Furuhashi Kazuhiro 古橋和拡

Researcher Number	50835121
Other IDs
Affiliation (Current)	2025: 名古屋大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2024 – 2025: 名古屋大学, 医学部附属病院, 講師 2021 – 2024: 名古屋大学, 医学部附属病院, 病院講師 2020 – 2021: 名古屋大学, 医学部附属病院, 助教 2019: 名古屋大学, 医学部附属病院, 病院助教
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related / Medium-sized Section 53:Organ-based internal medicine and related fields Except Principal Investigator Basic Section 53040:Nephrology-related / Basic Section 56010:Neurosurgery-related / Medium-sized Section 53:Organ-based internal medicine and related fields
Keywords	Principal Investigator 腎臓 / 間葉系幹細胞 / iPS細胞 / 空間トランスクリプトーム / 細胞外小胞 / 遺伝子編集 / 腎臓内科 / 医療工学 / 再生医療 / マクロファージ … More / 免疫 / ポドサイト / 再生 / 中空糸膜カラム … More Except Principal Investigator 間葉系幹細胞 / 腎線維化 / 神経再生 / ヒト由来歯髄幹細胞 / Neurod4 / 難治性腎疾患 / 人工多能性幹細胞 / 腎臓 / Exosomes / エクソソーム / 半月体形成性糸球体腎炎 / LncRNA / B細胞 / AKI / 虚血性腎障害 / AKI to CKD transition / ナノパーティクル / 制御性B細胞 / リンパ節 / バイオイメージング / 歯髄幹細胞 / 脊髄損傷 / TGF-β / マクロファージ / 下肢運動機能 / MCP-1 / M2マクロファージ / 損傷脊髄再生 / 免疫制御 / 神経転写因子 / 乳歯由来歯髄幹細胞 / immunomodulation / M2 macrophage / SHED / 血管内皮細胞 / エクリズマブ / EVs / 血栓性微小血管症 / 補体 / sEVs / aHUS / 非典型溶血性尿毒症症候群 / 糖尿病性腎臓病 / アンチセンスオリゴ / 糖尿病関連腎臓病 / KHK-C / ケトヘキソキナーゼ / フルクトース代謝 / 腎炎 / 腎疾患 / iPS細胞 / MSC / 線維化 / 血管周囲間葉系細胞 / 免疫 / 炎症 / FSGS / スクリーニング / ゼブラフィッシュ / 透過性因子 / 液性因子 / 巣状分節性糸球体硬化症 / ポドサイト / 脂肪由来幹細胞 / 核酸医薬 / マイクロRNA / 敗血症 / リポソーム / miRNA Less

iPS細胞・遺伝子編集・間葉系幹細胞カラム融合によるデザイン細胞外小胞治療の開発Principal Investigator
- Principal Investigator
  
  古橋和拡
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Nagoya University
A combinatorial nerve regeneration therapy using genetically modified dental pulp stem cells targeting the site of sciatic nerve injury and the anterior horn of the spinal cord
- Principal Investigator
  
  西村由介
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Nagoya University
空間トランスクリプトーム解析で解き明かす血管極を中心とした糸球体Principal Investigator
- Principal Investigator
  
  古橋和拡
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Nagoya University
腎疾患におけるlncRNAの役割の解明と新規治療法の開発
- Principal Investigator
  
  石本卓嗣
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Aichi Medical University
Research for clinical application of a novel treatment for kidney disease using human iPS cell-derived mesenchymal stem cells
- Principal Investigator
  
  田中章仁
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Nagoya University
腎所属リンパ節を標的とするAKI-to-CKD transitionの新規治療戦略の構築
- Principal Investigator
  
  佐藤由香
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Nagoya University
Periglomerular macrophages maintain podocyte homeostasisPrincipal Investigator
- Principal Investigator
  
  Furuhashi Kazuhiro
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Nagoya University
Development of Complement Function Tests for the Early Diagnosis of aHUS and Determination of Indications for Anti-complement Therapy
- Principal Investigator
  
  Kato Noritoshi
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Nagoya University
Development of Neural Regenerative Therapy Through Integration of Basic Helix-Loop-Helix Transcriptional Regulation and Stem Cell Therapy
- Principal Investigator
  
  Nishimura Yusuke
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Nagoya University
Novel therapeutic systems combining mesenchymal stem cell columns with iPS cell and gene editing technologies.Principal Investigator
- Principal Investigator
  
  Furuhashi Kazuhiro
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Nagoya University
Development of next-generation immune and inflammatory control methods focusing on the mechanisms of inflammation regulation in the microenvironment of mesenchymal stem cells.
- Principal Investigator
  
  Maruyama Shoichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Nagoya University
Development of a novel therapy for kidney disease using human iPS cell-derived mesenchymal stem cells
- Principal Investigator
  
  Tanaka Akihito
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Nagoya University
Targeting fructose metabolism to elucidate the pathogenesis of diabetic kidney disease and develop novel therapies.
- Principal Investigator
  
  Ishimoto Takuji
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Aichi Medical University
Analysis of function and novel therapy of mesenchymal mesenchymal stem cell marker Meflin
- Principal Investigator
  
  Saito Shoji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Nagoya University
Development of new cell therapy columns to solve current problems in mesenchymal stem cell therapyPrincipal Investigator
- Principal Investigator
  
  Furuhashi Kazuhiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Nagoya University
Development of a treatment for septic AKI using microRNAs and adipose stem cell-derived exosomes.
- Principal Investigator
  
  Noritoshi Kato
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Nagoya University
Novel CaMK4-mediated podocyte-specific therapy in refractory renal disease
- Principal Investigator
  
  Maeda Kayaho
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Nagoya University
Screening of humoral pathogenesis of idiopathic focal segmental glomerulosclerosis by proteinuria visualized transparent model animal
- Principal Investigator
  
  Maruyama Shoichi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Nagoya University

All 2025 2024 2023 2021

All Journal Article Presentation Patent

[Journal Article] In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney2025
- Author(s)
  Tsuboi Toshiki、Hattori Keita、Ishimoto Takuji、Imai Kentaro、Doke Tomohito、Hagita Junichiro、Ariyoshi Jumpei、Furuhashi Kazuhiro、Kato Noritoshi、Ito Yasuhiko、Kamiya Yukiko、Asanuma Hiroyuki、Maruyama Shoichi
- Journal Title
  
  Molecular Therapy Nucleic Acids
  
  Volume: 36 Issue: 1 Pages: 102387-102387
- DOI
  10.1016/j.omtn.2024.102387
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23H04067, KAKENHI-PROJECT-21H05025, KAKENHI-PROJECT-21K08254, KAKENHI-PROJECT-24K11399
[Journal Article] Detecting and exploring kidney-derived extracellular vesicles in plasma.2024
- Author(s)
  Komatsu S, Kato N, Kitai H, Funahashi Y, Noda Y, Tsubota S, Tanaka A, Sato Y, Maeda K, Saito S, Furuhashi K, Ishimoto T, Kosugi T, Maruyama S, Kadomatsu K.
- Journal Title
  
  Clin Exp Nephrol.
  
  Volume: - Issue: 7 Pages: 617-628
- DOI
  10.1007/s10157-024-02464-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K18251, KAKENHI-PROJECT-22K08349
[Journal Article] Long non-coding RNA lnc-CHAF1B-3 promotes renal interstitial fibrosis by regulating EMT-related genes in renal proximal tubular cells2023
- Author(s)
  Imai Kentaro、Ishimoto Takuji、Doke Tomohito、Tsuboi Toshiki、Watanabe Yu、Katsushima Keisuke、Suzuki Miho、Oishi Hideto、Furuhashi Kazuhiro、Ito Yasuhiko、Kondo Yutaka、Maruyama Shoichi
- Journal Title
  
  Molecular Therapy - Nucleic Acids
  
  Volume: 31 Pages: 139-150
- DOI
  10.1016/j.omtn.2022.12.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07570, KAKENHI-PROJECT-21K08254
[Patent] 間葉系幹細胞の培養方法2021
- Inventor(s)
  古橋和拡
- Industrial Property Rights Holder
  名古屋大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-054023
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19K08722
[Presentation] ヒト脱落乳歯由来幹細胞による脊髄損傷後の保護機構2023
- Author(s)
  西井智哉、西村由介、永島吉孝、古橋和拡
- Organizer
  日本脳神経外科学会総会
- Data Source
  KAKENHI-PROJECT-22K09280
[Presentation] 虚血性腎障害における所属リンパ節を介した免疫応答の解明2023
- Author(s)
  小崎　陽平、佐藤　由香、椙村　真裕、前田　佳哉輔、古橋　和拡、加藤　規利、小杉　智規、丸山　彰一、門松　健治
- Organizer
  第66回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-23K07716
[Presentation] 脂肪間葉系幹細胞を用いた腎炎治療の可能性 -治療特性とその作用機序-2021
- Author(s)
  古橋和拡
- Organizer
  再生医療学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08722
[Presentation] 生体内細胞動態からアプローチした脂肪由来間葉系幹細胞の糸球体腎炎モデルに対する治療機序の解明2021
- Author(s)
  古橋和拡
- Organizer
  第44回日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08722
[Presentation] MESENCHYMAL STEM CELLS EXERT RENOPROTECTION VIA EXTRACELLULAR VESICLE- MEDIATED MODULATION OF M2 MACROPHAGES AND SPLEEN-KIDNEY NETWORK2021
- Author(s)
  Kazuhiro Furuhashi
- Organizer
  The International Society for Stem Cell Research (ISSCR)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08722

1. Maruyama Shoichi (10362253)

# of Collaborated Projects: 13 results

# of Collaborated Products: 0 results
2. Tanaka Akihito (20846290)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
3. Ishimoto Takuji (00534835)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. 平山明由 (00572405)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. Maeda Kayaho (00836306)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. Noritoshi Kato (90716052)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 勝野敬之 (60642337)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 小杉智規 (90584681)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. Nishimura Yusuke (20447816)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. 秋山真一 (20500010)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 榎本篤 (20432255)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 永島吉孝 (20867684)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
13. 高須正規 (00503327)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 鈴木洋 (00587793)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. Saito Shoji (00635609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 杉浦悠毅 (30590202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 水野正司 (20303638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 夏目敦至 (30362255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 森崇 (40402218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 佐藤由香 (60846864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 堀口道子 (70632470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 大須賀浩二 (40378013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 伊藤恭彦 (60402632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. KAMIYA Yukiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. SUZUKI Miho

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 門松健治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Furuhashi Kazuhiro 古橋 和拡

Research Projects

Research Products

Co-Researchers

iPS細胞・遺伝子編集・間葉系幹細胞カラム融合によるデザイン細胞外小胞治療の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

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Research Institution

空間トランスクリプトーム解析で解き明かす血管極を中心とした糸球体Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

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Review Section

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Principal Investigator

Project Period (FY)

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Principal Investigator

Project Period (FY)

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Periglomerular macrophages maintain podocyte homeostasisPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

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Research Institution

Novel therapeutic systems combining mesenchymal stem cell columns with iPS cell and gene editing technologies.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

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Principal Investigator

Project Period (FY)

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Principal Investigator

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Development of new cell therapy columns to solve current problems in mesenchymal stem cell therapyPrincipal Investigator

Principal Investigator

Furuhashi Kazuhiro 古橋和拡

[Presentation] 生体内細胞動態からアプローチした脂肪由来間葉系幹細胞の糸球体腎炎モデルに対する治療機序の解明2021