Makino Hiroto 牧野紘士

… Alternative Names

MAKINO HIROTO 牧野紘士

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Researcher Number	50816022
Other IDs
Affiliation (Current)	2025: 富山大学, 学術研究部医学系, 助教
Affiliation (based on the past Project Information) *help	2023: 富山大学, 学術研究部医学系, 助教 2022: 富山大学, 附属病院, 助教 2018 – 2022: 富山大学, 附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related Except Principal Investigator Basic Section 56020:Orthopedics-related
Keywords	Principal Investigator c-Fos / 破骨細胞 / 脊椎 / 骨性欠損 / 椎体終板 / 椎間板 / 変形性脊椎症 / 黄色靭帯肥厚 / 疼痛 / 椎間板変性 … More Except Principal Investigator … More 椎間板再生 / 髄核細胞 / iPS細胞 / sc-RNA seq / spine / intervertebral disc / 線維輪細胞 / CILP / c-fos/AP-1 / .脊椎椎間板 / c-fos/AP-1阻害薬 / トランスジェニックマウス / 椎間板変性 / 細胞治療 / 再生治療 / ダイレクトリプログラミング / 思春期特発性側弯症 / 黄色靭帯 / 椎間板 / 脊椎 / 再生医学 / 関節病学 / 線維化 / 線維化抑制 / 細胞外マトリックス / 生体材料 / 羊膜 / 軟骨再生 Less

sc-RNAseq解析での高純度細胞体による椎間板再生とc-fos/AP-1阻害薬の疼痛制御機構
- Principal Investigator
  
  関庄二
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  University of Toyama
Development of molecular-targeted therapies for pain control on inhibiting porosity of the vertebral endplate and bone lossPrincipal Investigator
- Principal Investigator
  
  Makino Hiroto
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  University of Toyama
Regeneration of intervertebral disc and control of low back pain with selective inhibitor of c-fos/AP-1
- Principal Investigator
  
  Seki Shoji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  University of Toyama
Elucidative study to calarify the antifibrotic effect of amniotic extra-cellular matrix coated scaffold in cartilage regeneration.
- Principal Investigator
  
  Nogami Makiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  University of Toyama
Development of molecular-targeted therapies for degenerative spondylosis and painPrincipal Investigator
- Principal Investigator
  
  MAKINO HIROTO
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  University of Toyama

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Association of Inflammation, Ectopic Bone Formation, and Sacroiliac Joint Variation in Ossification of the Posterior Longitudinal Ligament2023
- Author(s)
  Tung Nguyen Tran Canh、He Zhongyuan、Makino Hiroto、Yasuda Taketoshi、Seki Shoji、Suzuki Kayo、Watanabe Kenta、Futakawa Hayato、Kamei Katsuhiko、Kawaguchi Yoshiharu
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 12 Issue: 1 Pages: 349-349
- DOI
  10.3390/jcm12010349
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16679
[Journal Article] Association between serum interleukin-17 levels and ectopic bone formation in OPLL patients with DISH2023
- Author(s)
  He Z, Tung NTC, Yahara Y, Makino H, Yasuda T, Seki S, Suzuki K, Futakawa H, Kamei K, Kawaguchi Y.
- Journal Title
  
  Rheumatology (Oxford) .
  
  Volume: 555 Issue: 8 Pages: 555-555
- DOI
  10.1093/rheumatology/kead555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08695, KAKENHI-PROJECT-22K19289, KAKENHI-PROJECT-23K23893
[Journal Article] Morphological characteristics of DISH in patients with OPLL and its association with high-sensitivity CRP: inflammatory DISH2022
- Author(s)
  Nguyen Tran Canh Tung、Yahara Yasuhito、Yasuda Taketoshi、Seki Shoji、Suzuki Kayo、Watanabe Kenta、Makino Hiroto、Kamei Katsuhiko、Mori Kanji、Kawaguchi Yoshiharu
- Journal Title
  
  Rheumatology
  
  Volume: 61 Issue: 10 Pages: 3981-3988
- DOI
  10.1093/rheumatology/keac051
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16679, KAKENHI-PROJECT-23K23893
[Journal Article] Efficacy of surgeon-directed postoperative local injection with an analgesic mixture in posterior fusion surgery for adolescent idiopathic scoliosis2022
- Author(s)
  Makino Hiroto、Seki Shoji、Kamei Katsuhiko、Yahara Yasuhito、Kawaguchi Yoshiharu
- Journal Title
  
  BMC Musculoskeletal Disorders
  
  Volume: 23 Issue: 1
- DOI
  10.1186/s12891-022-05158-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16679
[Journal Article] Association of Ligamentum Flavum Hypertrophy with Adolescent Idiopathic Scoliosis Progression-Comparative Microarray Gene Expression Analysis2022
- Author(s)
  Seki S, Iwasaki M, Makino H, Yahara Y, Kondo M, Kamei K, Futakawa H, Nogami M, Watanabe K, Tran Canh Tung N, Hirokawa T, Tsuji M, Kawaguchi Y.
- Journal Title
  
  Int J Mol Sci .
  
  Volume: 23 Issue: 9 Pages: 5038-5038
- DOI
  10.3390/ijms23095038
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03801, KAKENHI-PROJECT-21K16679, KAKENHI-PROJECT-23K23893
[Journal Article] Direct Reprogramming and Induction of Human Dermal Fibroblasts to Differentiate into iPS-Derived Nucleus Pulposus-like Cells in 3D Culture2022
- Author(s)
  Seki Shoji、Iwasaki Mami、Makino Hiroto、Yahara Yasuhito、Miyazaki Yoshitaka、Kamei Katsuhiko、Futakawa Hayato、Nogami Makiko、Tran Canh Tung Nguyen、Hirokawa Tatsuro、Tsuji Mamiko、Kawaguchi Yoshiharu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 7 Pages: 4059-4059
- DOI
  10.3390/ijms23074059
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03801, KAKENHI-PROJECT-21K16679
[Journal Article] Surgery for L5 radiculopathy with lumbosacral transitional vertebrae2021
- Author(s)
  牧野紘士、関庄二、安田剛敏、亀井克彦、川口善治
- Journal Title
  
  The Central Japan Journal of Orthopaedic Surgery & Traumatology
  
  Volume: 64 Issue: 2 Pages: 249-250
- DOI
  10.11359/chubu.2021.249
- NAID
  130008075693
- ISSN
  0008-9443, 1349-0885
- Year and Date
  2021-03-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K16679
[Journal Article] Effect of hyperdry amniotic membrane in preventing tendon adhesion in a rabbit model2021
- Author(s)
  Zukawa Mineyuki、Okabe Motonori、Osada Ryusuke、Makino Hiroto、Nogami Makiko、Seki Shoji、Yoshida Toshiko、Kimura Tomoatsu、Kawaguchi Yoshiharu
- Journal Title
  
  Journal of Orthopaedic Science
  
  Volume: ‐ Issue: 3 Pages: 707-712
- DOI
  10.1016/j.jos.2021.03.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09618, KAKENHI-PROJECT-22K19557, KAKENHI-PROJECT-20K12642
[Journal Article] 特集脊椎脊髄疾患に対する分類･評価法第3章　腰椎 JOABPEQ2020
- Author(s)
  牧野紘士、川口善治
- Journal Title
  
  脊椎脊髄ジャーナル
  
  Volume: 33 Issue: 4 Pages: 374-376
- DOI
  10.11477/mf.5002201373
- ISSN
  0914-4412
- Year and Date
  2020-04-25
- Data Source
  KAKENHI-PROJECT-18K16613
[Journal Article] Sacroiliac joint variation associated with diffuse idiopathic skeletal hyperostosis2020
- Author(s)
  Yahara Yasuhito、Yasuda Taketoshi、Kawaguchi Yoshiharu、Suzuki Kayo、Seki Shoji、Kondo Miho、Makino Hiroto、Kamei Katsuhiko、Kanamori Masahiko、Kimura Tomoatsu
- Journal Title
  
  BMC Musculoskeletal Disorders
  
  Volume: 21 Issue: 1
- DOI
  10.1186/s12891-020-3105-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16613
[Journal Article] Progressive paravertebral ligament ossification and pseudoarthrosis in the thoracic spine due to loss of function of the PHEX gene in a patient with X-linked hypophosphatemic rickets2020
- Author(s)
  Yahara Yasuhito、Niimi Hideki、Sugie Nana、Seki Shoji、Ueshima Ryo、Makino Hiroto、Kamei Katsuhiko、Kitajima Isao、Kawaguchi Yoshiharu
- Journal Title
  
  Journal of Orthopaedic Science
  
  Volume: - Issue: 1 Pages: 295-298
- DOI
  10.1016/j.jos.2020.06.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16613
[Journal Article] 特集周術期の疼痛管理･神経ブロックUpdate 脊椎手術後疼痛:周術期疼痛管理を中心に2020
- Author(s)
  牧野紘士、川口善治
- Journal Title
  
  関節外科　基礎と臨床
  
  Volume: 39 Issue: 7 Pages: 781-784
- DOI
  10.18885/JJS.0000000339
- ISSN
  0286-5394
- Year and Date
  2020-07-19
- Data Source
  KAKENHI-PROJECT-18K16613
[Journal Article] Increase of the Serum FGF-23 in Ossification of the Posterior Longitudinal Ligament2019
- Author(s)
  Kawaguchi Y, Kitajima I, Nakano M, Yasuda T, Seki S, Suzuki K, Yahara Y, Makino H, Ujihara Y, Ueno T, Kimura T
- Journal Title
  
  Global Spine J
  
  Volume: 9 Pages: 492-498
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16613
[Journal Article] Differential rod contouring on thoracolumbar/lumbar curvature in patients with adolescent idiopathic scoliosis: An analysis with intraoperative acquisition of three-dimensional imaging2019
- Author(s)
  Seki S, Yahara Y, Makino H, Kobayashi K, Nakano M, Hirano N, Watanabe K, Takahashi J, Kawaguchi Y, Kimura T
- Journal Title
  
  J Orthop Sci
  
  Volume: 24 Pages: 780-786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16613
[Journal Article] Differential proteome analysis in adolescent idiopathic scoliosis patients with thoracolumbar/lumbar curvatures2019
- Author(s)
  Makino H, Seki S, Kitajima I, Motomura H, Nogami M, Yahara Y, Ejiri N, Kimura T
- Journal Title
  
  BMC Musculoskeletal Disorders
  
  Volume: 20 Issue: 1
- DOI
  10.1186/s12891-019-2640-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16613
[Journal Article] Clinical Impact of Ossification of the Posterior Longitudinal Ligament Progression After Cervical Laminoplasty2019
- Author(s)
  Kawaguchi Y, Nakano M, Yasuda T, Seki S, Suzuki K, Yahara Y, Makino H, Kobayashi K, Kanamori M, Kimura T
- Journal Title
  
  Clin Spine Surg
  
  Volume: 32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16613
[Journal Article] Clinical impact of ossification of the posterior longitudinal ligament progression after cervical laminoplasty2019
- Author(s)
  Kawaguchi Y, Nakano M, Yasuda T, Seki S, Suzuki K, Yahara Y, Makino H, Kobayashi K, Kanamori M, Kimura T
- Journal Title
  
  Clinical Spine Surgery
  
  Volume: 32 Issue: 3 Pages: E133-E139
- DOI
  10.1097/bsd.0000000000000747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16613, KAKENHI-PROJECT-16K10815, KAKENHI-PROJECT-16K10816
[Journal Article] Three-Dimensional Computed Tomography Analysis of Spinal Canal Length Increase After Surgery for Adolescent Idiopathic Scoliosis: A Multicenter Study2019
- Author(s)
  Yahara Y, Seki S, Makino H, Watanabe K, Uehara M, Takahashi J, Kimura T
- Journal Title
  
  J Bone Joint Surg Am
  
  Volume: 101 Pages: 48-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16613
[Journal Article] The effect of multiple lesions in patients with ossification of the posterior longitudinal ligament of the cervical spine2018
- Author(s)
  Kawaguchi Y, Nakano M, Yasuda T, Seki S, Suzuki K, Yahara Y, Makino H, Kobayashi K, Kanamori M, Kimura T
- Journal Title
  
  Journal of Orthopaedic Science
  
  Volume: Epub ahead of print Issue: 3 Pages: 420-425
- DOI
  10.1016/j.jos.2018.11.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16613, KAKENHI-PROJECT-16K10815, KAKENHI-PROJECT-16K10816
[Journal Article] Lumbar spine surgery in patients with rheumatoid arthritis (RA): what affects the outcomes?2018
- Author(s)
  Seki Shoji、Hirano Norikazu、Matsushita Isao、Kawaguchi Yoshiharu、Nakano Masato、Yasuda Taketoshi、Motomura Hiraku、Suzuki Kayo、Yahara Yasuhito、Watanabe Kenta、Makino Hiroto、Kimura Tomoatsu
- Journal Title
  
  The Spine Journal
  
  Volume: 18 Issue: 1 Pages: 99-106
- DOI
  10.1016/j.spinee.2017.06.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10816, KAKENHI-PROJECT-18K16613
[Presentation] ダイレクトリプログラミング法によるヒト皮膚細胞から髄核細胞への分化誘導2023
- Author(s)
  関　庄二、牧野紘士、箭原康人、亀井克彦、二川隼人、野上真紀子、Nguyen Tran Canh Tung、廣川達郎、岩崎真美、辻真美子、宮崎義孝、川口善治
- Organizer
  日本軟骨代謝学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03801
[Presentation] 特発性側弯症患者における頂椎部黄色靭帯肥厚に着目した進行メカニズムの解明2022
- Author(s)
  関　庄二、牧野紘士、箭原康人、野上真紀子、渡邉健太、近藤美穂、亀井克彦、二川隼人、廣川達郎、岩崎真美、Nguyen Tran Canh Tung、川口善治
- Organizer
  日本整形外科基礎学術集会
- Data Source
  KAKENHI-PROJECT-20H03801
[Presentation] 腰部脊柱管狭窄症におけるSkip lesionに関連する因子の検討2021
- Author(s)
  牧野紘士, 関庄二, 安田剛敏, 鈴木賀代, 箭原康人, 渡邉健太, 亀井克彦, 川口善治
- Organizer
  第50回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-21K16679
[Presentation] 腰仙移行椎に伴ったL5神経根障害に対する手術加療の経験2020
- Author(s)
  牧野紘士, 関庄二, 安田剛敏, 箭原康人, 亀井克彦, 川口善治
- Organizer
  第135回中部日本整形外科災害外科学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16613
[Presentation] 思春期特発性側彎症患者における黄色靱帯肥厚のメカニズムの検討2020
- Author(s)
  関庄二, 近藤美穂, 牧野紘士, 亀井克彦, 箭原康人, 野上真紀子, 渡邉健太, 川口善治
- Organizer
  第35回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-18K16613
[Presentation] 特発性側彎症に対する後方矯正固定術における局所カクテル注射の術後鎮痛効果2020
- Author(s)
  牧野紘士, 関庄二, 箭原康人, 亀井克彦, 安田剛敏, 鈴木賀代, 川口善治
- Organizer
  第93回日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-18K16613
[Presentation] 腰部脊柱管狭窄症における脊柱管内の骨化・石灰化病変の関与2019
- Author(s)
  Makino H, Seki S, Kawaguchi Y, Yasuda Y, Suzuki K, Watanabe K, Kimura T
- Organizer
  第92回日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-18K16613
[Presentation] AISに対する後方矯正固定術後早期における身体活動状況の前向き調査2019
- Author(s)
  牧野紘士, 関庄二, 下条竜一, 川口善治
- Organizer
  第30回日本臨床スポーツ医学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16613
[Presentation] 特発性側弯症に対する後方矯正固定術における局所カクテル注射の術後鎮痛効果2019
- Author(s)
  牧野紘士、関庄二、亀井克彦、箭原康人、近藤美穂、川口善治、安田剛敏、木村友厚
- Organizer
  第53回日本側彎症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16613
[Presentation] AISに対する後方矯正固定術後超早期における身体活動状況の前向き調査2018
- Author(s)
  牧野紘士，関　庄二，川口善治，小林賢司，亀井克彦，木村友厚
- Organizer
  第52回日本側彎症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16613
[Presentation] Coronal MRI analysis of angular deformity of nerve roots in patients with lumbar foraminal stenosis2018
- Author(s)
  Makino H, Seki S, Kawaguchi Y, Yasuda Y, Suzuki K, Watanabe K, Kimura T
- Organizer
  ORS 2018 Annual meeting
- Data Source
  KAKENHI-PROJECT-18K16613
[Presentation] 椎間板変性および椎間板関連の疼痛に対する選択的c-Fos/AP-1阻害の治療効果2018
- Author(s)
  牧野紘士，関　庄二，箭原康人，塩沢俊一，妻木範行，木村友厚
- Organizer
  第131回中部日本整形外科災害外科学会・学術集会
- Data Source
  KAKENHI-PROJECT-18K16613
[Presentation] 脊椎手術における手術創感染（SSI）に対する予防的バンコマイシン（VCM）の投与法に関する検討2018
- Author(s)
  牧野紘士，関　庄二，川口善治，安田剛敏，鈴木賀代，木村友厚
- Organizer
  第130回中部日本整形外科災害外科学会・学術集会
- Data Source
  KAKENHI-PROJECT-18K16613
[Presentation] 骨形態における非リウマチ性上位頸髄障害に対する危険因子の検討2018
- Author(s)
  牧野紘士，川口善治，安田剛敏，関　庄二，鈴木賀代，箭原康人，小林賢司，木村友厚
- Organizer
  第47回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16613

1. Seki Shoji (00432112)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. Nogami Makiko (30750202)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. 箭原康人 (60456390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. 川口善治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Makino Hiroto 牧野 紘士

MAKINO HIROTO 牧野 紘士

Research Projects

Research Products

Co-Researchers

sc-RNAseq解析での高純度細胞体による椎間板再生とc-fos/AP-1阻害薬の疼痛制御機構

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of molecular-targeted therapies for pain control on inhibiting porosity of the vertebral endplate and bone lossPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regeneration of intervertebral disc and control of low back pain with selective inhibitor of c-fos/AP-1

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidative study to calarify the antifibrotic effect of amniotic extra-cellular matrix coated scaffold in cartilage regeneration.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of molecular-targeted therapies for degenerative spondylosis and painPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Association of Inflammation, Ectopic Bone Formation, and Sacroiliac Joint Variation in Ossification of the Posterior Longitudinal Ligament2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association between serum interleukin-17 levels and ectopic bone formation in OPLL patients with DISH2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Morphological characteristics of DISH in patients with OPLL and its association with high-sensitivity CRP: inflammatory DISH2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficacy of surgeon-directed postoperative local injection with an analgesic mixture in posterior fusion surgery for adolescent idiopathic scoliosis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of Ligamentum Flavum Hypertrophy with Adolescent Idiopathic Scoliosis Progression-Comparative Microarray Gene Expression Analysis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Direct Reprogramming and Induction of Human Dermal Fibroblasts to Differentiate into iPS-Derived Nucleus Pulposus-like Cells in 3D Culture2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Surgery for L5 radiculopathy with lumbosacral transitional vertebrae2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Effect of hyperdry amniotic membrane in preventing tendon adhesion in a rabbit model2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 特集 脊椎脊髄疾患に対する分類･評価法 第3章 腰椎 JOABPEQ2020

Makino Hiroto 牧野紘士

MAKINO HIROTO 牧野紘士

[Journal Article] 特集脊椎脊髄疾患に対する分類･評価法第3章　腰椎 JOABPEQ2020

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