OBARA Kazuo 小原一男

Researcher Number	60117611
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2013 – 2015: 静岡県立大学, 薬学部, 講師 2009 – 2011: University of Shizuoka, 薬学部, 講師 1997 – 2002: Department of Pharmacology, Faculty of Pharmaceutical Sciences, University of Sh, 薬学部, 講師
Review Section/Research Field	Principal Investigator General pharmacology / Applied health science / Applied health science Except Principal Investigator 応用薬理学・医療系薬学 / General pharmacology / Biological pharmacy / 医薬分子機能学
Keywords	Principal Investigator Rho / myosin phosphatase / protein kinase C / myosin phosphorylation / stretch stimulation / basilar artery / vascular smooth muscle / dog / プロテインキナーゼC / ミオシンリン酸化 … More / 伸展刺激 / 脳底動脈 / 血管平滑筋 / イヌ / CaMKII / GLUT4 / カルシウム / インテグリン / ストレッチ / 糖代謝 / 骨格筋 / ミオシンホスファターゼ / 脳低動脈 / 収縮 / ミオシンフォスファターゼ / ＧＬＵＴ４ / ＮＯ / ニトロシル化 / 糖取り込み / リアノジン受容体 / NO / カベオリン3 / PI3K / Akt / マウスヒラメ筋 / シグナル伝達 / NOS / 三次元培養 / L6細胞 / FAK … More Except Principal Investigator Rho / DAF-2 / Ca^<2+> / NO / mechanotransduction / チロシンキナーゼ / インテグリン / myogenic contraction / 筋原性収縮 / phosphorylation / Rho kinase / protein kinase C / tyrosine kinase / integrin / myogenic response / blood vessel / イメージング解析 / 循環調節機構 / 筋原性収縮反応 / cSrc ファミリー / メカノセンサー / タンパクチロシンリン酸化 / 血行力学受容 / Rho-kinase / 細胞内シグナリング / チロシンリン酸化 / イメージング / 低分子GTP結合タンパク / プロテインキナーゼC / リン酸化 / メカノトランスダクション / 血行力学受容・応答 / glucose / NO synthase / rat / β-cells / Islets of Langerhans / インスリン / NOC 7 / グルコース / NO合成酵素 / ラット / β細胞 / ランゲルハンス氏島 / cerebral vasospasm / cellular signaling / caveolin / caveola / cerebral artery / hemodynamic stress / 脳動脈 / カルシウム動態 / 脳血管攣縮 / 細胞情報伝達 / カベオリン / カベオラ / 脳血管 / 血行力学受容・応答機構 / 血行力学因子 / pressure / stretch / hemodynamics / cardiovascular system / protein tyosyl phosphorylation / tyrosine kinase inhibitor / biomechanics / mechano-transduction / 血管収縮 / 接着班キナーゼ活性 / 細胞内情報伝達 / 物理受容・応答 / チロシンキナーゼ阻害薬 / 循環系 / 細胞シグナリング / 実験治療学 / 血管 / チロシンリン酸化酵素 / 血行力学刺激 / バイオメカニクス / 循環 Less

NO/calcium regulation mechanism in stretch-induced glucose uptake of skeletal musclePrincipal Investigator
- Principal Investigator
  
  OBARA Kazuo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  University of Shizuoka
Molecular mechanisms of glucose metabolism induced by stretch in skeletal muscles.Principal Investigator
- Principal Investigator
  
  OBARA Kazuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  University of Shizuoka
Role of regulatory mechanism of myosin phosphatase in stretch-induced contraction of vascular smooth musclePrincipal Investigator
- Principal Investigator
  
  OBARA Kazuo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  University of Shizuoka
Realtime imaging analysis of tyrosine phosphorylation in response to hemodynamic forces
- Principal Investigator
  
  NAKAYAMA Koichi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  University of Shizuoka
Analysis of intracellular mechanisms contributing to insulin secretion from pancreatic β-cells
- Principal Investigator
  
  ISHIKAWA Tomohisa
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  University of Shizuoka
Uncoupling of force and myosin light chain phosphorylation produced by slow stretch in vascular smooth muscle.Principal Investigator
- Principal Investigator
  
  OBARA Kazuo
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Department of Pharmacology, Faculty of Pharmaceutical Sciences, University of Shizuoka
Role of caveolin located in the caveolae, identified as flask-shaped invaginations on the surface of the plasma membrane, involved in the mechanotrasduction of vascular system.
- Principal Investigator
  
  NAKAYAMA Koichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Department of Pharmacology, Faculty op Pharmaceutical Sciences, University of Shizuoka
Development of the modulator drug specifically targeting biomechanical reaction in the circulatory system and the application for experimental therapeutics.
- Principal Investigator
  
  NAKAYAMA Koichi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  University of Shizuoka

All 2016 2015 2014 2011 2010 2009 Other

All Journal Article Presentation Book

[Book] Specific Mechano-transduction signaling involved in myogenic response of the cerebral arteries. Mechanosensitivity in Cells and Tissues2009
- Author(s)
  Koichi Nakayama, Kazuo Obara, Tomohisa Ishikawa, Shigeru Nishizawa
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-21500687
[Journal Article] Myosin Phosphorylation Dissociated from Force under Hypoxic and Glucose-Free Conditions in the Guinea Pig Taenia Caeci.2014
- Author(s)
  Yukisato Ishida, Kazuo Obara, Richard J Paul
- Journal Title
  
  J. Muscle Res. Cell Motil.
  
  Volume: 35 Pages: 243-243
- Data Source
  KAKENHI-PROJECT-25350893
[Journal Article] Mechanism of potentiation by tea epigallocatechin of contraction in porcine coronary artery : The role of protein kinase Cδ-mediated CPI-17 phosphorylation2011
- Author(s)
  Kazuo Obara, Kiyotaka Ukai, Tomohisa Ishikawa
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 668 Pages: 414-418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500687
[Journal Article] Interactive role of protein phosphatase 2A and protein kinase Cα in the stretch-induced triphosphorylation of myosin light chain in canine cerebral artery2010
- Author(s)
  Kazuo Obara, Ayako Mitate, Kayo Nozawa, Makiko Watanabe, Yoshihiko Ito, Koichi Nakayama
- Journal Title
  
  Journal of Vascular Research
  
  Volume: 47 Pages: 115-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500687
[Journal Article] Interactive role of protein phosphatase 2A and protein kinase Ca in the stretch-induced triphosphorylation of myosin light chain in canine cerebral artery.2010
- Author(s)
  Kazuo Obara
- Journal Title
  
  Journal of Vascular Research
  
  Volume: 47 Pages: 115-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500687
[Journal Article] Interactive role of protein phosphatase 2A and protein kinase Cα in the stretch-induced triphosphorylation of myosin light chain in canine cerebral artery2010
- Author(s)
  Kazuo Obara
- Journal Title
  
  Journal of Vascular Research 47
  
  Pages: 115-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500687
[Presentation] マウス骨格筋の伸展誘発性糖取り込み機構2016
- Author(s)
  小原　一男、宇田　宗晃、滝口　茂幸、能代　裕也、石川　智久
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-25350893
[Presentation] ミオシン軽鎖3リン酸化調節におけるPP2Aの役割2015
- Author(s)
  小原一男
- Organizer
  第57回日本平滑筋学会総会
- Place of Presentation
  山口大学小串キャンパス（山口県宇部市）
- Year and Date
  2015-08-25
- Data Source
  KAKENHI-PROJECT-25350893
[Presentation] 骨格筋糖取り込み増強作用における緑茶エピガロカテキンガレートの脱リン酸化酵素阻害薬としての作用2015
- Author(s)
  小原一男
- Organizer
  静岡県立大学ＵＳフォーラム201５
- Place of Presentation
  静岡県立大学（静岡県静岡市）
- Year and Date
  2015-09-29
- Data Source
  KAKENHI-PROJECT-25350893
[Presentation] マウス骨格筋における伸展誘発性糖取り込み機構2015
- Author(s)
  小原一男
- Organizer
  筋生理の集い
- Place of Presentation
  慈恵会医科大学・高木会館（東京都港区）
- Year and Date
  2015-12-19
- Data Source
  KAKENHI-PROJECT-25350893
[Presentation] 緑茶エピガロカテキンガレートによる骨格筋糖取り込み増強作用への67LRを介する細胞骨格リモデリングの関与について2014
- Author(s)
  小原一男
- Organizer
  静岡県立大学ＵＳフォーラム2014
- Place of Presentation
  静岡市
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-25350893
[Presentation] イヌ脳底動脈平滑筋における緑茶カテキンの収縮増強作用2011
- Author(s)
  小原一男
- Organizer
  第53回日本平滑筋学会総会
- Place of Presentation
  東京
- Year and Date
  2011-08-03
- Data Source
  KAKENHI-PROJECT-21500687
[Presentation] マウスヒラメ筋におけるエピガロカテキンガレートによる糖取り込みへの過酸化水素の関与について2011
- Author(s)
  小原一男
- Organizer
  静岡県立大学USフォーラム
- Place of Presentation
  静岡
- Year and Date
  2011-09-27
- Data Source
  KAKENHI-PROJECT-21500687
[Presentation] イヌ脳底動脈の伸展誘発性収縮におけるミオシン輕鎖3リン酸化の役割2010
- Author(s)
  小原一男
- Organizer
  第87回に本生理学会大会
- Place of Presentation
  盛岡
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-21500687
[Presentation] 茶カテキンの血管平滑筋収縮増強作用における過酸化水素の役割2010
- Author(s)
  小原一男
- Organizer
  筋生理の集い
- Place of Presentation
  東京
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-21500687
[Presentation] 人工筋線維におけるエピガロカテキンガレートの糖取り込み作用2010
- Author(s)
  小原一男
- Organizer
  静岡県立大学USフォーラム2010
- Place of Presentation
  静岡
- Year and Date
  2010-08-03
- Data Source
  KAKENHI-PROJECT-21500687
[Presentation] Inhibitory role of phosphorylation of myosin light chain at threonine-9 in the mechanical activity of canine basilar artery.2010
- Author(s)
  Obara Kazuo
- Organizer
  16th World Congress on Basic and Clinical Pharmacology
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-21500687
[Presentation] 犬脳底動脈の伸展誘発性収縮におけるミオシン輕鎖3リン酸化の役割2010
- Author(s)
  小原一男
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-21500687
[Presentation] Inhibitory role of phosphorylation of myosin light chain at threonine-9 in the mechanical activity of canine basilar artery2010
- Author(s)
  Kazuo Obara
- Organizer
  16th World Congress on Basic and Clinical Pharmacology
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2010-07-20
- Data Source
  KAKENHI-PROJECT-21500687
[Presentation] 人工骨格線維におけるエピガロカテキンがレートの糖取り込み作用について2010
- Author(s)
  小原一男
- Organizer
  静岡県立大学USフォーラム
- Place of Presentation
  静岡
- Year and Date
  2010-08-03
- Data Source
  KAKENHI-PROJECT-21500687
[Presentation] 血管平滑筋に対する緑茶カテキンの作用2010
- Author(s)
  小原一男
- Organizer
  第39回日本心脈管作動物質学会
- Place of Presentation
  名古屋
- Year and Date
  2010-02-05
- Data Source
  KAKENHI-PROJECT-21500687
[Presentation] 血管平滑筋に対する茶カテキンの作用について2009
- Author(s)
  小原一男
- Organizer
  筋生理の集い
- Place of Presentation
  東京
- Year and Date
  2009-12-19
- Data Source
  KAKENHI-PROJECT-21500687
[Presentation] Role of triphosphorylation of myosin light chain in the contraction of the canine basilar artery2009
- Author(s)
  Kazuo Obara
- Organizer
  Satellite Symposium of the IUPS2009
- Place of Presentation
  名古屋
- Year and Date
  2009-07-23
- Data Source
  KAKENHI-PROJECT-21500687
[Presentation] Involvement of protein kinase Cα in the stretch-induced triphosphorylation of myosin light chain in canine cerebral artery2009
- Author(s)
  Kazuo Obara
- Organizer
  XXXVI International Congress of Physiological Sciences
- Place of Presentation
  京都
- Year and Date
  2009-07-31
- Data Source
  KAKENHI-PROJECT-21500687
[Presentation] 人工筋線維における糖取り込みに対するストレッチ刺激の影響について2009
- Author(s)
  小原一男
- Organizer
  静岡県立大学2007USフォーラム
- Place of Presentation
  静岡
- Year and Date
  2009-08-04
- Data Source
  KAKENHI-PROJECT-21500687
[Presentation] マウス骨格筋における緑茶エピガロカテキンガレートによる糖取り込み増強作用
- Author(s)
  小原一男、石川智久
- Organizer
  第61回中部日本生理学会大会
- Place of Presentation
  名古屋市
- Year and Date
  2014-11-06 – 2014-11-07
- Data Source
  KAKENHI-PROJECT-25350893
[Presentation] 緑茶エピガロカテキンガレートによる骨格筋糖取り込み増強機序の解明
- Author(s)
  小原一男
- Organizer
  静岡県立大学ＵＳフォーラム2013
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-25350893

1. TANABE Yoshiyuki (10275109)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. NAKAYAMA Koichi (50112769)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. ISHIKAWA Tomohisa (10201914)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. ASANO Toshio

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. ISHII Kunio (90137993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKEISHI Keiichi (90012608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 浅井敏雄

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 浅野俊雄

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OBARA Kazuo 小原 一男

Research Projects

Research Products

Co-Researchers

NO/calcium regulation mechanism in stretch-induced glucose uptake of skeletal musclePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of glucose metabolism induced by stretch in skeletal muscles.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of regulatory mechanism of myosin phosphatase in stretch-induced contraction of vascular smooth musclePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Realtime imaging analysis of tyrosine phosphorylation in response to hemodynamic forces

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of intracellular mechanisms contributing to insulin secretion from pancreatic β-cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Uncoupling of force and myosin light chain phosphorylation produced by slow stretch in vascular smooth muscle.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of caveolin located in the caveolae, identified as flask-shaped invaginations on the surface of the plasma membrane, involved in the mechanotrasduction of vascular system.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the modulator drug specifically targeting biomechanical reaction in the circulatory system and the application for experimental therapeutics.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Specific Mechano-transduction signaling involved in myogenic response of the cerebral arteries. Mechanosensitivity in Cells and Tissues2009

Author(s)

Publisher

Data Source

[Journal Article] Myosin Phosphorylation Dissociated from Force under Hypoxic and Glucose-Free Conditions in the Guinea Pig Taenia Caeci.2014

Author(s)

Journal Title

Data Source

[Journal Article] Mechanism of potentiation by tea epigallocatechin of contraction in porcine coronary artery : The role of protein kinase Cδ-mediated CPI-17 phosphorylation2011

Author(s)

Journal Title

Data Source

[Journal Article] Interactive role of protein phosphatase 2A and protein kinase Cα in the stretch-induced triphosphorylation of myosin light chain in canine cerebral artery2010

Author(s)

Journal Title

Data Source

[Journal Article] Interactive role of protein phosphatase 2A and protein kinase Ca in the stretch-induced triphosphorylation of myosin light chain in canine cerebral artery.2010

Author(s)

Journal Title

Data Source

[Journal Article] Interactive role of protein phosphatase 2A and protein kinase Cα in the stretch-induced triphosphorylation of myosin light chain in canine cerebral artery2010

Author(s)

Journal Title

Data Source

[Presentation] マウス骨格筋の伸展誘発性糖取り込み機構2016

Author(s)

Organizer

Place of Presentation

OBARA Kazuo 小原一男