TSUJIMOTO SHINICHI 辻本信一

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TSUJIMOTO Shinichi 辻本信一

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Researcher Number	50838034
Other IDs
Affiliation (Current)	2026: 横浜市立大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2020 – 2024: 横浜市立大学, 医学部, 助教 2019: 国立研究開発法人国立成育医療研究センター, 小児がんセンター, フェロー
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator AML / ゲノム / 代謝 / metabolome / glutaminase / L-asparaginase / メチル化阻害剤 / BCL2阻害剤 / エピゲノム解析 / 小児急性骨髄性白血病 … More / 急性骨髄性白血病 / ベネトクラックス / シタラビン / 脱メチル化剤 / Venetoclax / OxPhos / ベネトクラクス / OXPHOS / MYC / glutaminolysis / OxPHOS / PRDM16 / レチノイン酸 / APL / TBL1XR1-RARB / 急性前骨髄球性白血病 / retinoic acid pathway / RARB / 急性前骨髄急性白血病 Less

L-asparaginase for relapse/refractory AMLPrincipal Investigator
- Principal Investigator
  
  辻本信一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Yokohama City University
Development of Novel Therapeutic Strategies Based on Epigenomic Profiling for Refractory Pediatric AML with High PRDM16 ExpressionPrincipal Investigator
- Principal Investigator
  
  TSUJIMOTO Shinichi
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Yokohama City University
Elucidation of the pathophysiology of RARB translocation-positive acute promyelocytic leukemia and development of new target therapyPrincipal Investigator
- Principal Investigator
  
  TSUJIMOTO Shinichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Yokohama City University
  National Center for Child Health and Development

All 2025 2024 2022 2021 2019

All Journal Article Presentation

[Journal Article] Establishment of a high-risk pediatric AML-derived cell line YCU-AML2 with genetic and metabolic vulnerabilities2025
- Author(s)
  Ikeda Junji、Shiba Norio、Kato Shota、Kunimoto Hiroyoshi、Saito Yusuke、Sagisaka Maiko、Ito Mieko、Goto Hiroaki、Okuno Yusuke、Nakamura Wataru、Yoshitomi Masahiro、Takeuchi Masanobu、Ito Shuichi、Nakajima Hideaki、Kato Motohiro、Tsujimoto Shin-Ichi
- Journal Title
  
  International Journal of Hematology
  
  Volume: 121 Issue: 5 Pages: 694-705
- DOI
  10.1007/s12185-025-03929-x
- Data Source
  KAKENHI-PROJECT-21K15870, KAKENHI-PROJECT-24K11004
[Journal Article] Adverse prognostic impact of KIT exon 17 mutations despite negative flow cytometric measurable residual disease in pediatric acute myeloid leukemia with RUNX1::RUNX1T12024
- Author(s)
 Kato Shota、Tsujimoto Shin-Ichi、Matsubayashi Jun、Iwamoto Shotaro、Hiramatsu Hidefumi、Okuno Yusuke、Kamitori Tatsuya、Ohki Kentaro、Deguchi Takao、Kiyokawa Nobutaka、Kato Motohiro、Takita Junko、Tanaka Shiro、Adachi Souichi、Tomizawa Daisuke、Shiba Norio
- Journal Title
 
 Haematologica
 
 Volume: 110 Pages: 251-256
- DOI
 10.3324/haematol.2024.286243
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-24H00628, KAKENHI-PROJECT-23K18264, KAKENHI-PROJECT-21K15870
[Journal Article] Genome-wide DNA Methylation Analysis in Pediatric Acute Myeloid Leukemia.2022
- Author(s)
  Yamato G, Kawai T, Shiba N, Ikeda J, Hara Y, Ohki K, Tsujimoto SI, Kaburagi T, Yoshida K, Shiraishi Y, Miyano S, Kiyokawa N, Tomizawa D, Shimada A, Sotomatsu M, Arakawa H, Adachi S, Taga T, Horibe K, Ogawa S, Hata K, Hayashi Y.
- Journal Title
  
  Blood advances
  
  Volume: in press Issue: 11 Pages: 3207-3219
- DOI
  10.1182/bloodadvances.2021005381
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08350, KAKENHI-PROJECT-19K16762, KAKENHI-PROJECT-20K08157, KAKENHI-PROJECT-20K08744, KAKENHI-PROJECT-21K20937, KAKENHI-PROJECT-20K17414
[Journal Article] NUDT15 variants confer high incidence of second malignancies in children with acute lymphoblastic leukemia2021
- Author(s)
 Yoshida Masanori,Nakabayashi Kazuhiko,Yang Wentao,Sato-Otsubo Aiko,Tsujimoto Shin-ichi, Motohiro Kato et al
- Journal Title
 
 Blood Advances
 
 Volume: 5 Issue: 23 Pages: 5420-5428
- DOI
 10.1182/bloodadvances.2021005507
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-19K16762, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-19H03614, KAKENHI-PROJECT-20K08723, KAKENHI-PROJECT-21K06143
[Journal Article] Droplet digital polymerase chain reaction assay for the detection of the minor clone of KIT D816V in paediatric acute myeloid leukaemia especially showing RUNX1-RUNX1T1 transcripts.2021
- Author(s)
  Sasaki K, Tsujimoto S, Miyake M, Uchiyama Y, Ikeda J, Yoshitomi M, Shimosato Y, Tokumasu M, Matsuo H, Yoshida K, Ohki K, Kaburagi T, Yamato G, Hara Y, Takeuchi M, Kinoshita A, Tomizawa D, Taga T, Adachi S, Tawa A, Horibe K, Hayashi Y, Matsumoto N, Ito S, Shiba N.
- Journal Title
  
  British Journal of Haematology
  
  Volume: 194(2) Issue: 2 Pages: 414-422
- DOI
  10.1111/bjh.17569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08350, KAKENHI-PROJECT-19K16762, KAKENHI-PROJECT-19K16832, KAKENHI-PROJECT-20K08744, KAKENHI-PROJECT-20K17414, KAKENHI-PROJECT-21K20937
[Journal Article] Acute promyelocytic leukemia with a cryptic insertion of RARA into TBL1XR12019
- Author(s)
  Osumi Tomoo、Watanabe Akihiro、Okamura Kohji、Nakabayashi Kazuhiko、Yoshida Masanori、Tsujimoto Shin‐ichi、Uchiyama Meri、Takahashi Hiroyuki、Tomizawa Daisuke、Hata Kenichiro、Kiyokawa Nobutaka、Kato Motohiro
- Journal Title
  
  Genes, Chromosomes and Cancer
  
  Volume: 58 Issue: 11 Pages: 820-823
- DOI
  10.1002/gcc.22791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16762, KAKENHI-PROJECT-17H01588, KAKENHI-PROJECT-17H04234
[Presentation] Metabolic reprogramming by PRDM16 drives cytarabine resistance in acute myeloid leukemia2024
- Author(s)
  Junji Ikeda, Hiroyoshi Kunimoto, Shinichi Tsujimoto, Hideaki Nakajima
- Organizer
  第83回日本癌学会
- Data Source
  KAKENHI-PROJECT-21K15870
[Presentation] KMT2A::MLLT3融合遺伝子、MECOM高発現、KRAS変異を有する高リスクAML 細胞株YCU-AML2の樹立2024
- Author(s)
  Ikeda Junji, Tsujimoto Shinichi
- Organizer
  第86回　日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-24K11004
[Presentation] 急性骨髄性白血病においてPRDM16による代謝リプログラミングはシタラビン耐性を誘導する2024
- Author(s)
  Junji Ikeda, Hiroyoshi Kunimoto, Shinichi Tsujimoto, Hideaki Nakajima
- Organizer
  第66回日本小児血液・がん学会
- Data Source
  KAKENHI-PROJECT-21K15870
[Presentation] 著明な乳酸アシドーシスと重症貧血を呈した急性リンパ性白血病によるOncologic emergencyの1例2021
- Author(s)
  大西康裕, 多賀谷貴史, 植松悟子, 西村奈穂, 辻本信一, 富澤大輔, 松本公一
- Organizer
  日本小児救急医学会
- Data Source
  KAKENHI-PROJECT-19K16762
[Presentation] Myelodysplastic syndrome in a patient with 3-methylglutaconic aciduria type 22021
- Author(s)
  中野嘉子, 坂本謙一, 辻本信一, 進藤考洋, 大隅朋生, 松本公一, 富澤大輔, 加藤元博
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16762

1. SHIBA Norio

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 加藤実穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 滝田順子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TSUJIMOTO SHINICHI 辻本 信一

TSUJIMOTO Shinichi 辻本 信一

Research Projects

Research Products

Co-Researchers

L-asparaginase for relapse/refractory AMLPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Novel Therapeutic Strategies Based on Epigenomic Profiling for Refractory Pediatric AML with High PRDM16 ExpressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the pathophysiology of RARB translocation-positive acute promyelocytic leukemia and development of new target therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Establishment of a high-risk pediatric AML-derived cell line YCU-AML2 with genetic and metabolic vulnerabilities2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adverse prognostic impact of &lt;i&gt;KIT&lt;/i&gt; exon 17 mutations despite negative flow cytometric measurable residual disease in pediatric acute myeloid leukemia with &lt;i&gt;RUNX1::RUNX1T1&lt;/i&gt;2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome-wide DNA Methylation Analysis in Pediatric Acute Myeloid Leukemia.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <i>NUDT15</i> variants confer high incidence of second malignancies in children with acute lymphoblastic leukemia2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Droplet digital polymerase chain reaction assay for the detection of the minor clone of KIT D816V in paediatric acute myeloid leukaemia especially showing RUNX1-RUNX1T1 transcripts.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acute promyelocytic leukemia with a cryptic insertion of RARA into TBL1XR12019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Metabolic reprogramming by PRDM16 drives cytarabine resistance in acute myeloid leukemia2024

Author(s)

Organizer

Data Source

[Presentation] KMT2A::MLLT3融合遺伝子、MECOM高発現、KRAS変異を有する高リスクAML 細胞株YCU-AML2の樹立2024

Author(s)

Organizer

Data Source

[Presentation] 急性骨髄性白血病においてPRDM16による代謝リプログラミングはシタラビン耐性を誘導する2024

Author(s)

Organizer

Data Source

[Presentation] 著明な乳酸アシドーシスと重症貧血を呈した急性リンパ性白血病によるOncologic emergencyの1例2021

Author(s)

Organizer

Data Source

[Presentation] Myelodysplastic syndrome in a patient with 3-methylglutaconic aciduria type 22021

Author(s)

Organizer

Data Source

TSUJIMOTO SHINICHI 辻本信一

TSUJIMOTO Shinichi 辻本信一

[Journal Article] Adverse prognostic impact of <i>KIT</i> exon 17 mutations despite negative flow cytometric measurable residual disease in pediatric acute myeloid leukemia with <i>RUNX1::RUNX1T1</i>2024