TSUJI KOHEI 辻耕平

Researcher Number	50866639
Other IDs
Affiliation (Current)	2025: 東京科学大学, 総合研究院, 准教授
Affiliation (based on the past Project Information) *help	2025: 東京科学大学, 生体材料工学研究所, 准教授 2021 – 2024: 東京医科歯科大学, 生体材料工学研究所, 准教授 2020: 東京医科歯科大学, 生体材料工学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Basic Section 37030:Chemical biology-related Except Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Basic Section 54030:Infectious disease medicine-related / Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related
Keywords	Principal Investigator HIV / タンパク質分解誘導剤 / ペプチド / Polo-like kinase 1 / HIV latency / PKC agonist / エイズ / ジアシルグリセロール / kick & kill / 潜伏感染 … More / Protein Kinase C (PKC) / スクリーニング / タンパク質リン酸化酵素 / エイズ (AIDS) … More Except Principal Investigator ケモカイン受容体CXCR4 / ペプチドミメティック / 環状ペプチド / 感染症災害 / レジリエンス / 薬剤耐性 / 抗菌薬開発 / 薬物送達 / 中分子化合物 / コンジュゲート分子 / 上皮成長因子受容体 / 創薬リード / 中分子 / コンジュゲート / 上皮成長因子受容体EGFR Less

ケミカルノックダウンを用いたHIV潜伏感染細胞再活性化機構の解明Principal Investigator
- Principal Investigator
  
  辻耕平
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Institute of Science Tokyo
環状ペプチド誘導体を活用した標的選択的ハイブリッド型中分子医薬品の創製
- Principal Investigator
  
  玉村啓和
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Tokyo Medical and Dental University
Development of novel antibacterial agents using crystal structure-based drug screening
- Principal Investigator
  
  林宏典
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Tohoku University
HIVに倣う新規タンパク質分解誘導剤の開発とその応用Principal Investigator
- Principal Investigator
  
  辻耕平
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Tokyo Medical and Dental University
Explorational study in development of Protein Kinase C C1 domain-binding ligands for HIV curePrincipal Investigator
- Principal Investigator
  
  TSUJI KOHEI
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Tokyo Medical and Dental University
Development of target-selective mid-size drugs using cyclic peptide derivatives
- Principal Investigator
  
  Tamamura Hirokazu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Tokyo Medical and Dental University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Effect of Two-Photon Excitation to 8-Azacoumarin Derivatives as Photolabile Protecting Groups2024
- Author(s)
  Kobayakawa Takuya、Takano Hikaru、Ishii Takahiro、Bolah Peter、Tsuji Kohei、Ohashi Nami、Nomura Wataru、Furuta Toshiaki、Tamamura Hirokazu
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 3 Pages: 311-312
- DOI
  10.1248/cpb.c24-00013
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-03-16
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-23K14318, KAKENHI-PROJECT-23K23468
[Journal Article] Development of Small-Molecule Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins2024
- Author(s)
  Kobayakawa Takuya、Yokoyama Masaru、Tsuji Kohei、Boku Sayaka、Kurakami Masaki、Fujino Masayuki、Ishii Takahiro、Miura Yutaro、Nishimura Soshi、Shinohara Kouki、Yamamoto Kenichi、Bolah Peter、Kotani Osamu、Murakami Tsutomu、Sato Hironori、Tamamura Hirokazu
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 1 Pages: 41-47
- DOI
  10.1248/cpb.c23-00618
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-01-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-23K14318, KAKENHI-PROJECT-23K08062
[Journal Article] Low-molecular-weight Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins2023
- Author(s)
  Kobayakawa, T., M. Yokoyama, K. Tsuji, M. Fujino, M. Kurakami, T. Onishi, S. Boku, T. Ishii, Y.Miura, K. Shimohara, Y. Kishihara, N. Ohashi, O. Kotani, T. Murakami, H. Sato and H. Tamamura
- Journal Title
  
  RSC Advances
  
  Volume: 13 Issue: 3 Pages: 2156-2167
- DOI
  10.1039/d2ra06837k
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08615, KAKENHI-PROJECT-22K15243
[Journal Article] Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity2023
- Author(s)
  Ishii Takahiro、Kobayakawa Takuya、Matsuda Kouki、Tsuji Kohei、Ohashi Nami、Nakahata Shingo、Noborio Airi、Yoshimura Kazuhisa、Mitsuya Hiroaki、Maeda Kenji、Tamamura Hirokazu
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: 256 Pages: 115449-115449
- DOI
  10.1016/j.ejmech.2023.115449
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-23K14318, KAKENHI-PROJECT-23K15385
[Journal Article] Structure-Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moieties2023
- Author(s)
  Tsuji Kohei、Ishii Takahiro、Kobayakawa Takuya、Higashi-Kuwata Nobuyo、Shinohara Kouki、Azuma Chika、Miura Yutaro、Nakano Hiroki、Wada Naoya、Hattori Shin-ichiro、Bulut Haydar、Mitsuya Hiroaki、Tamamura Hirokazu
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 66 Issue: 19 Pages: 13516-13529
- DOI
  10.1021/acs.jmedchem.3c00777
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-23K14318
[Journal Article] Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement2023
- Author(s)
  Tsuji Kohei、Kobayakawa Takuya、Ishii Takahiro、Higashi-Kuwata Nobuyo、Azuma Chika、Shinohara Kouki、Miura Yutaro、Yamamoto Kenichi、Nishimura Soshi、Hattori Shin-ichiro、Bulut Haydar、Mitsuya Hiroaki、Tamamura Hirokazu
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 71 Issue: 12 Pages: 879-886
- DOI
  10.1248/cpb.c23-00562
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2023-12-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-23K14318
[Journal Article] Sensitivity to a CD4 mimic of a consensus clone of monkey-adapted CCR5-tropic SHIV-MK38C2023
- Author(s)
  Matsuura Kanako、Yamaura Mizuki、Sakawaki Hiromi、Himeno Ai、Pisil Yalcin、Kobayakawa Takuya、Tsuji Kohei、Tamamura Hirokazu、Matsushita Shuzo、Miura Tomoyuki
- Journal Title
  
  Virology
  
  Volume: 578 Pages: 171-179
- DOI
  10.1016/j.virol.2022.12.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362, KAKENHI-PROJECT-21H02970
[Journal Article] Dimerized fusion inhibitor peptides targeting the HR1?HR2 interaction of SARS-CoV-22023
- Author(s)
  Tsuji Kohei、Baffour-Awuah Owusu Kofi、Miura Yutaro、Ishii Takahiro、Shinohara Kouki、Kobayakawa Takuya、Emi Akino、Nakano Takashi、Suzuki Youichi、Tamamura Hirokazu
- Journal Title
  
  RSC Advances
  
  Volume: 13 Issue: 13 Pages: 8779-8793
- DOI
  10.1039/d2ra07356k
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362
[Journal Article] Development of anti-HBV agents targeting HBV capsid proteins2023
- Author(s)
  Kobayakawa Takuya、Amano Masayuki、Nakayama Miyuki、Tsuji Kohei、Ishii Takahiro、Miura Yutaro、Shinohara Kouki、Yamamoto Kenichi、Matsuoka Masao、Tamamura Hirokazu
- Journal Title
  
  RSC Medicinal Chemistry
  
  Volume: 14 Issue: 10 Pages: 1973-1980
- DOI
  10.1039/d3md00258f
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-23K14318, KAKENHI-PROJECT-23K24379
[Journal Article] Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates2023
- Author(s)
  Matsumoto Kaho、Kuwata Takeo、Tolbert William D.、Richard Jonathan、Ding Shilei、Prevost Jeremie、Takahama Shokichi、Judicate George P.、Ueno Takamasa、Nakata Hirotomo、Kobayakawa Takuya、Tsuji Kohei、Tamamura Hirokazu、Smith Amos B.、Pazgier Marzena、Finzi Andres、Matsushita Shuzo
- Journal Title
  
  Journal of Virology
  
  Volume: 97 Issue: 1
- DOI
  10.1128/jvi.01638-22
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05989, KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-21K19657
[Journal Article] Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-22023
- Author(s)
  Higashi-Kuwata Nobuyo、Tsuji Kohei、Hayashi Hironori、Bulut Haydar、Kiso Maki、Imai Masaki、Ogata-Aoki Hiromi、Ishii Takahiro、Kobayakawa Takuya、Nakano Kenta、et al.
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1076-1076
- DOI
  10.1038/s41467-023-36729-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362, KAKENHI-PROJECT-20K07134, KAKENHI-PROJECT-23H05465
[Journal Article] Potent and biostable inhibitors of the main protease of SARS-CoV-22022
- Author(s)
  Tsuji Kohei、Ishii Takahiro、Kobayakawa Takuya、Higashi-Kuwata Nobuyo、Azuma Chika、Nakayama Miyuki、Onishi Takato、Nakano Hiroki、Wada Naoya、Hori Miki、et al.
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 11 Pages: 105365-105365
- DOI
  10.1016/j.isci.2022.105365
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362, KAKENHI-PROJECT-20K07134
[Journal Article] Exploratory studies on soluble small molecule CD4 mimics as HIV entry inhibitors2022
- Author(s)
  Tsuji Kohei、Kobayakawa Takuya、Konno Kiju、Masuda Ami、Takahashi Kohei、Ohashi Nami、Yoshimura Kazuhisa、Kuwata Takeo、Matsushita Shuzo、Harada Shigeyoshi、Tamamura Hirokazu
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 56 Pages: 116616-116616
- DOI
  10.1016/j.bmc.2022.116616
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15951, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-20H03362
[Journal Article] Development of ultra-high affinity bivalent ligands targeting the polo-like kinase 12022
- Author(s)
  Tsuji Kohei、Hymel David、Ma Buyong、Tamamura Hirokazu、Nussinov Ruth、Burke Terrence R.
- Journal Title
  
  RSC Chemical Biology
  
  Volume: 3 Issue: 9 Pages: 1111-1120
- DOI
  10.1039/d2cb00153e
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362
[Journal Article] Hybrids of small CD4 mimics and gp41-related peptides as dual-target HIV entry inhibitors2022
- Author(s)
  Wang Rongyi、Tsuji Kohei、Kobayakawa Takuya、Liu Yishan、Yoshimura Kazuhisa、Matsushita Shuzo、Harada Shigeyoshi、Tamamura Hirokazu
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 76 Pages: 117083-117083
- DOI
  10.1016/j.bmc.2022.117083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362, KAKENHI-PROJECT-21H02970
[Journal Article] Fluorescence Resonance Energy Transfer-based Screening for Protein Kinase C Ligands Using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones2021
- Author(s)
  Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nami Ohashi, Wataru Nomura, Hirokazu Tamamura
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 19 Issue: 38 Pages: 8264-8271
- DOI
  10.1039/d1ob00814e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21253, KAKENHI-PROJECT-20K15951, KAKENHI-PROJECT-20H03362, KAKENHI-PROJECT-19H02827
[Journal Article] Small-Molecule Anti-HIV-1 Agents Based on HIV-1 Capsid Proteins2021
- Author(s)
  Kobayakawa Takuya、Yokoyama Masaru、Tsuji Kohei、Fujino Masayuki、Kurakami Masaki、Boku Sayaka、Nakayama Miyuki、Kaneko Moemi、Ohashi Nami、Kotani Osamu、Murakami Tsutomu、Sato Hironori、Tamamura Hirokazu
- Journal Title
  
  Biomolecules
  
  Volume: 11 Issue: 2 Pages: 208-208
- DOI
  10.3390/biom11020208
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08558, KAKENHI-PROJECT-20K15951, KAKENHI-PROJECT-18H03046, KAKENHI-PROJECT-19K22488
[Journal Article] Development of Methods for Convergent Synthesis of Chloroalkene Dipeptide Isosteres and Its Application2021
- Author(s)
  Kobayakawa Takuya、Azuma Chika、Watanabe Yuki、Sawamura Shunsuke、Taniguchi Atsuhiko、Hayashi Yoshio、Tsuji Kohei、Tamamura Hirokazu
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 86 Issue: 7 Pages: 5091-5101
- DOI
  10.1021/acs.joc.0c03019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07001, KAKENHI-PROJECT-19K16312, KAKENHI-PROJECT-20H03362
[Journal Article] Potent leads based on CA-19L, an anti-HIV active HIV-1 capsid fragment2021
- Author(s)
  Tsuji Kohei、Wang Rongyi、Kobayakawa Takuya、Owusu Kofi Baffour-Awuah、Fujino Masayuki、Kaneko Moemi、Yamamoto Naoki、Murakami Tsutomu、Tamamura Hirokazu
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 30 Pages: 115923-115923
- DOI
  10.1016/j.bmc.2020.115923
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08558, KAKENHI-PROJECT-20K15951, KAKENHI-PROJECT-18H03046, KAKENHI-PROJECT-19K22488
[Journal Article] Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors2021
- Author(s)
  Kobayakawa Takuya、Tsuji Kohei、Konno Kiju、Himeno Ai、Masuda Ami、Yang Tingting、Takahashi Kohei、Ishida Yusuke、Ohashi Nami、Kuwata Takeo、Matsumoto Kaho、Yoshimura Kazuhisa、Sakawaki Hiromi、Miura Tomoyuki、Harada Shigeyoshi、Matsushita Shuzo、Tamamura Hirokazu
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 64 Issue: 3 Pages: 1481-1496
- DOI
  10.1021/acs.jmedchem.0c01153
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15951, KAKENHI-PROJECT-18H02854, KAKENHI-PROJECT-18K06032, KAKENHI-PROJECT-18K08458, KAKENHI-PROJECT-19K22488, KAKENHI-PROJECT-19H03146, KAKENHI-PROJECT-21K05989, KAKENHI-PROJECT-21K08501
[Journal Article] A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells With a Combination of Latency-Reversing Agents Containing DAG-Lactone PKC Activators2021
- Author(s)
  Matsuda Kouki、Kobayakawa Takuya、Kariya Ryusho、Tsuchiya Kiyoto、Ryu Shoraku、Tsuji Kohei、Ishii Takahiro、Gatanaga Hiroyuki、Yoshimura Kazuhisa、Okada Seiji、Hamada Akinobu、Mitsuya Hiroaki、Tamamura Hirokazu、Maeda Kenji
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 12 Pages: 636276-636276
- DOI
  10.3389/fmicb.2021.636276
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15951, KAKENHI-PROJECT-20K17480, KAKENHI-PROJECT-19K22488, KAKENHI-PROJECT-20H03362
[Journal Article] Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain ? binding peptide macrocycles2021
- Author(s)
  Hymel David、Tsuji Kohei、Grant Robert A.、Chingle Ramesh M.、Kunciw Dominique L.、Yaffe Michael B.、Burke Terrence R.
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 19 Issue: 36 Pages: 7843-7854
- DOI
  10.1039/d1ob01120k
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15951
[Journal Article] Synthesis of Hydrophilic Caged DAG-lactone for Chemical Biology Applications2020
- Author(s)
  Takuya Kobayakawa, Hikaru Takano, Takahiro Ishii, Kohei Tsuji, Nami Ohashi, Wataru Nomura, Toshiaki Furuta, Hirokazu Tamamura
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 18 Issue: 22 Pages: 4217-4223
- DOI
  10.1039/d0ob00807a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21253, KAKENHI-PROJECT-20K15951, KAKENHI-PROJECT-19H02827, KAKENHI-PROJECT-19K22488, KAKENHI-PROJECT-16H06280
[Journal Article] Uncoupling the Folding-Function Paradigm of Lytic Peptides to Deliver Impermeable Inhibitors of Intracellular Protein?Protein Interactions2020
- Author(s)
  Miller Stephen E.、Tsuji Kohei、Abrams Rachel P.M.、Burke Terrence R.、Schneider Joel P.
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 142 Issue: 47 Pages: 19950-19955
- DOI
  10.1021/jacs.0c07921
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15951
[Journal Article] Exploratory studies on CA-15L, an anti-HIV active HIV-1 capsid fragment2020
- Author(s)
  Tsuji Kohei、Owusu Kofi Baffour-Awuah、Kobayakawa Takuya、Wang Rongyi、Fujino Masayuki、Kaneko Moemi、Yamamoto Naoki、Murakami Tsutomu、Tamamura Hirokazu
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 28 Issue: 11 Pages: 115488-115488
- DOI
  10.1016/j.bmc.2020.115488
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08558, KAKENHI-PROJECT-20K15951, KAKENHI-PROJECT-18H03046, KAKENHI-PROJECT-19K22488
[Journal Article] A new genre of fluorescence recovery assay to evaluate polo-like kinase 1 ATP-competitive inhibitors2020
- Author(s)
  Tsuji Kohei、Hymel David、Burke Terrence R.
- Journal Title
  
  Analytical Methods
  
  Volume: 12 Issue: 36 Pages: 4418-4421
- DOI
  10.1039/d0ay01223h
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15951
[Journal Article] Bivalent HIV-1 fusion inhibitors based on peptidomimetics2020
- Author(s)
  Kobayakawa Takuya、Ebihara Kento、Tsuji Kohei、Kawada Takuma、Fujino Masayuki、Honda Yuzuna、Ohashi Nami、Murakami Tsutomu、Tamamura Hirokazu
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 28 Issue: 24 Pages: 115812-115812
- DOI
  10.1016/j.bmc.2020.115812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08558, KAKENHI-PROJECT-20K15951, KAKENHI-PROJECT-18H03046, KAKENHI-PROJECT-19K22488
[Journal Article] Chemically Programmable and Switchable CAR‐T Therapy2020
- Author(s)
  Qi Junpeng、Tsuji Kohei、Hymel David、Burke Terrence R.、Hudecek Michael、Rader Christoph、Peng Haiyong
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 59 Issue: 29 Pages: 12178-12185
- DOI
  10.1002/anie.202005432
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15951
[Presentation] 抗SARS-CoV-2メインプロテアーゼ阻害剤 TKB272の研究開発2023
- Author(s)
  青木宏美、鍬田伸好、辻耕平、林宏典、Haydar Bulut、今井正樹、服部真一朗、高松悠樹、助長義和、岡村匡史、三隅将吾、河岡義裕、玉村啓和、満屋裕明
- Organizer
  第31回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-23K07918
[Presentation] HIV-1研究を基盤としたSARS-CoV-2膜融合阻害ペプチドの創製2023
- Author(s)
  辻　耕平
- Organizer
  日本薬学会第143年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15243
[Presentation] UTILIZATION OF A NON-SPECIFIC KINASE INHIBITOR FOR THE DEVELOPMENT OF HIGH-AFFINITY BIVALENT POLO-LIKE KINASE 1 POLO-BOX DOMAIN INHIBITORS2023
- Author(s)
  Kohei Tsuji, Hirokazu Tamamura, Terrence R. Burke, Jr.
- Organizer
  第60回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-22K15243
[Presentation] 抗ウイルス薬の創薬研究　～HIV研究から学ぶSARS-CoV-2阻害剤の創製～2023
- Author(s)
  辻耕平
- Organizer
  第55回若手ペプチド夏の勉強会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15243
[Presentation] 抗SARS-CoV-2メインプロテアーゼ阻害剤の創薬研究開発2023
- Author(s)
  鍬田伸好、辻耕平、林宏典、石井貴大、小早川拓也、中野堅太、服部真一朗、岸本直樹、高宗暢暁、青木宏美、Haydar Bulut、Debananda Das、今井正樹、木曽真紀、助永義和、高松悠樹、岡村匡史、三隅将吾、河岡義裕、玉村啓和、満屋裕明
- Organizer
  第37回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-23K07918
[Presentation] 大学における創薬研究　～抗ウイルス薬の創製を目指して～2023
- Author(s)
  辻　耕平
- Organizer
  日本薬学会第143年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15243
[Presentation] 大学での創薬研究　～抗ウイルス薬の創製を目指して～2022
- Author(s)
  辻　耕平
- Organizer
  医療薬学フォーラム2022/第30回クリニカルファーマシーシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22K15243
[Presentation] DEVELOPMENT OF FUSION INHIBITOR PEPTIDES OF SARS-COV-2 LEARNED FROM ANTI-HIV-1 AGENTS2022
- Author(s)
  Kohei Tsuji, Kofi Baffour-Awuah Owusu, Takuya Kobayakawa, Youichi Suzuki, Hirokazu Tamamura
- Organizer
  第59回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-22K15243
[Presentation] Exploration of novel class anti-HIV-1 agents derived from a viral capsid protein2022
- Author(s)
  K. Tsuji; R. Wang; K. B.-A. Owusu; T. Kobayakawa; T. Murakami; H. Tamamura
- Organizer
  The 12th International Peptide Symposium/The 36th European Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03362
[Presentation] 二価結合型超高親和性Polo-like kinase 1阻害剤の創製2022
- Author(s)
  辻　耕平、玉村啓和、Terrence R. Burke, Jr.
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-22K15243
[Presentation] Exploration of novel class anti-HIV-1 agents derived from a viral capsid protein2022
- Author(s)
  K. Tsuji; R. Wang; K. B.-A. Owusu; T. Kobayakawa; T. Murakami; H. Tamamura
- Organizer
  The 12th International Peptide Symposium/The 36th European Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15243
[Presentation] HIV-1カプシドタンパク質由来の抗HIV-1ペプチドの創製研究2022
- Author(s)
  [1]辻　耕平、Kofi Baffour-Awuah Owusu、王　容義、小早川拓也、村上　努、玉村啓和
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K15951
[Presentation] 抗ウイルス薬の創製研究と中圧分取装置2022
- Author(s)
  辻　耕平
- Organizer
  日本ビュッヒ株式会社分取クロマトセミナー2022
- Invited
- Data Source
  KAKENHI-PROJECT-22K15243
[Presentation] Development of HIV-1 fusion inhibitors based on dimeric derivatives of the C34 peptide and its peptidomimetics2021
- Author(s)
  Tamamura H, Kobayakawa T, Ebihara K, Murakami T, Tsuji K
- Organizer
  The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03362
[Presentation] Explorative study in development of anti-HIV-1 peptides based on HIV-1 capsid protein segments2021
- Author(s)
  [1]K. Tsuji; R. Wang; K. B.-A. Owusu; T. Kobayakawa; T. Murakami; H. Tamamura
- Organizer
  The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15951
[Presentation] A FRET-BASED ASSAY SYSTEM FOR PROTEIN KINASE C LIGAND SCREENING USING 1,2-DIACYLGLYCEROL-LACTONE DERIVATIVE2021
- Author(s)
  [3]Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nami Ohashi, Wataru Nomura, Hirokazu Tamamura
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-20K15951
[Presentation] A FRET-BASED ASSAY SYSTEM FOR PROTEIN KINASE C LIGAND SCREENING USING 1,2-DIACYLGLYCEROL-LACTONE DERIVATIVE2021
- Author(s)
  Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nami Ohashi, Wataru Nomura, Hirokazu Tamamura
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-20H03362
[Presentation] DIMERIZED SMALL MOLECULE HIV-1 FUSION INHIBITORS WITH DRAMATIC ENHANCEMENT OF THEIR ANTI-HIV-1 ACTIVITIES2021
- Author(s)
  [2]Kohei Tsuji, Takuya Kobayakawa, Kento Ebihara, Takuma Kawada, Masayuki Fujino, Yuzuna Honda, Nami Ohashi, Tsutomu Murakami, Hirokazu Tamamura
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-20K15951
[Presentation] 細胞内リン酸化シグナル伝達の制御に基づく抗HIV剤、抗がん剤の創薬研究2020
- Author(s)
  辻　耕平
- Organizer
  2020年6月19日（金）医工連携セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-20K15951

1. Tamamura Hirokazu (80217182)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. 小早川拓也 (30801526)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 林宏典 (00752916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. NOMURA Wataru

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. MURAKAMI Tsutomu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. FUJINO Masayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
7. HARADA Shigeyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. KUWATA Takeo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 谷口敦彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TSUJI KOHEI 辻 耕平

Research Projects

Research Products

Co-Researchers

ケミカルノックダウンを用いたHIV潜伏感染細胞再活性化機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

環状ペプチド誘導体を活用した標的選択的ハイブリッド型中分子医薬品の創製

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel antibacterial agents using crystal structure-based drug screening

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

HIVに倣う新規タンパク質分解誘導剤の開発とその応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Explorational study in development of Protein Kinase C C1 domain-binding ligands for HIV curePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of target-selective mid-size drugs using cyclic peptide derivatives

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Effect of Two-Photon Excitation to 8-Azacoumarin Derivatives as Photolabile Protecting Groups2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Development of Small-Molecule Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Low-molecular-weight Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure-Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moieties2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Sensitivity to a CD4 mimic of a consensus clone of monkey-adapted CCR5-tropic SHIV-MK38C2023

TSUJI KOHEI 辻耕平