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NEMOTO Hideo  根本 英雄

ORCIDConnect your ORCID iD *help
Researcher Number 60006351
Other IDs
Affiliation (based on the past Project Information) *help 2008: University of Toyama, 大学院・医学薬学研究部 (薬学), 教授
2008: 富山大学, 大学院・医学薬学研究部, 教授
2007 – 2008: University of Toyama, 大学院・医学薬学研究部(薬学), 教授
2005: University of Toyama, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授
2003 – 2004: 富山医科薬科大学, 薬学部, 教授 … More
2000 – 2001: 富山医科薬科大学, 薬学部, 教授
1994 – 1995: 東北大学, 薬学部, 助手
1986 – 1988: 東北大学, 薬学部, 助手 Less
Review Section/Research Field
Principal Investigator
Chemical pharmacy / Chemical pharmacy / Drug development chemistry
Except Principal Investigator
Chemical pharmacy / Drug development chemistry
Keywords
Principal Investigator
OSW-1 / ベンゾシクロブテン / オルトキノジメタン / 構造活性相関 / structure-activity relationship / steroid / anticancer agent / antitumor activity / シスプラチン / ステロイド … More / 抗癌剤 / 抗腫瘍活性 / Sendai virus / retro-electron-demanded Diels-Alder reaction / dihydrofuran / benzocyclobutene / o-quinozimethane / anti-virus activity / sodium salt of sulfate / halenaouinol / 抗ウィルス剤 / フラン環 / アマンタジン / 四環系化合物 / 分子内環化付加反応 / 多環系天然物 / Sendaiウイルス / 逆電子要請型環化付加反応 / ジヒドロフラン / 抗ウイルス活性 / モノサルフェートナトリウム塩 / ハレナキノール / Chiral Cyclobutanone / Concerted 1,2-Rearrangenmet / Asymmetric Dihydroxylation / Asymmetric Epoxidation / Cyclopropylidene / 不斉エポシキ化反応 / シクロプロピチデン / 協奏的1,2転位反応 / 光学活性シクロブタノン / 協奏的1, 2転位反応 / 不斉ジヒドロキシ化反応 / 不斉エポキシ化反応 / シクロプロピリデン / 有機化学 / 生理活性 / ウイルス / 合成化学 / 抗ウイルス作用 / インフルエンザ … More
Except Principal Investigator
分子内Diels-Alder反応 / Stereoselective Synthesis / Terpene / Alkaloid / Steroid / Biologically Active Natural Product / Intramolecular Double Michael Reaction / Organic Synthesis / 環化反応 / 生理活性化天然化合物 / 有機合成化学 / 不斉合成 / 立体選択的合成 / テルペン / アルカロイド / ステロイド / 生理活性天然物 / 分子内二重共役付加反応 / 有機合成 / ヒマカレン / ヒドロアズレン / セドラン / ステモダン / アチシン / アコニチン型アルカロイド / 分子内Double Michael反応 / Spironslactone / Geneserine / Physovenine / Physostigmine / Tandem Electrocyclic-〔3,3〕sigmatropic Reaction / Benzocyclobutene / 有機化学 / 生理活性 / 癌 / 合成化学 / 構造活性相関 / 薬物設計 / 腫瘍細胞 / アポトーシス Less
  • Research Projects

    (8 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (7 People)
  •  Design, Synthesis, and Biological Evaluation of Macrosphelide- based Compounds for Development of New Anticancer Agents

    • Principal Investigator
      MATSUYA Yuji
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      University of Toyama
  •  Design and Synthesis of Furan-fused Polycyclic Compounds for Development of New Anti-influenza AgentsPrincipal Investigator

    • Principal Investigator
      NEMOTO Hideo
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      University of Toyama
  •  Design and Synthesis of New Anticancer Agents Based on OSW-1 Having Potent Antitumor Activity as a Lead CompoundPrincipal Investigator

    • Principal Investigator
      NEMOTO Hideo
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      University of Toyama
      Toyama Medical and Pharmaceutical University
  •  Synthetic Studies on Furan-fused Polycyclic Natural Products and Its DerivativesPrincipal Investigator

    • Principal Investigator
      NEMOTO Hideo
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
  •  A Development of New method for the Synthesis of Chiral Cyclobutanones-A Synthetic Approach to Trichothecane Type of MacrolidesPrincipal Investigator

    • Principal Investigator
      NEMOTO Hideo
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      TOHOKU UNIVERSITY
  •  Syntheses of Biologically Active Natural Products by Intramolecular Double Michael Reaction

    • Principal Investigator
      IHARA Masataka
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      TOHOKU UNIVERSITY
  •  Benzocyclobuteneの機能を活用する生理活性化合物の高選択的合成

    • Principal Investigator
      福本 圭一郎
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Tohoku University
  •  分子内Diels-Alder反応の効率的利用:共通合成素子を経るテルペン類の合成

    • Principal Investigator
      福本 圭一郎
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Tohoku University

All 2009 2008 2007 2005 2003 Other

All Journal Article Presentation

  • [Journal Article] Mechanism of Apoptosis Induced by a Newly Synthesized Derivative of Macrosphelides with a Thiazole Side Chain2009

    • Author(s)
      Ahmed, K., Matsuya, Y., Nemoto, H., Zaldi, S. F. H., Sugiyama, T., Yoshihisa, Y., Shimizu, T., Kondo, T.
    • Journal Title

      Chemico Biological Interactions 177

      Pages: 218-226

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Journal Article] Studies toward Intramolecular Cycloaddition of o-Quinodimethane with an Oxazole Moiety.2009

    • Author(s)
      Matsuya, Y., Qin, H., Nemoto, H.
    • Journal Title

      Heterocycles 79(掲載確定)

    • NAID

      40016543106

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590099
  • [Journal Article] Total Synthesis of 2 -Nor-macrosphelide A and B.2009

    • Author(s)
      Matsuya, Y., Matsushita, T., Sakamoto, K., Nemoto, H.
    • Journal Title

      Heterocycles 77

      Pages: 483-492

    • NAID

      40016405889

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Journal Article] Mechanism of Apoptosis Induced by a Newly Synthesized Derivative of Macrosphelides with a Thiazole Side Chain2009

    • Author(s)
      Ahmed, K. ; Matsuya, Y. ; Nemoto, H. ; Zaidi, S. F. H. ; Sugiyama, T. ; Yoshihisa, Y. ; Shimizu, T. ; Kondo, T.
    • Journal Title

      Chem. Biol. Interact 177

      Pages: 218-226

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Journal Article] Studies toward Intramolecular Cycloaddition of o-Quinodimethane with an Oxazole Moiety2009

    • Author(s)
      Matsuya, Y, Qin, H, Nemoto, H
    • Journal Title

      Heterocycles 79(Prepress)

    • NAID

      40016543106

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590099
  • [Journal Article] Total Synthesis of 2-Nor-macrosphelide A and B2009

    • Author(s)
      Matsuya, Y. ; Matsushita, T. ; Sakamoto, K. ; Nemoto, H.
    • Journal Title

      Heterocycles 77

      Pages: 483-492

    • NAID

      40016405889

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Journal Article] Approach to a New Dihydrofuran-Fused Cyclic System by a Remarkable Switching of endo/exo Selectivity of a [4+2] Cycloaddition Reaction2008

    • Author(s)
      Matsuya, Y.; Imamura, Y.; Miyahara, T.; Ochiai, H.; Nemoto, H.
    • Journal Title

      European Journal of Organic Chemistry

      Pages: 1426-1430

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590099
  • [Journal Article] Approach to a New Dihydrofuran-Fused Cyclic System by a Remarkable Switching of endo/exo Selectivity of a [4+2] Cycloaddition Reaction2008

    • Author(s)
      Matsuya, Y, Imamura, Y, Miyahara, T, Ochiai, H., Nemoto, H.
    • Journal Title

      Eur. J. Org. Chem

      Pages: 1426-1430

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590099
  • [Journal Article] Enhancement of Macrosphelide-induced Apoptosis by Mild Hyperthermia2007

    • Author(s)
      Ahmed, K. ; Zhao, Q.-L. ; Matsuya, Y. ; Yu, D.-Y. ; Salunga, T. L. ; Nemoto, H. ; Kondo, T.
    • Journal Title

      Int. J. Hyperthermia 23+

      Pages: 353-361

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Journal Article] Enhancement of Macrosphelide-induced Apoptosis by Mild Hyperthermia2007

    • Author(s)
      Ahmed, K.;Zhao, Q.-L.;Matsuya, Y.;Yu, D.-Y, ;Salunga, T. L;Nemoto, H.;Kondo, T.
    • Journal Title

      International Journal of Hyperthermia 23

      Pages: 353-361

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Journal Article] Rapid and Transient Intracellular Oxidative Stress Due to Novel Macrosphelides Trigger Apoptosis via Fas/caspase-8-dependent Pathway in Human Lymphoma U937 Cells2007

    • Author(s)
      Ahmed, K.; Zhao, Q.-L.; Matsuya, Y.;Yu, D.-Y, ; Feril, L. B., Jr.; Nemoto, H.; Kondo, T.
    • Journal Title

      Chemico Biological Interactions 170

      Pages: 86-99

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Journal Article] Rapid and Transient Intracellular Oxidative Stress Due to Novel Macrosphelides Trigger Apoptosis via Fas/caspase-8-dependent Pathway in Human Lymphoma U937 Cells2007

    • Author(s)
      Ahmed, K. ; Zhao, Q.-L. ; Matsuya, Y. ; Yu, D.-Y. ; Feril, L. B., Jr. ; Nemoto, H. ; Kondo, T.
    • Journal Title

      Chem. Biol. Interact 170

      Pages: 86-99

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Journal Article] A Practical Asymmetric Synthesis of trans-4,5-Benzhydrindane-1-ones as a Precursor of A-Nor B-Aromatic Steroidal Compounds2005

    • Author(s)
      Yuji Matsuya, Seiji Masuda, Takakatsu Itoh, Taiki Murai, Hideo Nemoto
    • Journal Title

      The Journal of Organic Chemistry 70(17)

      Pages: 6898-3903

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390004
  • [Journal Article] Synthesis and Antitumor Activity of the Estrane Analogue of OSW-12005

    • Author(s)
      Yuji Matsuya, Seiji Masuda, Noriko Ohsawa, Solange Adam, Theophile Tschamber, Jacques Eustache, Keiichi Kamoshita, Yoshikazu Sukenaga, Hideo Nemoto
    • Journal Title

      European Journal of Organic Chemistry (5)

      Pages: 803-808

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390004
  • [Journal Article] Total Synthesis of A-Nor B-Aromatic OSW-1 Aglycon : A Highly Effective Approach to Optically Active trans-4,5-Benzhydrindane2003

    • Author(s)
      Yuji Matsuya, Takakatsu Itoh, Hideo Nemoto
    • Journal Title

      European Journal of Organic Chemistry (12)

      Pages: 2221-2224

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390004
  • [Journal Article] Design, Synthesis, and Biological Evaluation of Artificial Macrosphelides in Search for New Apoptosis-inducing Agents

    • Author(s)
      Matsuya, Y. ; Kobayashi, Y. ; Kawaguchi, T. ; Hori, A. ; Watanabe, Y. ; Ishihara, K. ; Ahmed, K. ; Wei, Z.-L. ; Yu, D. Y. ; Zhao, Q.-L.; Kondo, T. ; Nemoto, H.
    • Journal Title

      Chem. Eur. J. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Presentation] Synthesis of Novel Artificial Macrosphelides as a New Apoptosis Inducing Agent2008

    • Author(s)
      Matsuya Y., Kobayash Y., Ishihara K., Kawaguchi T., Ahmed K., Zhao Q.-L., Kondo T., and Nemoto H
    • Organizer
      The 20^<th> French-Japanese Symposium on Medicinal and Fine Chemistry
    • Place of Presentation
      Bordeaux, France
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Presentation] アポトーシス誘導による新規抗癌剤開発を指向したアザマクロスフェライド類の合成2008

    • Author(s)
      小林勇太, 堀綾奈, 松谷裕二, Ahmed K., Zhao Q.-L., 近藤隆, 根本英雄
    • Organizer
      創薬懇話会2008
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Presentation] アザマクロスフェライド類の合成研究2008

    • Author(s)
      小林勇太, 松谷裕二, 根本英雄
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Presentation] Aza-macrosphelide類の合成とアポトーシス誘導活性2008

    • Author(s)
      小林勇太, 堀綾奈, 松谷裕二, Ahmed K., Zhao Q.-L., 近藤隆, 根本英雄
    • Organizer
      第38回複素環化学討論会
    • Place of Presentation
      福山
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Presentation] Chemistry and Biology of Benzocyclobutenes : Facile o-Quinodimethane Formation and Transformation to New Bioactive Compounds2008

    • Author(s)
      Matsuya Y, Sasaki K., Ohsawa N, , Yu D.-Y, Zhao Q.-L, Ahmed K., Wei Z.-L., Kondo T, and Nemoto H.
    • Organizer
      XXth International Symposium on Medicinal Chemistry
    • Place of Presentation
      Vienna
    • Data Source
      KAKENHI-PROJECT-19590099
  • [Presentation] Synthesis and Bioactivity of Macrosphelide-based Artificial Compounds2008

    • Author(s)
      Matsuya Y., Kawaguchi T., Ahmed K., Zhao Q.-L., Kondo T., and Nemoto H.
    • Organizer
      The First International Symposium on Process Chemistry
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Presentation] Macrosphelide-Epothiloneハイブリッド化を基盤とした分子設計と創薬2008

    • Author(s)
      堀綾奈, 渡邊優香, 河村知美, 松谷裕二, , Ahmed K., Zhao Q.-L., 近藤隆, 根本英雄
    • Organizer
      創薬懇話会2008
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Presentation] Design and Synthesis of Macrosphelide Aza-analogues2008

    • Author(s)
      Kobayashi Y., Matsuya Y., and Nemoto H
    • Organizer
      The First International Symposium on Process Chemistry
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Presentation] Search for a New Anti -Cancer Agent by Design, Synthesis, and Biological Evaluation of Macrosphelide -BasedNon-Natural Compounds.2008

    • Author(s)
      Matsuya Y., Kobayash Y., Ishihara K., Kawaguchi T., Ahmed K., Zhao Q. -L., Kondo T., Nemoto H.
    • Organizer
      XXth International Symposium on Medicinal Chemistry
    • Place of Presentation
      Vienna, Austria
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Presentation] 複素環含有マクロスフェライドの合成とアポトーシス誘導活性2008

    • Author(s)
      堀綾奈, 松谷裕二, Ahmed K., Zhao Q.-L., 近藤隆, 根本英雄
    • Organizer
      日本薬学会北陸支部第118回例会
    • Place of Presentation
      富山
    • Year and Date
      2008-07-05
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Presentation] 複素環側鎖を導入した人工型macrosphelide類の設計と合成2008

    • Author(s)
      渡邊優香, 河村知美, 堀綾奈, 松谷裕二, Ahmed K., Zhao Q.-L., 近藤隆, 根本英雄
    • Organizer
      第38回複素環化学討論会
    • Place of Presentation
      福山
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Presentation] Search for a New Anti-Cancer Agent by Design, Synthesis, and Biological Evaluation of Macrosphelide-Based Non-Natural Compounds2008

    • Author(s)
      Matsuya Y., Kobayash Y., Ishihara K., Kawaguchi T., Ahmed K., Zhao Q.-L., Kondo T., and Nemoto H
    • Organizer
      XXth International Symposium on Medicinal Chemistry
    • Place of Presentation
      Vienna, Austria
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Presentation] マクロスフェライド類を基盤としたドラッグデザインと合成2008

    • Author(s)
      堀綾奈, 松谷裕二, 根本英雄
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Presentation] "Benzocyclobutene" Synthetic Organic Chemistry and Medicinal Chemistry.2008

    • Author(s)
      Nemoto H.
    • Organizer
      The 20^<th> French-Japanese Symposium on Medicinal and Fine Chemistry
    • Place of Presentation
      Bordeaux, France
    • Data Source
      KAKENHI-PROJECT-19590099
  • [Presentation] Hyperthermia-induced apoptosis and its enhancement by novel chemical compounds2008

    • Author(s)
      Kondo T., Yu D.Y., Matsuya Y., Zhao Q.L., Ahmed K., Wei Z.L., Hori T., and Nemoto H.
    • Organizer
      10th International Congress on Hyperthermic Oncology
    • Place of Presentation
      Munich, Germany
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Presentation] 新規マクロスフェライド誘導体によるアポトーシス誘導とその分子機構2008

    • Author(s)
      近藤隆, エヘメドカンワル, 松谷裕二, 趙慶利, 根本英雄
    • Organizer
      第17回日本アポトーシス研究会学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-19590098
  • [Presentation] フラン融合縮環系の効率的構築と誘導体化、および抗インフルエンザ活性評価2007

    • Author(s)
      小林 真也、佐々木 和重、鈴木 望美、松谷 裕二、落合 宏、根本 英雄
    • Organizer
      第37回複素環化学討論会
    • Place of Presentation
      長野市若里市民文化ホール
    • Year and Date
      2007-10-18
    • Data Source
      KAKENHI-PROJECT-19590099
  • [Presentation] フラン融合縮環系の効率的構築と誘導体化、および抗インフルエンザ活性評価2007

    • Author(s)
      小林真也、佐々木和重、鈴木望美、松谷裕二、落合宏、根本英雄
    • Organizer
      第37回複素環化学討論会
    • Place of Presentation
      長野
    • Data Source
      KAKENHI-PROJECT-19590099
  • [Presentation] 含窒素型マクロスフェライド類縁体の設計と合成2007

    • Author(s)
      小林 勇太、松谷 裕二、根本 英雄
    • Organizer
      創薬懇話会
    • Place of Presentation
      富山観光ホテル
    • Year and Date
      2007-12-19
    • Data Source
      KAKENHI-PROJECT-19590098
  • 1.  MATSUYA Yuji (50255858)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 34 results
  • 2.  KONDO Takashi (40143937)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 18 results
  • 3.  OCHIAI Hiroshi (30018692)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 4.  福本 圭一郎 (50004586)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  TOYOOKA Naoki (10217565)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  IHARA Masataka (00006339)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  永井 光雄 (90164392)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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