HATANO MEGUMI 波多野恵

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Hatano Megumi 波多野恵

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Researcher Number	50867992
Other IDs
Affiliation (Current)	2026: 東京科学大学, 大学院医歯学総合研究科, 助教
Affiliation (based on the past Project Information) *help	2024 – 2025: 東京科学大学, 大学院医歯学総合研究科, 助教 2023 – 2024: 東京医科歯科大学, 大学院医歯学総合研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Medium-sized Section 50:Oncology and related fields
Keywords	Principal Investigator 代謝関連肝がん / エピゲノム / 高脂肪食 / 代謝 / メタボリックシンドローム / 肝がん / MASH Except Principal Investigator 消化器癌 / エピゲノム / 難治性がん … More / 腫瘍微小免疫環境 / ヒストン / 腫瘍免疫環境 / ヒストン修飾 / エピジェネティクス / 肝癌 / 膵癌 / 樹状細胞 / CAR-T細胞療法 / がん不均一性 / ラクチル化 / 乳酸代謝 / 免疫治療 / マウスモデル / 胃がん / シングルセル解析 / 多重ゲノム編集 / ゲノム編集 / 複合免疫療法 / 代謝異常 / 腫瘍微小環境 / ヒストンラクチル化 / 内在性レトロウイルス / 分子サブタイプ / 多様性 / 難治性消化器癌 Less

正常免疫マウス腫瘍モデルを応用したヒト腹膜播種性スキルス胃がんの複合免疫療法開発
- Principal Investigator
  
  島田周
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Institute of Science Tokyo
代謝関連肝癌におけるヒストン修飾酵素KDM6B異常の病態解明と新規治療法の開発Principal Investigator
- Principal Investigator
  
  波多野恵
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Institute of Science Tokyo
Analysis of abnormal lactate metabolism and lysine lactylation modification mechanism in cancer and stromal cell interactions
- Principal Investigator
  
  秋山好光
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Institute of Science Tokyo
Establishment of dendritic cells-activated CAR-T cell therapy to overcome tumor heterogeneity
- Principal Investigator
  
  田中真二
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Institute of Science Tokyo
Development of advanced therapy for refractory cancer based on elucidation of in vivo diversity mechanisms
- Principal Investigator
  
  田中真二
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Institute of Science Tokyo
  Tokyo Medical and Dental University
Analysis of tumor microenvironmental alterations in refractory cancer based on histone modification changes and development of novel therapeutic strategies
- Principal Investigator
  
  秋山好光
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Institute of Science Tokyo
Elucidation of the Pathogenesis and Development of Novel Therapies for Metabolic-Associated HCCPrincipal Investigator
- Principal Investigator
  
  Hatano Megumi
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Institute of Science Tokyo
  Tokyo Medical and Dental University

All 2025 2024 2023

All Journal Article Presentation Book

[Book] 【微小環境から読み解く肝癌】脂肪負荷に対する肝癌の耐性機序2024
- Author(s)
  波多野恵
- Publisher
  (株)アークメディア
- Data Source
  KAKENHI-PROJECT-23K15388
[Journal Article] Integrative transcriptome profiling elucidates molecular and immunovascular characteristics of macrotrabecular HCC2025
- Author(s)
  Taniai T, Shimada S, Akiyama Y, Hatano M, Yasukawa K, Igarashi Y, Tsukihara S, Tanji Y, Kodera K, Okazaki K, Haruki K, Nara A, Yagi K, Akahoshi K, Ban D, Asahina Y, Ikegami T, Tanabe M, Tanaka S.
- Journal Title
  
  Hepatology
  
  Volume: - Issue: 2 Pages: 231-248
- DOI
  10.1097/hep.0000000000001284
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27670
[Journal Article] Identification and clinical implications of endogenous retrovirus elements suppressed by SETDB1 in hepatocellular carcinoma2024
- Author(s)
  Igarashi Y, Akiyama Y, Shimada S, Watanabe S, Hatano M, Kodera K, Okazaki K, Tanji Y, Tsukihara S, Taniai T, Nara A, Yamane M, Kamachi A, Umemura K, Yasukawa K, Ono H, Akahoshi K, Tanabe M, Haruki K, Furukawa K, Ikegami T, Tanaka S.
- Journal Title
  
  JHEP Reports
  
  Volume: 7 Issue: 3 Pages: 101307-101307
- DOI
  10.1016/j.jhepr.2024.101307
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27670, KAKENHI-PROJECT-24K02320, KAKENHI-PROJECT-24K11898
[Journal Article] 脂肪負荷に対する肝癌の耐性機序2024
- Author(s)
  波多野恵、秋山好光、島田周、田中真二.
- Journal Title
  
  肝胆
  
  Volume: 88 Pages: 459-465
- Data Source
  KAKENHI-PROJECT-24K02320
[Journal Article] Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer2024
- Author(s)
  Tsukihara Shu、Akiyama Yoshimitsu、Shimada Shu、Hatano Megumi、Igarashi Yosuke、Taniai Tomohiko、Tanji Yoshiaki、Kodera Keita、Yasukawa Koya、Umeura Kentaro、Kamachi Atsushi、Nara Atsushi、Okuno Keisuke、Tokunaga Masanori、Katoh Hiroto、Ishikawa Shumpei、Ikegami Toru、Kinugasa Yusuke、Eto Ken、Tanaka Shinji
- Journal Title
  
  Oncogene
  
  Volume: 44 Issue: 11 Pages: 724-738
- DOI
  10.1038/s41388-024-03243-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04990, KAKENHI-PROJECT-23K27670, KAKENHI-PROJECT-24K02320
[Journal Article] 胆道癌におけるエピゲノム異常とその臨床的意義2024
- Author(s)
  蒲池厚志、秋山好光、島田周、波多野恵、田中真二.
- Journal Title
  
  胆と膵
  
  Volume: 45 Pages: 835-843
- Data Source
  KAKENHI-PROJECT-24K02320
[Journal Article] Loss of SFXN1 mitigates lipotoxicity and predicts poor outcome in non-viral hepatocellular carcinoma2023
- Author(s)
  Yagi K, Shimada S, Akiyama Y, Hatano M, Asano D, Ishikawa Y, Ueda H, Watanabe S, Akahoshi K, Ono H, Tanabe M, Tanaka S.
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 9449-9449
- DOI
  10.1038/s41598-023-36660-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19554, KAKENHI-PROJECT-23K27670
[Journal Article] Loss of KDM6B epigenetically confers resistance to lipotoxicity in nonalcoholic fatty liver disease?related HCC2023
- Author(s)
  Hatano M, Akiyama Y, Shimada S, Yagi K, Akahoshi K, Itoh M, Tanabe M, Ogawa Y, Tanaka S.
- Journal Title
  
  Hepatology Communications
  
  Volume: 7 Issue: 10
- DOI
  10.1097/hc9.0000000000000277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19554, KAKENHI-PROJECT-23K27670
[Presentation] KDM6B発現低下によりNAFLD関連肝がん細胞は脂肪毒性への耐性を獲得する2024
- Author(s)
  波多野恵
- Organizer
  第67回日本糖尿病学会学術総会
- Data Source
  KAKENHI-PROJECT-23K15388
[Presentation] NAFLD 関連肝がんにおける脂肪毒性への耐性獲得機序の解明.2024
- Author(s)
  波多野恵、秋山好光、島田周、八木宏平、赤星径一、伊藤美智子、田邉稔、小川佳宏、田中真二.
- Organizer
  第97 回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-24K02320
[Presentation] NAFLD関連肝がんにおける脂肪毒性への耐性獲得機序の解明2024
- Author(s)
  波多野恵
- Organizer
  第97回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K15388

1. 田中真二 (30253420)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
2. 秋山好光 (80262187)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
3. 島田周 (20609705)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
4. 森正樹 (70190999)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 石川俊平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HATANO MEGUMI 波多野 恵

Hatano Megumi 波多野 恵

Research Projects

Research Products

Co-Researchers

正常免疫マウス腫瘍モデルを応用したヒト腹膜播種性スキルス胃がんの複合免疫療法開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

代謝関連肝癌におけるヒストン修飾酵素KDM6B異常の病態解明と新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of abnormal lactate metabolism and lysine lactylation modification mechanism in cancer and stromal cell interactions

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of dendritic cells-activated CAR-T cell therapy to overcome tumor heterogeneity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of advanced therapy for refractory cancer based on elucidation of in vivo diversity mechanisms

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of tumor microenvironmental alterations in refractory cancer based on histone modification changes and development of novel therapeutic strategies

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the Pathogenesis and Development of Novel Therapies for Metabolic-Associated HCCPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 【微小環境から読み解く肝癌】脂肪負荷に対する肝癌の耐性機序2024

Author(s)

Publisher

Data Source

[Journal Article] Integrative transcriptome profiling elucidates molecular and immunovascular characteristics of macrotrabecular HCC2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification and clinical implications of endogenous retrovirus elements suppressed by SETDB1 in hepatocellular carcinoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 脂肪負荷に対する肝癌の耐性機序2024

Author(s)

Journal Title

Data Source

[Journal Article] Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 胆道癌におけるエピゲノム異常とその臨床的意義2024

Author(s)

Journal Title

Data Source

[Journal Article] Loss of SFXN1 mitigates lipotoxicity and predicts poor outcome in non-viral hepatocellular carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of KDM6B epigenetically confers resistance to lipotoxicity in nonalcoholic fatty liver disease?related HCC2023

HATANO MEGUMI 波多野恵

Hatano Megumi 波多野恵