ASANO TAKAKI 浅野孝基

… Alternative Names

浅野孝基アサノタカキ

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Researcher Number	50835501
Affiliation (Current)	2025: 広島大学, 原爆放射線医科学研究所, 准教授
Affiliation (based on the past Project Information) *help	2025: 広島大学, 原爆放射線医科学研究所, 准教授 2023: 広島大学, 原爆放射線医科学研究所, 准教授 2022: 広島大学, 病院(医), 助教
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / 0803:Pathology, infection/immunology, and related fields Except Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords	Principal Investigator 原発性免疫不全症 / 疾患モデルノックインマウス / CYLD異常症 / 先天性免疫異常症 / GP130 / IL6ST / 高IgE症候群 / 次世代シークエンサー / 巨大血小板性血小板減少 / 血小板減少症 / 孤立性先天性無脾症 … More Except Principal Investigator … More ロングリード / 次世代シーケンサー / 診断率向上 / ロングリードシーケンス / 診断困難例 / 原発性免疫不全症 / RNAシーケンス / 全ゲノム解析 / ロングリードNGS Less

新規免疫不全症「CYLD異常症」の病態解明：疾患モデルマウスを用いたN-of-1問題の克服Principal Investigator
- Principal Investigator
  
  浅野孝基
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Hiroshima University
高IgE症候群の新しい病型である常染色体顕性IL6ST異常症の臨床病型・分子病態の解明Principal Investigator
- Principal Investigator
  
  浅野孝基
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Hiroshima University
孤立性先天性無脾症の新規責任遺伝子の同定と新しい疾患概念の確立Principal Investigator
- Principal Investigator
  
  浅野孝基
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0803:Pathology, infection/immunology, and related fields
- Research Institution
  Hiroshima University
Long-read sequencing analysis for difficult to diagnose cases of primary immunodeficiency
- Principal Investigator
  
  岡田賢
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Hiroshima University

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children2024
- Author(s)
  Bastard Paul、Gervais Adrian、Taniguchi Maki、Saare Liisa、Sarekannu Karita、Le Voyer Tom、Philippot Quentin、Rosain Jeremie、Bizien Lucy、Asano Takaki、、、、、Okada Satoshi、Puel Anne、Cobat Aurelie、Casanova Jean-Laurent、COVID Clinicians、GEN-COVID Study Group、COVID Human Genetic Effort
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 221 Issue: 2
- DOI
  10.1084/jem.20231353
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14979, KAKENHI-PROJECT-22K20772, KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-23K07268, KAKENHI-PROJECT-23K09603, KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-23K24302
[Journal Article] Human STAT1 gain of function with chronic mucocutaneous candidiasis: A comprehensive review for strengthening the connection between bedside observations and laboratory research2023
- Author(s)
  Asano Takaki、Noma Kosuke、Mizoguchi Yoko、Karakawa Shuhei、Okada Satoshi
- Journal Title
  
  Immunological Reviews
  
  Volume: 322 Issue: 1 Pages: 81-97
- DOI
  10.1111/imr.13300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14979, KAKENHI-PROJECT-22K20772, KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-23K07291, KAKENHI-PROJECT-21K15905, KAKENHI-PROJECT-23K24302
[Journal Article] Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 22023
- Author(s)
  Nguyen Tina、Lau Anthony、Bier Julia、Cooke Kristen C.、Lenthall Helen、Ruiz-Diaz Stephanie、Avery Danielle T.、Brigden Henry、Zahra David、Sewell William A、Droney Luke、Okada Satoshi、Asano Takaki、et al.
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 220 Issue: 6
- DOI
  10.1084/jem.20221020
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20772, KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-23K24302
[Journal Article] Isolated Chronic Mucocutaneous Candidiasis due to a Novel Duplication Variant of IL17RC2023
- Author(s)
  Noma Kosuke、Tsumura Miyuki、Nguyen Tina、Asano Takaki、Sakura Fumiaki、Tamaura Moe、Imanaka Yusuke、Mizoguchi Yoko、Karakawa Shuhei、Hayakawa Seiichi、Shoji Takayo、Hosokawa Junichi、Izawa Kazushi、Ling Yun、Casanova Jean-Laurent、Puel Anne、Tangye Stuart G.、Ma Cindy S.、Ohara Osamu、Okada Satoshi
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 44 Issue: 1 Pages: 18-18
- DOI
  10.1007/s10875-023-01601-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15921, KAKENHI-PROJECT-23K14979, KAKENHI-PROJECT-22K20772, KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-23K07268, KAKENHI-PROJECT-23K07291, KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-21K15905, KAKENHI-PROJECT-23K24302
[Journal Article] Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-192023
- Author(s)
  Matuozzo Daniela、Talouarn Estelle、Marchal Astrid、Zhang Peng、Manry Jeremy、Seeleuthner Yoann、Zhang Yu、Bolze Alexandre、Chaldebas Matthieu、Milisavljevic Baptiste、Gervais Adrian、Bastard Paul、Asano Takaki、et al.
- Journal Title
  
  Genome Medicine
  
  Volume: 15 Issue: 1
- DOI
  10.1186/s13073-023-01173-8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20772
[Journal Article] Fatal COVID-19 Infection in Two Children with STAT1 Gain-of-Function2023
- Author(s)
  Staines-Boone Aide Tamara、Vignesh Pandiarajan、Tsumura Miyuki、de la Garza Fernandez German、Tyagi Reva、Rawat Amit、Das Jhumki、Tomomasa Dan、Asano Takaki、Hijikata Atsushi、Salazar-Galvez Yuridia、Kanegane Hirokazu、Okada Satoshi、Reyes Saul O Lugo
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 44 Issue: 1 Pages: 20-20
- DOI
  10.1007/s10875-023-01634-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14979, KAKENHI-PROJECT-22K20772, KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-22K07887, KAKENHI-PROJECT-23K07268, KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-23K24302
[Journal Article] A complementary approach for genetic diagnosis of inborn errors of immunity using proteogenomic analysis2023
- Author(s)
  Sakura F, Noma K, Asano T, Tanita K, Toyofuku E, Kato K, Tsumura M, Nihira H, Izawa K, Mitsui-Sekinaka K, Konno R, Kawashima Y, Mizoguchi Y, Karakawa S, Hayakawa S, Kawaguchi H, Imai K, Nonoyama S, Yasumi T, Ohnishi H, Kanegane H, Ohara O, Okada S
- Journal Title
  
  PNAS Nexus
  
  Volume: 2 Issue: 4 Pages: 1-12
- DOI
  10.1093/pnasnexus/pgad104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-22K07887, KAKENHI-PROJECT-22K20772, KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-23K07291, KAKENHI-PROJECT-21K15905, KAKENHI-PROJECT-22K15939, KAKENHI-PROJECT-23K24302
[Journal Article] Human RELA dominant-negative mutations underlie type I interferonopathy with autoinflammation and autoimmunity2023
- Author(s)
  Moriya Kunihiko、Nakano Tomohiro、Honda Yoshitaka、Tsumura Miyuki、Ogishi Masato、、、Izawa Kazushi、Asano Takaki、Kakuta Fumihiko、Abukawa Daiki、、、Boisson Bertrand、Puel Anne、Casanova Jean-Laurent、Nishikomori Ryuta、Ohga Shouichi、Okada Satoshi、Sasahara Yoji、Kure Shigeo
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 220 Issue: 9
- DOI
  10.1084/jem.20212276
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14979, KAKENHI-PROJECT-22K20772, KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-23K07268, KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-20K16924, KAKENHI-PROJECT-23K24302
[Journal Article] Novel NF-kappa B Inhibitor Alpha Gain-of-Function Variant in an Infant with Lymphocytosis and Recurrent Serratia Bacteremia2023
- Author(s)
  Gunderman Lauren M.、Asano Takaki、Casanova Jean-Laurent、Boisson Bertrand、Khojah Amer
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: - Issue: 6 Pages: 1122-1126
- DOI
  10.1007/s10875-023-01481-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20772
[Journal Article] Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia2022
- Author(s)
  Zhang Q, Matuozzo D, Le Pen J, Lee D, Moens L, Asano T, Bohlen J, Liu Z, Moncada-Velez M, Kendir-Demirkol Y, Jing H, Bizien L, Marchal A, Abolhassani H, Delafontaine S, Bucciol G; COVID Human Genetic Effort (group author), et al.
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 219 Issue: 8
- DOI
  10.1084/jem.20220131
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-23K24302
[Journal Article] Inborn errors of immunity with loss- and gain-of-function germline mutations in STAT12022
- Author(s)
  Asano Takaki、Utsumi Takanori、Kagawa Reiko、Karakawa Shuhei、Okada Satoshi
- Journal Title
  
  Clinical and Experimental Immunology
  
  Volume: 149 Issue: 2 Pages: 252-261
- DOI
  10.1093/cei/uxac106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15904, KAKENHI-PROJECT-22K20772
[Journal Article] Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency2022
- Author(s)
  Campbell TM, Liu Z, Zhang Q, Moncada-Velez M, Covill LE, Zhang P, Alavi Darazam I, Bastard P, Bizien L, Bucciol G, Lind Enoksson S, Jouanguy E, ...; COVID Human Genetic Effort (group author: Satoshi Okada), Bergman P, Abel L, Cobat A, Casanova JL, Meyts I, Bryceson YT.
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 219 Issue: 7
- DOI
  10.1084/jem.20220202
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-23K24302
[Presentation] 宿主因子に着目したMIS-Cの分子病態2023
- Author(s)
  浅野孝基
- Organizer
  広島免疫不全研究会
- Invited
- Data Source
  KAKENHI-PROJECT-23K14979
[Presentation] 放射線高感受性を示すと考えられる新規原発性免疫不全症の同定2023
- Author(s)
  浅野孝基、松村梨紗、阿久津シルビア夏子、松浦伸也
- Organizer
  中国地区放射線影響研究会
- Data Source
  KAKENHI-PROJECT-22K20772
[Presentation] 新生児マススクリーニング検査の現状と今後ー広島県からの報告ー2023
- Author(s)
  浅野孝基
- Organizer
  日本マススクリーニング学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K14979
[Presentation] 重症COVID-19を引き起こす宿主遺伝因子としてのX連鎖潜性TLR7欠損症の同定2023
- Author(s)
  浅野孝基, Bertrand Boisson, Jean-Laurent Casanova
- Organizer
  第5回日本免疫不全・自己炎症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K20772
[Presentation] 小児COVID-19関連多系統炎症症候群（MIS-C）の遺伝的素因と発症機序2023
- Author(s)
  浅野孝基
- Organizer
  日本臨床免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K14979
[Presentation] IL17RC新規重複変異による慢性粘膜皮膚カンジダ症2023
- Author(s)
  野間廉輔、津村弥来、浅野孝基、溝口洋子、荘司貴代、岡田賢
- Organizer
  第5回日本免疫不全・自己炎症学会学術集会
- Data Source
  KAKENHI-PROJECT-22K20772
[Presentation] 本邦初の常染色体顕性IL6ST異常症の２症例の同定と分子病態の解明2023
- Author(s)
  芦原康介、浅野孝基、野間康輔、津村弥来、豊福悦史、関根朗雅、今井耕輔、岡田賢
- Organizer
  第5回日本免疫不全・自己炎症学会学術集会
- Data Source
  KAKENHI-PROJECT-22K20772
[Presentation] 小児COVID-19関連多系統炎症症候群(MIS-C)の遺伝的素因と発症機序2023
- Author(s)
  浅野孝基
- Organizer
  日本臨床免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K20772
[Presentation] 宿主因子に着目したMIS-Cの分子病態2023
- Author(s)
  浅野孝基
- Organizer
  広島免疫不全研究会
- Data Source
  KAKENHI-PROJECT-22K20772
[Presentation] 先天性免疫異常症に対する新生児マススクリーニング検査と広島県での現状2023
- Author(s)
  浅野孝基
- Organizer
  第50回日本マススクリーニング学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K20772
[Presentation] 小児COVID-19関連多系統炎症性症候群（MIS-C）の遺伝的素因と発症機序2023
- Author(s)
  浅野孝基、岡田賢
- Organizer
  第51回日本臨床免疫学会総会（合同開催：第60回日本消化器免疫学会総会）
- Invited
- Data Source
  KAKENHI-PROJECT-22K20772
[Presentation] 放射線高感受性を示すと考えられる新規原発性免疫不全症の同定2023
- Author(s)
  浅野孝基、松村梨紗、阿久津シルビア夏子、松浦伸也
- Organizer
  中国地区放射線影響研究会
- Data Source
  KAKENHI-PROJECT-23K14979
[Presentation] 新生児マススクリーニング検査の現状と今後ー広島県からの報告ー2023
- Author(s)
  浅野孝基
- Organizer
  日本マススクリーニング学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K20772

1. 岡田賢 (80457241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 金兼弘和 (00293324)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 小原收 (20370926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 坂田園子 (50897907)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TSUMURA Miyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 玉浦萌

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 香川礼子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ASANO TAKAKI 浅野 孝基

浅野 孝基 アサノ タカキ

Research Projects

Research Products

Co-Researchers

新規免疫不全症「CYLD異常症」の病態解明：疾患モデルマウスを用いたN-of-1問題の克服Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

高IgE症候群の新しい病型である常染色体顕性IL6ST異常症の臨床病型・分子病態の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

孤立性先天性無脾症の新規責任遺伝子の同定と新しい疾患概念の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Long-read sequencing analysis for difficult to diagnose cases of primary immunodeficiency

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human STAT1 gain of function with chronic mucocutaneous candidiasis: A comprehensive review for strengthening the connection between bedside observations and laboratory research2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 22023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isolated Chronic Mucocutaneous Candidiasis due to a Novel Duplication Variant of IL17RC2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-192023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fatal COVID-19 Infection in Two Children with STAT1 Gain-of-Function2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A complementary approach for genetic diagnosis of inborn errors of immunity using proteogenomic analysis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human RELA dominant-negative mutations underlie type I interferonopathy with autoinflammation and autoimmunity2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel NF-kappa B Inhibitor Alpha Gain-of-Function Variant in an Infant with Lymphocytosis and Recurrent Serratia Bacteremia2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inborn errors of immunity with loss- and gain-of-function germline mutations in STAT12022

ASANO TAKAKI 浅野孝基

浅野孝基アサノタカキ

[Presentation] 放射線高感受性を示すと考えられる新規原発性免疫不全症の同定2023

[Presentation] 小児COVID-19関連多系統炎症症候群（MIS-C）の遺伝的素因と発症機序2023

[Presentation] 小児COVID-19関連多系統炎症症候群(MIS-C)の遺伝的素因と発症機序2023

[Presentation] 放射線高感受性を示すと考えられる新規原発性免疫不全症の同定2023