OBATA Fumiya 小幡文弥

Researcher Number	60129236
Other IDs
Affiliation (based on the past Project Information) *help	2011: 北里大学, 医療衛生学部, 教授 2003 – 2008: Kitasato University, School of Allied Health Sciences, Professor, 医療衛生学部, 教授 2005: Kitasato University, 医療衛星学部, 教授 2005: 北里大学, 医療衛生部, 教授 2002: 北里大学, 医学衛生学部, 助教授 … More 1995 – 2002: 北里大学, 医療衛生学部, 助教授 1999: 北里大学, 医学部, 助教授 1994: 北里大学, 医学部, 講師 1990 – 1992: 北里大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Urology / Urology Except Principal Investigator Biological Sciences / Neurology / Neurology / Urology
Keywords	Principal Investigator PCR / Th2 / Th1 / IL-4 / IFN-γ / 腎臓移植 / T細胞レセプター / 腎移植 / IL-10 / T-cell receptor (TCR) … More / clonality / バイオプシー / V遺伝子使用頻度 / 浸潤細胞 / 浸潤T細胞 / 拒絶反応 / 慢性拒絶反応 / cytokines / chronic rejection / acute rejection / kidney transplantation / INF-γ / サイトカイン / 急性拒絶反応 / 腎蔵移植 / Th1 and Th2 / inter leukin-4 / interferon-gamma / T-cell receptor / biopsy / rejection / renal allografts / 遺伝子増幅法 / クローナリティー解析 / IL4 / TH2 / TH1 / CD8 / CD4 / TCRαβ / クロナリティー / CDR3-diversity / V-gene usage / infiltrating cell / renal transplantation / 移植腎拒絶反応 / 移植腎浸潤細胞 / CDR3多様性 / クローナリティー / T-Cell Receptor / Infiltrating Lymphocytes / Rejection / Renal Transplantation / 同種免疫応答 / MLR / HLAーDR / T細胞抗原受容体 / PCR法 / 浸潤リンパ球 / クレアチン / フローPRA / 血清クレアチニン / PRA / Western Blot / Flow PRA / 抗HLA抗体 / 抗HLA 抗体 … More Except Principal Investigator 常染色体優性 / 家族性パーキンソニズム / PARK8 / Park8 / ポジショナルクローニング / 家族性パーキンソン病 / familial Parkinsonisum / I2020T / DRDN / LRRK2 / Familial Parkinsonism / 常染色体優れ / 家族制パーキンソニズム / Park 8 / アデノウィルスベクター / ハイリスク群 / ネオアジュバント / 遺伝子治療 / 前立腺癌 / パーキンソニズム / 遺伝子 Less

Neoadjuvant in situ gene therapy with adenoviral delivery of HSV-tK gene for patients with high-risk prostate cancer
- Principal Investigator
  
  SATOH Takefumi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kitasato University
Clonality analysis of anti-HLA antibodies involved in chronic allograft rejectionPrincipal Investigator
- Principal Investigator
  
  OBATA Fumiya
- Project Period (FY)
  2005 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kitasato University
相模原地区における家族性パーキンソニズムの原因遺伝子の探索
- Principal Investigator
  
  長谷川一子
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
Causative gene detection and its functional analysis for autosomal dominant Sagamihara Parkinsonism
- Principal Investigator
  
  HASEGAWA Kazuko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  National Hospital Orgainzation, Sagamihara National Hospital, Clinical Research center
相模原地区における家族性パーキンソニズムの原因遺伝子の探索
- Principal Investigator
  
  長谷川一子
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kitasato University
相模原地区における家族性パーキンソニズムの原因遺伝子の探索
- Principal Investigator
  
  長谷川一子
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kitasato University
Comparative analysis of immune cells participating in acute and chronic rejection of kidney allografts.Principal Investigator
- Principal Investigator
  
  OBATA Fumiya
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  KITASATO UNIVERSITY
相模原地区における家族性パーキンソニズムの原因遺伝子の探索
- Principal Investigator
  
  長谷川一子
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kitasato University
相模原地区における家族性パーキンソニズムの原因遺伝子の探索
- Principal Investigator
  
  長谷川一子
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kitasato University
相模原地区における家族性パーキンソニズムの原因遺伝子の探索
- Principal Investigator
  
  長谷川一子
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kitasato University
Linkage analysis of a Japanese family with autosomal dominant Parkinsonism
- Principal Investigator
  
  HASEGAWA Kazuko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kitasato University
相模原地区における家族性パーキンソニズムの原因遺伝子の探索
- Principal Investigator
  
  HASEGAWA Kazuko
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kitasato University
Analysis of the T-cell clonality in renal allografts using biopsy specimens.Principal Investigator
- Principal Investigator
  
  OBATA Fumiya
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kitasato University
Analysis of the T-cell receptor expressed by renal allograft infiltrating cellsPrincipal Investigator
- Principal Investigator
  
  OBATA Fumiya
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kitasato University
Sequence analysis of T-cell receptor participating in rejection of renal allografts.Principal Investigator
- Principal Investigator
  
  OBATA Fumiya
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kitasato University School of Medicine

All 2012 2011 2010 2009 2008 2007 2006 2005

All Journal Article Presentation Book

[Book] 新規キナーゼ様分子LRRK2の機能解析ブレインサイエンスレビュー2008(伊藤正男、川合述史編)2008
- Author(s)
  小幡文弥
- Publisher
  クバクロ、東京
- Data Source
  KAKENHI-PROJECT-17591699
[Book] ブレインサイエンスレビュー2008分担課題 : 新規キナーゼ様分子LRRK2の機能解析2008
- Author(s)
  小幡文弥
- Total Pages
  229
- Publisher
  クバクロ(東京)
- Data Source
  KAKENHI-PROJECT-17591699
[Journal Article] Hydrogen peroxide increases interleukin-12 p40/p70 molecular ratio and induces Th2-predominantresponses in mice2006
- Author(s)
  Obata F, Hoshino A, Toyama A.
- Journal Title
  
  Scand J Immunol 63(2)
  
  Pages: 125-130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591699
[Journal Article] Hydrogen peroxide increases interleukin-12 p40/p70 molecular ratio and induces Th2-predominant responses in mice2006
- Author(s)
  Obata F, et al.
- Journal Title
  
  Scand J Immunol 63・2
  
  Pages: 125-130
- Data Source
  KAKENHI-PROJECT-17591699
[Journal Article] An LRRK2 Mutation as a cause for the Parkinsonism in the Original PARK8 Family2005
- Author(s)
  M Funayama, K Hasegawa, E Ohta, N Kawashima, M Komiyama, H Kowa, S Tsuji, F Obata
- Journal Title
  
  Ann Neurology 57
  
  Pages: 918-921
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590843
[Journal Article] Contribution of CD4^+ and CD8^+T-cells and interferon-gamma to the progress ofchronic rejection of kidney allografts : The Th1 response mediates both acute and chronic rejection.2005
- Author(s)
  Obata F, et al.
- Journal Title
  
  Transplant Immunol 14・1
  
  Pages: 21-25
- Data Source
  KAKENHI-PROJECT-17591699
[Journal Article] Expression of stress-related genes in a cadmium-resistant A549 human cell line2005
- Author(s)
  Croute F, Beau B, Murat JC, Vincent C, Komatsu H, Obata F, Soleilhavoup JP.
- Journal Title
  
  J Toxicol Environ Health A. 68(9)
  
  Pages: 703-718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591699
[Journal Article] An LRRK2 Mutation as a cause for the Parkinsonism in the Original PARK8 Family2005
- Author(s)
  M Funayama, K Hasegawa, E Ohta, N Kawashima, M Komiyama, H Kowa, S Tsuji, F Obata
- Journal Title
  
  Ann Neurol 57
  
  Pages: 918-921
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590843
[Journal Article] Contribution of CD4+ and CD8+T-cells and interferon-gamma to the progress of chronic rejection of kidney allografts : The Th1 response mediates both acute and chronic rejection2005
- Author(s)
  Obata F, Yoshida K, Ohkubo M, Ikeda Y, Taoka Y, Takeuchi Y, Shinohara N, Endo T,Baba S.
- Journal Title
  
  Transplant Immunol 14(1)
  
  Pages: 21-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591699
[Presentation] Systemic T-cell activation following neoadjuvant in situ gene therapy in high-risk prostate cancer patients2012
- Author(s)
  Satoh T, Kubo M, Tabata K, Kurosaka S, Matsumoto K, Fujita T, Obata F, Nasu Y, Kumon H, Kadmon D, Brenner MK, Thompson TC, Baba S
- Organizer
  American Urological Association Annual Meeting
- Place of Presentation
  Atlanta, USA
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-21592060
[Presentation] Enhanced CD8+Tcell activation after in situ gene therapy of repeated HSV-tk injection andganciclovir administration in prostate cancer patients2011
- Author(s)
  Kubo M, Satoh T, Tabata K, Matsumoto K, Baba S, Obata F
- Organizer
  第40回日本免疫学会総会・学術集会
- Place of Presentation
  幕張
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-21592060
[Presentation] ハイリスク前立腺癌に対するネオアジュバントHSV-tk遺伝子治療の検討2011
- Author(s)
  佐藤威文, 久保誠, 田畑健一, 黒坂眞二, 柳澤信之, 松本和将, 藤田哲夫, 佐藤絵里奈, 伊東一郎, 小幡文弥, 三枝信, 岡安勲, 那須保友, 公文裕巳, 馬場志郎
- Organizer
  第49回日本癌治療学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-27
- Data Source
  KAKENHI-PROJECT-21592060
[Presentation] Enhanced CD8+ Tcell activation after in situ gene therapy of repeated HSV-tk injection andganciclovir administration in prostate cancer patients2011
- Author(s)
  Kubo M, Satoh T, Tabata K, Matsumoto K, Baba S, Obata F
- Organizer
  第40回日本免疫学会総会・学術集会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-21592060
[Presentation] Immune responses in prostate cancer patients received in situ gene therapy of repeated HSV-tk injection and ganciclovir administration2010
- Author(s)
  Kubo M, Satoh T, Tabata K, Matsumoto K, Baba S, Obata F
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe
- Year and Date
  2010-08-22
- Data Source
  KAKENHI-PROJECT-21592060
[Presentation] Immune responses in prostate cancer patients received in situ gene therapy of repeated HSV-tk injection and ganciclovir administration2010
- Author(s)
  Kubo M, Satoh T, Tabata K, Matsumoto K, Baba S, Obata F
- Organizer
  16th Japan Society of Gene Therapy
- Place of Presentation
  Utsunomiya
- Year and Date
  2010-07-01
- Data Source
  KAKENHI-PROJECT-21592060
[Presentation] Neoadjuvant In Situ Gene Therapy for Prostate Cancer : Kitasato Trial2010
- Author(s)
  佐藤威文、久保誠、柳澤信之、田畑健一、松本和将、佐藤絵里奈、大草洋、岩村正嗣、小幡文弥、岡安勲、那須保友、公文裕巳、馬場志郎
- Organizer
  平成21年度科学技術振興調整費国際共同研究の推進「アジア人の癌体質と遺伝子治療共同臨床研究」第3回国際研究者打合せ会
- Place of Presentation
  岡山
- Year and Date
  2010-03-04
- Data Source
  KAKENHI-PROJECT-21592060
[Presentation] The increase of activated CD8+T cells in prostate cancer patients received in situ gene therapy of repeated HSV-tk injection and ganciclovir administration2009
- Author(s)
  Kubo M, Satoh T, Tabata K, Matsumoto K, Baba S, Obata F
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-21592060
[Presentation] Neoadjuvant In Situ Gene Therapy for Prostate Cancer2009
- Author(s)
  佐藤威文、久保誠、柳澤信之、田畑健一、松本和将、佐藤絵里奈、大草洋、岩村正嗣、小幡文弥、岡安勲、那須保友、公文裕巳、馬場志郎
- Organizer
  平成20年度科学技術振興調整費国際共同研究の推進「アジア人の癌体質と遺伝子治療共同臨床研究第2回国際研究者打合せ会
- Place of Presentation
  岡山
- Year and Date
  2009-03-04
- Data Source
  KAKENHI-PROJECT-21592060
[Presentation] ハイリスク前立腺癌に対するネオアジュバント遺伝子治療の検討2009
- Author(s)
  佐藤威文、久保誠、柳澤信之、田畑健一、松本和将、佐藤絵里奈、大草洋、岩村正嗣、小幡文弥、岡安勲、那須保友、公文裕巳、馬場志郎
- Organizer
  第97回日本泌尿器科学会総会
- Place of Presentation
  岡山
- Year and Date
  2009-04-16
- Data Source
  KAKENHI-PROJECT-21592060
[Presentation] Correlation analysis among serum anti HLA antibodies, CD4+, CD8+, and CD19+ cells in renal allografts2008
- Author(s)
  Obata F, Yoshida K, Takeuchi Y, Tsuchida M, Endo T, Baba S.
- Organizer
  XXII International Congress of The Transplantation Society
- Place of Presentation
  Sydney
- Year and Date
  2008-08-11
- Data Source
  KAKENHI-PROJECT-17591699
[Presentation] Correlation analysis among serum anti HLA antibodies, CD4^+, CD8^+, and CD19^+ cells in renal allografts.2008
- Author(s)
  Obata F
- Organizer
  XXII International Congress of The Transplantation Society
- Place of Presentation
  Sydney
- Year and Date
  2008-08-11
- Data Source
  KAKENHI-PROJECT-17591699
[Presentation] ハイリスク前立腺癌に対するHSV-tkネオアジュバント遺伝子治療2008
- Author(s)
  佐藤威文、久保誠、柳澤信之、田畑健一、松本和将、佐藤絵里奈、大草洋、岩村正嗣、小幡文弥、岡安勲、那須保友、公文裕巳、馬場志郎
- Organizer
  平成20年度科学技術振興調整費国際共同研究の推進「アジア人の癌体質と遺伝子治療共同臨床研究」第1回国際研究者会議
- Place of Presentation
  岡山
- Year and Date
  2008-06-07
- Data Source
  KAKENHI-PROJECT-21592060
[Presentation] Immune responses in prostate cancer patients received in situ gene therapy of repeated HSV-tk injection and ganciclovir administration2008
- Author(s)
  Kubo M, Satoh T, Tabata K, Matsumoto K, Baba S, Obata F
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-21592060
[Presentation] 血漿交換とステロイド療法に低容量Rituximab併用投与にて長期改善を認めた抗体関連拒絶反応の1例2007
- Author(s)
  吉田一成、竹内康雄、若井陽希、馬場志郎、小池淳樹、小幡文弥
- Organizer
  第16回日本組織適合性学会大会
- Place of Presentation
  東京
- Year and Date
  2007-09-11
- Data Source
  KAKENHI-PROJECT-17591699
[Presentation] ABO不適合腎移植患者における抗体関連拒絶の1例2007
- Author(s)
  平山貴博、吉田一成、小幡文弥、竹内康雄、小池淳樹、遠藤忠雄、馬場志郎
- Organizer
  第43回日本移植学会総会
- Place of Presentation
  仙台
- Year and Date
  2007-11-24
- Data Source
  KAKENHI-PROJECT-17591699
[Presentation] 腎移植患者における抗HLA抗体の変動に関する解析?第2報2006
- Author(s)
  小幡文弥、吉田一成、土田繭美、竹内康雄、遠藤忠雄、馬場志郎
- Organizer
  第42回日本移植学会総会
- Place of Presentation
  仙台
- Year and Date
  2006-09-09
- Data Source
  KAKENHI-PROJECT-17591699
[Presentation] 腎移植患者における抗HLA抗体の変動解析?第2報2006
- Author(s)
  比佐華菜子、吉田一成、竹内康雄、遠藤忠雄、馬場志郎、小幡文弥
- Organizer
  第15回日本組織適合性学会大会
- Place of Presentation
  東京
- Year and Date
  2006-09-30
- Data Source
  KAKENHI-PROJECT-17591699
[Presentation] 腎移植患者における抗HLA抗体の変動解析2005
- Author(s)
  松井由紀子、吉田一成、竹内康雄、大久保みどり、遠藤忠雄、馬場志郎、小幡文弥
- Organizer
  第14回日本組織適合性学会大会
- Place of Presentation
  熊本
- Year and Date
  2005-10-03
- Data Source
  KAKENHI-PROJECT-17591699
[Presentation] 腎移植患者における抗HLA抗体の変動に関する解析2005
- Author(s)
  小幡文弥、吉田一成、竹内康雄、大久保みどり、遠藤忠雄、馬場志郎
- Organizer
  第41回日本移植学会総会
- Place of Presentation
  新潟
- Year and Date
  2005-10-30
- Data Source
  KAKENHI-PROJECT-17591699

1. HASEGAWA Kazuko (70146372)

# of Collaborated Projects: 9 results

# of Collaborated Products: 2 results
2. KUSUNOKI Junichi (70276129)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. YOSHIDA Kazunari (10174921)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. 古澤英明 (20260854)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SATOH Takefumi (50286332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
6. BABA Shiro (00051889)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
7. MATSUMOTO Kazumasa (70306603)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
8. OKAYASU Isao (20014342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. YANAGISAWA Nobuyuki (80337914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. KUBU Makoto (40464804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
11. TABATA Kenichi (20327414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
12. 坂井文彦 (60129450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 熊野和雄 (80137918)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OBATA Fumiya 小幡 文弥

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Clonality analysis of anti-HLA antibodies involved in chronic allograft rejectionPrincipal Investigator

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Comparative analysis of immune cells participating in acute and chronic rejection of kidney allografts.Principal Investigator

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Analysis of the T-cell clonality in renal allografts using biopsy specimens.Principal Investigator

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Analysis of the T-cell receptor expressed by renal allograft infiltrating cellsPrincipal Investigator

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Sequence analysis of T-cell receptor participating in rejection of renal allografts.Principal Investigator

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OBATA Fumiya 小幡文弥