Komai Toshihiko 駒井俊彦

… Alternative Names

KOMAI TOSHIHIKO 駒井俊彦

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Researcher Number	50803938
Other IDs
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2019 – 2025: 東京大学, 医学部附属病院, 助教 2017: 東京大学, 医学部附属病院, 特任臨床医
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related Except Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Collagenous pathology/Allergology
Keywords	Principal Investigator 全身性エリテマトーデス / 自己免疫疾患 / 抑制性サイトカイン / 線維化 / 全身性強皮症 / TGF-β / TGF-beta / サイトカインシナジー / 免疫代謝 / mTOR / 液性免疫 / アルギニン / アミノ酸センサー … More Except Principal Investigator … More 自己免疫疾患 / T細胞 / B細胞 / 加齢関連T細胞 / Egr2 / TGF-β / Ｔ細胞 / ThA細胞 / 自己免疫性間質性肺炎 / 肺線維症 / CD4陽性T細胞 / 膠原病 / TGF-β1 / 自己免疫性疾患 / 間質性肺炎 / ノックアウトマウス / TGF-beta / サイトカイン / TGF-beta3 / IL-10 / TGF-β3 / LAG3 / 制御性T細胞 Less

Elucidating the Role of Novel Aging-Associated ThA Cells in the Pathogenesis of Systemic Lupus Erythematosus
- Principal Investigator
  
  岡村僚久
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  The University of Tokyo
全身性強皮症の病態制御におけるTGF-β3の役割の解明Principal Investigator
- Principal Investigator
  
  駒井俊彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  The University of Tokyo
Single-cell multiome profiling and functional analysis of human age-associated T cells in autoimmune diseases
- Principal Investigator
  
  岡村僚久
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  The University of Tokyo
Verification of humoral immune regulation mediated by arginine sensor GATSL3Principal Investigator
- Principal Investigator
  
  Komai Toshihiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  The University of Tokyo
Elucidation of pathogenesis of autoimmune-mediated interstitial lung disease based on epigenomic analysis
- Principal Investigator
  
  OKAMURA Tomohisa
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  The University of Tokyo
Inhibitory cytokine-producing Treg-mediated control of autoimmunity
- Principal Investigator
  
  Fujio Keishi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2017 2016

All Journal Article Presentation

[Journal Article] Machine learning-driven immunophenotypic stratification of mixed connective tissue disease, corroborating the clinical heterogeneity2024
- Author(s)
  Izuka Shinji、Komai Toshihiko、Itamiya Takahiro、Ota Mineto、Nagafuchi Yasuo、Shoda Hirofumi、Matsuki Kosuke、Yamamoto Kazuhiko、Okamura Tomohisa、Fujio Keishi
- Journal Title
  
  Rheumatology
  
  Volume: - Issue: 3 Pages: 1409-1416
- DOI
  10.1093/rheumatology/keae158
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16355, KAKENHI-PROJECT-22KJ0995, KAKENHI-PROJECT-21H02960
[Journal Article] Characteristics of anti-melanoma differentiation associated gene 5 antibody-positive dermatomyositis with thrombotic microangiopathy2024
- Author(s)
  Ushijima Toshiyuki Shiki、Komai Toshihiko、Izuka Shinji、Shoda Hirofumi、Fujio Keishi
- Journal Title
  
  Modern Rheumatology
  
  Volume: - Issue: 5 Pages: 973-977
- DOI
  10.1093/mr/roae009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16355, KAKENHI-PROJECT-22KJ0995
[Journal Article] Resolution of exacerbated rheumatoid arthritis-associated interstitial lung disease under baricitinib treatment2023
- Author(s)
  Komai T、Sawada T、Tsuchiya H、Harada H、Shoda H、Fujio K
- Journal Title
  
  Scandinavian Journal of Rheumatology
  
  Volume: 53 Issue: 2 Pages: 146-148
- DOI
  10.1080/03009742.2023.2274707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16355
[Journal Article] Elevation of serum tenascin‐C levels in dermatomyositis patients2023
- Author(s)
  Nishiwaki Aya、Komai Toshihiko、Nagafuchi Yasuo、Tsuchida Yumi、Shoda Hirofumi、Fujio Keishi
- Journal Title
  
  International Journal of Rheumatic Diseases
  
  Volume: 26 Issue: 8 Pages: 1635-1639
- DOI
  10.1111/1756-185x.14659
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16355
[Journal Article] Immunomics analysis of rheumatoid arthritis identified precursor dendritic cells as a key cell subset of treatment resistance.2023
- Author(s)
  Yamada S, Nagafuchi Y, Wang M, Ota M, Hatano H, Takeshima Y, Okubo M, Kobayashi S, Sugimori Y, Masahiro N, Yoshida R, Hanata N, Suwa Y, Tsuchida Y, Iwasaki Y, Sumitomo S, Kubo K, Shimane K, Setoguchi K, Azuma T, Kanda H, Shoda H, Zhang X, Yamamoto K, Ishigaki K, Okamura T, Fujio K
- Journal Title
  
  Ann Rheum Dis
  
  Volume: Epub ahead of print Issue: 6 Pages: 1-11
- DOI
  10.1136/ard-2022-223645
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24369, KAKENHI-PROJECT-23K24373, KAKENHI-PROJECT-22K15493
[Journal Article] Transforming Growth Factor-β3 Inhibits Antibody Production by Human B Cells.2017
- Author(s)
  Tsuchida Y, Sumitomo S, Ishigaki K, Suzuki A, Kochi Y, Okamura T, Yamamoto K, Fujio K.
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 1 Pages: 1-16
- DOI
  10.1371/journal.pone.0169646
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19566, KAKENHI-PROJECT-16K15510, KAKENHI-PROJECT-15H05787
[Journal Article] The effects of TGF-βs on immune responses2016
- Author(s)
  Fujio K, Komai T, Inoue M, Morita K, Okamura T, Yamamoto K.
- Journal Title
  
  Japanese Journal of Clinical Immunology
  
  Volume: 39 Issue: 1 Pages: 51-58
- DOI
  10.2177/jsci.39.51
- NAID
  130005151098
- ISSN
  0911-4300, 1349-7413
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09918, KAKENHI-PROJECT-16K15510
[Presentation] Development of interstitial pneumonia with autoimmune features in conditional Tgfb3 deletion2023
- Author(s)
  Toshihiko Komai, Tomohisa Okamura, Masanori Kono, Kazuhiko Yamamoto, Keishi Fujio
- Organizer
  ACR (American College of Rheumatology) Convergence 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16355
[Presentation] 自己免疫性間質性肺炎の病態制御におけるTGF-β3の役割の解明2023
- Author(s)
  駒井俊彦, 岡村僚久, 河野正憲, 山本一彦, 藤尾圭志
- Organizer
  第10回JCRベーシックリサーチカンファレンス
- Data Source
  KAKENHI-PROJECT-22K16355
[Presentation] Immunophenotypic Categorization: A New Approach to Systemic Immune-Mediated Diseases.2023
- Author(s)
  Izuka Shinji, Toshihiko Komai, Takahiro Itamiya, Mineto Ota, Saeko Yamada, Yasuo Nagafuchi, Hirofumi Shoda, Kosuke Matsuki, Kazuhiko Yamamoto, Tomohisa Okamura, Keishi Fujio
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24369
[Presentation] Recategorization of systemic immune-mediated diseases by immunophenotyping2022
- Author(s)
  Izuka Shinji, Toshihiko Komai, Takahiro Itamiya, Mineto Ota, Saeko Yamada, Yasuo Nagafuchi, Hirofumi Shoda, Kosuke Matsuki, Kazuhiko Yamamoto, Tomohisa Okamura, Keishi Fujio
- Organizer
  APLAR 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24369
[Presentation] アルギニンセンサーCastor1の全身性免疫応答における役割の解明2022
- Author(s)
  楠田　岳, 駒井　俊彦, 岡村　僚久, 藤尾　圭志
- Organizer
  第7回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-23K24369
[Presentation] Immunophenotypic categorization of systemic immune-mediated diseases2022
- Author(s)
  Izuka Shinji, Toshihiko Komai, Takahiro Itamiya, Mineto Ota, Yasuo Nagafuchi, Hirofumi Shoda, Kazuhiko Yamamoto, Tomohisa Okamura, Keishi Fujio
- Organizer
  American College of Rheumatology convergence 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24369
[Presentation] Immunological functions of Castor1 in B cells2022
- Author(s)
  Takeshi Kusuda, Toshihiko Komai, Tomohisa Okamura, Keishi Fujio
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24369
[Presentation] 末梢血免疫担当細胞による自己免疫疾患層別化の試み2022
- Author(s)
  猪塚真志, 駒井俊彦, 板宮孝紘, 太田峰人, 山田紗依子, 永渕泰雄, 庄田宏文, 松木康祐, 山本一彦, 岡村僚久, 藤尾圭志
- Organizer
  第9回JCRベーシックリサーチカンファレンス
- Data Source
  KAKENHI-PROJECT-23K24369
[Presentation] Analysis of class-switching to IgG4 in memory B cell subsets of IgG4-Related Disease2021
- Author(s)
  Aya Nishiwaki, Toshihiko Komai1 Yasuo Nagafuchi, Mineto Ota1, Ryochi Yoshida, Hiroaki Hatano, Haruka Tsuchiya, Saeko Yamada, Masahiro Nakano, Mai Okubo, Satomi Kobayashi, Yusuke Sugimori, Yusuke Takeshima, Yukiko Iwasaki, Shuji Sumitomo, Hirofumi Shoda, Kazuhiko Yamamoto, Tomohisa Okamura, and Keishi Fujio
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] IgG4関連疾患におけるトランスクリプトーム解析とBCRレパトア解析2021
- Author(s)
  西脇　彩, 駒井　俊彦, 岡村　僚久, 吉田　良知, 波多野　裕明, 大久保　麻衣, 小林　聖未, 杉森　祐介, 中野　正博, 竹島　雄介, 太田　峰人, 土屋　遥香, 永渕　泰雄, 岩崎由希子, 住友秀次, 庄田　宏文, 山本　一彦, 藤尾　圭志
- Organizer
  第6回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] CASTOR1の液性免疫における役割の同定2021
- Author(s)
  楠田　岳, 駒井　俊彦, 岡村　僚久, 藤尾　圭志
- Organizer
  第49回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] IgG4関連疾患における末梢血免疫担当細胞のサブセットの検討2020
- Author(s)
  西脇　彩, 駒井　俊彦, 岡村　僚久, 吉田　良知, 波多野　裕明, 太田　峰人,　永渕　泰雄,　土屋　遥香,　山田紗依子, 中野　正博, 大久保　麻衣, 小林　聖未, 杉森　祐介, 竹島　雄介, 岩崎由希子, 住友秀次, 庄田　宏文, 山本　一彦, 藤尾　圭志
- Organizer
  第48回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] Protective roles of TGF-β3 in interstitial pneumonia with autoimmune features2020
- Author(s)
  Toshihiko Komai, Tomohisa Okamura, Ryochi Yoshida, Kazuhiko Yamamoto, Keishi Fujio
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] Immunophenotypic analysis of peripheral blood mononuclear cells in IgG4-Related Disease2020
- Author(s)
  Aya Nishiwaki, Toshihiko Komai, Tomohisa Okamura, Ryochi Yoshida, Hiroaki Hatano, Mineto Ota, Yasuo Nagafuchi, Haruka Tsuchiya, Saeko Yamada, Masahiro Nakano, Mai Okubo1, Satomi Kobayashi1, Yusuke Sugimori, Yusuke Takeshima, Yukiko Iwasaki, Shuji Sumitomo, Hirofumi Shoda, Kazuhiko Yamamoto, Keishi Fujio
- Organizer
  22th Asia-Pacific League of Associations for Rheumatology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] Jazf1遺伝子はLAG3+ TregからのIL-10産生を負に制御する2019
- Author(s)
  河野正憲, 岡村僚久, 駒井俊彦, 井上眞璃子, 岩崎由希子, 住友秀次, 庄田宏文, 山本一彦, 藤尾圭志
- Organizer
  第47回日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] Inhibitory cytokine synergy of IL-10 and TGF-β3 contributes to humoral immune tolerance mediated by metabolic reprogramming2019
- Author(s)
  Toshihiko Komai, Tomohisa Okamura, Mariko Inoue, Morita Kaoru, Yukiko Iwasaki, Shuji Sumitomo, Hirofumi Shoda, Kazuhiko Yamamoto, and Keishi Fujio
- Organizer
  第63回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] 抑制性サイトカイン協調によるB細胞の免疫代謝リプログラミング2019
- Author(s)
  駒井俊彦, 岡村　僚久, 井上眞璃子, 岩崎由希子, 住友秀次, 庄田宏文, 山本一彦, 藤尾圭志
- Organizer
  第68回アレルギー学会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] The role of Jazf1 in the production of IL-10 in Tr1 cells2019
- Author(s)
  Masanori Kono, Tomohisa Okamura1, Mariko Inoue, Toshihiko Komai, Yukiko Iwasaki, Yusuke Takeshima, Shuji Sumitomo, Hirofumi Shoda, Kazuhiko Yamamoto, and Keishi Fujio
- Organizer
  第63回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] Jazf1遺伝子はTr1細胞におけるIL-10産生を制御する2019
- Author(s)
  河野正憲, 岡村僚久, 駒井俊彦, 井上眞璃子, 岩崎由希子, 住友秀次, 庄田宏文, 山本一彦, 藤尾圭志
- Organizer
  第5回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] CD4陽性T細胞における転写因子Klf1を介したPD-L1発現誘導機構2017
- Author(s)
  照屋周造、岡村僚久、竹島雄介、駒井俊彦、井上真璃子、岩崎由希子、山本一彦、藤尾圭志
- Organizer
  第45回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K15510
[Presentation] B細胞を抑制するCD4陽性CD25陰性LAG3陽性制御性T細胞2016
- Author(s)
  藤尾圭志、岡村僚久、駒井俊彦、井上眞璃子、森田薫、住友秀次、山本一彦
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Year and Date
  2016-04-21
- Invited
- Data Source
  KAKENHI-PROJECT-16K15510
[Presentation] TGF-β3およびIL-10による協調性液性免疫制御機構の解明2016
- Author(s)
  井上眞璃子、岡村僚久、駒井俊彦、森田薫、照屋周造、岩崎由希子、住友秀次、山本一彦、藤尾圭志
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-16K15510

1. OKAMURA Tomohisa (10528996)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
2. Fujio Keishi (70401114)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
3. INOUE MARIKO (60816601)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 住友秀次 (20392996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
5. MORITA KAORU

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. TERUYA SHUZO

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. TSUCHIDA Yumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Komai Toshihiko 駒井 俊彦

KOMAI TOSHIHIKO 駒井 俊彦

Research Projects

Research Products

Co-Researchers

Elucidating the Role of Novel Aging-Associated ThA Cells in the Pathogenesis of Systemic Lupus Erythematosus

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

全身性強皮症の病態制御におけるTGF-β3の役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Single-cell multiome profiling and functional analysis of human age-associated T cells in autoimmune diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Verification of humoral immune regulation mediated by arginine sensor GATSL3Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of pathogenesis of autoimmune-mediated interstitial lung disease based on epigenomic analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Inhibitory cytokine-producing Treg-mediated control of autoimmunity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Machine learning-driven immunophenotypic stratification of mixed connective tissue disease, corroborating the clinical heterogeneity2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characteristics of anti-melanoma differentiation associated gene 5 antibody-positive dermatomyositis with thrombotic microangiopathy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Resolution of exacerbated rheumatoid arthritis-associated interstitial lung disease under baricitinib treatment2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elevation of serum tenascin‐C levels in dermatomyositis patients2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunomics analysis of rheumatoid arthritis identified precursor dendritic cells as a key cell subset of treatment resistance.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transforming Growth Factor-β3 Inhibits Antibody Production by Human B Cells.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The effects of TGF-βs on immune responses2016

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Presentation] Development of interstitial pneumonia with autoimmune features in conditional Tgfb3 deletion2023

Komai Toshihiko 駒井俊彦

KOMAI TOSHIHIKO 駒井俊彦