Shima Akihiro 嶋昭紘

… Alternative Names

SHIMA Akihiro 嶋昭紘

嶋昭絋シマアキヒロ

島昭絋シマアキヒロ

島昭紘シマアキヒロ

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Researcher Number	60011590
External Links
Affiliation (Current)	2025: 東京大学, 名誉教授, 名誉教授
Affiliation (based on the past Project Information) *help	2003 – 2005: The University of Tokyo, Graduate school of Frontier Sciences, Professor Emeritus, 大学院・新領域創成科学研究科, 名誉教授 1998 – 2002: University of Tokyo, Graduate School of Frontier Sciences, Prof., 大学院・新領域創成科学研究科, 教授 1993 – 1997: The University of Tokyo, Graduate School of Science, Professor, 大学院・理学系研究科, 教授 1996: 東京大学, 理学部, 教授 1994: 東京大学, 大学院理学系研究科, 教授 1986 – 1993: 東京大学, 理学部, 教授 1986: 東京大学, 理学部・動物学教室, 教授
Review Section/Research Field	Principal Investigator 放射線5生物学 / 広領域 / Laboratory animal science / Biological Sciences / 環境影響評価(含放射線生物学) Except Principal Investigator 放射線5生物学 / 動物発生・生理学 / Genetics/Genome dynamics / Biological Sciences / Experimental pathology / 環境影響評価(含放射線生物学)
Keywords	Principal Investigator メダカ / 生殖細胞突然変異 / 突然変異 / 優性致死 / 奇形 / 細胞死 / germ cell mutation / ENU / viable mutation / total mutation … More / dominant lethals / male germ cells / the Medaka (Oryzias latipes) / 放射線 / Medaka / RBE / トリチウムシミュレーター / 発生異常 / 体細胞突然変異 / ヒト / マウス / カイコ / ショウジョウバエ / prothoracic glands / single-pollen analysis / polysemous codon / caspase / extrachromosomal DNA / gene homing / telomere / エクジソン分泌 / 前胸腺抑制ホルモン / タバコ培養細胞 / 嗅覚受容体 / 神経伝達物質 / ラン色細菌 / ウニ左右性関連遺伝子 / 前胸線抑制ペプチド(PTSP)産生器官 / メダカ生殖細胞自然突然変異率 / 利己的遺伝子 / レトロトランスポゾン / 表層微小管 / 一花粉解析法 / 生殖細胞自然突然変異率 / 多義語コドン / カスパーゼ活性 / 染色体外DNA / 利子的遺伝子 / テロメア特異的レトロトランスポゾン / research resources / International symposium / International collaboration / Medaka Genome Initiative (MGI) / medaka genome / 国際協力 / メダカの特性 / 基礎知識の啓蒙 / 市民 / 公開講座「メダカの学校2001」 / 公開シンポジュウム / 知的所有権 / 総括班会議 / Medaka Genome Initiatives(MGI) / メダカゲノムシークエンシング / 課題名の発展的変更 / 中間ヒアリング / 班会議 / 定例班会議 / メダカゲノムプロジェクト / 拡大班会議 / Symposium on Medaka Genomics 2002 / MGI / EMBO Course / メダカゲノムイニシアチブ / 研究資材 / 国際シンポジュウム / 国際共同研究 / メダカゲノムイニシアチブ(MGI) / メダカゲノム / pollen tube / mate choice / meiosis regulation genes / spermatogenesis / sex chromosome / endocrine organ / sexual strategy / 受精管 / 配偶者選択 / 減数分裂制御遺伝子群 / 精子形成 / 性染色体 / 内分泌器官 / 性戦略 / Synergistic / Additive / gamma-rays / Mutagenesis / Germ cell / 遺伝影響 / 化学物質 / 複合被曝 / ethylnitrosourea / external malformation / multiple genetic endpoints / :原子炉放射線 / エチルニトロソウレア / 原子炉放射線 / ガンマー線 / 誘発奇形 / 特定座位法 / DNA alterations / maturation / specific-locus test system / AP-PCRフィンガープリンティング / 精原細胞 / 分化精原細胞 / 精母細胞 / 精細胞 / 精子 / γ線 / DNA変異 / 生存突然変異 / 総突然変異 / 分化 / 雄生殖細胞 / Malformation / Dominant lethals / Selection / Developmental process / Radiation / Specific-locus mutation / Tester Medaka / 淘汰 / 発生過程 / 特定座位突然変異 / テスタ-メダカ / Polymorphism / Inbred strains / Germーcell mutations / Chromosomes / Biochemical characteristics / Morphological characteristics / Laboratory animals / 近,交系 / DNA多型 / 近交系 / 染色体 / 生化学的特性 / 形態学的特性 / 実験動物 / 線量率効果 / RFLPs / 修復 / 標準的生物種 / 継世代的影響 / 環境要因 / 染色体異常 / フィルター減衰方式 / 空間減衰方式 / 種分化 / 小型魚類 … More Except Principal Investigator 染色体異常 / 突然変異 / 人体影響 / 国際比較生理生化学会議 / 複合効果 / 磁場 / 自然突然変異 / p53 / メダカ / 生殖細胞突然変異 / 発生異常 / 継世代的影響 / 重点領域研究 / 放射線影響 / 放射線発がん / 放射線応答 / 遺伝要因 / HLA / 間期死反応 / 優性致死 / 環境変異原 / シンポジウム / トリチウム / Vertebrates / Medaka / Mutation rate / Spontaneous mutation / Transposition / Transposon / 脊椎動物 / 突然変異率 / 転移 / トランスポゾン / apoptosis / mechanism for maintaining of genome stability / medaka / cells / 胚死 / 低線量 / 高感受性集団 / 分化型精原細胞 / 精原幹細胞 / 雄生殖細胞 / メダカ生殖細胞突然変異 / ATM遺伝子 / p53遺伝子 / チェックポイント / TUNEL陽性細胞 / 父性発現 / ESTマーカー / P53 / 細胞死 / 精原細胞 / 自然突然変異率 / 特定座位法 / Polymorphism / Expression of paternal genome / MBT / Speruatogenesis / Medaka fish / γ-rays / ポジショナルクローニング / 色素細胞 / アポトーシス / ゲノム安定性保持機構 / 生殖細胞 / Transmission to descendants / Radionucides / Functional Defects / Molecular Changes / Maldevelopment / Damage in the reproductive system / Transgenerational Effects / Man-made Toxic Agents / 機能的障害 / 精子・卵子障害 / チェルノブイリ放射能汚染の遺伝的影響 / 子孫への伝達 / 放射能汚染 / 機能的異常 / 分子遺伝学的異常 / 形態異常 / 生殖器障害 / 新人為起源有害物質 / restriction length polymorphism / threshold-like response / X chromosome inactivation / germ cell mutation / UV skin cancer / excision repair / photolyase / DNA strand break / 胸腺腫 / 閾値様反応 / ユビキチン活性化酵素 / 紫外線損傷 / 除去修復遺伝子 / DNA二本鎖切断修復 / クローナリティ / しきい線量 / 制限酵素断片長多型 / しきい値様反応 / X染色体不活性化 / 紫外線皮膚癌 / 除去修復 / 光回復酵素 / DNA鎖切断 / Water quality / Inland waters ecosystem / Limnology / Species differentiation / Phelogeny / Adrianichthydei / Sulawesi / Indonesia / 陸水調査 / 地理的分布 / Xenopoecirus / Adrianichthys / Oryzias / メダカ属魚類 / ポソ湖 / スラウェシ島 / 水質 / 陸水生態系 / 陸水学 / 種分化 / 系統 / メダカ亜目魚類 / スラベシ / インドネシア / 放射線 / 遺伝損傷 / 環境因子 / 早老症 / 骨粗鬆症 / アルツハイアー病 / 生理的老化 / 老化 / クリプト / 小腸 / リンパ球 / 連続照射 / トリチウムシミュレーター / トリチウム水 / DNA修復 / 奇形の誘発 / 細胞内情報伝達 / 遺伝子損傷性ストレス / 標的理論 / ゲノム不安定性 / レドックス制御 / 低線量放射線 / 制がん / シグナル伝達 / 微量放射線 / 間期死 / DNA修復能 / 均衡転座 / 継世代影響 / 微粒子 / 難分解物質 / 電磁気 / 環境要因 / 生存突然変異 / HLA‐DRα鎖遺伝子 / トランジション / MNNG / P‐450 / FISH / 生形態形成 / DNA損傷と修復 / 紫外線 / 太陽光 / 光生物学 / 珪肺症 / <crp>___ー遺伝子 / 特定座位 / ダイオキシン / 難分解性物質 / 小頭症 / RBE / 有機結合トリチウム / 細胞致死 / 細胞のがん化 / 線量率効果 / トリチウム体内取り込み / トリチウム医生物効果 / トリチウム環境動態 / 核融合トリチウム / トリチウム総合研究 Less

Contribution of transposable elements to spontaneous mutation rates in medaka fish
- Principal Investigator
  
  KOGA Akihiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Genetics/Genome dynamics
- Research Institution
  Nagoya University
Steering committe on study of medaka as a model for organization and evolution of the nuclear genomePrincipal Investigator
- Principal Investigator
  
  SHIMA Akihiro
- Project Period (FY)
  1999 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Elucidation of mechanism for fixation of mutations occurred in germ cells using medaka.Principal Investigator
- Principal Investigator
  
  FUKAMACHI Shoji, 嶋昭紘
- Project Period (FY)
  1999 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
A Comprehensive Study on Intrusion and Cooperation of GenomesPrincipal Investigator
- Principal Investigator
  
  SHIMA Akihiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  広領域
- Research Institution
  The University of Tokyo
生命科学におけるモデルとしてのメダカに関する研究動向調査Principal Investigator
- Principal Investigator
  
  嶋昭紘
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
A Crossdisciplinary Study on the Benefits of Sexual ReproductionPrincipal Investigator
- Principal Investigator
  
  SHIMA Akihiko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  広領域
- Research Institution
  University of Tokyo
放射線影響研究の新しい展開
- Principal Investigator
  
  佐々木正夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Kyoto University
Genetic effects of combined gamma-rays-ENU treatments as revealed by the Medaka specific-locus test systemPrincipal Investigator
- Principal Investigator
  
  SHIMA Akihiro
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  University of Tokyo
"Man-Earth System : A scientific approach to realize human society in harmony with the Earth"-Transgenerational Effects of Man-made Environmental Toxic Agents Contaminating the Earth-
- Principal Investigator
  
  NOMURA Taisei
- Project Period (FY)
  1993 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
環境要因の人体影響(基礎班)
- Principal Investigator
  
  志賀健
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
環境要因の人体影響-人体影響に関与する遺伝的要因
- Principal Investigator
  
  阿部達生
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Prefectural University of Medicine
放射線応答の制御機構に関する研究
- Principal Investigator
  
  佐々木正夫
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  放射線5生物学
- Research Institution
  Kyoto University
PHYLOGENY AND SPECIES DIFFERENTIATION OF ADRIANICHTHYDEIS IN INDONESIA.
- Principal Investigator
  
  OKINO Tokio, 宇和紘
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Shinshu University
Studies on expression of radiation damage and modifying repair mechanisms
- Principal Investigator
  
  SATO Kouki
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  放射線5生物学
- Research Institution
  National Institute of Radiological Sciences
Changes in mutagenesis sensitivity with maturation of male germ cells as revealed by the Medaka specific-locus test systemPrincipal Investigator
- Principal Investigator
  
  SHIMA Akihiro
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  放射線5生物学
- Research Institution
  The University of Tokyo
Development of a detection system for germ-cell mutagenesis with high sensitivity and multiple genetic endpoints using the Japanese MedakaPrincipal Investigator
- Principal Investigator
  
  SHIMA Akihiro
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  放射線5生物学
- Research Institution
  The University of Tokyo
環境要因の人体影響ー人体影響に関与する遺伝的要因
- Principal Investigator
  
  阿部達生
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Prefectural University of Medicine
第3回国際比較生理生化学会議をわが国における生物科学の発展に結びつける方策の検討
- Principal Investigator
  
  高橋景一
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  動物発生・生理学
- Research Institution
  The University of Tokyo
環境要因の人体影響ー人体影響に関与する遺伝的要因
- Principal Investigator
  
  阿部達生
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Prefectural University of Medicine
第3回国際比較生理生化学会議にむけての研究会等の開催
- Principal Investigator
  
  高橋景一
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  動物発生・生理学
- Research Institution
  The University of Tokyo
「第11回国際光生物学会議」開催準備のための統合研究
- Principal Investigator
  
  武部啓
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  放射線5生物学
- Research Institution
  Kyoto University
トリチウムの総合研究(総括班)
- Principal Investigator
  
  高島良正
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Fusion Research
- Research Institution
  Kyushu University
トリチウム水の個体レベルにおける医生物効果と作用機構
- Principal Investigator
  
  澤田昭三
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Fusion Research
- Research Institution
  Hiroshima University
第3回国際比較生理生化学会議にむけてのシンポジウム等の開催
- Principal Investigator
  
  高橋景一
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  動物発生・生理学
- Research Institution
  The University of Tokyo
環境要因の継世代的影響と遺伝リスクPrincipal Investigator
- Principal Investigator
  
  嶋昭紘
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Development of the Japanese Medaka as a Laboratory Animal with Genetic and Environmental Control.Principal Investigator
- Principal Investigator
  
  SHIMA Akihiro
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  University of Tokyo
Selection Mechanisms for Mutants As Studied by the Medaka Specific-Locus Test System.Principal Investigator
- Principal Investigator
  
  SHIMA Akihiro
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  放射線5生物学
- Research Institution
  The University of Tokyo
トリチウムシミュレーターを用いた生物影響の研究Principal Investigator
- Principal Investigator
  
  嶋昭紘
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Fusion Research
- Research Institution
  The University of Tokyo
第3回国際比較生理生化学会議におけるシンポジウム等の企画
- Principal Investigator
  
  高橋景一
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  動物発生・生理学
- Research Institution
  The University of Tokyo
環境要因の継世代的影響と遺伝リスクPrincipal Investigator
- Principal Investigator
  
  嶋昭紘
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
環境要因の人体影響(基礎班)
- Principal Investigator
  
  武部啓
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
トリチウムシミュレーターを用いた生物照射実験とトリチウム生物影響の評価Principal Investigator
- Principal Investigator
  
  嶋昭紘
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Fusion Research
- Research Institution
  The University of Tokyo
老化研究のストラテジー
- Principal Investigator
  
  朝長正徳
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokyo
遺伝損傷の機構と発現
- Principal Investigator
  
  武部啓
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  放射線5生物学
- Research Institution
  Kyoto University
環境要因の継世代的影響と遺伝リスクPrincipal Investigator
- Principal Investigator
  
  嶋昭紘
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
環境要因の人体影響(基礎班)
- Principal Investigator
  
  武部啓
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
環境要因の人体影響(基礎班)
- Principal Investigator
  
  武部啓
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
トリチウムシミュレータを用いた生物照射実験とトリチウム生物影響の評価
- Principal Investigator
  
  井尻憲一
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Fusion Research
- Research Institution
  The University of Tokyo
環境汚染の継世代的影響
- Principal Investigator
  
  池永満生
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for Environmental Science
- Research Institution
  Kyoto University

All 2006 2005

All Journal Article

[Journal Article] Vertebrate DNA transposon as a natural mutator : The medaka fish Tol2 element contributes to genetic variation without recognizable traces2006
- Author(s)
  Koga A, Iida A, Hori H, Shimada A, Shima A
- Journal Title
  
  Molecular Biology and Evolution (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570002
[Journal Article] Vertebrate DNA transposon as a natural mutator : The medaka fish Tol2 element contributes to genetic variation without recognizable traces2006
- Author(s)
  Koga A, Iida A, Hori H, Shimada A, Shima A
- Journal Title
  
  Molecular Biology and Evolution 23・9(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570002
[Journal Article] Targeted reduction of the DNA methylation level with 5-azacytidine promotes excision of the medaka fish Tol2 transposable element.2006
- Author(s)
  Iida A, Shimada A, Shima A, Takamatsu N, Hori H, Takeuchi K, Koga A
- Journal Title
  
  Genetical Research 88・3(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570002
[Journal Article] Targeted reduction of the DNA methylation level with 5-azacytidine promotes excision of the medaka fish Tol2 transposable element.2006
- Author(s)
  Iida A, Shimada A, Shima A, Takamatsu N, Hori H, Takeuchi K, Koga A
- Journal Title
  
  Genetical Research 88・1(印刷中)
- Data Source
  KAKENHI-PROJECT-16570002
[Journal Article] Targeted reduction of the DNA methylation level with 5-azacytidine promotes excision of the medaka fish Tol2 transposable element2006
- Author(s)
  Iida A, Shimada A, Shima A, Takamatsu N, Hori H, Takeuchi K, Koga A
- Journal Title
  
  Genetical Research (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570002
[Journal Article] Reversion mutation of i^b oculocutaneous albinism to wild-type pigmentation in medaka fish2005
- Author(s)
  Iida A, Takamatsu N, Hori H, Wakamatsu Y, Shimada A, Shima A, Koga A
- Journal Title
  
  Pigment Cell Research 18
  
  Pages: 382-384
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570002
[Journal Article] Reversion mutation of i^b oculocutaneous albinism to wild-type pigmentation in medaka fish2005
- Author(s)
  Iida A, Takamatsu N, Hori H, Wakamatsu Y, Shimada A, Shima A, Koga A
- Journal Title
  
  Pigment Cell Research 18・5
  
  Pages: 382-384
- Data Source
  KAKENHI-PROJECT-16570002
[Journal Article] Reversion mutation of i^b oculocutaneous albinism to wild-type pigmentation in medaka fish2005
- Author(s)
  Ida A, Takamatsu N, Hori H, Wakamatsu Y, Shimada A, Shima A, Koga A
- Journal Title
  
  Pigment Cell Research 18・5
  
  Pages: 382-384
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570002

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Shima Akihiro 嶋 昭紘

SHIMA Akihiro 嶋 昭紘

嶋 昭絋 シマ アキヒロ

島 昭絋 シマ アキヒロ

島 昭紘 シマ アキヒロ

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Steering committe on study of medaka as a model for organization and evolution of the nuclear genomePrincipal Investigator

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Elucidation of mechanism for fixation of mutations occurred in germ cells using medaka.Principal Investigator

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Review Section

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A Comprehensive Study on Intrusion and Cooperation of GenomesPrincipal Investigator

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生命科学におけるモデルとしてのメダカに関する研究動向調査Principal Investigator

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A Crossdisciplinary Study on the Benefits of Sexual ReproductionPrincipal Investigator

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Genetic effects of combined gamma-rays-ENU treatments as revealed by the Medaka specific-locus test systemPrincipal Investigator

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Shima Akihiro 嶋昭紘

SHIMA Akihiro 嶋昭紘

嶋昭絋シマアキヒロ

島昭絋シマアキヒロ

島昭紘シマアキヒロ