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ARAI Takao  新井 孝夫

ORCIDConnect your ORCID iD *help
Researcher Number 60107422
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2009 – 2011: 東京理科大学, 理工学部・応用生物科学科, 教授
1996 – 1997: 東京理科大学, 理工学部, 教授
1994 – 1995: SUT Facult.of Sci.and Tech.Associate Professor, 理工学部, 助教授
1993 – 1995: 東京理科大学, 理工学部・応用生物科学科, 助教授
1994: 東京理科大学, 理工学部応用生物科学科, 助教授
1990 – 1992: 東京理科大学, 理工学部, 助教授
1989: 筑波大学, 基礎医学系, 講師
Review Section/Research Field
Principal Investigator
Cell biology / 分子細胞生物学
Except Principal Investigator
Neurochemistry/Neuropharmacology / Bioproduction chemistry/Bioorganic chemistry
Keywords
Principal Investigator
微小管 / PHF / モノクローナル抗体 / 翻訳後修飾 / 神経突起 / アルツハイマー病 / チューブリンアイソフォーム / エピトープ / 等電点電気泳動 / 微小管結合タンパク質 … More / モノクロ-ナル抗体 / epitopes / anti-tubulin antibodies / isoelectric focusing / posttranslational modification / isoforms / tubulin / microtubules / neurites / アイソファーム / 抗チューブリン抗体 / アイソフォーム / チューブリン / 等電点 / リン酸化 / MAP1B / MAPIB / 相補的ペプチド / 抗イディオタイプ抗体 / チュ-ブリン / アルツハイマ-脳 / 微小管タンパク質 … More
Except Principal Investigator
microtubule / neuritegenesis / nerve growth factor / neuronal cell death / lectin / central nerve neuronal cell / glycoconjugate / neuron / アレルギー性脳脊髄炎 / 多発性硬化症 / チューブリン / モノクローナル抗体 / 中枢神経細胞株 / 神経突起 / 神経細胞死 / 神経細胞栄養因子 / 微小管 / レクチン / 複合糖鎖 / 中枢神経系樹立細胞株 / ニューロン / 活性窒素 / 活性酸素 / 変性神経疾患 / 酸化ストレス / ネオエキヌリン / 一酸化窒素 / アルカロイド / ネオエキヌリンA / 神経科学 / 抗生物質 / 老化 / 痴呆 / 薬理学 Less
  • Research Projects

    (10 results)
  • Research Products

    (13 results)
  • Co-Researchers

    (15 People)
  •  Investigation of the mechanism of neuroprotection by neoechinulin A

    • Principal Investigator
      WATANABE Nobuo
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      Tokyo University of Science
  •  モノクローナル抗体をもちいたラット脳の成熟に伴うチューブリンの翻訳後修飾の探索Principal Investigator

    • Principal Investigator
      新井 孝夫
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Tokyo University of Science
  •  Studies on the cellular and molecular mechanism of neuron network construction

    • Principal Investigator
      IKEKITA Masahiko
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo University of Science
  •  アルツハイマー病脳におけるチューブリン翻訳後修飾と微小管の機能異常Principal Investigator

    • Principal Investigator
      新井 孝夫
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo University of Science
  •  アルツハイマー脳におけるMAP1Bの異常なリン酸化と微小管の機能異常Principal Investigator

    • Principal Investigator
      新井 孝夫
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo University of Science
  •  Role of structurally and functionally differentiated microtubules in outgrowth and differentiation of neurites.Principal Investigator

    • Principal Investigator
      ARAI Takao
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Science University of Tokyo (SUT)
  •  アルツハイマー脳におけるMAPIBの異常なリン酸化と微小管の機能異常Principal Investigator

    • Principal Investigator
      新井 孝夫
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo University of Science
  •  微小管と弱く相互作用するタンパク質を認識するモノクロ-ナル抗体の作製Principal Investigator

    • Principal Investigator
      新井 孝夫
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      分子細胞生物学
    • Research Institution
      Tokyo University of Science
  •  モノクロ-ナル抗体を用いたアルツハイマ-脳沈着PHFの意味づけPrincipal Investigator

    • Principal Investigator
      新井 孝夫
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo University of Science
  •  モノクローナル抗体をもちいたアルツハイマー脳沈着PHFの意味づけPrincipal Investigator

    • Principal Investigator
      新井 孝夫
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      University of Tsukuba

All 2012 2011 2010 2009

All Journal Article Presentation

  • [Journal Article] Prolonged nitric oxide treatment induces tau aggregation in SH-SY5Y cells2012

    • Author(s)
      Takahashi M, Nonaka T, Hasegawa M, Watanabe N, Arai T
    • Journal Title

      Neuroscience Letters

      Volume: 510 Pages: 48-52

    • Data Source
      KAKENHI-PROJECT-21580131
  • [Journal Article] Neoechinulin A impedes the progression of rotenone-induced cytotoxicity in PC12 cells2011

    • Author(s)
      Akashi S, Kimura T, Takeuchi T, Kuramochi K, Kobayashi S, Sugawara F, Watanabe N, Arai T
    • Journal Title

      Biological & Pharmaceutical Bulletin

      Volume: 34 Pages: 243-248

    • NAID

      130000402197

    • Data Source
      KAKENHI-PROJECT-21580131
  • [Journal Article] S-nitrosation of cellular proteins by NO donors in rat embryonic fibroblast 3Y1 cells : factors affecting S-nitrosation2011

    • Author(s)
      Ryuman N, Watanabe N, Arai T
    • Journal Title

      Oxidative Medicine and Cellular Longevity

      Volume: 450317

    • Data Source
      KAKENHI-PROJECT-21580131
  • [Journal Article] Synthesis and Neuroprotective Action of Optically Pure Neoechinulin A and Its Analogs2010

    • Author(s)
      Aoki T, Ohnishi K, Kimoto M, Fujieda S, Kuramochi K, Takeuchi T, Nakazaki A, Watanabe N, Sugawara F, Arai T, Kobayashi S
    • Journal Title

      Pharmaceuticals

      Volume: 3 Pages: 1063-1069

    • Data Source
      KAKENHI-PROJECT-21580131
  • [Journal Article] SIN-1 cytotoxicity to PC12 cells is mediated by thiol-sensitive short-lived substances generated through SIN-1 decomposition in culture medium2009

    • Author(s)
      Konishi K, Watanabe N, Arai T
    • Journal Title

      Nitric Oxide

      Volume: 4 Pages: 270-278

    • Data Source
      KAKENHI-PROJECT-21580131
  • [Presentation] Neoechinulin A confers resistance against nitrosative stress despite inducing a significant depletion of cellular GSH2011

    • Author(s)
      Watanabe N, Akashi S, Nakagawa T, Okada T, Takeuchi T, Kuramochi K, Sugawara F, Kobayashi S, Arai T
    • Organizer
      18th Annual Meeting of the Society for Free Radical Biology and Medicine
    • Place of Presentation
      Atlanta, GA, USA
    • Year and Date
      2011-12-18
    • Data Source
      KAKENHI-PROJECT-21580131
  • [Presentation] Neoechinulin A confers cytoprotection against nitrosative stresses in PC12 cells while paradoxically decreasing GSH contents2011

    • Author(s)
      Nakagawa T, Akashi S, Okada T, Konishi K, Ogura Y, Kuramochi K, Kobayashi S, Sugawara F, Takeuchi T, Watanabe N, Arai T
    • Organizer
      5th Biannual Meeting of the Society for Free Radical Research-Asia
    • Place of Presentation
      Kagoshima, Japan
    • Year and Date
      2011-09-01
    • Data Source
      KAKENHI-PROJECT-21580131
  • [Presentation] Neoechinulin A impedes cell death induced by mitochondrial complex I inhibitor rotenone2011

    • Author(s)
      Akashi S, Kimura T, Takeuchi T, Kuramochi K, Kobayashi S, Sugawara F, Watanabe N, Arai T
    • Organizer
      18th Annual Meeting of the Society for Free Radical Biology and Medicine
    • Place of Presentation
      Atlanta, GA, USA
    • Year and Date
      2011-12-18
    • Data Source
      KAKENHI-PROJECT-21580131
  • [Presentation] The mechanistic study of cytotoxicity induced by SIN-1 in PC12 cells2011

    • Author(s)
      Okada T, Konishi K, Nakashima M, Watanabe N, Arai T
    • Organizer
      5th Biannual Meeting of the Society for Free Radical Research-Asia
    • Place of Presentation
      Kagoshima, Japan
    • Year and Date
      2011-09-01
    • Data Source
      KAKENHI-PROJECT-21580131
  • [Presentation] Nitric oxide induces tau protein aggregation in SY5Y cells2011

    • Author(s)
      Takahashi M, Chin Y, Hasegawa M, Nonaka T, Watanabe N, Arai T
    • Organizer
      5th Biannual Meeting of the Society for Free Radical Research-Asia
    • Place of Presentation
      Kagoshima, Japan
    • Year and Date
      2011-09-01
    • Data Source
      KAKENHI-PROJECT-21580131
  • [Presentation] Prolonged nitric oxide treatment induces tau aggregation in SH-SY5Y cells2011

    • Author(s)
      Takahashi M, Nonaka T, Hasegawa M, Watanabe N, Arai T
    • Organizer
      8th Annual Meeting of the Society for Free Radical Biology and Medicine
    • Place of Presentation
      Atlanta, GA, USA
    • Year and Date
      2011-12-18
    • Data Source
      KAKENHI-PROJECT-21580131
  • [Presentation] SIN-1 cytotoxicity to PC12 cells is mediated by thiol-sensitive short-lived substances generated through SIN-1 decomposition in culture medium2010

    • Author(s)
      Watanabe N, Konishi K, Arai T
    • Organizer
      The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-06-14
    • Data Source
      KAKENHI-PROJECT-21580131
  • [Presentation] Nitric oxide induces tau protein oligomerization in SY5Y cells2010

    • Author(s)
      Takahashi M, Chin Y, Hasegawa M, Nonaka T, Watanabe N, Arai T
    • Organizer
      The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-06-14
    • Data Source
      KAKENHI-PROJECT-21580131
  • 1.  藤井 敏弘 (50126702)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 2.  大塚 仁也 (90103035)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  WATANABE Nobuo (80396928)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  KURAMOCHI Kouji (90408708)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 5.  KOBAYASHI Susumu (70101102)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 6.  IKEKITA Masahiko (70138981)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  KOJIMA Shuuji (90119579)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  TASHIRO Fumio (70089332)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  TOMOOKA Yasuhiro (10197949)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  VINCENDON Guy
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  MERSEL Mirsial
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  ZANETTA Jean P
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  MERSEL Mirsi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  ZANETTA Jean
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  渡邊 伸央
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 13 results

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