YOSHIMOTO Tadashi 芳本忠

Researcher Number	60088870
External Links
Affiliation (based on the past Project Information) *help	2013 – 2015: 摂南大学, 理工学部, 教授 2013: 摂南大学, 理工生命, 教授 2010: 摂南大学, 理工学部, 教授 2010: Nagasaki University, 理工学部, 教授 2009: Nagasaki University, 大学院・医歯薬学総合研究科, 教授 … More 2007 – 2009: Nagasaki University, 医歯薬学総合研究科, 教授 2008: 長崎大学, 大学院・医歯薬学総合研究科(薬学系), 教授 2005 – 2006: 長崎大学, 大学院医歯薬学総合研究科, 教授 2002: Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 1994 – 2001: 長崎大学, 薬学部, 教授 1987 – 1993: School of Pharmaceutical Sciences, Nagasaki University, 薬学部, 助教授 1986: 長崎大, 薬学部, 助教授 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Structural biochemistry / Applied biochemistry / Structural biochemistry Except Principal Investigator Chemical pharmacy / Biological pharmacy / Structural biochemistry / Biological Sciences
Keywords	Principal Investigator プロリン / 阻害剤 / プロテアーゼ / X線結晶解析 / プロリルエンドペプチダーゼ / クローニング / ペプチダーゼ / プロリルアミノペプチダーゼ / peptidase / 遺伝子組換え … More / 健忘症 / prolyl endopeptidase / プロリン特異性 / クロ-ニング / プロリルエンドペプチダ-ゼ / 痴呆症 / 糖尿病 / 治療薬 / アミノペプチダーゼ / インヒビター / セリン酵素 / 立体構造 / バソプレシン / アセチルコリンエステラーゼ / Z-Pro-prolinal / Post-proline cleaving enzyme / Vasopressin / Prolyl endopeptidase / Anti-amnesic effect / アルデヒド誘導体 / プロリン特異性エンドペプチダーゼ / 抗健忘症薬 / structure / mutagenesis / mechanism / proline / prolylaminopeptidase / ペプチダ-ゼ / ペプチドホルモン / X線構造解析 / ピロリトン / 複合体解析 / protease II / Alzheimer's disease / protease / プロテア-ゼII / 塩基配列決定 / プロテアーゼ2 / 脳 / アルツハイマー症 / 触媒機構 / アルツハイマー病 / 蛋白分解酵素 / アミロイドタンパク / gene / nucleotide sequence / cloning / inhibitor / amnesia / anti-amnesia / プロテア-ゼ / DNA / 痴呆薬 / 塩基配列 / 抗健忘 / インヒビタ- / プロリルトリペプチジルペプチダーゼ / 米ぬか / 歯周病 / 結晶解析 / 感染症 / X線結晶構造解析 / 酵素 / 構造生物学 / メチオニンアミノペプチダーゼ / 医薬品 / オリゴペプチダーゼB / トリパノソーマ / マラリア / 部位特異的変異 / プロテオリシス / 基質認識 / エステラーゼ / オリゴペプチダーゼ / ピログルタミルペプチダーゼ / 結晶 / 酵素反応 / 触媒 / 健忘 / ペプチダーゼ、 / オリゴペプチダーゼ、 / ブロリルオリゴペプチダーゼ / プロリルエンドペプチダーゼ、 / 基質特異性 / 合成基質 / 結晶、 / 結晶解析、 … More Except Principal Investigator 基質特異性 / X線結晶構造解析 / Stereospecific Synthesis / Crown rust fungi / Nyctinastic movement / Specific enzyme / Mushrooms / Self-inhibitor / Host-specific Toxin / Phytopathology / 植物病原菌生産ペプチド / 輪斑病菌生産植物毒素 / 対昆虫摂食阻害物質 / 胞子自己発芽抑制因子 / 植物病源生産毒素 / 宿主特異的的毒素 / 植物病原体 / エンバク冠さび病 / 植物の就眠運動 / プロリン特異的酵素 / 植物病原菌 / 立体選択的合成反応 / 海洋天然物 / 植物の就眼運動 / 特異的酵素 / キノコ類 / 自己発芽抑制因子 / 宿主特異的毒素 / 植物病理学 / Ample supply of useful enzymes / Development of chiral synthon / Modification of amino acid / Organometalic Chenistry / Asymmetric Synthesis / Biologically active natural products / Protein Phosphayase Inhibitor / Tautomycin,A / アレニルスルホニウム / 甘味成分 / 海洋性天然物 / 生物活性天然物 / アミノ酸修飾 / 生理活性微量天然物合成 / 有用酵素の量的供給 / 不斉合成素子の開発 / アミノ酸装飾 / 有機金属化合物の利用 / 不斉合成 / 生理活発微量天然物合成 / ピューロマイシン感受性 / アミノペプチダーゼN / 基質阻害 / M1ファミリー / S9ファミリー / アミノペプチダーゼ / オリゴペプチダーゼB / ペプチダーゼ / MDRファミリー / 臨床検査 / 結晶構造解析 / コンフォメーション変化 / 基質認識機構 / ケトン体 / 3-ヒドロキシ酪酸脱水素酵素 / SDRファミリー / タンパク質と酵素 / QCM法 / FRAP / X線結晶化構造解析 / 樹状突起 / 微小管制御ナノシステム / tubulin / MAP2 / WGA / グルココルチコイド / HPA axis / ナノメディシン / 神経ステロイド / ストレス性精神疾患 Less

New inhibitor for proline specific peptidases which cause severalPrincipal Investigator
- Principal Investigator
  
  Yoshimoto Tadashi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  Setsunan University
Structural analyses of the high molecular mass peptidases belonging to M1 and S9 families
- Principal Investigator
  
  ITO Kiyoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyushu University of Health and Welfare
  Nagasaki University
Structure analyses of key enzymes from trypanosoma and malaria for the development of new drugsPrincipal Investigator
- Principal Investigator
  
  YOSHIMOTO Tadashi
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Nagasaki University
Protein engineering of the enzymes for clinical analysis based on their three dimensional structures
- Principal Investigator
  
  ITO Kiyoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Nagasaki University
神経極性を形づくる微小管重合を制御する神経ステロイド
- Principal Investigator
  
  植田弘師
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Structure analysis of proline specific peptidases which have unique specificity and structurePrincipal Investigator
- Principal Investigator
  
  YOSHIMOTO adashi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Nagasaki University
プロリン特異性ペプチダーゼの選択的オリゴペプチダーゼ作用とプロリン特異性機構解明Principal Investigator
- Principal Investigator
  
  芳本忠
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nagasaki University
アセチルコリンエステラーゼが持つペプチダーゼ作用に着目した新規阻害剤の開発Principal Investigator
- Principal Investigator
  
  芳本忠
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagasaki University
プロリン特異性ペプチダーゼの構造とプロリン特異性発現機構の解明Principal Investigator
- Principal Investigator
  
  芳本忠
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagasaki University
プロリン特異性ペプチダーゼの構造とプロリン特異性発現機構の解明Principal Investigator
- Principal Investigator
  
  芳本忠
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagasaki University
プロリルエンドペプチダーゼ・インヒビターが示す抗健忘作用の機構解明Principal Investigator
- Principal Investigator
  
  芳本忠
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagasaki University
プロリン特異性ペプチダーゼの構造とプロリン特異性機構解明Principal Investigator
- Principal Investigator
  
  芳本忠
- Project Period (FY)
  1996 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nagasaki University
Synthetic Studies for Ample Supply of Biologically Active Natural Products
- Principal Investigator
  
  IRIE Hiroshi
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Ngasaki University
Studies on catalytic mechanism of prolyl endopeptidase by genetic method and biological significance of it in the brainPrincipal Investigator
- Principal Investigator
  
  YOSHIMOTO Tadashi
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagasaki University
Studies on Anti-Amnesiac Effect of Specific Inhibitor for Prolyl EndopeptidasePrincipal Investigator
- Principal Investigator
  
  YOSHIMOTO Tadashi
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagasaki University
Chemical Studies on the Substances Concerning Plants and Plant Pathogenic Fungi
- Principal Investigator
  
  IRIE Hiroshi
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Nagasaki University
Studies on the anti-amnesic effect of specific inhibitors for prolyl endopeptidase.Principal Investigator
- Principal Investigator
  
  YOSHIMOTO Tadashi
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagasaki University, School of Pharmaceutical Sciences

All 2015 2014 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation Book Patent

[Book] 日本の結晶学（Ⅱ）　その輝かしい発展2014
- Author(s)
  芳本忠
- Total Pages
  485
- Publisher
  日本結晶学会
- Data Source
  KAKENHI-PROJECT-25450138
[Book] Handbook of Proteolytic Enzymes (3^<rd> ed.)2013
- Author(s)
  Kiyoshi Ito, Yoshitaka Nakajima, and Tadashi Yoshimoto
- Total Pages
  4104
- Publisher
  Academic Press Prolyl oligopeptidase
- Data Source
  KAKENHI-PROJECT-23590081
[Book] Handbook of Proteolytic Enzymes (3^<rd> ed.)2013
- Author(s)
  Kiyoshi Ito, Yoshitaka Nakajima, and Tadashi Yoshimoto
- Total Pages
  4104
- Publisher
  Academic Press Prolyl aminopeptidase
- Data Source
  KAKENHI-PROJECT-23590081
[Book] Prolyl aminopeptidase in Handbook of Proteolytic Enzymes (3rd ed.)2013
- Author(s)
  Kiyoshi Ito, Yoshitaka Nakajima, and Tadashi Yoshimoto
- Total Pages
  4104
- Publisher
  Elsevier Ltd.
- Data Source
  KAKENHI-PROJECT-23590081
[Book] Handbook of Proteolytic Enzymes (3^<rd> ed.)2013
- Author(s)
  Yoshitaka Nakajima, Kiyoshi Ito, and Tadashi Yoshimoto
- Total Pages
  4104
- Publisher
  Academic Press Prolyl tripeptidylpeptidase
- Data Source
  KAKENHI-PROJECT-23590081
[Book] Prolyl oligopeptidase in Handbook of Proteolytic Enzymes (3rd ed.)2013
- Author(s)
  Kiyoshi Ito, Yoshitaka Nakajima, and Tadashi Yoshimoto
- Total Pages
  4104
- Publisher
  Elsevier Ltd.
- Data Source
  KAKENHI-PROJECT-23590081
[Book] Prolyl tripeptidylpeptidase in Handbook of Proteolytic Enzymes (3rd ed.)2013
- Author(s)
  Yoshitaka Nakajima, Kiyoshi Ito, and Tadashi Yoshimoto
- Total Pages
  4104
- Publisher
  Elsevier Ltd.
- Data Source
  KAKENHI-PROJECT-23590081
[Book] 生化学辞典(今堀和友、山川民夫監修)2008
- Author(s)
  芳本忠
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-19370043
[Book] 構造生物学-ポストゲノム時代のタンパク質研究-(倉光,杉山編)(腎機能を知るためのタンパク質)2007
- Author(s)
  芳本忠,伊藤潔,中島義隆
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-19570108
[Book] 構造生物学(倉光、杉山編)(病原菌の戦い)2007
- Author(s)
  伊藤潔、中嶋義隆、芳本忠
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-19370043
[Journal Article] Prolyl oligopeptidase inhibition-induced growth arrest of human gastric cancer cells,2014
- Author(s)
  Kanayo Suzuki, Minoru Sakaguchi, Satoshi Tanaka, Tadashi Yoshimoto , Masanori Takaoka,
- Journal Title
  
  Biochim. Biophys. Res. Commun.
  
  Volume: 443 Pages: 91-96
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25450138
[Journal Article] Prolyl oligopeptidase is a glyceraldehyde-3-phosphate dehydrogenase-binding protein that regulates genotoxic stress-induced cell death2013
- Author(s)
  Matsuda T., Sakaguchi, M., Tanaka, S., Yoshimoto, T., Takaoka, M
- Journal Title
  
  Int. J. Biochem. Cell Bio.
  
  Volume: 45 Pages: 850-857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450138
[Journal Article] Crystal Structure of Serine Dehydrogenase from Escherichia coli : Important role of the C-terminal region for closed-complex formation2011
- Author(s)
  Ryuji Yamazawa, Yoshitaka Nakajima, Karin Mushiake, Tadashi Yoshimoto, Kiyoshi Ito
- Journal Title
  
  J. Biochem
  
  Volume: 149 Pages: 701-712
- NAID
  10030585881
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590081
[Journal Article] Substitution of Glu122 by glutamine revealed the function of the second water molecule as a proton donor in the binuclear metal enzyme, creatininase2010
- Author(s)
  Yamashita, K., Nakajima, Y., Matsushita, H., Nishiya, Y., Yamazawa, R., Wu, Y., Matsubara, F., Oyama, H., Ito, K., Yoshimoto, T.
- Journal Title
  
  J.Mol.Biol. 396
  
  Pages: 1081-1096
- NAID
  120006984734
- Data Source
  KAKENHI-PROJECT-19370043
[Journal Article] Substitution of Glu122 by glutamine revealed the function of the second water molecule as a proton donor in the binuclear metal enzyme, creatininase2010
- Author(s)
  Yamashita K., Nakajima Y., Matsushita H., Nishiya Y., Yamazawa R., Wu Y., Matsubara F., Oyama H., Ito K., Yoshimoto T.
- Journal Title
  
  J.Mol.Biol.
- NAID
  120006984734
- Data Source
  KAKENHI-PROJECT-19370043
[Journal Article] Structure of aminopeptidase N from Escherichia coli complexed with the transition state alnalogue aminophosphinic inhibitor PL2502009
- Author(s)
  Fournie-Zaluski, M. C., Poras, H., Roques, B P., Nakajima, Y., Ito, K., Yoshimoto, T.
- Journal Title
  
  Acta Crystal.D 65
  
  Pages: 814-822
- Data Source
  KAKENHI-PROJECT-19370043
[Journal Article] Structure of aminopeptidase N from Escherichia coli complexed with the transition state alnalogue aminophosphinic inhibitor PL250, Marie-Claude Fournie-Zaluski, Herve Poras and Bernard P.Roques2009
- Author(s)
  中嶋義隆, 伊藤潔, 芳本忠
- Journal Title
  
  Acta Crystal.D. 65
  
  Pages: 814-822
- Data Source
  KAKENHI-PROJECT-19370043
[Journal Article] ペプチド最終分解系に関するエキソペプチダーゼの構造と機能2009
- Author(s)
  伊藤潔, 中嶋義隆, 田中信忠, 芳本忠
- Journal Title
  
  生化学 81
  
  Pages: 5-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370043
[Journal Article] ペプチド最終分解系に関与するエキソペプチダーゼの構造と機能2009
- Author(s)
  伊藤潔、中嶋義隆、田中信忠、芳本忠
- Journal Title
  
  生化学 81
  
  Pages: 5-16
- NAID
  10024915560
- Data Source
  KAKENHI-PROJECT-19370043
[Journal Article] Closed Complex of the D-3-Hydroxybutyrate Dehydrogenase Induced by an Enantiomeric Competitive Inhibitor2009
- Author(s)
  Kanako Nakashima, Kiyoshi Ito, Yoshitaka Nakajima, Ryuji Yamazawa, Syunsuke Miyakawa, and Tadashi, Yoshimoto
- Journal Title
  
  J. Biochem. 145(4)
  
  Pages: 467-479
- NAID
  10026302096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570108
[Journal Article] Closed Complex of the D-3-Hydroxybutyrate Dehydrogenase Induced by an Enantiomeric Competitive Inhibitor : Importance of Gln196 in Stable Ternary Complex Formation.2009
- Author(s)
  Kanako Nakashima, Kiyoshi Ito, Yoshitaka Nakajima, Ryuji Yamazawa, Syunsuke. Miyakawa, Tadashi Yoshimoto
- Journal Title
  
  J.Biochem. 145,(4)
  
  Pages: 467-479
- Data Source
  KAKENHI-PROJECT-19370043
[Journal Article] Closed Complex of the D-3-Hydroxybutyrate dehydrogenase induced by an enantiomeric competitive inhibitor : Importance of Gln196 in stable ternary complex formation2009
- Author(s)
  Nakashima, K., Ito, K., Nakajima, Y., Yamazawa, R., Miyakawa, S., Yoshimoto, T.
- Journal Title
  
  J.Biochem. 145(4)
  
  Pages: 467-479
- Data Source
  KAKENHI-PROJECT-19370043
[Journal Article] Novel Inhibitor for Prolyl Tripeptidyl Aminopeptidase from Porphyromonas gingivalis and Details of Substrate-Recognition Mechanism2008
- Author(s)
  Yue Xu, Yoshitaka Nakajima, Kiyoshi Ito, Heng Zheng, Hiroshi Oyama, Ulrich Heiser, Torsten Hoffmann, Ulf-Torsten Gartner, Hans-Ulrich Demuth, and Tadashi Yoshimoto
- Journal Title
  
  J. Mol. Biol. 375(3)
  
  Pages: 708-719
- NAID
  120006984748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570108
[Journal Article] Dipeptidyl Aminopeptidase IV from Stenotrophomonas maltophilia Exhibited 4-Hydroxyproline Residue.2008
- Author(s)
  Nakajima Y., Ito K., Toshima T., Egawa T., Zheng. H., Oyama H., Wu Y-F., Takahashi E., Kyono. K., Yoshimoto T.
- Journal Title
  
  J.Bacteriol. 190(23)
  
  Pages: 7819-7829
- Data Source
  KAKENHI-PROJECT-19370043
[Journal Article] Dipeptidyl Aminopeptidase IV from Stenotrophomonas maltophilia Exhibited an Activity against Substrate Containing 4-Hydroxyproline Residue2008
- Author(s)
  Yoshitaka Nakajima, Kiyoshi Ito, Tsubasa Toshima, Takashi Egawa, Heng Zheng, Hiroshi Oyama, Wu Yu-Fan, Eiji Takahashi, Kiyoshi Kyono, and Tadashi Yoshimoto
- Journal Title
  
  J. Bacteriol. 190(23)
  
  Pages: 7819-7829
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570108
[Journal Article] Dipeptidyl aminopeptidase IV from Stenotrophomonas maltophilia exhibited an activity against substrate containing 4-hydroxyproline residue2008
- Author(s)
  Nakajima, Y., Ito, K., Toshima, T. Egawa, T., Zheng. H., Oyama, H., Wu, Y-F., Takahashi, E., Kyono. K., Yoshimoto, T.
- Journal Title
  
  J.Bacteriol. 190(23)
  
  Pages: 7819-7829
- Data Source
  KAKENHI-PROJECT-19370043
[Journal Article] Novel Inhibitor for Prolyl Tripeptidyl aminopeptidase from Porphyromonas gingivalis and details of substrate-recognition mechanism2008
- Author(s)
  Xu, Y., Nakajima, Y., Ito, K., Zheng, H., Oyama, H., Heiser, U., Hoffmann, T., Gartner, U-T., Demuth. H-U., Yoshimoto, T.
- Journal Title
  
  J.Mol.Biol. 375(3)
  
  Pages: 708-719
- NAID
  120006984748
- Data Source
  KAKENHI-PROJECT-19370043
[Journal Article] 微生物酵素の生化学的および構造生物学的研究と医療への応用2007
- Author(s)
  芳本忠
- Journal Title
  
  薬学雑誌 127
  
  Pages: 1035-1045
- Data Source
  KAKENHI-PROJECT-19370043
[Journal Article] 微生物酵素の生化学的および構造生物学的研究と医療への応用2007
- Author(s)
  芳本忠
- Journal Title
  
  薬学雑誌 127
  
  Pages: 1035-1045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370043
[Patent] プロリルトリペプチジルペプチダーゼ阻害剤2015
- Inventor(s)
  芳本忠、中嶋義隆、西村仁、伊藤潔、安形博菜
- Industrial Property Rights Holder
  学校法人常翔学園
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-141260
- Filing Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-25450138
[Presentation] 米ぬか由来の歯周病菌プロリルトリペプチジルペプチダーゼ阻害タンパク質2015
- Author(s)
  安形博菜、西村仁、中嶋義隆、伊藤潔、芳本忠
- Organizer
  日本農芸化学会大会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25450138
[Presentation] A NEW INHIBITOR FROM RICE FOR PROLYL TRIPEPTIDYL PEPTIDASE FROM PORPHYROMONAS GINGIVALIS2015
- Author(s)
  Hirona Agata, Hitoshi Nishimura, Yoshitaka Nakajima, Kiyoshi Ito, and Tadashi Yoshimoto
- Organizer
  Internationnal Proteolysis Society
- Place of Presentation
  マレーシア
- Year and Date
  2015-10-05
- Data Source
  KAKENHI-PROJECT-25450138
[Presentation] 歯周病菌のプロリルトリペプチジルペプチダーゼを阻害する米ぬか由来タンパク質2015
- Author(s)
  ○安形博菜1, 西村仁1,中嶋義隆1, 伊藤潔 2, 芳本忠
- Organizer
  生物工学会
- Place of Presentation
  鹿児島
- Year and Date
  2015-10-26
- Data Source
  KAKENHI-PROJECT-25450138
[Presentation] エノキタケ抽出物の歯周病菌由来プロリルトリペプチジルペプチダーゼ阻害作用2014
- Author(s)
  安形博菜, 中嶋義隆, 伊藤潔、芳本忠
- Organizer
  日本生物工学会大会
- Place of Presentation
  札幌コンベンション
- Year and Date
  2014-08-09
- Data Source
  KAKENHI-PROJECT-25450138
[Presentation] 細菌由来オリゴペプチダーゼBの基質阻害2012
- Author(s)
  Malik Suliman Mohamed Mustafa, 中嶋義隆, 尾山廣, 芳本忠, 小山裕也, 大河原晋, 岩田修永, 伊藤潔
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  マリンメッセ福岡（福岡）
- Data Source
  KAKENHI-PROJECT-23590081
[Presentation] Crystal structure of the G179S mutant creatininase revealed a possible substrate entry mechanism2010
- Author(s)
  黒川裕美, 芳本忠, 伊藤潔
- Organizer
  日本生化学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-19370043
[Presentation] Crystal Structure of FAD-dependent D-Glucose Dehydrogenase complexed with an inhibitor2010
- Author(s)
  中嶋義隆, 西矢芳昭, 芳本忠, 伊藤潔
- Organizer
  日本生化学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-19370043
[Presentation] プロリン特異性ペプチダーゼ2009
- Author(s)
  芳本忠, 他
- Organizer
  生化学会シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-19370043
[Presentation] D-3-ヒドロキシ酪酸脱水素酵素の部位特異的変異体の解析2007
- Author(s)
  伊藤潔, 中島加奈子, 中島義隆, 芳本忠
- Organizer
  日本生化学会九州支部例会
- Place of Presentation
  宮崎市
- Year and Date
  2007-05-20
- Data Source
  KAKENHI-PROJECT-19570108
[Presentation] Streptococcus 由来プリンヌクレオシドホスホリラーゼの構造と基質特異性2007
- Author(s)
  武吉智也, 中嶋義隆, 伊藤潔, 芳本忠
- Organizer
  平成19年度第24回日本薬学会九州支部大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19370043
[Presentation] The three dimensional structure of aminopeptidase N and wide substrate recoenition mechanism2007
- Author(s)
  芳本忠
- Organizer
  International Proteolysis Society
- Place of Presentation
  パトラス (ギリシャ)
- Year and Date
  2007-10-23
- Data Source
  KAKENHI-PROJECT-19370043
[Presentation] Hyp基質に活性を示すS. maltophilia ジペプチジルアミノペプチダーゼIVの構造的特徴2007
- Author(s)
  十島翼, 中嶋義隆, 伊藤潔, 尾山廣, 芳本忠
- Organizer
  平成19年度第24回日本薬学会九州支部大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19370043

1. ITO Kiyoshi (50201926)

# of Collaborated Projects: 7 results

# of Collaborated Products: 29 results
2. NAKAJIMA Yoshitaka (80372770)

# of Collaborated Projects: 4 results

# of Collaborated Products: 30 results
3. KABASHIMA Tsutomu (20274673)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. IRIE Hiroshi (00025686)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YONEYAMA Masanori (00411710)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TOMIOKA Kiyoshi (50114575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. FUJII Nobutaka (60109014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SHIBASAKI Masakatsu (30112767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HASHIMOTO Syunichi (80107391)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. FUJITA Tetsuro (40027024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MAYAMA Shigeyuki (00112251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. UENO Tamio (20026579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TSUDA Yoshisuke (40077508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 植田弘師 (00145674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 井上誠 (60380987)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 藤田亮介 (70380855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 細見彰 (00004440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YOSHIMOTO Tadashi 芳本 忠

Research Projects

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New inhibitor for proline specific peptidases which cause severalPrincipal Investigator

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Structural analyses of the high molecular mass peptidases belonging to M1 and S9 families

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Structure analyses of key enzymes from trypanosoma and malaria for the development of new drugsPrincipal Investigator

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Protein engineering of the enzymes for clinical analysis based on their three dimensional structures

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神経極性を形づくる微小管重合を制御する神経ステロイド

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Structure analysis of proline specific peptidases which have unique specificity and structurePrincipal Investigator

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プロリン特異性ペプチダーゼの選択的オリゴペプチダーゼ作用とプロリン特異性機構解明Principal Investigator

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アセチルコリンエステラーゼが持つペプチダーゼ作用に着目した新規阻害剤の開発Principal Investigator

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プロリン特異性ペプチダーゼの構造とプロリン特異性発現機構の解明Principal Investigator

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プロリン特異性ペプチダーゼの構造とプロリン特異性発現機構の解明Principal Investigator

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プロリルエンドペプチダーゼ・インヒビターが示す抗健忘作用の機構解明Principal Investigator

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プロリン特異性ペプチダーゼの構造とプロリン特異性機構解明Principal Investigator

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Synthetic Studies for Ample Supply of Biologically Active Natural Products

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Studies on catalytic mechanism of prolyl endopeptidase by genetic method and biological significance of it in the brainPrincipal Investigator

Principal Investigator

YOSHIMOTO Tadashi 芳本忠

[Book] 日本の結晶学（Ⅱ）　その輝かしい発展2014