NAGATOMO Takafumi 長友孝文

Researcher Number	60121240
External Links
Affiliation (based on the past Project Information) *help	2004 – 2007: Niigata University of Pharmacy and Applied Life Sciences, Dept of Pharmacology, Professor, 薬学部, 教授 2003: 新潟薬科大学, 薬学部・薬理学教室, 教授 1997: 新潟薬科大学, 薬化学, 教授 1996 – 1997: 新潟薬科大学, 薬理学, 教授 1990: Niigata College of Pharmacy, Professor, 薬学部・薬理学教室, 教授 1989: 新潟薬科大学, 薬理, 教授 1988: 新潟薬大, 薬理, 教授
Review Section/Research Field	Principal Investigator General pharmacology / General pharmacology
Keywords	Principal Investigator NMR / ^3H-prazosin / DNA / ^3HーCGP12177 / モデリング / ^3H-CGP12177 / ラット / Polymixin B / Heparin / Heart muscle membrane … More / beta_1-adrenoceptors / alpha_1-Adrenoceptors / アドレナリン性α_1受容体 / ヘパリン / アドレナリン性β_1-受容体 / アドレナリンα_1-受容体 / ポリミキシンB / ヘパソン / ^3Hーprazosin / 心筋膜 / アドレナリン性β_1ー受容体 / アドレナリン性α_1ー受容体 / constitutively active / inverse agonist / structure-activity relationships / modeling / sarpogrelate / 5-HT2A receptors / 5-HT_<2A>結合部位 / 5-HZ_2遮断薬 / 5-HT_<2A>遮断薬 / インバースアゴニスト / 構成的活性 / インバースアゴニスト / 構造活性相関 / サルポグレラート / 5-HT2遮断薬 / membrane / interaction / Three dimentional structure / β-adrenoceptor / リガンド-受容体相互作用 / 三次元構造 / β作動薬 / β受容体 / 相互作用 / βアドレナリン受容体 / molecular modeling / beta_3-adrenoceptor / beta-blocker / 結合実験法 / β_3-受容体 / 白色脂肪組織 / β_3-アドレナリン性受容体 / β-遮断薬 / 分子設計システム Less

Study on the clarification of molecular and pharmacological structure-activity relationships of 5-HT2A antagonistsPrincipal Investigator
- Principal Investigator
  
  NAGATOMO Takafumi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Nigata University of Phermacy and Applied Life Sciences
Analysis of 3-dimentional structure β-adrenoceptor ligands and receptor complex by NMRPrincipal Investigator
- Principal Investigator
  
  NAGATOMO Takafumi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Niigata University of Pharmacy and Applied Life Sciences
Analysis of relationships between structure and activity of beta _3-adrenoceptor agonists and antagonists by molecular modelingPrincipal Investigator
- Principal Investigator
  
  NAGATOMO Takafumi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Department of Pharmacology, Niigata College of Pharmacy
The Role of Carbohydrate Moiety in Alpha_1-adrenoceptors in Rat Heart : Composition with those of Beta_1-adrenoceptors (1988-1989).Principal Investigator
- Principal Investigator
  
  NAGATOMO Takafumi
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Nigata University of Phermacy and Applied Life Sciences

All 2007 2006 2005 2004 2003 Other

All Journal Article Presentation

[Journal Article] Identification of amino acid residues Important for sarpogrelate binding to the human 5-hydroxytryptamine_<2A> serotonin receptor.2006
- Author(s)
  Muntasir HA, Rashid M, Komiyama T, Kawakami J, Nagatomo T:
- Journal Title
  
  Journal of Pharmacological Science (投稿中)
- NAID
  10020346174
- Data Source
  KAKENHI-PROJECT-17590231
[Journal Article] Molecular modeling of SWR-0342SA, a β3-selective agonist, with β1- and β3-adrenoceptor2005
- Author(s)
  Ahmed M, Ishiguro M, Nagatomo T.
- Journal Title
  
  Life Sciences 78
  
  Pages: 2019-2023
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590239
[Journal Article] Beta-blockers show inverse agonism to a constitutively active mutant of β_1-adrenergic receptor2005
- Author(s)
  Ahmed M, Muntasir HA, Hossain M, Ishiguro M, Komiyama T, Muramatsu I, Kurose H, Nagatomo T.
- Journal Title
  
  Life Science (submitted)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590239
[Journal Article] Comparison of the binding affinity of some newly synthesized phenyletanolamine and phenoxypropanolamine compounds at recombinant human β- and α1-adrenoceptor subtypes2005
- Author(s)
  Ahmed M, Hanaoka Y, Kiso T, Kakita T, Ohtusubo Y, Muramatsu I, Nagatomo T.
- Journal Title
  
  J Pharm Pharmacol 57
  
  Pages: 75-81
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590239
[Journal Article] Molecular characterization of pharmacological properties and selectivity of SWR-0315NA for β-adrenoceptors2004
- Author(s)
  Ahmed M, Hanaoka Y, Kiso T, Kakita T, Otsubo Y, Nagatomo T.
- Journal Title
  
  Biol Pharm Bull 27
  
  Pages: 718-722
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590239
[Journal Article] Molecular Pharmacology of β-adrenergic blockers2004
- Author(s)
  Nakamura T, Ahmed M, Suzki J, Kaneko K, Katayama H, Nagatomo T.
- Journal Title
  
  Pharmacometics 66
  
  Pages: 141-149
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590239
[Journal Article] Binding and functional affinity of some newly synthesized agonists for recombinant human β_3-adrenoceptor2003
- Author(s)
  Ahmed M, Hanaoka Y, Nagatomo T, Kiso T, Kakita T, Kurose H, Nagao T.
- Journal Title
  
  J Pharm Pharmcol 55
  
  Pages: 1-5
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590239
[Journal Article] Beta-blockers show partial inverse agonism to a novel constitutively active mutant of β_1-adrenoceptor
- Author(s)
  Ahmed M, Nagatomo T
- Journal Title
  
  The 15th World Congress of Pharmacology. July 2-7. Beijing, China
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590239
[Journal Article] Molecular characterization of pharmacological properties and selectivity of SWR-0315NA for β-adrenoceptors
- Author(s)
  Ahmed M, Hanaoka Y, Kiso T, Kakita T, Ohtsubo Y, Nagatomo T.
- Journal Title
  
  The 4^<th> International Symposium on Receptor Mechanisms, Signal Transduction and Drug Effects. (May 22-24,2003,Fukui)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590239
[Presentation] Mechanism of inverse agonist action of sarpogrelate at the constitutive active human 5-HT_<2A> receptor revealed by molecular modeling2007
- Author(s)
  長友孝文
- Organizer
  第35回薬物活性シンポジウム
- Place of Presentation
  広島県歯科医師会館
- Data Source
  KAKENHI-PROJECT-17590231
[Presentation] Mechanism of inverse agonist action of sarpogrelate at the constitutive active human 5-HT_<2A> receptor revealed by molecular modeling.2007
- Author(s)
  Muntasir HA, Bhuiyan MA, Hossain M, Ishiguro M, Nagatomo T.
- Organizer
  35th Drug-Activity Symposium
- Place of Presentation
  Hiroshima
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590231
[Presentation] Mechanism of inverse agonist action of sarpogrelate at the constitutive active human 5-HT_<2A> receptor reveptor revealed by molecular modeling2007
- Author(s)
  長友孝文
- Organizer
  第35回薬物活性シンポジウム
- Place of Presentation
  広島県歯科医師会館
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590231

1. OHNUKI Toshio (60288230)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. KATAYAMA Hajime (70113024)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. KANEKO Kimiyoshi (90133462)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. TAKATSU Noriyuki (60201597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SUGIHARA Takumichi (40222054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MARUYAMA Keiko (30219563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TSUCHIHASHI Hiroshi (50155397)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAGATOMO Takafumi 長友 孝文

Research Projects

Research Products

Co-Researchers

Study on the clarification of molecular and pharmacological structure-activity relationships of 5-HT2A antagonistsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of 3-dimentional structure β-adrenoceptor ligands and receptor complex by NMRPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of relationships between structure and activity of beta _3-adrenoceptor agonists and antagonists by molecular modelingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Role of Carbohydrate Moiety in Alpha_1-adrenoceptors in Rat Heart : Composition with those of Beta_1-adrenoceptors (1988-1989).Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Identification of amino acid residues Important for sarpogrelate binding to the human 5-hydroxytryptamine_<2A> serotonin receptor.2006

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Molecular modeling of SWR-0342SA, a β3-selective agonist, with β1- and β3-adrenoceptor2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Beta-blockers show inverse agonism to a constitutively active mutant of β_1-adrenergic receptor2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Comparison of the binding affinity of some newly synthesized phenyletanolamine and phenoxypropanolamine compounds at recombinant human β- and α1-adrenoceptor subtypes2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Molecular characterization of pharmacological properties and selectivity of SWR-0315NA for β-adrenoceptors2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Molecular Pharmacology of β-adrenergic blockers2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Binding and functional affinity of some newly synthesized agonists for recombinant human β_3-adrenoceptor2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] Beta-blockers show partial inverse agonism to a novel constitutively active mutant of β_1-adrenoceptor

Author(s)

Journal Title

Description

Data Source

[Journal Article] Molecular characterization of pharmacological properties and selectivity of SWR-0315NA for β-adrenoceptors

Author(s)

Journal Title

Description

Data Source

[Presentation] Mechanism of inverse agonist action of sarpogrelate at the constitutive active human 5-HT_<2A> receptor revealed by molecular modeling2007

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Mechanism of inverse agonist action of sarpogrelate at the constitutive active human 5-HT_<2A> receptor revealed by molecular modeling.2007

Author(s)

NAGATOMO Takafumi 長友孝文