臣、菅野裕一朗、佐々木崇光、吉成浩一
- Organizer
  第4回医薬品毒性機序研究会
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] 肝のCYP3A4発現における肝星細胞の役割2021
- Author(s)
  伊豆倉裕翔、保坂卓臣、森田華帆、志津怜太、佐々木崇光、菅野裕一朗、吉成浩一
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-19K07226
[Presentation] 化学物質による肝発がん予測のためのラットCAR活性化作用評価2021
- Author(s)
  佐藤拓海、志津怜太、三浦佳恵、保坂卓臣、菅野裕一朗、吉成浩一
- Organizer
  第48回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] PXR活性化評価系構築のための、リガンド依存的に構造変化し活性化するPXR変異体の作製2021
- Author(s)
  志津怜太、西口輝、田代紗莉依、佐藤拓海、菅原彩加、保坂卓臣、菅野裕一朗、佐々木崇光、吉成浩一
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] 非遺伝毒性肝がんを誘発する化学物質の核内受容体活性化作用2021
- Author(s)
  三浦佳恵、志津怜太、佐藤拓海、保坂卓臣、菅野裕一朗、吉成浩一
- Organizer
  第48回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] 乳幼児期マウスにおける核内受容体CARの活性化が甲状腺ホルモンシグナルに及ぼす影響2021
- Author(s)
  田代紗莉依、志津怜太、保坂卓臣、菅野裕一朗、吉成浩一
- Organizer
  第4回医薬品毒性機序研究会
- Data Source
  KAKENHI-PROJECT-20K07202
[Presentation] PXR活性化は肝がん細胞の上皮間葉転換抑制を介して肝がんの進行を抑制する2021
- Author(s)
  志津怜太、吉成浩一
- Organizer
  第80回日本癌学会学術年会
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] 核内受容体PXRによる肝がん進行抑制機序の解析2021
- Author(s)
  佐藤拓海、志津怜太、馬場遼之介、石村麻衣、保坂卓臣、菅野裕一朗、吉成浩一
- Organizer
  第4回医薬品毒性機序研究会
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] Contribution of CAR activation to the chemical-induced non-genotoxic liver cancer in rats.2021
- Author(s)
  Sato Takumi、Shizu Ryota、Miura Yoshie、Yoshinari Kouichi
- Organizer
  フォーラム2021衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] ラット反復投与毒性試験データベースを利用した小葉中心性肝細胞肥大の発現機序解析2021
- Author(s)
  柴田尚輝、志津怜太、保坂卓臣、菅野裕一朗、吉成浩一
- Organizer
  第38回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20K07202
[Presentation] 転写共役因子との相互作用に着目したアンドロゲン受容体バリアント７の恒常的な活性化機序の解析2021
- Author(s)
  山下大輔、志津怜太、西口輝、保坂卓臣、菅野裕一朗、吉成浩一
- Organizer
  フォーラム2021衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] PXR活性化の肝化学発がんへの影響の理解と機序解明2021
- Author(s)
  志津怜太、吉成浩一
- Organizer
  第3回医薬品毒性機序研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16352
[Presentation] 転写因子TFE3を介したヒト肝細胞におけるCYP3A4の転写調節2021
- Author(s)
  保坂卓臣、勝山早苗、志津怜太、佐々木崇光、菅野裕一朗、吉成浩一
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-19K07226
[Presentation] 化学物質によるラットCAR活性化スクリーニング系の確立2021
- Author(s)
  佐藤拓海、志津怜太、三浦佳恵、保坂卓臣、菅野裕一朗、佐々木崇光、吉成浩一
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] 乳幼児期における核内受容体CAR活性化の甲状腺ホルモンシグナルに対する影響2021
- Author(s)
  田代紗莉依、志津怜太、保坂卓臣、菅野裕一朗、吉成浩一
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2021
- Data Source
  KAKENHI-PROJECT-20K07202
[Presentation] 乳幼児期における核内受容体CAR活性化の甲状腺ホルモンシグナルに対する影響2021
- Author(s)
  田代紗莉依、志津怜太、保坂卓臣、菅野裕一朗、吉成浩一
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2021
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] ヒト腸管由来LS180細胞でのrosiglitazoneによるCYP3A4誘導機序の解析2021
- Author(s)
  佐々木貴章、保坂卓臣、鶴田聡志、志津怜太、佐々木崇光、菅野裕一朗、吉成浩一
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-19K07226
[Presentation] ラットにおける化学物質による非遺伝毒性肝発癌に対するCAR活性化の寄与2021
- Author(s)
  佐藤拓海、志津怜太、三浦佳恵、保坂卓臣、佐々木崇光、菅野裕一朗、吉成浩一
- Organizer
  フォーラム2021衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-21K15317
[Presentation] ヒト腸管由来細胞でのrosiglitazoneによるCYP3A4誘導機序の解析2020
- Author(s)
  佐々木貴章、保坂卓臣、志津怜太、佐々木崇光、吉成浩一
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07226
[Presentation] 化学物質によるPXR活性化のマウス肝発がんへの影響解析2020
- Author(s)
  志津怜太、石村麻衣、信澤純人、保坂卓臣、佐々木崇光、柿崎暁、吉成浩一
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K16352
[Presentation] 肝細胞肥大を誘発する薬物の核内受容体活性化能の解析2020
- Author(s)
  大橋真帆、志津怜太、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  第２回医薬品毒性機序研究会
- Data Source
  KAKENHI-PROJECT-19K16352
[Presentation] 化学物質によるPXR活性化のマウス肝発がんへの影響解析2020
- Author(s)
  志津怜太、石村麻衣、信澤純人、保坂卓臣、佐々木崇光、柿崎暁、吉成浩一
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20K07202
[Presentation] 化学物質によるPXR活性化のマウス肝発がんへの影響解析2020
- Author(s)
  志津怜太、石村麻衣、信澤純人、保坂卓臣、佐々木崇光、柿崎暁、吉成浩一
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K07226
[Presentation] リガンド依存的なタンパク質構造変化に着目したPXR活性化評価系の構築2020
- Author(s)
  西口輝、志津怜太、保坂卓臣、佐々木崇光、菅野裕一朗、吉成浩一
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2020
- Data Source
  KAKENHI-PROJECT-19K07226
[Presentation] 抗てんかん薬によるCARの活性化はPPARαの抑制を介して血中脂質レベルを増加させる2020
- Author(s)
  志津怜太、江崎香奈子、保坂卓臣、佐々木崇光、菅野裕一朗、吉成浩一
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会
- Data Source
  KAKENHI-PROJECT-20K07202
[Presentation] フェノバルビタールによる肝発がんへのPXR活性化の影響2019
- Author(s)
  石村麻衣、志津怜太、曽部圭一郎、江崎香奈子、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  フォーラム2019衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] マウスにおける核内受容体PXR活性化薬長期間投与の肝発がんへの影響2019
- Author(s)
  石村麻衣、志津怜太、吉成浩一
- Organizer
  令和元年度内外環境応答・代謝酵素研究会
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] Interaction between CAR and YAP is a possible underlying mechanism of phenobarbital-dependent hepatocarcinogenesis and its species difference2019
- Author(s)
  Ryota Shizu, Taiki Abe, Keichiro Sobe, Mai Ishimura, Yuto Amaike, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Organizer
  Cold Spring Harbor Asia meeting on Liver, Biology, Diseases & Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] Interaction between CAR and YAP is a possible underlying mechanism of phenobarbital-dependent hepatocarcinogenesis and its species difference.2019
- Author(s)
  Ryota Shizu, Taiki Abe, Keichiro Sobe, Mai Ishimura, Yuto Amaike, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Organizer
  Cold Spring Harbor Asia meeting on Liver, Biology, Diseases & Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16352
[Presentation] The role of YAP in CAR dependent hepatocyte proliferation.2019
- Author(s)
  Ryota Shizu
- Organizer
  フォーラム2019衛生薬学・環境トキシコロジー
- Invited
- Data Source
  KAKENHI-PROJECT-19K16352
[Presentation] The role of YAP in CAR dependent hepatocyte proliferation2019
- Author(s)
  Ryota Shizu, Kouichi Yoshinari
- Organizer
  フォーラム2019衛生薬学・環境トキシコロジー
- Invited
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] 核内受容体CAR活性化による肝発がんプロモーションの分子機序解析2019
- Author(s)
  志津怜太、曽部圭一郎、阿部太紀、石村麻衣、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  第1回医薬品毒性機序研究会
- Data Source
  KAKENHI-PROJECT-17H07004
[Presentation] 薬物のシトクロムP450反応性と肝障害誘発性の関連性解析2019
- Author(s)
  米川恵理、山崎弘量、清水佑記、佐々木崇光、渡邉美智子、志津怜太、保坂卓臣、竹下潤一、吉成浩一
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CARはPPARα依存的な脂質代謝調節を抑制する2019
- Author(s)
  志津怜太、江崎加奈子、吉成浩一
- Organizer
  令和元年度内外環境応答・代謝酵素研究会
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] Interaction with YAP is a possible underlying mechanism for CAR-dependent hepatocarcinogenesis2019
- Author(s)
  Ryota Shizu, Taiki Abe, Keiichiro Sobe, Mai Ishimura, Takuomi Hosaka, Takamitsu Sasakim Kouichi Yoshinari
- Organizer
  The 12th International Meeting of the International Society for the Study of Xenobiotics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] Interaction with YAP is a possible underlying mechanism for CAR-dependent hepatocarcinogenesis.2019
- Author(s)
  Ryota Shizu, Taiki Abe, Keiichiro Sobe, Mai Ishimura, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Organizer
  ISSX2019: 12th international ISSX meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16352
[Presentation] フェノバルビタールによる肝発がんへの PXR 活性化の影響2019
- Author(s)
  石村麻衣、志津怜太、曽部圭一郎、江崎香奈子、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  フォーラム2019衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-19K16352
[Presentation] 薬物のシトクロムP450反応性に着目した薬剤性肝障害評価2018
- Author(s)
  米川恵理、清水佑記、佐々木崇光、渡邉美智子、志津怜太、保坂卓臣、竹下潤一、吉成浩一
- Organizer
  平成30年度内外環境応答・代謝酵素研究会（鳥取）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CARおよびPXRによる肝細胞増殖調節におけるYAPの関与2018
- Author(s)
  石村麻衣、天池優斗、阿部太紀、志津怜太、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] 核内受容体 CAR の活性化が PPARα 依存的な脂質代謝調節に及ぼす影響2018
- Author(s)
  江崎香奈子、志津怜太、大塚祐多、石井千鶴、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  日本薬学会第138年会（金沢）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CARによるPPARα依存的な脂質代謝の調節2018
- Author(s)
  江崎香奈子、志津怜太、大塚祐多、石井千鶴、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  平成30年度内外環境応答・代謝酵素研究会
- Data Source
  KAKENHI-PROJECT-17H07004
[Presentation] 核内受容体CARおよびPXRによる肝細胞増殖調節におけるYAPの関与2018
- Author(s)
  石村麻衣、天池優斗、阿部太紀、志津怜太、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  日本薬学会第138年会（金沢）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] CAR依存的肝細胞増殖におけるCARとYAPの相互作用の役割2018
- Author(s)
  志津怜太、曽部圭一郎、阿部太紀、石村麻衣、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  平成30年度内外環境応答・代謝酵素研究会
- Data Source
  KAKENHI-PROJECT-17H07004
[Presentation] The influence of nuclear receptor CAR activation on PPARα-dependent lipid metabolism.2018
- Author(s)
  Kanako Ezaki, Ryota Shizu, Yuta Otsuka, Chizuru Ishii, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinar
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H07004
[Presentation] Intramolecular interaction of CAR regulates heterodimerization with RXRα2018
- Author(s)
  Ryota Shizu, Jungki Min, Lars C Pedersen, Masahiko Negishi, Kouichi Yoshinari
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H07004
[Presentation] シトクロムP450反応性を利用した肝障害誘発性薬物の判別2018
- Author(s)
  米川恵理、清水佑記、佐々木崇光、渡邉美智子、志津怜太、保坂卓臣、竹下潤一、吉成浩一
- Organizer
  第45回日本毒性学会学術年会（大阪）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] Acceleration of murine hepatocyte proliferation by imazaril through the activation of nuclear receptor PXR2018
- Author(s)
  Shohei Yoshimaru, Ryota Shizu, Satoshi Tsuruta, Yuto Amaike, Makoto Kano, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Organizer
  The 22nd North American Meeting of the International Society for the Study of Xenobiotics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] A possible involvement of transcriptional coactivators in the inflammation-dependent downregulation of PXR-mediated CYP3A induction.2018
- Author(s)
  Maya Okamura, Ryota Shizu, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Organizer
  2018 International Meeting on 22nd Microsomal Drug Oxidation and 33rd Japanese Society for the Study of Xenobiotics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] Imazalil activates the nuclear receptor PXR to accelerate CAR-mediated hepatocyte proliferation in mice.2018
- Author(s)
  Shohei Yoshimaru, Ryota Shizu, Satoshi Tsuruta, Yuto Amaike, Makoto Kano, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Organizer
  The 8th international congress of Asian Society of Toxicology (ASIATOX)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] 網羅的な化学物質のシトクロムP450阻害活性評価2018
- Author(s)
  佐々木崇光、渡邉美智子、川野拓歩、猿橋ひとみ、小倉瑠衣、志津怜太、保坂卓臣、吉成浩一
- Organizer
  平成30年度内外環境応答・代謝酵素研究会（鳥取）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] ラットにおける肝化学発がんと核内受容体活性化の関連性2017
- Author(s)
  田部美紗子、志津怜太、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CARを介した肝細胞増殖のインビトロ評価系の構築と機序解析2017
- Author(s)
  吉成浩一、阿部太紀、天池優斗、志津怜太、保坂卓臣、佐々木崇光
- Organizer
  第24回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] ラットにおける肝化学発がんと核内受容体活性化の関連性2017
- Author(s)
  田部美紗子、志津怜太、保坂卓臣、鶴田聡志、志津怜太、佐々木崇光、吉成浩一
- Organizer
  平成29年度内外環境応答・代謝酵素研究会（福岡）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 肝臓と腸管におけるCYP3A4誘導プロファイルの異同解明2017
- Author(s)
  鶴田聡志、保坂卓臣、志津怜太、佐々木崇光、吉成浩一
- Organizer
  第63回日本薬学会東海支部大会（岐阜）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] フェノバルビタールによる核内受容体CARの活性化機構2017
- Author(s)
  志津怜太、武藤信吾、根岸正彦、吉成浩一
- Organizer
  第63回日本薬学会東海支部大会
- Data Source
  KAKENHI-PROJECT-17H07004
[Presentation] A possible role of NF-kB in the anti-inflammatory effects of activated PXR2017
- Author(s)
  Maya Okamura, Taiki Abe, Satoshi Tsuruta, Ryota Shizu, Takuomi Hosaka, Takamitsu Sasaki, Susumu Kodama, Kouichi Yoshinari
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 薬剤性肝障害時の核内受容体 PXR の抗炎症作用における NF-κB の役割2017
- Author(s)
  岡村麻絢、阿部太紀、鶴田聡志、志津怜太、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  第24回日本免疫毒性学会学術年会（青森）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] CAR utilizes EGF signaling for activation2017
- Author(s)
  Ryota Shizu, Masahiko Negishi, Kouichi Yoshinari
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] Influence of food additives on nuclear receptor PXR2017
- Author(s)
  吉丸祥平、志津怜太、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  第22回静岡健康・長寿学術フォーラム（静岡）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] アンドロゲンレセプターの遺伝子一塩基変異のホモ二量体形成への影響2017
- Author(s)
  志津怜太、Su-Jun Lee、根岸正彦、吉成浩一
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-17H07004
[Presentation] Application of cytochrome P450 reactivity assessment to the prediction of livertoxicity of pesticides2017
- Author(s)
  川野拓歩、渡邉美智子、佐々木崇光、隠岐仁美、清水佑記、竹下潤一、志津怜太、保坂卓臣、吉成浩一
- Organizer
  第22回静岡健康・長寿学術フォーラム（静岡）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] Influence of food additives on nuclear receptor PXR2017
- Author(s)
  吉丸祥平、志津怜太、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  第22回静岡健康・長寿学術フォーラム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] SREBP-2によるCYP3A4の転写制御2017
- Author(s)
  宮嵜靖之、保坂卓臣、志津怜太、佐々木崇光、吉成浩一
- Organizer
  日本薬物動態学会第32回年会（東京）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体PXRの抗炎症作用におけるNF-κBの寄与の解析2017
- Author(s)
  岡村麻絢、阿部太紀、鶴田聡志、志津怜太、保坂卓臣、佐々木崇光、児玉進、吉成浩一
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] アンドロゲンレセプターの遺伝子一塩基変異のホモ二量体形成への影響2017
- Author(s)
  志津怜太、Su-Jun Lee、根岸正彦、吉成浩一
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 化学物質のP450反応性と反復投与毒性の関連性2017
- Author(s)
  渡邉美智子、佐々木崇光、清水佑記、櫛田まどか、隠岐仁美、竹下潤一、志津怜太、保坂卓臣、吉成浩一
- Organizer
  第63回日本薬学会東海支部大会（岐阜）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CAR依存的な肝細胞増殖へのYAPの関与2017
- Author(s)
  天池優斗、阿部太紀、志津怜太、保坂卓臣、佐々木崇光、松沢　厚、吉成浩一
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] コレステロールレベル調節因子SREBP-2によるCYP3A4の転写制御2017
- Author(s)
  宮嵜靖之、保坂卓臣、志津怜太、佐々木崇光、吉成浩一
- Organizer
  第63回日本薬学会東海支部大会（岐阜）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CARを介した肝細胞増殖のインビトロ評価系の構築と機序解析2017
- Author(s)
  吉成浩一、阿部太紀、天池優斗、志津怜太、保坂卓臣、佐々木崇光
- Organizer
  第24回肝細胞研究会（旭川）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] CAR utilizes EGF signaling for activation.2017
- Author(s)
  Ryota Shizu, Masahiko Negishi, Kouichi Yoshinari
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-17H07004
[Presentation] 核内受容体CARおよびPXRによる肝細胞増殖調節におけるYAPの関与2017
- Author(s)
  鶴田聡志、保坂卓臣、志津怜太、佐々木崇光、吉成浩一
- Organizer
  日本薬物動態学会第32回年会（東京）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] PPARγはヒト腸管由来LS180細胞におけるCYP3A4誘導の新規制御因子である2017
- Author(s)
  保坂卓臣、鶴田聡志、志津怜太、佐々木崇光、吉成浩一
- Organizer
  平成29年度内外環境応答・代謝酵素研究会（福岡）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] Role of YAP in CAR-mediated proliferation of mouse hepatocytes2017
- Author(s)
  Yuto Amaike, Taiki Abe, Ryota Shizu, Takuomi Hosaka, Takamitsu Sasaki, Atsushi Matsuzawa, Kouichi Yoshinari
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CAR依存的な肝細胞増殖へのYAPの関与2017
- Author(s)
  天池優斗、阿部太紀、志津怜太、保坂卓臣、佐々木崇光、松沢厚、吉成浩一
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419

1. Yoshinari Kouichi (60343399)

# of Collaborated Projects: 5 results

# of Collaborated Products: 59 results
2. Hosaka Takuomi (30611579)

# of Collaborated Projects: 4 results

# of Collaborated Products: 51 results
3. Sasaki Takamitsu (20382674)

# of Collaborated Projects: 3 results

# of Collaborated Products: 40 results
4. 柿崎暁 (80344935)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 永田清 (80189133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Negishi Masahiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. KANNO Yuichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 松沢厚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shizu Ryota 志津 怜太

Research Projects

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Development of a Treatment Strategy for Hepatocellular CarcinomaThorough Nuclear Receptor PXR-Mediated Inhibition of Epithelial-Mesenchymal TransitionPrincipal Investigator

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Understanding the influence of PXR activation on the epithelial mesenchymal transition of liver cancer cellsPrincipal Investigator

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Investigation of the next-generation and late-onset effects of drugs focusing on liver maturation and liver function regulated by the nuclear receptors PXR and CAR

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Elucidation of the molecular mechanism of CYP3A4 induction in the human intestine and its differences from the liver

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Identification of the molecular mechanism of nuclear receptor CAR-mediated liver carcinogenesis and its species differences.Principal Investigator

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Nuclear receptor PXR-mediated hepatocyte proliferation: understanding of its mechanism and human relevance

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Development of evaluation methods for drug-induced liver injury based on both chemical structure/biological reactivity of drugs and individual factors

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Establishment of in vitro evaluation system for the activation of nuclear receptor CAR and PXRPrincipal Investigator

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[Journal Article] PPARα Induces the Expression of CAR That Works as a Negative Regulator of PPARα Functions in Mouse Livers2023

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[Journal Article] Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development2022

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[Journal Article] Development of a strategy to identify and evaluate direct and indirect activators of constitutive androstane receptor in rats2022

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[Journal Article] The influence of the long‐term chemical activation of the nuclear receptor pregnane X receptor (PXR) on liver carcinogenesis in mice2021

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[Journal Article] Glucocorticoid receptor dimerization in the cytoplasm might be essential for nuclear localization2021

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[Journal Article] PXR suppresses PPARα-dependent HMGCS2 gene transcription by inhibiting the interaction between PPARα and PGC1α2021

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Shizu Ryota 志津怜太