ARAI Takao 新井孝夫

Researcher Number	60107422
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2009 – 2011: 東京理科大学, 理工学部・応用生物科学科, 教授 1996 – 1997: 東京理科大学, 理工学部, 教授 1994 – 1995: SUT Facult.of Sci.and Tech.Associate Professor, 理工学部, 助教授 1993 – 1995: 東京理科大学, 理工学部・応用生物科学科, 助教授 1994: 東京理科大学, 理工学部応用生物科学科, 助教授 1990 – 1992: 東京理科大学, 理工学部, 助教授 1989: 筑波大学, 基礎医学系, 講師
Review Section/Research Field	Principal Investigator Cell biology / 分子細胞生物学 Except Principal Investigator Neurochemistry/Neuropharmacology / Bioproduction chemistry/Bioorganic chemistry
Keywords	Principal Investigator 微小管 / PHF / モノクローナル抗体 / 翻訳後修飾 / 神経突起 / アルツハイマー病 / チューブリンアイソフォーム / エピトープ / 等電点電気泳動 / 微小管結合タンパク質 … More / モノクロ-ナル抗体 / epitopes / anti-tubulin antibodies / isoelectric focusing / posttranslational modification / isoforms / tubulin / microtubules / neurites / アイソファーム / 抗チューブリン抗体 / アイソフォーム / チューブリン / 等電点 / リン酸化 / MAP1B / MAPIB / 相補的ペプチド / 抗イディオタイプ抗体 / チュ-ブリン / アルツハイマ-脳 / 微小管タンパク質 … More Except Principal Investigator microtubule / neuritegenesis / nerve growth factor / neuronal cell death / lectin / central nerve neuronal cell / glycoconjugate / neuron / アレルギー性脳脊髄炎 / 多発性硬化症 / チューブリン / モノクローナル抗体 / 中枢神経細胞株 / 神経突起 / 神経細胞死 / 神経細胞栄養因子 / 微小管 / レクチン / 複合糖鎖 / 中枢神経系樹立細胞株 / ニューロン / 活性窒素 / 活性酸素 / 変性神経疾患 / 酸化ストレス / ネオエキヌリン / 一酸化窒素 / アルカロイド / ネオエキヌリンA / 神経科学 / 抗生物質 / 老化 / 痴呆 / 薬理学 Less

Investigation of the mechanism of neuroprotection by neoechinulin A
- Principal Investigator
  
  WATANABE Nobuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Tokyo University of Science
モノクローナル抗体をもちいたラット脳の成熟に伴うチューブリンの翻訳後修飾の探索Principal Investigator
- Principal Investigator
  
  新井孝夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Tokyo University of Science
Studies on the cellular and molecular mechanism of neuron network construction
- Principal Investigator
  
  IKEKITA Masahiko
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo University of Science
アルツハイマー病脳におけるチューブリン翻訳後修飾と微小管の機能異常Principal Investigator
- Principal Investigator
  
  新井孝夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo University of Science
アルツハイマー脳におけるMAP1Bの異常なリン酸化と微小管の機能異常Principal Investigator
- Principal Investigator
  
  新井孝夫
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo University of Science
Role of structurally and functionally differentiated microtubules in outgrowth and differentiation of neurites.Principal Investigator
- Principal Investigator
  
  ARAI Takao
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Science University of Tokyo (SUT)
アルツハイマー脳におけるMAPIBの異常なリン酸化と微小管の機能異常Principal Investigator
- Principal Investigator
  
  新井孝夫
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo University of Science
微小管と弱く相互作用するタンパク質を認識するモノクロ-ナル抗体の作製Principal Investigator
- Principal Investigator
  
  新井孝夫
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  分子細胞生物学
- Research Institution
  Tokyo University of Science
モノクロ-ナル抗体を用いたアルツハイマ-脳沈着PHFの意味づけPrincipal Investigator
- Principal Investigator
  
  新井孝夫
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo University of Science
モノクローナル抗体をもちいたアルツハイマー脳沈着PHFの意味づけPrincipal Investigator
- Principal Investigator
  
  新井孝夫
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba

All 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] Prolonged nitric oxide treatment induces tau aggregation in SH-SY5Y cells2012
- Author(s)
  Takahashi M, Nonaka T, Hasegawa M, Watanabe N, Arai T
- Journal Title
  
  Neuroscience Letters
  
  Volume: 510 Pages: 48-52
- Data Source
  KAKENHI-PROJECT-21580131
[Journal Article] Neoechinulin A impedes the progression of rotenone-induced cytotoxicity in PC12 cells2011
- Author(s)
  Akashi S, Kimura T, Takeuchi T, Kuramochi K, Kobayashi S, Sugawara F, Watanabe N, Arai T
- Journal Title
  
  Biological & Pharmaceutical Bulletin
  
  Volume: 34 Pages: 243-248
- NAID
  130000402197
- Data Source
  KAKENHI-PROJECT-21580131
[Journal Article] S-nitrosation of cellular proteins by NO donors in rat embryonic fibroblast 3Y1 cells : factors affecting S-nitrosation2011
- Author(s)
  Ryuman N, Watanabe N, Arai T
- Journal Title
  
  Oxidative Medicine and Cellular Longevity
  
  Volume: 450317
- Data Source
  KAKENHI-PROJECT-21580131
[Journal Article] Synthesis and Neuroprotective Action of Optically Pure Neoechinulin A and Its Analogs2010
- Author(s)
  Aoki T, Ohnishi K, Kimoto M, Fujieda S, Kuramochi K, Takeuchi T, Nakazaki A, Watanabe N, Sugawara F, Arai T, Kobayashi S
- Journal Title
  
  Pharmaceuticals
  
  Volume: 3 Pages: 1063-1069
- Data Source
  KAKENHI-PROJECT-21580131
[Journal Article] SIN-1 cytotoxicity to PC12 cells is mediated by thiol-sensitive short-lived substances generated through SIN-1 decomposition in culture medium2009
- Author(s)
  Konishi K, Watanabe N, Arai T
- Journal Title
  
  Nitric Oxide
  
  Volume: 4 Pages: 270-278
- Data Source
  KAKENHI-PROJECT-21580131
[Presentation] Neoechinulin A confers resistance against nitrosative stress despite inducing a significant depletion of cellular GSH2011
- Author(s)
  Watanabe N, Akashi S, Nakagawa T, Okada T, Takeuchi T, Kuramochi K, Sugawara F, Kobayashi S, Arai T
- Organizer
  18th Annual Meeting of the Society for Free Radical Biology and Medicine
- Place of Presentation
  Atlanta, GA, USA
- Year and Date
  2011-12-18
- Data Source
  KAKENHI-PROJECT-21580131
[Presentation] Neoechinulin A confers cytoprotection against nitrosative stresses in PC12 cells while paradoxically decreasing GSH contents2011
- Author(s)
  Nakagawa T, Akashi S, Okada T, Konishi K, Ogura Y, Kuramochi K, Kobayashi S, Sugawara F, Takeuchi T, Watanabe N, Arai T
- Organizer
  5th Biannual Meeting of the Society for Free Radical Research-Asia
- Place of Presentation
  Kagoshima, Japan
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-21580131
[Presentation] Neoechinulin A impedes cell death induced by mitochondrial complex I inhibitor rotenone2011
- Author(s)
  Akashi S, Kimura T, Takeuchi T, Kuramochi K, Kobayashi S, Sugawara F, Watanabe N, Arai T
- Organizer
  18th Annual Meeting of the Society for Free Radical Biology and Medicine
- Place of Presentation
  Atlanta, GA, USA
- Year and Date
  2011-12-18
- Data Source
  KAKENHI-PROJECT-21580131
[Presentation] The mechanistic study of cytotoxicity induced by SIN-1 in PC12 cells2011
- Author(s)
  Okada T, Konishi K, Nakashima M, Watanabe N, Arai T
- Organizer
  5th Biannual Meeting of the Society for Free Radical Research-Asia
- Place of Presentation
  Kagoshima, Japan
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-21580131
[Presentation] Nitric oxide induces tau protein aggregation in SY5Y cells2011
- Author(s)
  Takahashi M, Chin Y, Hasegawa M, Nonaka T, Watanabe N, Arai T
- Organizer
  5th Biannual Meeting of the Society for Free Radical Research-Asia
- Place of Presentation
  Kagoshima, Japan
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-21580131
[Presentation] Prolonged nitric oxide treatment induces tau aggregation in SH-SY5Y cells2011
- Author(s)
  Takahashi M, Nonaka T, Hasegawa M, Watanabe N, Arai T
- Organizer
  8th Annual Meeting of the Society for Free Radical Biology and Medicine
- Place of Presentation
  Atlanta, GA, USA
- Year and Date
  2011-12-18
- Data Source
  KAKENHI-PROJECT-21580131
[Presentation] SIN-1 cytotoxicity to PC12 cells is mediated by thiol-sensitive short-lived substances generated through SIN-1 decomposition in culture medium2010
- Author(s)
  Watanabe N, Konishi K, Arai T
- Organizer
  The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2010-06-14
- Data Source
  KAKENHI-PROJECT-21580131
[Presentation] Nitric oxide induces tau protein oligomerization in SY5Y cells2010
- Author(s)
  Takahashi M, Chin Y, Hasegawa M, Nonaka T, Watanabe N, Arai T
- Organizer
  The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2010-06-14
- Data Source
  KAKENHI-PROJECT-21580131

1. 藤井敏弘 (50126702)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. 大塚仁也 (90103035)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. WATANABE Nobuo (80396928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KURAMOCHI Kouji (90408708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. KOBAYASHI Susumu (70101102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. IKEKITA Masahiko (70138981)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KOJIMA Shuuji (90119579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TASHIRO Fumio (70089332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TOMOOKA Yasuhiro (10197949)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. VINCENDON Guy

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MERSEL Mirsial

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ZANETTA Jean P

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MERSEL Mirsi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ZANETTA Jean

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 渡邊伸央

# of Collaborated Projects: 0 results

# of Collaborated Products: 13 results

ARAI Takao 新井 孝夫

Research Projects

Research Products

Co-Researchers

Investigation of the mechanism of neuroprotection by neoechinulin A

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

モノクローナル抗体をもちいたラット脳の成熟に伴うチューブリンの翻訳後修飾の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the cellular and molecular mechanism of neuron network construction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アルツハイマー病脳におけるチューブリン翻訳後修飾と微小管の機能異常Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

アルツハイマー脳におけるMAP1Bの異常なリン酸化と微小管の機能異常Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Role of structurally and functionally differentiated microtubules in outgrowth and differentiation of neurites.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アルツハイマー脳におけるMAPIBの異常なリン酸化と微小管の機能異常Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

微小管と弱く相互作用するタンパク質を認識するモノクロ-ナル抗体の作製Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

モノクロ-ナル抗体を用いたアルツハイマ-脳沈着PHFの意味づけPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

モノクローナル抗体をもちいたアルツハイマー脳沈着PHFの意味づけPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Journal Article] Prolonged nitric oxide treatment induces tau aggregation in SH-SY5Y cells2012

Author(s)

Journal Title

Data Source

[Journal Article] Neoechinulin A impedes the progression of rotenone-induced cytotoxicity in PC12 cells2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] S-nitrosation of cellular proteins by NO donors in rat embryonic fibroblast 3Y1 cells : factors affecting S-nitrosation2011

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis and Neuroprotective Action of Optically Pure Neoechinulin A and Its Analogs2010

Author(s)

Journal Title

Data Source

[Journal Article] SIN-1 cytotoxicity to PC12 cells is mediated by thiol-sensitive short-lived substances generated through SIN-1 decomposition in culture medium2009

Author(s)

Journal Title

Data Source

ARAI Takao 新井孝夫