Jimbo Koji 神保光児

Researcher Number	50915478
Other IDs	https://orcid.org/0000-0002-2031-7385
Affiliation (Current)	2026: 東京大学, 医科学研究所, 助教
Affiliation (based on the past Project Information) *help	2024 – 2025: 東京大学, 医科学研究所, 助教 2022 – 2023: 東京大学, 医科学研究所, 医員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator HTLV-1 / 白血病幹細胞 / 成人T細胞白血病リンパ腫 (ATL) / 慢性移植片対宿主病 / T細胞老化 / 造血細胞移植 / p38-MAPK経路 / 抗老化 / フローサイトメトリー / 老化T細胞 … More / 免疫老化 / 免疫再構築 / 移植片対宿主病（GVHD） / 同種造血細胞移植 Less

Identification of leukemic stem cells in adult T-cell leukemia/lymphoma and their association with disease development and refractoriness to treatmentPrincipal Investigator
- Principal Investigator
  
  神保光児
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
Mechanism of T cell senescence after hematopoietic cell transplantation and its impact on chronic graft-versus-host diseasePrincipal Investigator
- Principal Investigator
  
  Jimbo Koji
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo

All 2025 2024 2023 2022 Other

All Journal Article Presentation Other

[Journal Article] Prognosis of aggressive adult T-cell leukemia/lymphoma with central nervous system infiltration and utility of CD7 versus CADM1 flowcytometric plots of cerebrospinal fluid.2025
- Author(s)
  Jimbo K, Ishigaki T, Sakashita M, Andoh S, Ichimura H, Ito A, Yokoyama K, Sato A, Fukuda T, Uchimaru K, Nannya Y.
- Journal Title
  
  Ann Hematol.
  
  Volume: 104(1) Pages: 635-640
- DOI
  10.1007/s00277-025-06186-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16317
[Journal Article] Flow cytometric profiles with CD7 and CADM1 in CD4+ T cells are promising indicators for prognosis of aggressive ATL.2024
- Author(s)
  Jimbo K, Kawamata T, Inamoto Y, Ito A, Yokoyama K, Sato A, Fukuda T, Uchimaru K, Nannya Y.
- Journal Title
  
  Blood Adv.
  
  Volume: 8(14) Issue: 14 Pages: 3760-3770
- DOI
  10.1182/bloodadvances.2024013089
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16317
[Journal Article] Progression of adult T‐cell leukemia/lymphoma from smoldering to acute type due to branched subclonal evolution2023
- Author(s)
  Jimbo Koji、Yamagishi Makoto、Suzuki Yutaka、Suzuki Kako、Mizukami Motoko、Yokoyama Kazuaki、Sato Aki、Nagamura‐Inoue Tokiko、Nannya Yasuhito、Uchimaru Kaoru
- Journal Title
  
  eJHaem
  
  Volume: 4 Issue: 4 Pages: 1188-1190
- DOI
  10.1002/jha2.776
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16317, KAKENHI-PROJECT-21K08386, KAKENHI-PROJECT-23K24248
[Journal Article] Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia2022
- Author(s)
  Jimbo Koji、Hattori Ayuna、Koide Shuhei、Ito Takahiro、Sasaki Katsuhiro、Iwai Kazuhiro、Nannya Yasuhito、Iwama Atsushi、Tojo Arinobu、Konuma Takaaki
- Journal Title
  
  Leukemia
  
  Volume: 37 Issue: 1 Pages: 122-133
- DOI
  10.1038/s41375-022-01750-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-22K16317, KAKENHI-PROJECT-22H04988, KAKENHI-PROJECT-20K07337, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05499, KAKENHI-PROJECT-20K08748
[Journal Article] Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of β-catenin degradation2022
- Author(s)
  Jimbo K, Nakajima-Takagi Y, Ito T, Koide S, Nannya Y, Iwama A, Tojo A, Konuma T
- Journal Title
  
  Leukemia
  
  Volume: In press Issue: 6 Pages: 1550-1562
- DOI
  10.1038/s41375-022-01564-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08748, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-22K16317
[Presentation] HTLV-1キャリアの長期プロウイルス量動態モデルを用いたATL発症危険度の推定2024
- Author(s)
  神保光児, 野島正寛, 鳥内恵子, 山岸誠, 山野嘉久, 内丸薫, 南谷泰仁
- Organizer
  第10回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16317
[Presentation] HTLV-1キャリアにおけるHTLV-1プロウイルス量の長期動態モデルの提唱2024
- Author(s)
  神保光児, 野島正寛, 鳥内恵子, 山岸誠, 山野嘉久, 内丸薫, 南谷泰仁
- Organizer
  第86回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16317
[Presentation] CD7とCADM1を用いたフローサイトメトリープロファイルはATL臨床経過を反映し予後を推定する2023
- Author(s)
  神保光児、川俣豊隆、稲本賢弘、横山和明、佐藤亜紀、福田隆浩、内丸薫、南谷泰仁
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16317
[Presentation] 自家造血細胞移植後の HHV-6B 再活性化を契機に血球貪食症候群を発症した 1 例2023
- Author(s)
  神保　光児、横山　和明、福山　朋房、藤田　純美子、佐藤　亜紀、川俣　豊隆、南谷　泰仁
- Organizer
  第18回日本血液学会関東甲信越地方会
- Data Source
  KAKENHI-PROJECT-22K16317
[Presentation] フローサイトメトリーによる正常T細胞とATL腫瘍細胞の分離は臨床経過と予後の推定に有用である2023
- Author(s)
  神保光児, 川俣豊隆, 稲本賢弘, 横山和明, 佐藤亜紀, 福田隆浩, 内丸薫, 南谷泰仁
- Organizer
  第9回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16317
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1. 小出周平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 小沼貴晶

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Jimbo Koji 神保 光児

Research Projects

Research Products

Co-Researchers

Identification of leukemic stem cells in adult T-cell leukemia/lymphoma and their association with disease development and refractoriness to treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of T cell senescence after hematopoietic cell transplantation and its impact on chronic graft-versus-host diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Prognosis of aggressive adult T-cell leukemia/lymphoma with central nervous system infiltration and utility of CD7 versus CADM1 flowcytometric plots of cerebrospinal fluid.2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Flow cytometric profiles with CD7 and CADM1 in CD4+ T cells are promising indicators for prognosis of aggressive ATL.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Progression of adult T‐cell leukemia/lymphoma from smoldering to acute type due to branched subclonal evolution2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of β-catenin degradation2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] HTLV-1キャリアの長期プロウイルス量動態モデルを用いたATL発症危険度の推定2024

Author(s)

Organizer

Data Source

[Presentation] HTLV-1キャリアにおけるHTLV-1プロウイルス量の長期動態モデルの提唱2024

Author(s)

Organizer

Data Source

[Presentation] CD7とCADM1を用いたフローサイトメトリープロファイルはATL臨床経過を反映し予後を推定する2023

Author(s)

Organizer

Data Source

[Presentation] 自家造血細胞移植後の HHV-6B 再活性化を契機に血球貪食症候群を発症した 1 例2023

Author(s)

Organizer

Data Source

[Presentation] フローサイトメトリーによる正常T細胞とATL腫瘍細胞の分離は臨床経過と予後の推定に有用である2023

Author(s)

Organizer

Data Source

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Jimbo Koji 神保光児