mandai shintaro 萬代新太郎

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Mandai Shintaro 萬代新太郎

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Researcher Number	50824330
Other IDs
Affiliation (Current)	2026: 東京科学大学, 大学院医歯学総合研究科, 准教授
Affiliation (based on the past Project Information) *help	2026: 東京科学大学, 大学院医歯学総合研究科, 准教授 2024: 東京医科歯科大学, 大学院医歯学総合研究科, テニュアトラック准教授 2024: 東京科学大学, 大学院医歯学総合研究科, 准教授 2022 – 2023: 東京医科歯科大学, 東京医科歯科大学病院, 助教 2020 – 2021: 東京医科歯科大学, 医学部附属病院, 助教 2019: 東京医科歯科大学, 医学部附属病院, 特任助教 2018: 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related / Medium-sized Section 52:General internal medicine and related fields / 0902:General internal medicine and related fields
Keywords	Principal Investigator 慢性腎臓病 / 老化 / サルコペニア / 骨格筋 / アルツハイマー病 / タウ / 血液脳関門 / 認知症 / 腎性老化 / 細胞外小胞 … More / リン酸化 / 腎臓 / WNK / シグナル伝達 / WNKキナーゼ Less

腎性老化を惹起する不良化細胞外小胞の分子機序の解明：透析代替薬創製を目指してPrincipal Investigator
- Principal Investigator
  
  萬代新太郎
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Institute of Science Tokyo
Elucidating the mechanism of blood-brain barrier breakdown and cognitive dysfunction in chronic kidney diseasePrincipal Investigator
- Principal Investigator
  
  萬代新太郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Institute of Science Tokyo
Elucidating the Mechanism of Sarcopenia and Renal Senescence via Chronic Kidney Disease-Derived Extracellular VesiclesPrincipal Investigator
- Principal Investigator
  
  Shintaro Mandai
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Institute of Science Tokyo
  Tokyo Medical and Dental University
Biomarkers and therapeutic targets for chronic kidney disease and sarcopeniaPrincipal Investigator
- Principal Investigator
  
  Mandai Shintaro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tokyo Medical and Dental University
Identification and functional analysis of WNK kinase signaling in skeletal muscle hypertrophyPrincipal Investigator
- Principal Investigator
  
  Mandai Shintaro
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0902:General internal medicine and related fields
- Research Institution
  Tokyo Medical and Dental University

All 2025 2024 2021 2020 2018

All Journal Article Presentation

[Journal Article] Response Letter to Comment on: The Effect of Antihypertensive Therapy on Skeletal Muscle Mass and Bone Mineral Density in Patients With End-Stage Kidney Disease2025
- Author(s)
  Suzukawa Rena、Mandai Shintaro、Hashimoto Hiroko、Shikuma Satomi、Kimura Mai、Toma Hayato、Sakaguchi Yuki、Shiraishi Sayuka、Toshima Noriyuki、Hoshino Motoki、Kimura Moe、Ota Jun、Horiuchi Susumu、Adachi Susumu、Uchida Shinichi
- Journal Title
  
  Journal of Renal Nutrition
  
  Volume: Online Issue: 4 Pages: 560-561
- DOI
  10.1053/j.jrn.2025.03.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24K22093, KAKENHI-PROJECT-23K14728
[Journal Article] Development of Adult Renal Tubular Organoids from Different Human Individuals in a Single Medium2025
- Author(s)
  Mori M, Mori Y, Nakao Y, Mandai S, Fujiki T, Kikuchi H, Ando F, Susa K, Mori T, Waseda Y, Yoshida S, Fujii Y, Sohara E, Uchida S
- Journal Title
  
  JMA Journal
  
  Volume: 8 Issue: 1 Pages: 191-197
- DOI
  10.31662/jmaj.2024-0244
- ISSN
  2433-328X, 2433-3298
- Year and Date
  2025-01-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24K22093
[Journal Article] Nationwide mortality following acute type B aortic dissection and the survival advantage of obesity among dialysis patients in Japan2024
- Author(s)
  Nakano Yuta、Mandai Shintaro、Mori Yutaro、Ando Fumiaki、Susa Koichiro、Mori Takayasu、Iimori Soichiro、Naito Shotaro、Sohara Eisei、Fushimi Kiyohide、Uchida Shinichi
- Journal Title
  
  Journal of Nephrology
  
  Volume: 38 Issue: 2 Pages: 503-510
- DOI
  10.1007/s40620-024-02147-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24K22093
[Journal Article] Takayasu arteritis manifesting as acute kidney injury and congestion due to renal artery stenosis and myocarditis: a case report2024
- Author(s)
  Hara Misato、Mandai Shintaro、Mori Takayasu、Maejima Yasuhiro、Uchida Shinichi
- Journal Title
  
  European Heart Journal - Case Reports
  
  Volume: 8 Issue: 8
- DOI
  10.1093/ehjcr/ytae347
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24K22093
[Journal Article] Sex disparities in the risk of urgent dialysis following acute aortic dissections in Japan2024
- Author(s)
  Nakano Yuta、Mandai Shintaro、Takahashi Daiei、Ikenouchi Ken、Mori Yutaro、Ando Fumiaki、Susa Koichiro、Mori Takayasu、Iimori Soichiro、Naito Shotaro、Sohara Eisei、Fushimi Kiyohide、Uchida Shinichi
- Journal Title
  
  iScience
  
  Volume: 27 Issue: 8 Pages: 110577-110577
- DOI
  10.1016/j.isci.2024.110577
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24K22093
[Journal Article] Importance of IFT140 in Patients with Polycystic Kidney Disease Without a Family History2024
- Author(s)
  Fujimaru Takuya、Mori Takayasu、Sekine Akinari、Chiga Motoko、Mandai Shintaro、Kikuchi Hiroaki、Mori Yutaro、Hara Yu、Fujiki Tamami、Ando Fumiaki、Susa Koichiro、Iimori Soichiro、Naito Shotaro、Hanazawa Ryoichi、Hirakawa Akihiro、Mochizuki Toshio、Suwabe Tatsuya、Ubara Yoshifumi、Uchida Shinichi、Sohara Eisei
- Journal Title
  
  Kidney International Reports
  
  Volume: 9 Issue: 9 Pages: 2685-2694
- DOI
  10.1016/j.ekir.2024.06.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19610, KAKENHI-PROJECT-24K02465, KAKENHI-PROJECT-24K11381, KAKENHI-PROJECT-24K22093, KAKENHI-PROJECT-24K19143
[Journal Article] Vasopressin Induces Urinary Uromodulin Secretion By Activating PKA (Protein Kinase A)2021
- Author(s)
  Nanamatsu Azuma、Mori Takayasu、Ando Fumiaki、Furusho Taisuke、Mandai Shintaro、Susa Koichiro、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Hypertension
  
  Volume: epub Issue: 6 Pages: 1953-1963
- DOI
  10.1161/hypertensionaha.121.17127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17733, KAKENHI-PROJECT-19H01049, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-21H02933, KAKENHI-PROJECT-21K08249, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-20K16514
[Journal Article] Calcium-based phosphate binder use is associated with lower risk of osteoporosis in hemodialysis patients2021
- Author(s)
  Hashimoto Hiroko、Shikuma Satomi、Mandai Shintaro、Adachi Susumu、Uchida Shinichi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 1648-1648
- DOI
  10.1038/s41598-021-81287-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17276, KAKENHI-PROJECT-20K16514
[Journal Article] Genetic Background and Clinicopathologic Features of Adult-onset Nephronophthisis2021
- Author(s)
  Fujimaru Takuya、Kawanishi Kunio、et al.
- Journal Title
  
  Kidney International Reports
  
  Volume: 未定 Issue: 5 Pages: 1346-1354
- DOI
  10.1016/j.ekir.2021.02.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17730, KAKENHI-PROJECT-19K17699, KAKENHI-PROJECT-20K22926, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-20H03697, KAKENHI-PROJECT-21K08249, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-20K16514
[Journal Article] Burden of kidney disease on the discrepancy between reasons for hospital admission and death: An observational cohort study2021
- Author(s)
  Mandai Shintaro、Ando Fumiaki、Mori Takayasu、Susa Koichiro、Iimori Soichiro、Naito Shotaro、Sohara Eisei、Uchida Shinichi、Fushimi Kiyohide、Rai Tatemitsu
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 11 Pages: 0258846-0258846
- DOI
  10.1371/journal.pone.0258846
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-20K16514
[Journal Article] Severe Dialysis-Related Amyloidosis Spared the Brain: An Autopsy Case of a Patient Receiving Hemodialysis for 41 Years.2021
- Author(s)
  Mandai S, Yamada T, Uchihara T, Iida T, Ito T, Sato H, Sato K, Chida Y, Hirokawa K, Noda Y
- Journal Title
  
  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
  
  Volume: 80 Issue: 10 Pages: 997-999
- DOI
  10.1093/jnen/nlab022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03555, KAKENHI-PROJECT-20K16514
[Journal Article] Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD2 in the kidney2021
- Author(s)
  Takahashi Naohiro、Kikuchi Hiroaki、Usui Ayaka、Furusho Taisuke、Fujimaru Takuya、Fujiki Tamami、Yanagi Tomoki、Matsuura Yoshiaki、Asano Kenichi、Yamamoto Kouhei、Ando Fumiaki、Susa Koichiro、Mandai Shintaro、Mori Takayasu、Rai Tatemitsu、Uchida Shinichi、Arita Makoto、Sohara Eisei
- Journal Title
  
  Clinical and Experimental Nephrology
  
  Volume: 25 Issue: 5 Pages: 445-455
- DOI
  10.1007/s10157-021-02021-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00495, KAKENHI-PROJECT-19H01049, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-21K06877, KAKENHI-PROJECT-21K16181, KAKENHI-PROJECT-21K20710, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-20K16514
[Journal Article] Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease2020
- Author(s)
  Furusho T, Sohara E, Mandai S, Kikuchi H, Takahashi N, Fujimaru T, Hashimoto H, Arai Y, Ando F, Zeniya M, Mori T, Susa K, Isobe K, Nomura N, Yamamoto K, Okado T, Rai T, Uchida S
- Journal Title
  
  Kidney International
  
  Volume: 97 Issue: 4 Pages: 713-727
- DOI
  10.1016/j.kint.2019.11.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-19K21299, KAKENHI-PROJECT-20K17244, KAKENHI-PROJECT-20K17276, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-20K16514
[Journal Article] WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO42018
- Author(s)
  Mandai S, Mori T, Nomura N, Furusho T, Arai Y, Kikuchi H, Sasaki E, Sohara E, Rai T, Uchida S
- Journal Title
  
  Scientific reports
  
  Volume: 8 Issue: 1 Pages: 9101-9101
- DOI
  10.1038/s41598-018-27414-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-19K21299, KAKENHI-PROJECT-16K09642
[Presentation] WNK1キナーゼはFOXO4の細胞核内局在、転写活性を調節し、骨格筋肥大を制御する2018
- Author(s)
  萬代新太郎, 森崇寧, 野村尚弘, 古荘泰佑, 新井洋平, 菊池寛昭, 佐々木絵美, 蘇原映誠, 頼建光, 内田信一
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19K21299
[Presentation] WNK1 Regulates Skeletal Muscle Hypertrophy by Modulating Phosphorylation, Nuclear Localization, and Transcriptional Activity of FoxO42018
- Author(s)
  Mandai Shintaro、Mori Takayasu、Nomura Naohiro、Furusho Taisuke、Arai Yohei、Kikuchi Hiroaki、Sasaki Emi、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
- Organizer
  The 51th Annual Meeting of the American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21299

1. 森崇寧

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 橋本博子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 内田信一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 菊池寛昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 川西邦夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 頼建光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 内原俊記

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 有田誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

mandai shintaro 萬代 新太郎

Mandai Shintaro 萬代 新太郎

Research Projects

Research Products

Co-Researchers

腎性老化を惹起する不良化細胞外小胞の分子機序の解明：透析代替薬創製を目指してPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the mechanism of blood-brain barrier breakdown and cognitive dysfunction in chronic kidney diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the Mechanism of Sarcopenia and Renal Senescence via Chronic Kidney Disease-Derived Extracellular VesiclesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Biomarkers and therapeutic targets for chronic kidney disease and sarcopeniaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification and functional analysis of WNK kinase signaling in skeletal muscle hypertrophyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Response Letter to Comment on: The Effect of Antihypertensive Therapy on Skeletal Muscle Mass and Bone Mineral Density in Patients With End-Stage Kidney Disease2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of Adult Renal Tubular Organoids from Different Human Individuals in a Single Medium2025

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Nationwide mortality following acute type B aortic dissection and the survival advantage of obesity among dialysis patients in Japan2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Takayasu arteritis manifesting as acute kidney injury and congestion due to renal artery stenosis and myocarditis: a case report2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sex disparities in the risk of urgent dialysis following acute aortic dissections in Japan2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Importance of IFT140 in Patients with Polycystic Kidney Disease Without a Family History2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vasopressin Induces Urinary Uromodulin Secretion By Activating PKA (Protein Kinase A)2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Calcium-based phosphate binder use is associated with lower risk of osteoporosis in hemodialysis patients2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic Background and Clinicopathologic Features of Adult-onset Nephronophthisis2021

Author(s)

mandai shintaro 萬代新太郎

Mandai Shintaro 萬代新太郎