Kobayashi Tomoko 小林朋子

Researcher Number	50876977
Affiliation (Current)	2025: 名古屋大学, 医学部附属病院, 病院助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 名古屋大学, 医学部附属病院, 病院助教
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Keywords	Principal Investigator 甲状腺 / 下垂体 / バイオマーカー / irAE / thyroid irAEs / biomarker / pituitary irAEs Except Principal Investigator 内分泌

内分泌腺HLAネオエピトープの同定及び特異的T細胞による革新的がん免疫療法への挑戦
- Principal Investigator
  
  稲葉秀文
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Wakayama Medical University
Research for biomarkers of pituitary dysfunction induced by immune checkpoint inhibitorsPrincipal Investigator
- Principal Investigator
  
  Kobayashi Tomoko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Nagoya University

All 2024 2023 2022 2021

All Journal Article Presentation Book

[Book] 月刊　腫瘍内科　解説2. 免疫チェックポイント阻害薬による内分泌有害事象2023
- Author(s)
  小林朋子, 岩間信太郎, 有馬寛
- Total Pages
  6
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-21K16352
[Book] 糖尿病最新の治療2022-2024　「免疫チェックポイント阻害薬による1型糖尿病」2021
- Author(s)
  小林朋子、有馬寛
- Total Pages
  372
- Publisher
  南江堂
- ISBN
  4524229965
- Data Source
  KAKENHI-PROJECT-21K16352
[Journal Article] Rapidly progressive interstitial lung disease with positive anti-MDA5 antibody as an immune-related complication of nivolumab: A case report2024
- Author(s)
  Kato Sayaka、Sakamoto Koji、Sato Tomonori、Kobayashi Tomoko、Shindo Yuichiro、Morise Masahiro、Iwama Shintaro、Arima Hiroshi、Ishii Makoto
- Journal Title
  
  Respiratory Investigation
  
  Volume: 62 Issue: 2 Pages: 313-316
- DOI
  10.1016/j.resinv.2024.01.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08202, KAKENHI-PROJECT-21K16352, KAKENHI-PROJECT-23K24386
[Journal Article] Clinical characteristics and potential biomarkers of thyroid and pituitary immune-related adverse events2024
- Author(s)
  Kobayashi Tomoko、Iwama Shintaro、Arima Hiroshi
- Journal Title
  
  Endocr J
  
  Volume: 71 Issue: 1 Pages: 23-29
- DOI
  10.1507/endocrj.EJ23-0524
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16352, KAKENHI-PROJECT-23K24386
[Journal Article] Risk of Thyroid Dysfunction in PD-1 Blockade Is Stratified by the Pattern of TgAb and TPOAb Positivity at Baseline2023
- Author(s)
  Zhou Xin、Iwama Shintaro、Kobayashi Tomoko、Ando Masahiko、Arima Hiroshi
- Journal Title
  
  The Journal of Clinical Endocrinology & Metabolism
  
  Volume: 108 Issue: 10 Pages: e1056-e1062
- DOI
  10.1210/clinem/dgad231
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16352, KAKENHI-PROJECT-23K24386
[Journal Article] Amino acid polymorphisms in human histocompatibility leukocyte antigen class II and proinsulin epitope have impacts on type 1 diabetes mellitus induced by immune-checkpoint inhibitors2023
- Author(s)
  Inaba Hidefumi、Morita Shuhei、Kosugi Daisuke、Asai Yuki、Kaido Yosuke、Ito Saya、Hirobata Tomonao、Inoue Gen、Yamamoto Yuki、Jinnin Masatoshi、Kimura Hiroaki、Ota Masao、Okudaira Yuko、Nakatani Hiroyasu、Kobayashi Tomoko、Iwama Shintaro、Arima Hiroshi、Matsuoka Takaaki
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1165004-1165004
- DOI
  10.3389/fimmu.2023.1165004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07365, KAKENHI-PROJECT-21K08544, KAKENHI-PROJECT-21K16352, KAKENHI-PROJECT-23K24386
[Journal Article] Anti-tumor effects of anti-programmed cell death-1 antibody treatment are attenuated in streptozotocin-induced diabetic mice2023
- Author(s)
  Ito Masaaki、Iwama Shintaro、Sugiyama Daisuke、Yasuda Yoshinori、Okuji Takayuki、Kobayashi Tomoko、Zhou Xin、Yamagami Ayana、Onoue Takeshi、Miyata Takashi、Sugiyama Mariko、Hagiwara Daisuke、Suga Hidetaka、Banno Ryoichi、Nishikawa Hiroyoshi、Arima Hiroshi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 5939-5939
- DOI
  10.1038/s41598-023-33049-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16352, KAKENHI-PROJECT-22H00455, KAKENHI-PROJECT-23K24386
[Journal Article] Elevated TSH Level, TgAb, and Prior Use of Ramucirumab or TKIs as Risk Factors for Thyroid Dysfunction in PD-L1 Blockade2022
- Author(s)
  Kobayashi Tomoko、Iwama Shintaro、Morise Masahiro、Hashimoto Naozumi、Arima Hiroshi 他
- Journal Title
  
  The Journal of Clinical Endocrinology & Metabolism
  
  Volume: 107 Issue: 10 Pages: e4115-e4123
- DOI
  10.1210/clinem/dgac467
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07910, KAKENHI-PROJECT-21K16352
[Journal Article] Immune checkpoint inhibitor-related thyroid dysfunction.2022
- Author(s)
  Iwama S, Kobayashi T, Yasuda Y, Arima H.
- Journal Title
  
  Best Practice & Research Clinical Endocrinology & Metabolism
  
  Volume: 36 Issue: 3 Pages: 101660-101660
- DOI
  10.1016/j.beem.2022.101660
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16352
[Journal Article] CD4+ T cells are essential for the development of destructive thyroiditis induced by anti-PD-1 antibody in thyroglobulin-immunized mice2021
- Author(s)
  Yasuda Y, Iwama S, Sugiyama D, Okuji T, Kobayashi T, Ito M, Okada N, Enomoto A, Ito S, Yan Y, Sugiyama M, Onoue T, Tsunekawa T, Ito Y, Takagi H, Hagiwara D, Goto M, Suga H, Banno R, Takahashi M, Nishikawa H, Arima H.
- Journal Title
  
  Science Translational Medicine
  
  Volume: 13 Issue: 593
- DOI
  10.1126/scitranslmed.abb7495
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08976, KAKENHI-PROJECT-17H06162, KAKENHI-PROJECT-21K16352
[Journal Article] Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline2021
- Author(s)
  Iwama S, Kobayashi T, Arima H, et al.
- Journal Title
  
  The Journal of Clinical Endocrinology & Metabolism
  
  Volume: 107 Issue: 4 Pages: e1620-e1630
- DOI
  10.1210/clinem/dgab829
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08976, KAKENHI-PROJECT-21K16352
[Journal Article] Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors2021
- Author(s)
  Kobayashi T, Iwama S, Sugiyama D, Yasuda Y, Okuji T, Ito M, Ito S, Sugiyama M, Onoue T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Nishikawa H, Arima H
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 9 Issue: 5 Pages: e002493-e002493
- DOI
  10.1136/jitc-2021-002493
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06162, KAKENHI-PROJECT-21K16352
[Presentation] 免疫チェックポイント阻害剤による下垂体機能低下症とグルココルチコイド誘発性副腎皮質機能低下症との鑑別を要した１例2024
- Author(s)
  藤枝久美子、尾上剛史、太田美穂子、小林朋子、有馬寛
- Organizer
  第252回日本内科学会東海地方会
- Data Source
  KAKENHI-PROJECT-21K16352
[Presentation] 抗PD-1抗体と抗CTLA-4抗体の併用療法による下垂体障害の臨床的特徴2023
- Author(s)
  小林朋子、岩間信太郎、鈴木浩二、大竹宏輝、井土哲史、山上綾菜、Zhou Xin、安田康紀、有馬寛
- Organizer
  第49回日本神経内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-21K16352
[Presentation] 免疫チェックポイント阻害薬による甲状腺・下垂体障害2023
- Author(s)
  小林朋子、岩間信太郎、有馬寛
- Organizer
  第96回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K16352
[Presentation] 新型コロナウイルス感染後に抗PD-1抗体/抗CTLA-4抗体併用療法による甲状腺機能低下症とACTH単独欠損症を発症した１例2023
- Author(s)
  前田龍太郎、小林朋子、山上綾菜、三輪田勤、尾上剛史、岩間信太郎、有馬寛
- Organizer
  第249回日本内科学会東海地方会
- Data Source
  KAKENHI-PROJECT-21K16352
[Presentation] ストレプトゾトシン糖尿病マウスにおける抗PD-1抗体の大腸癌細胞株に対する抗腫瘍効果低下とメモリーT細胞分画、PD-1発現およびPD-L1発現の検討2023
- Author(s)
  伊藤雅晃，岩間信太郎，安田康紀，井土哲志，奥地剛之，山上綾菜，Zhou Xin，小林朋子，有馬寛
- Organizer
  第96回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K16352
[Presentation] 抗PD-1抗体関連甲状腺機能異常症の臨床的特徴と抗甲状腺抗体価との関連2023
- Author(s)
  山上綾菜，岩間信太郎, 小林朋子, Zhou Xin, 伊藤雅晃, 奥地剛之, 安田康紀, 有馬寛
- Organizer
  第96回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K16352
[Presentation] ストレプトゾトシン糖尿病マウスにおける抗PD-1抗体の抗腫瘍効果低下とケモカインの関連2023
- Author(s)
  伊藤雅晃，岩間信太郎，安田康紀，井土哲志，奥地剛之，山上綾菜，Zhou Xin，小林朋子，有馬寛
- Organizer
  第41回内分泌代謝学サマーセミナー
- Data Source
  KAKENHI-PROJECT-21K16352
[Presentation] 免疫チェックポイント阻害薬による内分泌障害の臨床的特徴及び発症予測マーカーの検討2023
- Author(s)
  小林朋子
- Organizer
  第96回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K16352
[Presentation] The risk of thyroid dysfunction in PD-1 blockade is stratified by the number of positive anti-thyroid antibodies at baseline.2023
- Author(s)
  ZHOU XIN、岩間信太郎、小林朋子、山上綾菜、井土哲志、伊藤雅晃、奥地剛之、安田康紀、有馬寛
- Organizer
  第96回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K16352
[Presentation] 免疫チェックポイント阻害薬関連下垂体機能低下症の臨床像と原因薬剤の関連2023
- Author(s)
  岩間信太郎、小林朋子、有馬寛
- Organizer
  第49回日本神経内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-21K16352
[Presentation] ストレプトゾトシン糖尿病マウスにおける抗PD-1抗体の大腸癌細胞株に対する抗腫瘍効果低下とケモカインの関連2022
- Author(s)
  伊藤雅晃，岩間信太郎，奥地剛之，安田康紀，山上綾菜，Zhou Xin，小林朋子，有馬寛
- Organizer
  第95回日本内分泌学会総会
- Data Source
  KAKENHI-PROJECT-21K16352
[Presentation] 抗PD-1抗体療法開始前の抗甲状腺抗体の存在は非小細胞肺癌患者の生存期間延長と相関する2022
- Author(s)
  奥地剛之、岩間信太郎、小林朋子、山上綾菜、Zhou Xin、伊藤雅晃、安田康紀、有馬寛
- Organizer
  第95回日本内分泌学会総会
- Data Source
  KAKENHI-PROJECT-21K16352
[Presentation] イピリムマブ・ニボルマブ併用療法による甲状腺障害の臨床的特徴と高リスクマーカー2022
- Author(s)
  小林朋子、岩間信太郎、山上綾菜、伊藤雅晃、奥地剛之、安田康紀、有馬寛
- Organizer
  第95回日本内分泌学会総会
- Data Source
  KAKENHI-PROJECT-21K16352
[Presentation] 免疫チェックポイント阻害薬関連１型糖尿病4例の治療奏効率の検討2022
- Author(s)
  伊藤雅晃，岩間信太郎，小林朋子，有馬寛
- Organizer
  第65回日本糖尿病学会学術集会
- Data Source
  KAKENHI-PROJECT-21K16352
[Presentation] 抗PD-L1抗体による甲状腺障害の発症リスク因子の検討2022
- Author(s)
  小林朋子、岩間信太郎、山上綾菜、Zhou Xin、伊藤雅晃、安田康紀、有馬寛
- Organizer
  第65回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-21K16352
[Presentation] 免疫チェックポイント阻害薬による下垂体障害2021
- Author(s)
  小林朋子
- Organizer
  第94回日本内分泌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K16352
[Presentation] ペムブロリズマブ誘発ACTH分泌低下症を契機に中枢性尿崩症の診断に至った肺腺癌の１例2021
- Author(s)
  山上綾菜, 小林朋子, 岩間信太郎, 有馬寛
- Organizer
  第245回日本内科学会東海地方会
- Data Source
  KAKENHI-PROJECT-21K16352

1. 稲葉秀文 (70447770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 岩間信太郎 (00733536)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 森田修平 (50372868)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 木村博昭 (70593622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. ARIMA Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 森瀬昌宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 阪本考司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 西川博嘉

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# of Collaborated Products: 1 results

Kobayashi Tomoko 小林 朋子

Research Projects

Research Products

Co-Researchers

内分泌腺HLAネオエピトープの同定及び特異的T細胞による革新的がん免疫療法への挑戦

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research for biomarkers of pituitary dysfunction induced by immune checkpoint inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 月刊 腫瘍内科 解説2. 免疫チェックポイント阻害薬による内分泌有害事象2023

Author(s)

Total Pages

Publisher

Data Source

[Book] 糖尿病最新の治療2022-2024 「免疫チェックポイント阻害薬による1型糖尿病」2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Rapidly progressive interstitial lung disease with positive anti-MDA5 antibody as an immune-related complication of nivolumab: A case report2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical characteristics and potential biomarkers of thyroid and pituitary immune-related adverse events2024

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Risk of Thyroid Dysfunction in PD-1 Blockade Is Stratified by the Pattern of TgAb and TPOAb Positivity at Baseline2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Amino acid polymorphisms in human histocompatibility leukocyte antigen class II and proinsulin epitope have impacts on type 1 diabetes mellitus induced by immune-checkpoint inhibitors2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-tumor effects of anti-programmed cell death-1 antibody treatment are attenuated in streptozotocin-induced diabetic mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elevated TSH Level, TgAb, and Prior Use of Ramucirumab or TKIs as Risk Factors for Thyroid Dysfunction in PD-L1 Blockade2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immune checkpoint inhibitor-related thyroid dysfunction.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD4+ T cells are essential for the development of destructive thyroiditis induced by anti-PD-1 antibody in thyroglobulin-immunized mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] 免疫チェックポイント阻害剤による下垂体機能低下症とグルココルチコイド誘発性副腎皮質機能低下症との鑑別を要した１例2024

Kobayashi Tomoko 小林朋子

[Book] 月刊　腫瘍内科　解説2. 免疫チェックポイント阻害薬による内分泌有害事象2023

[Book] 糖尿病最新の治療2022-2024　「免疫チェックポイント阻害薬による1型糖尿病」2021