Shirane Kenjiro 白根健次郎

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SHIRANE Kenjiro 白根健次郎

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Researcher Number	50855004
Other IDs	https://orcid.org/0000-0002-8528-7404
Affiliation (Current)	2026: 大阪大学, 大学院医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2026: 大阪大学, 大学院医学系研究科, 講師 2022 – 2024: 大阪大学, 大学院医学系研究科, 講師
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (III) / Basic Section 42030:Animal life science-related / Basic Section 44020:Developmental biology-related Except Principal Investigator Medium-sized Section 42:Veterinary medical science, animal science, and related fields
Keywords	Principal Investigator CRISPR/Cas9 / 機能スクリーニング / シングルセル解析 / 卵母細胞分化 / レトロトランスポゾン活性化 / マウス系統差 / トランスクリプトーム多様性 / ゲノム多様性 / マウス卵母細胞 / レトロトランスポゾン転写物 … More / 体外再構築系 / 転写因子ネットワーク / エピゲノム / 発生能獲得 / 転写制御因子 / ヒストン修飾 / DNAメチル化 / エピゲノム性差 / 卵母細胞 … More Except Principal Investigator 異種 / 幹細胞 / 生殖細胞 Less

転移因子発現を基盤とする卵母細胞の新規エピゲノム確立機構Principal Investigator
- Principal Investigator
  
  白根健次郎
- Project Period (FY)
  2026 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Osaka
卵母細胞における転移因子活性化プログラムを利用した発生保証機構Principal Investigator
- Principal Investigator
  
  白根健次郎
- Project Period (FY)
  2026 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Osaka
臍帯血流を介した幹細胞由来始原生殖細胞移植法の確立と応用
- Principal Investigator
  
  西村俊哉
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Osaka University
Defining the role of retrotransposon activation in oogenesisPrincipal Investigator
- Principal Investigator
  
  白根健次郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Osaka University
Characterizing the roles of oocyte-specific factors in inhibiting unique features of the sperm epigenomePrincipal Investigator
- Principal Investigator
  
  SHIRANE Kenjiro
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  Osaka University

All 2025 2024 2023 2022

All Journal Article Presentation

[Journal Article] Combined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells2024
- Author(s)
  Kubo Naoki、Uehara Ryuji、Uemura Shuhei、Ohishi Hiroaki、Shirane Kenjiro、Sasaki Hiroyuki
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 3266-3266
- DOI
  10.1038/s41467-024-47699-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15037, KAKENHI-PROJECT-22K15084, KAKENHI-PROJECT-24K01938, KAKENHI-PROJECT-24K09414
[Journal Article] Control of epigenomic landscape and development of fetal male germ cells through L-serine metabolism2024
- Author(s)
  Yohei Hayashi, Jintaro Kaneko, Yumi Ito-Matsuoka, Asuka Takehara, Mayuka Funakoshi, So Maezawa, Kenjiro Shirane, Shigeki Furuya, Yasuhisa Matsui
- Journal Title
  
  iScience
  
  Volume: 27 Issue: 9 Pages: 110702-110702
- DOI
  10.1016/j.isci.2024.110702
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24K01938, KAKENHI-PROJECT-22K06245, KAKENHI-PROJECT-23K05788
[Journal Article] Epigenetic dynamics of partially methylated domains in human placenta and trophoblast stem cells2024
- Author(s)
  Toh Hidehiro、Okae Hiroaki、Shirane Kenjiro、Sato Tetsuya、Hamada Hirotaka、Kikutake Chie、Saito Daisuke、Arima Takahiro、Sasaki Hiroyuki、Suyama Mikita
- Journal Title
  
  BMC Genomics
  
  Volume: 25 Issue: 1 Pages: 1050-1050
- DOI
  10.1186/s12864-024-10986-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24H00645, KAKENHI-PROJECT-24K01938, KAKENHI-PROJECT-24K02590, KAKENHI-PROJECT-24K22173
[Journal Article] Epigenetic Mechanisms Governing Female and Male Germline Development in Mammals2023
- Author(s)
  Shirane K and Lorincz M.
- Journal Title
  
  Sexual Development
  
  Volume: 16 Issue: 5-6 Pages: 365-387
- DOI
  10.1159/000529336
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15125
[Journal Article] The DNMT3A ADD domain is required for efficient de novo DNA methylation and maternal imprinting in mouse oocytes2023
- Author(s)
  Uehara Ryuji、Au Yeung Wan Kin、Toriyama Keisuke、Ohishi Hiroaki、Kubo Naoki、Toh Hidehiro、Suetake Isao、Shirane Kenjiro、Sasaki Hiroyuki
- Journal Title
  
  PLOS Genetics
  
  Volume: 19 Issue: 8 Pages: e1010855-e1010855
- DOI
  10.1371/journal.pgen.1010855
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15037, KAKENHI-PROJECT-22K15084, KAKENHI-PROJECT-22K06174, KAKENHI-PROJECT-18K06095, KAKENHI-PROJECT-22K15125, KAKENHI-PUBLICLY-22H04675
[Journal Article] ADAD2 functions in spermiogenesis and piRNA biogenesis in mice2023
- Author(s)
  Lu Yonggang、Nagamori Ippei、Kobayashi Hisato、Kojima‐Kita Kanako、Shirane Kenjiro、Chang Hsin‐Yi、Nishimura Toru、Koyano Takayuki、Yu Zhifeng、Castaneda Julio M.、Matsuyama Makoto、Kuramochi‐Miyagawa Satomi、Matzuk Martin M.、Ikawa Masahito
- Journal Title
  
  Andrology
  
  Volume: 11 Issue: 4 Pages: 698-709
- DOI
  10.1111/andr.13400
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H05033, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-22K15103, KAKENHI-PROJECT-22K15125, KAKENHI-PROJECT-23K21282
[Journal Article] Dual role of <i>Ovol2</i> on the germ cell lineage segregation during gastrulation in mouse embryogenesis2022
- Author(s)
  Naitou Yuki、Nagamatsu Go、Hamazaki Nobuhiko、Shirane Kenjiro、Hayashi Masafumi、Hayashi Makoto、Kobayashi Satoru、Hayashi Katsuhiko
- Journal Title
  
  Development
  
  Volume: 149 Issue: 4 Pages: 1-13
- DOI
  10.1242/dev.200319
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05545, KAKENHI-PROJECT-19J20553, KAKENHI-PROJECT-22K15125, KAKENHI-ORGANIZER-18H05544, KAKENHI-PLANNED-18H05552
[Journal Article] The dynamic chromatin landscape and mechanisms of DNA methylation during mouse germ cell development2022
- Author(s)
  Kenjiro Shirane
- Journal Title
  
  Genes Genet. Syst.
  
  Volume: 97 Issue: 1 Pages: 3-14
- DOI
  10.1266/ggs.21-00069
- ISSN
  1341-7568, 1880-5779
- Year and Date
  2022-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15125
[Presentation] 卵母細胞分化を制御する転写因子ネットワーク2025
- Author(s)
  白根健次郎
- Organizer
  有性生殖研究会
- Invited
- Data Source
  KAKENHI-PROJECT-24K01938
[Presentation] Defining the role of oocyte-inducing factors and their connective networks in oogenesis2024
- Author(s)
  Kenjiro Shirane, Stephane Vincent, Laszlo Tora, Hiroyuki Sasaki, Katsuhiko Hayashi
- Organizer
  次世代ARTキックオフシンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K01938
[Presentation] Mechanisms and roles of sexually dimorphic epigenome regulation in mammalian germ cells2024
- Author(s)
  白根健次郎、林克彦
- Organizer
  日本人類遺伝学会
- Invited
- Data Source
  KAKENHI-PROJECT-24K01938
[Presentation] Defining the role of oocyte-inducing factors and their connective networks in oogenesis2024
- Author(s)
  Kenjiro Shirane, Stephane Vincent, Laszlo Tora, Hiroyuki Sasaki, Katsuhiko Hayashi
- Organizer
  日本分子生物学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K01938
[Presentation] Defining the role of oocyte-inducing factors and their connective networks in oogenesis2023
- Author(s)
  Kenjiro Shirane
- Organizer
  2023 Germinal Stem Cell Biology, Gordon Research Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15125

1. 西村俊哉 (00803842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 林克彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 久保直樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 伊川正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 有馬隆博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 岡江寛明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shirane Kenjiro 白根 健次郎

SHIRANE Kenjiro 白根 健次郎

Research Projects

Research Products

Co-Researchers

転移因子発現を基盤とする卵母細胞の新規エピゲノム確立機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

卵母細胞における転移因子活性化プログラムを利用した発生保証機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

臍帯血流を介した幹細胞由来始原生殖細胞移植法の確立と応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Defining the role of retrotransposon activation in oogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Characterizing the roles of oocyte-specific factors in inhibiting unique features of the sperm epigenomePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Combined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Control of epigenomic landscape and development of fetal male germ cells through L-serine metabolism2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epigenetic dynamics of partially methylated domains in human placenta and trophoblast stem cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epigenetic Mechanisms Governing Female and Male Germline Development in Mammals2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The DNMT3A ADD domain is required for efficient de novo DNA methylation and maternal imprinting in mouse oocytes2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ADAD2 functions in spermiogenesis and piRNA biogenesis in mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dual role of <i>Ovol2</i> on the germ cell lineage segregation during gastrulation in mouse embryogenesis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The dynamic chromatin landscape and mechanisms of DNA methylation during mouse germ cell development2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Presentation] 卵母細胞分化を制御する転写因子ネットワーク2025

Author(s)

Shirane Kenjiro 白根健次郎

SHIRANE Kenjiro 白根健次郎