KITAGAWA Kouki 北川幸己

Researcher Number	60093853
Other IDs	https://orcid.org/0000-0001-6026-7063
External Links
Affiliation (based on the past Project Information) *help	2010 – 2014: 新潟薬科大学, 薬学部, 教授 1998 – 2008: 新潟薬科大学, 薬学部, 教授 1994 – 1995: 新潟薬科大学, 薬学部, 教授 1993: 徳島大学, 薬学部, 助教授
Review Section/Research Field	Principal Investigator Chemical pharmacy / Chemical pharmacy / Living organism molecular science Except Principal Investigator Drug development chemistry / Nerve anatomy/Neuropathology
Keywords	Principal Investigator 固相ペプチド合成 / コレシストキニン / 硫酸化チロシン / 化学合成 / Cholecystokinin / Solid-Phase Peptide Synthesis / Chemical Synthesis / 質量分析 / 硫酸化チロシン含有ペプチド / チオエステル縮合法 … More / MALDI-TOF-MS / α-コノトキシン / タンパク質硫酸化 / Protein Sulfation / チオエステルセグメント縮合 / ジスルフィド結合 / ペプチド性貝毒 / コノトキシン / Mass Spectrometry / O-Sulfated Tyrosine Containing Peptide / cholecystokinin / α-conotoxin / thioester segment condensation / sulfated tyrosine / solid-phase peptide synthesis / chemical synthesis / protein sulfation / MALDI-TOFMS / Tyrosin Sulfate Cluster / α-Conotoxin / Thioester Condensation / Tyrosine Sulfate / 硫酸化チロシンクラスター / Thioester Segment Condensation / Gastrin-II / イオン対形成 / 脱硫酸化反応 / 脱保護反応 / 大分子型コレシストキニン / チオエステル法 / マススペクトル / チオエステルセグメント縮合法 / ガストリン-II / 蛋白質硫酸化 / Gastrin / Gastro-Intestimal Peptide Hormone / O-Sulfated Tyrosine / フラグメント縮合 / 安全弁付き保護基 / 二次イオン分析法 / マススペグトロメトリー / ガストリン / 消化管ペプチドホルモン / 硫酸化酵素 / 硫酸基転移酵素 / 固相ペプチド化学合成 / 硫酸化ペプチド / 生体分子 / 硫酸化モチーフ / クローニング / 基質認識機構 / プロテオーム解析 / ペプチド合成 / 基質配列モチーフ / チロシン硫酸化酵素 / ファージディスプレイ / モノクローナル抗体 / 硫酸化タンパク質 … More Except Principal Investigator ペプチド / ペプチドプローブ / 化学合成ペプチド / NF-kB / ケミカルバイオロジー / ペプチド合成 / 転写調節因子 / アフィニティー精製 / NF-KappaB / 核内調節因子 / 転写因子 / タンパク質 / スクリーニング / コラーゲン / 医薬分子設計 / シナプス性制御 / 免疫組織化学 / 神経内分泌 / 視床下部 / カルシウム / 細胞内情報伝達系 / エネルギー変換 / ミトコンドリア / ATP合成酵素 Less

A Drug Discovery-study targeting the transcriptional factor, NF-KappaB
- Principal Investigator
  
  ASADA Shinichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nigata University of Phermacy and Applied Life Sciences
Preparation of monoclonal antibody against sulfated protein and its application to sulfo-proteomics studiesPrincipal Investigator
- Principal Investigator
  
  KITAGAWA Kouki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Nigata University of Phermacy and Applied Life Sciences
Chemical biology of collagen toward drug development
- Principal Investigator
  
  KOIDE Takaki
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Waseda University
Peptide synthesis and its application to elucidate the functional aspects of sulfated peptides and proteinsPrincipal Investigator
- Principal Investigator
  
  KITAGAWA Kouki
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Nigata University of Phermacy and Applied Life Sciences
Analysis of O-sulfotyrosine-mediated bio-interactions using synthetic peptidesPrincipal Investigator
- Principal Investigator
  
  KITAGAWA Kouki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Nigata University of Phermacy and Applied Life Sciences
Studies on the Sulfated Tyrosine Containing Peptides Using a Novel Solid-Phase Synthetic MethodPrincipal Investigator
- Principal Investigator
  
  KITAGAWA Kouki
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Niigata College of Pharmacy
Syntheses of Big-Molecular-Form Sulfated Peptide Hormones Using Novel Synthetic StrategyPrincipal Investigator
- Principal Investigator
  
  KITAGAWA Kouki
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Niigata College of Pharmacy
ミトコンドリアATP合成酵素-分子構築,エネルギー変換とCa制御の分子機作の解明
- Principal Investigator
  
  樋口富彦
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
視床下部神経内分泌系を統御する神経機構の電顕免疫組織化学的研究
- Principal Investigator
  
  久野節二
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The University of Tokushima

All 2010 2009 2008 2004 2003 2002 2001 Other

All Journal Article Presentation

[Journal Article] A collagen-mimetic triple helical supramolecule that evokes integrin-dependent cell responses2010
- Author(s)
  C.M.Yamazaki, Y.Kadoya, K.Hozumi, H.Okano-Kosugi, S.Asada, K.Kitagawa, M.Nomizu, T.Koide
- Journal Title
  
  Biomaterials 31
  
  Pages: 1925-1934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] A structure-activity relationship study elucidating the mechanism of sequence-specific collagen recognition by the chaperone HSP472010
- Author(s)
  Y.Nishikawa, Y.Takahara, S.Asada, A.Shigenaga, A.Otaka, K.Kitagawa, T.Koide
- Journal Title
  
  Bioorg.Med.Chem. 18
  
  Pages: 3767-3775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] A collagen-like triple helical supramolecule that evokes integrin-dependent cell response2010
- Author(s)
  C.M. Yamazaki, Y. Kadoya, K. Hozumi, H. Okano-Kosugi, S. Asada, K. Kitagawa, M. Nomizu, T. Koide
- Journal Title
  
  Biomaterials 31
  
  Pages: 1925-1934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] Development of a high-throughput screening system for the compounds that inhibit collagen-protein interactions2009
- Author(s)
  H. Okano-Kosugi, O. Matsushita, S. Asada, A. B. Herr, K. Kitagawa, T. Koide
- Journal Title
  
  Anal.Biochem. 394
  
  Pages: 125-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] Development of a high-throughput screening system for the compounds that inhibit collagen-protein interactions2009
- Author(s)
  H.Okano-Kosugi, O.Matsushita, S.Asada, A.B.Herr, K.Kitagawa, T.Koide
- Journal Title
  
  Anal.Biochem. 394
  
  Pages: 125-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] Totally synthetic collagen-like gels by intermolecular folding of designed peptides, (Proceeding for 30th European Peptide Symposium)2009
- Author(s)
  C.M.Yamazaki, S.Asada, K.Kitagawa, T.Koide
- Journal Title
  
  Peptides 2008
  
  Pages: 458-459
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] Totally synthetic collagen-like gels by intermoleoular folding of designed peptides.2009
- Author(s)
  C. M. Yamazaki, S. Asada, K. Kitagawa, T. Koide
- Journal Title
  
  Peptides 2008
  
  Pages: 458-459
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] Artificial Collagen Gels via Self-assembly of De Novo Designed Peptides2008
- Author(s)
  C. M. Yamazaki, S. Asada, K. Kitagawa, T. Koide
- Journal Title
  
  Biopolyniers (Peptide Science) 90
  
  Pages: 816-823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] Artificial Collagen Gels via Self-assembly of De Novo Designed Peptides2008
- Author(s)
  C.M.Yamazaki, S.Asada, K.Kitagawa, T.Koide
- Journal Title
  
  Biopolymers(Peptide Science) 90
  
  Pages: 816-823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] Artificial collagen gels via self-assembly of de novo designed peptides2008
- Author(s)
  C.M. Yamazaki, S. Asada, K. Kitagawa, T. Koide
- Journal Title
  
  Biopolymers (Peptide Science) 90
  
  Pages: 816-823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390032
[Journal Article] Total chemical synthesis of large CCK isoforms using a thioester segment condensation approach2004
- Author(s)
  Kouki Kitagawa et al.
- Journal Title
  
  Tetrahedron Vol.60
  
  Pages: 907-918
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13672241
[Journal Article] Total Chemical synthesis of large CCK isoforms using a thioester Segment condensation approach2004
- Author(s)
  Kouki Kitagawa
- Journal Title
  
  Tetrahedron 60
  
  Pages: 907-918
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13672241
[Journal Article] Solid-phase synthesis of tyrosine sulfate containing α-conotoxins2003
- Author(s)
  Kouki Kitagawa et al.
- Journal Title
  
  Peptides 2002 (Proceedings of the 27^<th> European Peptide Symposium)
  
  Pages: 164-165
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13672241
[Journal Article] Solid-phase synthesis of tyrosine sulfate containing α-conotoxins2003
- Author(s)
  Kouki Kitagawa
- Journal Title
  
  Peptides 2002
  
  Pages: 164-165
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13672241
[Journal Article] Ionic interaction of the Tyr(SO3H) residue with the cationic Functional group in the biomolecule2002
- Author(s)
  Kouki Kitagawa
- Journal Title
  
  Frontiers in Protein Chemistry and Biotechnology
  
  Pages: 45-50
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13672241
[Journal Article] Ionic interaction of the Tyr(SO_3H) residue with the cationic Functional group in the biomolecule2002
- Author(s)
  Kouki Kitagawa
- Journal Title
  
  Frontiers in Protein Chemistry and Biotechnology (Proceedings of the 4^<th> International Symposium on Frontiers in Protein Chemistry and Biotechnology)
  
  Pages: 45-50
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13672241
[Journal Article] Facile solid-phase synthesis of sulfated tyrosine-containing : Peptides : Part II. Total synthesis of human big gastrin-II and its C-terminal-extended peptide (G-Gly sulfate) by the solid-phase segment condensation approach.2001
- Author(s)
  Kouki Kitagawa et al.
- Journal Title
  
  Chemical & Pharmaceutical Bulletin Vol.49
  
  Pages: 958-963
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13672241
[Journal Article] Facile solid-phase synthesis of sulfated tyrosine-containing peptides : Part II. Total synthesis of human big gastrin-II and its C-terminal-extended peptide (G-Gly sulfate) by the solid-phase segment condensation approach2001
- Author(s)
  Kouki Kitagawa
- Journal Title
  
  Chemical & Pharmaceutical Bulletin 49
  
  Pages: 958-963
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13672241
[Presentation] A 384-plate screening of the compounds that inhibit collagen-protein interactions2009
- Author(s)
  H. Kosugi, S. Asada, K. Kitagawa, T. Koide, et al.
- Organizer
  8th Pan-Pacific Connective Tissue Societies Symposium
- Place of Presentation
  横須賀
- Year and Date
  2009-06-06
- Data Source
  KAKENHI-PROJECT-19390032
[Presentation] Totally synthetic collagen-like gels by intermolecular folding of designed peptides2008
- Author(s)
  C.M. Yamazaki, S. Asada, K. Kitagawa, T. Koide
- Organizer
  30th European Peptide Symposium
- Place of Presentation
  ヘルシンキ
- Year and Date
  2008-09-04
- Data Source
  KAKENHI-PROJECT-19390032
[Presentation] Totally synthetic collagen-like gels by intermoleoular folding of designed peptides2008
- Author(s)
  Chisato M. Yamazaki, Shinichi Asada, Kouki Kitagawa, Takaki Koide
- Organizer
  30th European Peptide Symposium
- Place of Presentation
  Helsinki, Finland
- Data Source
  KAKENHI-PROJECT-19390032
[Presentation] TPST によるチロシン硫酸化に必要な最短基質ペプチド鎖長の検討
- Author(s)
  頓所さやか、海沼将、加賀崎佳央里、北川幸己、浅田真一
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都会館（京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-23510265
[Presentation] TPSTによるチロシン硫酸化に最適な基質ペプチド配列の探索
- Author(s)
  頓所さやか、海沼将、加賀崎佳央里、関川由美、北川幸己、浅田真一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸（神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-23510265

1. ASADA Shinichi (50424883)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
2. SEKIGAWA Yumi (50329330)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KOIDE Takaki (70322253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
4. 樋口富彦 (50035557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 久野節二 (70136216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KITAGAWA Kouki 北川 幸己

Research Projects

Research Products

Co-Researchers

A Drug Discovery-study targeting the transcriptional factor, NF-KappaB

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Preparation of monoclonal antibody against sulfated protein and its application to sulfo-proteomics studiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chemical biology of collagen toward drug development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Peptide synthesis and its application to elucidate the functional aspects of sulfated peptides and proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of O-sulfotyrosine-mediated bio-interactions using synthetic peptidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the Sulfated Tyrosine Containing Peptides Using a Novel Solid-Phase Synthetic MethodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Syntheses of Big-Molecular-Form Sulfated Peptide Hormones Using Novel Synthetic StrategyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ミトコンドリアATP合成酵素-分子構築,エネルギー変換とCa制御の分子機作の解明

Principal Investigator

Project Period (FY)

Research Category

Research Institution

視床下部神経内分泌系を統御する神経機構の電顕免疫組織化学的研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A collagen-mimetic triple helical supramolecule that evokes integrin-dependent cell responses2010

Author(s)

Journal Title

Data Source

[Journal Article] A structure-activity relationship study elucidating the mechanism of sequence-specific collagen recognition by the chaperone HSP472010

Author(s)

Journal Title

Data Source

[Journal Article] A collagen-like triple helical supramolecule that evokes integrin-dependent cell response2010

Author(s)

Journal Title

Data Source

[Journal Article] Development of a high-throughput screening system for the compounds that inhibit collagen-protein interactions2009

Author(s)

Journal Title

Data Source

[Journal Article] Development of a high-throughput screening system for the compounds that inhibit collagen-protein interactions2009

Author(s)

Journal Title

Data Source

[Journal Article] Totally synthetic collagen-like gels by intermolecular folding of designed peptides, (Proceeding for 30th European Peptide Symposium)2009

Author(s)

Journal Title

KITAGAWA Kouki 北川幸己