Shima Akihiro 嶋昭紘

… Alternative Names

SHIMA Akihiro 嶋昭紘

嶋昭絋シマアキヒロ

島昭絋シマアキヒロ

島昭紘シマアキヒロ

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Researcher Number	60011590
External Links
Affiliation (Current)	2023: 東京大学, 名誉教授, 名誉教授
Affiliation (based on the past Project Information) *help	2003 – 2005: The University of Tokyo, Graduate school of Frontier Sciences, Professor Emeritus, 大学院・新領域創成科学研究科, 名誉教授 1998 – 2002: University of Tokyo, Graduate School of Frontier Sciences, Prof., 大学院・新領域創成科学研究科, 教授 1993 – 1997: The University of Tokyo, Graduate School of Science, Professor, 大学院・理学系研究科, 教授 1996: 東京大学, 理学部, 教授 1994: 東京大学, 大学院理学系研究科, 教授 1986 – 1993: 東京大学, 理学部, 教授 1986: 東京大学, 理学部・動物学教室, 教授
Review Section/Research Field	Principal Investigator 放射線5生物学 / Laboratory animal science / 広領域 / 環境影響評価(含放射線生物学) / Biological Sciences Except Principal Investigator 動物発生・生理学 / 放射線5生物学 / 環境影響評価(含放射線生物学) / Experimental pathology / Biological Sciences / Genetics/Genome dynamics
Keywords	Principal Investigator メダカ / 生殖細胞突然変異 / 突然変異 / 細胞死 / 奇形 / 優性致死 / ショウジョウバエ / カイコ / マウス / ヒト … More / 体細胞突然変異 / 発生異常 / トリチウムシミュレーター / RBE / Medaka / 放射線 / the Medaka (Oryzias latipes) / male germ cells / dominant lethals / total mutation / viable mutation / ENU / germ cell mutation / 小型魚類 / 種分化 / 空間減衰方式 / フィルター減衰方式 / 染色体異常 / 環境要因 / 継世代的影響 / 標準的生物種 / 修復 / RFLPs / 線量率効果 / 実験動物 / 形態学的特性 / 生化学的特性 / 染色体 / 近交系 / DNA多型 / 近,交系 / Laboratory animals / Morphological characteristics / Biochemical characteristics / Chromosomes / Germーcell mutations / Inbred strains / Polymorphism / テスタ-メダカ / 特定座位突然変異 / 発生過程 / 淘汰 / Tester Medaka / Specific-locus mutation / Radiation / Developmental process / Selection / Dominant lethals / Malformation / 雄生殖細胞 / 分化 / 総突然変異 / 生存突然変異 / DNA変異 / γ線 / 精子 / 精細胞 / 精母細胞 / 分化精原細胞 / 精原細胞 / AP-PCRフィンガープリンティング / specific-locus test system / maturation / DNA alterations / 特定座位法 / 誘発奇形 / ガンマー線 / 原子炉放射線 / エチルニトロソウレア / :原子炉放射線 / multiple genetic endpoints / external malformation / ethylnitrosourea / 複合被曝 / 化学物質 / 遺伝影響 / Germ cell / Mutagenesis / gamma-rays / Additive / Synergistic / 性戦略 / 内分泌器官 / 性染色体 / 精子形成 / 減数分裂制御遺伝子群 / 配偶者選択 / 受精管 / sexual strategy / endocrine organ / sex chromosome / spermatogenesis / meiosis regulation genes / mate choice / pollen tube / メダカゲノム / メダカゲノムイニシアチブ(MGI) / 国際共同研究 / 国際シンポジュウム / 研究資材 / メダカゲノムイニシアチブ / EMBO Course / MGI / Symposium on Medaka Genomics 2002 / 拡大班会議 / メダカゲノムプロジェクト / 定例班会議 / 班会議 / 中間ヒアリング / 課題名の発展的変更 / メダカゲノムシークエンシング / Medaka Genome Initiatives(MGI) / 総括班会議 / 知的所有権 / 公開シンポジュウム / 公開講座「メダカの学校2001」 / 市民 / 基礎知識の啓蒙 / メダカの特性 / 国際協力 / medaka genome / Medaka Genome Initiative (MGI) / International collaboration / International symposium / research resources / テロメア特異的レトロトランスポゾン / 利子的遺伝子 / 染色体外DNA / カスパーゼ活性 / 多義語コドン / 生殖細胞自然突然変異率 / 一花粉解析法 / 表層微小管 / レトロトランスポゾン / 利己的遺伝子 / メダカ生殖細胞自然突然変異率 / 前胸線抑制ペプチド(PTSP)産生器官 / ウニ左右性関連遺伝子 / ラン色細菌 / 神経伝達物質 / 嗅覚受容体 / タバコ培養細胞 / 前胸腺抑制ホルモン / エクジソン分泌 / telomere / gene homing / extrachromosomal DNA / caspase / polysemous codon / single-pollen analysis / prothoracic glands … More Except Principal Investigator 染色体異常 / 突然変異 / 国際比較生理生化学会議 / 人体影響 / 磁場 / 複合効果 / トリチウム / シンポジウム / 環境変異原 / 優性致死 / 間期死反応 / HLA / 遺伝要因 / 放射線応答 / 放射線発がん / 放射線影響 / 重点領域研究 / 継世代的影響 / 発生異常 / 生殖細胞突然変異 / メダカ / p53 / 自然突然変異 / トリチウム総合研究 / 核融合トリチウム / トリチウム環境動態 / トリチウム医生物効果 / トリチウム体内取り込み / 線量率効果 / 細胞のがん化 / 細胞致死 / 有機結合トリチウム / RBE / 小頭症 / 難分解性物質 / ダイオキシン / 特定座位 / <crp>___ー遺伝子 / 珪肺症 / 光生物学 / 太陽光 / 紫外線 / DNA損傷と修復 / 生形態形成 / FISH / P‐450 / MNNG / トランジション / HLA‐DRα鎖遺伝子 / 生存突然変異 / 環境要因 / 電磁気 / 難分解物質 / 微粒子 / 継世代影響 / 均衡転座 / DNA修復能 / 間期死 / 微量放射線 / シグナル伝達 / 制がん / 低線量放射線 / レドックス制御 / ゲノム不安定性 / 標的理論 / 遺伝子損傷性ストレス / 細胞内情報伝達 / 奇形の誘発 / DNA修復 / トリチウム水 / トリチウムシミュレーター / 連続照射 / リンパ球 / 小腸 / クリプト / 老化 / 生理的老化 / アルツハイアー病 / 骨粗鬆症 / 早老症 / 環境因子 / 遺伝損傷 / 放射線 / インドネシア / スラベシ / メダカ亜目魚類 / 系統 / 種分化 / 陸水学 / 陸水生態系 / 水質 / スラウェシ島 / ポソ湖 / メダカ属魚類 / Oryzias / Adrianichthys / Xenopoecirus / 地理的分布 / 陸水調査 / Indonesia / Sulawesi / Adrianichthydei / Phelogeny / Species differentiation / Limnology / Inland waters ecosystem / Water quality / DNA鎖切断 / 光回復酵素 / 除去修復 / 紫外線皮膚癌 / X染色体不活性化 / しきい値様反応 / 制限酵素断片長多型 / しきい線量 / クローナリティ / DNA二本鎖切断修復 / 除去修復遺伝子 / 紫外線損傷 / ユビキチン活性化酵素 / 閾値様反応 / 胸腺腫 / DNA strand break / photolyase / excision repair / UV skin cancer / germ cell mutation / X chromosome inactivation / threshold-like response / restriction length polymorphism / 新人為起源有害物質 / 生殖器障害 / 形態異常 / 分子遺伝学的異常 / 機能的異常 / 放射能汚染 / 子孫への伝達 / チェルノブイリ放射能汚染の遺伝的影響 / 精子・卵子障害 / 機能的障害 / Man-made Toxic Agents / Transgenerational Effects / Damage in the reproductive system / Maldevelopment / Molecular Changes / Functional Defects / Radionucides / Transmission to descendants / 生殖細胞 / ゲノム安定性保持機構 / アポトーシス / 色素細胞 / ポジショナルクローニング / γ-rays / Medaka fish / Speruatogenesis / MBT / Expression of paternal genome / Polymorphism / 特定座位法 / 自然突然変異率 / 精原細胞 / 細胞死 / P53 / ESTマーカー / 父性発現 / TUNEL陽性細胞 / チェックポイント / p53遺伝子 / ATM遺伝子 / メダカ生殖細胞突然変異 / 雄生殖細胞 / 精原幹細胞 / 分化型精原細胞 / 高感受性集団 / 低線量 / 胚死 / cells / medaka / mechanism for maintaining of genome stability / apoptosis / トランスポゾン / 転移 / 突然変異率 / 脊椎動物 / Transposon / Transposition / Spontaneous mutation / Mutation rate / Medaka / Vertebrates Less

Contribution of transposable elements to spontaneous mutation rates in medaka fish
- Principal Investigator
  
  KOGA Akihiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Genetics/Genome dynamics
- Research Institution
  Nagoya University
Steering committe on study of medaka as a model for organization and evolution of the nuclear genomePrincipal Investigator
- Principal Investigator
  
  SHIMA Akihiro
- Project Period (FY)
  1999 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Elucidation of mechanism for fixation of mutations occurred in germ cells using medaka.Principal Investigator
- Principal Investigator
  
  FUKAMACHI Shoji, 嶋昭紘
- Project Period (FY)
  1999 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
A Comprehensive Study on Intrusion and Cooperation of GenomesPrincipal Investigator
- Principal Investigator
  
  SHIMA Akihiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  広領域
- Research Institution
  The University of Tokyo
生命科学におけるモデルとしてのメダカに関する研究動向調査Principal Investigator
- Principal Investigator
  
  嶋昭紘
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
A Crossdisciplinary Study on the Benefits of Sexual ReproductionPrincipal Investigator
- Principal Investigator
  
  SHIMA Akihiko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  広領域
- Research Institution
  University of Tokyo
放射線影響研究の新しい展開
- Principal Investigator
  
  佐々木正夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Kyoto University
Genetic effects of combined gamma-rays-ENU treatments as revealed by the Medaka specific-locus test systemPrincipal Investigator
- Principal Investigator
  
  SHIMA Akihiro
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  University of Tokyo
"Man-Earth System : A scientific approach to realize human society in harmony with the Earth"-Transgenerational Effects of Man-made Environmental Toxic Agents Contaminating the Earth-
- Principal Investigator
  
  NOMURA Taisei
- Project Period (FY)
  1993 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
環境要因の人体影響(基礎班)
- Principal Investigator
  
  志賀健
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
環境要因の人体影響-人体影響に関与する遺伝的要因
- Principal Investigator
  
  阿部達生
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Prefectural University of Medicine
放射線応答の制御機構に関する研究
- Principal Investigator
  
  佐々木正夫
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  放射線5生物学
- Research Institution
  Kyoto University
PHYLOGENY AND SPECIES DIFFERENTIATION OF ADRIANICHTHYDEIS IN INDONESIA.
- Principal Investigator
  
  OKINO Tokio, 宇和紘
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Shinshu University
Studies on expression of radiation damage and modifying repair mechanisms
- Principal Investigator
  
  SATO Kouki
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  放射線5生物学
- Research Institution
  National Institute of Radiological Sciences
Changes in mutagenesis sensitivity with maturation of male germ cells as revealed by the Medaka specific-locus test systemPrincipal Investigator
- Principal Investigator
  
  SHIMA Akihiro
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  放射線5生物学
- Research Institution
  The University of Tokyo
Development of a detection system for germ-cell mutagenesis with high sensitivity and multiple genetic endpoints using the Japanese MedakaPrincipal Investigator
- Principal Investigator
  
  SHIMA Akihiro
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  放射線5生物学
- Research Institution
  The University of Tokyo
環境要因の人体影響ー人体影響に関与する遺伝的要因
- Principal Investigator
  
  阿部達生
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Prefectural University of Medicine
第3回国際比較生理生化学会議をわが国における生物科学の発展に結びつける方策の検討
- Principal Investigator
  
  高橋景一
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  動物発生・生理学
- Research Institution
  The University of Tokyo
環境要因の人体影響ー人体影響に関与する遺伝的要因
- Principal Investigator
  
  阿部達生
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Prefectural University of Medicine
第3回国際比較生理生化学会議にむけての研究会等の開催
- Principal Investigator
  
  高橋景一
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  動物発生・生理学
- Research Institution
  The University of Tokyo
「第11回国際光生物学会議」開催準備のための統合研究
- Principal Investigator
  
  武部啓
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  放射線5生物学
- Research Institution
  Kyoto University
トリチウムの総合研究(総括班)
- Principal Investigator
  
  高島良正
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Fusion Research
- Research Institution
  Kyushu University
トリチウム水の個体レベルにおける医生物効果と作用機構
- Principal Investigator
  
  澤田昭三
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Fusion Research
- Research Institution
  Hiroshima University
第3回国際比較生理生化学会議にむけてのシンポジウム等の開催
- Principal Investigator
  
  高橋景一
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  動物発生・生理学
- Research Institution
  The University of Tokyo
環境要因の継世代的影響と遺伝リスクPrincipal Investigator
- Principal Investigator
  
  嶋昭紘
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Development of the Japanese Medaka as a Laboratory Animal with Genetic and Environmental Control.Principal Investigator
- Principal Investigator
  
  SHIMA Akihiro
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  University of Tokyo
Selection Mechanisms for Mutants As Studied by the Medaka Specific-Locus Test System.Principal Investigator
- Principal Investigator
  
  SHIMA Akihiro
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  放射線5生物学
- Research Institution
  The University of Tokyo
トリチウムシミュレーターを用いた生物影響の研究Principal Investigator
- Principal Investigator
  
  嶋昭紘
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Fusion Research
- Research Institution
  The University of Tokyo
第3回国際比較生理生化学会議におけるシンポジウム等の企画
- Principal Investigator
  
  高橋景一
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  動物発生・生理学
- Research Institution
  The University of Tokyo
環境要因の継世代的影響と遺伝リスクPrincipal Investigator
- Principal Investigator
  
  嶋昭紘
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
環境要因の人体影響(基礎班)
- Principal Investigator
  
  武部啓
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
トリチウムシミュレーターを用いた生物照射実験とトリチウム生物影響の評価Principal Investigator
- Principal Investigator
  
  嶋昭紘
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Fusion Research
- Research Institution
  The University of Tokyo
老化研究のストラテジー
- Principal Investigator
  
  朝長正徳
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokyo
遺伝損傷の機構と発現
- Principal Investigator
  
  武部啓
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  放射線5生物学
- Research Institution
  Kyoto University
環境要因の継世代的影響と遺伝リスクPrincipal Investigator
- Principal Investigator
  
  嶋昭紘
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
環境要因の人体影響(基礎班)
- Principal Investigator
  
  武部啓
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
環境要因の人体影響(基礎班)
- Principal Investigator
  
  武部啓
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
トリチウムシミュレータを用いた生物照射実験とトリチウム生物影響の評価
- Principal Investigator
  
  井尻憲一
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Fusion Research
- Research Institution
  The University of Tokyo
環境汚染の継世代的影響
- Principal Investigator
  
  池永満生
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for Environmental Science
- Research Institution
  Kyoto University

All 2006 2005

All Journal Article

[Journal Article] Vertebrate DNA transposon as a natural mutator : The medaka fish Tol2 element contributes to genetic variation without recognizable traces2006
- Author(s)
  Koga A, Iida A, Hori H, Shimada A, Shima A
- Journal Title
  
  Molecular Biology and Evolution (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570002
[Journal Article] Vertebrate DNA transposon as a natural mutator : The medaka fish Tol2 element contributes to genetic variation without recognizable traces2006
- Author(s)
  Koga A, Iida A, Hori H, Shimada A, Shima A
- Journal Title
  
  Molecular Biology and Evolution 23・9(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570002
[Journal Article] Targeted reduction of the DNA methylation level with 5-azacytidine promotes excision of the medaka fish Tol2 transposable element.2006
- Author(s)
  Iida A, Shimada A, Shima A, Takamatsu N, Hori H, Takeuchi K, Koga A
- Journal Title
  
  Genetical Research 88・3(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570002
[Journal Article] Targeted reduction of the DNA methylation level with 5-azacytidine promotes excision of the medaka fish Tol2 transposable element.2006
- Author(s)
  Iida A, Shimada A, Shima A, Takamatsu N, Hori H, Takeuchi K, Koga A
- Journal Title
  
  Genetical Research 88・1(印刷中)
- Data Source
  KAKENHI-PROJECT-16570002
[Journal Article] Targeted reduction of the DNA methylation level with 5-azacytidine promotes excision of the medaka fish Tol2 transposable element2006
- Author(s)
  Iida A, Shimada A, Shima A, Takamatsu N, Hori H, Takeuchi K, Koga A
- Journal Title
  
  Genetical Research (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570002
[Journal Article] Reversion mutation of i^b oculocutaneous albinism to wild-type pigmentation in medaka fish2005
- Author(s)
  Iida A, Takamatsu N, Hori H, Wakamatsu Y, Shimada A, Shima A, Koga A
- Journal Title
  
  Pigment Cell Research 18
  
  Pages: 382-384
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570002
[Journal Article] Reversion mutation of i^b oculocutaneous albinism to wild-type pigmentation in medaka fish2005
- Author(s)
  Iida A, Takamatsu N, Hori H, Wakamatsu Y, Shimada A, Shima A, Koga A
- Journal Title
  
  Pigment Cell Research 18・5
  
  Pages: 382-384
- Data Source
  KAKENHI-PROJECT-16570002
[Journal Article] Reversion mutation of i^b oculocutaneous albinism to wild-type pigmentation in medaka fish2005
- Author(s)
  Ida A, Takamatsu N, Hori H, Wakamatsu Y, Shimada A, Shima A, Koga A
- Journal Title
  
  Pigment Cell Research 18・5
  
  Pages: 382-384
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570002

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Shima Akihiro 嶋 昭紘

SHIMA Akihiro 嶋 昭紘

嶋 昭絋 シマ アキヒロ

島 昭絋 シマ アキヒロ

島 昭紘 シマ アキヒロ

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Steering committe on study of medaka as a model for organization and evolution of the nuclear genomePrincipal Investigator

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Elucidation of mechanism for fixation of mutations occurred in germ cells using medaka.Principal Investigator

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Review Section

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A Comprehensive Study on Intrusion and Cooperation of GenomesPrincipal Investigator

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生命科学におけるモデルとしてのメダカに関する研究動向調査Principal Investigator

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A Crossdisciplinary Study on the Benefits of Sexual ReproductionPrincipal Investigator

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Genetic effects of combined gamma-rays-ENU treatments as revealed by the Medaka specific-locus test systemPrincipal Investigator

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Shima Akihiro 嶋昭紘

SHIMA Akihiro 嶋昭紘

嶋昭絋シマアキヒロ

島昭絋シマアキヒロ

島昭紘シマアキヒロ