Hayashi Matsuhiko 林松彦

… Alternative Names

HAYASHI Matsuhiko 林松彦

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Researcher Number	60129608
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2017: 慶應義塾大学, 医学部(信濃町), 教授 2015: 慶應義塾大学, 医学部, 教授 2009 – 2013: Keio University, 医学部, 教授 2007 – 2008: Keio University, School of Medicine, Associate Professor 2006: 慶應義塾大学, 医学部, 助教授 … More 2000 – 2004: 慶應義塾大学, 医学部, 助教授 2003: KEIO UNIVERSITY, SCHOOL OF MEDICINE, ASSOCIATE PROFESSOR, 医学部, 教授 1995 – 1997: 慶應義塾大学, 医学部, 助教授 1995 – 1996: 慶応義塾大学, 医学部, 助教授 1991 – 1994: 慶應義塾大学, 医学部, 専任講師 Less
Review Section/Research Field	Principal Investigator Kidney internal medicine / Kidney internal medicine / General physiology Except Principal Investigator Biological Sciences / Kidney internal medicine / 内科学一般 / Endocrinology
Keywords	Principal Investigator NFκB / 慢性腎臓病 / IκB / 近位尿細管 / 腎臓 / 血管石灰化 / NFkB / Isoproterenol / Cl^-channel / cytokine … More / DNA microarray / NF-κB / nephrotoxic serum nephritis / Cre-recombinase / Lox-P / 自然発症高血圧ラット / Na-H交換体 / インスリン / 陰イオン交換体2型 / AE2 / 強制発現(transfection) / 細胞内局在 / 細胞極性 / MDCK細胞 / イノシトール3リン酸 / イノシトール3リン酸受容体 / 免疫組織化学 / カルシウムイオン / 共焦点レーザー顕微鏡 / 血管平滑筋 / NFAT / TRPC6 / NFkappaB / Klf4 / 転写調節因子 / リン代謝 / β-介在細胞 / 単離細胞 / Gs-蛋白 / Cl^- channel / beta型介在細胞 / G蛋白 / β型介在細胞 / isoproterenol / prostaglandin E_2 / 百日咳毒素 / beta-intercalated cells / Kidney / Isolated cells / Gs-protein / メサンギウム細胞 / RAGE / NF-IL6 / NFkappaBETA / IkappaBETA / mesangial cells / 実験腎炎 / アデノウィルス / 間質障害 / Experimental glomerulonephritis / Adenovirus / Proximal tubules / Interstitial damage / 進行性腎障害 / Thy1.1腎炎 / Thymosin β10 / アンジオテンシン変換酵素2型 / NKκB / progressive renal diseases / Thy 1.1 nephritis / Thymosin β-10 / angiotensin converting enzyme type 2 / loxP / transgenic mouse / Cre recombinase / tie-2 / AQP7 … More Except Principal Investigator インスリン抵抗性 / 高血圧 / Pressure natriuresis curve / Intracellular calcium / Protein kinase C / Nitric oxide / SNP / COUP-TF / FHL2 / SERM / coactivator / 若年性遺伝性高血圧 / 不死化リンパ芽球 / 更年期 / 食塩感受性 / Dahl食塩感受性ラット / NO / 筋小胞体Caポンプ / 更年期高血圧 / 細胞内カルシウム代謝 / 卵巣摘出術 / 圧利尿反応 / 血小板 / エストロゲン / ダールラット / Postmenopause / Hypertension / Salt sensitivity / Dahl salt-sensitive rats / アンジオテンシン / 受容体 / 細胞外基質 / Angiotensin / Receptor / Extracellular Matrix / リンパ芽球 / 遺伝 / インスリン受容体 / insulin resistance / lymphoblast / hypertension / エストロゲン受容体 / コアクチベーター / FHL-2 / COUP-TFI / 転写共役因子 / corepressor / 核内受容体 / コリプレッサー / Estrogen Receptor / バイグリカン / プロテオグリカン / 腎臓 / 線維化 / 腎障害 / リモデリング / Biglycan / Proteoglycan / Kidney / Fibrosis Less

Studies on molecular pathological network of vascular and valvular calcification in CKD and survey for therapeutic targetPrincipal Investigator
- Principal Investigator
  
  Hayashi Matsuhiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
The studies on the roles of transcriptional factors in pathogenesis of vascular calcification by chronic kidney disease and their application for the therapyPrincipal Investigator
- Principal Investigator
  
  HAYASHI Matsuhiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
The study on the molecular relationships between TRPC6, NFκB, and NFAT in the progress of chronic kidney diseasesPrincipal Investigator
- Principal Investigator
  
  HAYASHI Matsuhiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
Study on cell-specific roles of nudear factor KB in the progression of renal diseases with genetically modified animalsPrincipal Investigator
- Principal Investigator
  
  HAYASHI Matsuhiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
Identification of target molecule for the treatment of progressive renal diseases and its application for gene therapy.Principal Investigator
- Principal Investigator
  
  HAYASHI Matsuhiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
Mechanisms of attenuation of renal injury in biglycan transgenic mice
- Principal Investigator
  
  SASAMURA Hiroyuki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
Cellular insulin resistance in Epstein-Barr virus-transformed lymphoblasts from young insulin-resistant Japanese men
- Principal Investigator
  
  SARUTA Takao
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Department of Internal Medicine, Keio University School of Medicine
INVESTIGATION OF MECHANISM OF PREVENTION OF ATHEROSCLEROSIS BY SELECTIVE ESTROGEN RECEPTOR MODULATORS (SERM)
- Principal Investigator
  
  SARUTA Takao
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Endocrinology
- Research Institution
  KEIO UNIVERSITY
若年性遺伝性高血圧におけるインスリン抵抗性関連遺伝子の追究-不死化リンパ芽球を用いた細胞レベルのインスリン抵抗性-
- Principal Investigator
  
  SARUTA Takao
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Investigation of effects of angiotensin type 2 receptors on extracellular matrix synthesis for renal therapy
- Principal Investigator
  
  SASAMURA Hiroyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
Establishment of gene therapy targeted for renal mesangial and proximal tubular cellsPrincipal Investigator
- Principal Investigator
  
  HAYASHI Matsuhiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
Molecular biological studies on the roles of NFkappaBETA and NF-IL6 in the experimental glomerulonephritis and diabetic nephropathy.Principal Investigator
- Principal Investigator
  
  HAYASHI Matsuhiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
陰イオン交換体2型とNa^+/H^+交換体3型の機能的・構造的協関関係Principal Investigator
- Principal Investigator
  
  林松彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Keio University
腎糸球体・尿細管細胞の細胞内情報伝達におけるイノシトール3燐酸受容体多様性の役割Principal Investigator
- Principal Investigator
  
  林松彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
Genetic Background and Underlying Mechanism in the Development of Postmenopausal Hypertension
- Principal Investigator
  
  SARUTA Takao
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Keio University
自然発症高血圧ラット腎近位尿細管細胞機能異常の生理学的ならびに分子生物学的解明Principal Investigator
- Principal Investigator
  
  林松彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
The roles of G-proteins in the functional regulation of beta-intercalated cells of the kidney cortexPrincipal Investigator
- Principal Investigator
  
  HAYASHI Matsuhiko
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  School of Medicine, Keio University

[Journal Article] Podocyte-specific NF-κB inhibition ameliorates proteinuria in adriamycin-induced nephropathy in mice.2017
- Author(s)
  Yamashita M, Yoshida T, Suzuki S, Homma K, Hayashi M.
- Journal Title
  
  Clin Exp Nephrol
  
  Volume: 21 Pages: 16-26
- DOI
  10.1007/s10157-016-1268-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09271
[Journal Article] Klotho suppresses the renin-angiotensin system in adriamycin nephropathy.2017
- Author(s)
  Takenaka T, Inoue T, Miyazaki T, Kobori H, Nishiyama A, Ishii N, Hayashi M, Suzuki H.
- Journal Title
  
  Nephrol Dial Transplant
  
  Volume: 印刷中 Pages: 791-800
- DOI
  10.1093/ndt/gfw340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461229, KAKENHI-PROJECT-15K09271, KAKENHI-PROJECT-16K09625
[Journal Article] Smooth muscle-selective nuclear factor-kB inhibition reduces phosphate-induced arterial medial calcification in mice with chronic kidney disease2017
- Author(s)
  Tadashi Yoshida, Maho Yamashita, Chihiro Horimai, Matsuhiko Hayashi.
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 6
- DOI
  10.1161/jaha.117.007248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09271
[Journal Article] Endothelial Kluppel-Like Factor 4 Mediates the Protective Effect of Statins against Ischemic AKI.2016
- Author(s)
  Yoshida T, Yamashita M, Iwai M, Hayashi M.
- Journal Title
  
  J Am Soc Nephrol 2016, 27(5): 1379-88
  
  Volume: 27 Pages: 1379-1388
- DOI
  10.1681/asn.2015040460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09271
[Journal Article] Role of Kruppel-Like Factor 4 and its Binding Proteins in Vascular Disease.2014
- Author(s)
  Yoshida T, Hayashi M.
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591200
[Journal Article] Deletion of Krüppel-like factor 4 in endothelial and hematopoietic cells enhances neointimal formation following vascular injury2014
- Author(s)
  Yoshida T, Yamashita M, Horimai C, Hayashi M.
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 3
- DOI
  10.1161/jaha.113.000622
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591200, KAKENHI-PROJECT-24591239
[Journal Article] High glucose concentration does not modulate the formation of arterial medial calcification in experimental uremic rats2013
- Author(s)
  Yoshida T, Yamashita M, Horimai C, Hayashi M.
- Journal Title
  
  Journal of Vascular Research
  
  Volume: 50 Pages: 512-20
- DOI
  10.1159/000355263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591200, KAKENHI-PROJECT-24591239
[Journal Article] Smooth muscle-selective inhibition of nuclear factor-κB attenuates smooth muscle phenotypic switching and neointima formation following vascular injury2013
- Author(s)
  Yoshida T, Yamashita M, Horimai C, Hayashi M.
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 2
- DOI
  10.1161/jaha.113.000230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591200, KAKENHI-PROJECT-24591239
[Journal Article] Krüppel-like factor 4 contributes to high phosphate-induced phenotypic switching of vascular smooth muscle cells into osteogenic cells.2012
- Author(s)
  Tadashi Yoshida, Maho Yamashita, Matsuhiko Hayashi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 287 Pages: 25706-25714
- DOI
  10.1074/jbc.m112.361360
- Data Source
  KAKENHI-PROJECT-23591200
[Journal Article] Aldosterone-induced kidney injury is mediated by NFκB activation.2011
- Author(s)
  Fukuda S, Horimai C, Harada K, Wakamatsu T, Fukasawa H, Muto S, Itai A, Hayashi M
- Journal Title
  
  Clincal & Experimental Nephrology 15
  
  Pages: 41-49
- NAID
  10029004386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590961
[Journal Article] Aldosterone-induced kidney injury is mediated by NFκB activation.2011
- Author(s)
  Fukuda S, Horimai C,Harada K, Wakamatsu T,Fukasawa H, Muto S, Itai A,Hayashi M.
- Journal Title
  
  Clinical & Experimental Nephrology
  
  Volume: 15 Pages: 41-49
- NAID
  10029004386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590961
[Journal Article] Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp 130-signaling cytokines in rodents.2010
- Author(s)
  Kanazawa H, Ieda M, Kimura K, Arai T, Kawaguchi-Manabe H, Matsuhashi T, Endo J, Sano M, Kawakami T, Kimura T, Monkawa T, Hayashi M, Iwanami A, Okano H, Okada Y, Ishibashi-Ueda H, Ogawa S, Fukuda K.
- Journal Title
  
  Journal of the Clinical Investigation 120
  
  Pages: 408-421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590961
[Journal Article] Possible association of tumor necrosis factor receptor 2 gene polymorphism with severe hypertension using the extreme discordant phenotype design.2009
- Author(s)
  Eguchi T, Maruyama T, Ohno Y, Morii T, Hirao K, Hirose H, Kawabe H, Saito I, Hayashi M, Saruta T.
- Journal Title
  
  Hypertension Research 32
  
  Pages: 775-779
- NAID
  10026123147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590961
[Journal Article] NF-κB-dependent genes induced by proteinuria and identified using DNA microarrays.2008
- Author(s)
  Takase 0, Marumo T, Hishikawa K, Fujita T, Quigg RJ, Hayashi M.
- Journal Title
  
  Clinical and Exp erimental Nephrol ogy 12
  
  Pages: 181-188
- NAID
  10024141137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590961
[Journal Article] NF-κ B-dependent genes induced by proteinuria and identified using DNA microarrays2008
- Author(s)
  Takase, O, Marumo, T, Hishikawa, K, Fujita, T, Quigg, RJ, Hayashi, M
- Journal Title
  
  Clinical and Experimental Nephrology (in press)
- NAID
  10024141137
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590903
[Journal Article] Inhibition of NF-kappaB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis.2008
- Author(s)
  Takase 0, Minto AW, Puri TS, Cunningham PN, Jacob A, Hayashi M, Quigg RJ.
- Journal Title
  
  Kidney International 73
  
  Pages: 567-577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590961
[Journal Article] NF-kappaB-dependent genes induced by proteinuria and identified using DNA microarrays2008
- Author(s)
  Takase O, Marumo T, Hishikawa K, Fujita T, Quigg RJ, Hayashi M.
- Journal Title
  
  Clin Exp Nephrol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590903
[Journal Article] Inhibition of NF-kappaB-dependent Bc1-xL expression by clusterin promotes albumin-induced tubular cell apoptosis2008
- Author(s)
  Takase, O, Minto, AW, Puri, TS, Cunningham, PN, Jacob, A, Hayashi, M, Quigg, RJ
- Journal Title
  
  Kidney International 73
  
  Pages: 567-577
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590903
[Journal Article] Inhibition of NF-kappaB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis2008
- Author(s)
  Takase O, Minto AW, Puri TS, Cunningham PN, Jacob A, Hayashi M, Quigg RJ.
- Journal Title
  
  Kidney International 73
  
  Pages: 567-577
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590903
[Journal Article] NF-κB-dependent genes induced by proteinuria and identified using DNA microarrays2008
- Author(s)
  Takase O, Marumo T, Hishikawa K, Fujita T, Quigg RJ, Hayashi M.
- Journal Title
  
  Clinical and Experimental Nephrology (In press)
- NAID
  10024141137
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590903
[Journal Article] Inhibition of NF-kappaB-dependent Bc1-xL expression by clusterin promotes albumin-induced tubular cell apoptosis2008
- Author(s)
  Takase O, Minto AW, Puri TS, Cunningham PN, Jacob A, Hayashi M, Quigg RJ.
- Journal Title
  
  Kidney Int 73
  
  Pages: 567-577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590903
[Journal Article] Snail1 is involved in the renal epithelial-mesenchymal transition2007
- Author(s)
  Yoshino J, Monkawa T, Tsuji M, Inukai M, Itoh H, Hayashi M.
- Journal Title
  
  Biochem Biophys Res Comm 362
  
  Pages: 63-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590903
[Journal Article] Microarray analysis of a reversible model and an irreversible model of anti-Thy-1 nephritis.2006
- Author(s)
  Tsuji M, Monkawa T, Yoshino J, Asai M, Fukuda S, Kawachi H, Shimizu F, Hayashi M, Saruta T
- Journal Title
  
  Kidney International 69・6
  
  Pages: 996-1004
- Data Source
  KAKENHI-PROJECT-18590903
[Journal Article] Intrarenal injection of bone marrow-derived angiogenic cells reduces endothelial injury and mesangial cell activation in experimental glomerulonephritis.2005
- Author(s)
  Uchimura H, Marumo T, Takase O, Kawachi H, Shimizu F, Hayashi M, Saruta T, Hishikawa K, Fujita T.
- Journal Title
  
  Journal of the American Society of Nephrology 16(4)
  
  Pages: 997-1004
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590859
[Journal Article] Glomerular expression of biglycan and decorin and urinary levels of decorin in primary glomerular disease.2004
- Author(s)
  M.Kuroda, H.Sasamura, E.Kobayashi, R.Shimizu-Hirota, Y.Nakazato, M.Hayashi, T.Saruta.
- Journal Title
  
  Clinical Nephrology 61(1)
  
  Pages: 7-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571036
[Journal Article] Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin.2004
- Author(s)
  Ichihara A, Hayashi M, Kaneshiro Y, Suzuki F, Nakagawa T, Tada Y, Koura Y, Nishiyama A, Okada H, Uddin MN, Nabi AH, Ishida Y, Inagami T, Saruta T.
- Journal Title
  
  Journal of Clinical Investigation 114(8)
  
  Pages: 1128-1135
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590859
[Journal Article] Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin.2004
- Author(s)
  Ichihara A, Hayashi M, et al.
- Journal Title
  
  Journal of the Clinical Investigation 114巻8号
  
  Pages: 1128-1135
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590859
[Journal Article] Spironolactone in combination with cilazapril ameliorates proteinuria and renal interstitial fibrosis in rats with anti-Thy-i irreversible nephritis.2004
- Author(s)
  Asai M, Monkawa T, Marumo T, Fukuda S, Tsuji M, Yoshino J, Kawachi H, Shimizu F, Hayashi M, Saruta T
- Journal Title
  
  Hypertension Research 27(12)
  
  Pages: 971-978
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590859
[Journal Article] Extracellular matrix glycoprotein biglycan enhances vascular smooth muscle cell proliferation and migration.2004
- Author(s)
  R.Shimizu-Hirota, H.Sasamura, M.Kuroda, B.Kobayashi, M.Hayashi, T.Saruta.
- Journal Title
  
  Circulation Research 94
  
  Pages: 1067-1074
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571036
[Journal Article] Leukemia inhibitory factor is involved in tubular regeneration after experimental acute renal failure.2003
- Author(s)
  Yoshino J, Monkawa T, Tsuji M, Hayashi M, Saruta T.
- Journal Title
  
  Journal of American Society of Nephrology 14(12)
  
  Pages: 3090-3101
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590859
[Journal Article] Hepatocyte growth factor regulates proteoglycan synthesis in interstitial fibroblasts.2003
- Author(s)
  E.Kobayashi, H.Sasamura, M.Mifune, R.Shimizu-Hirota, M.Kuroda, M.Hayashi, T.Saruta.
- Journal Title
  
  Kidney International 64
  
  Pages: 1179-1188
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571036
[Journal Article] Prepubertal treatment with angiotensin receptor blocker causes partial attenuation of hypertension and renal damage in adult Dahl salt-sensitive rats.2002
- Author(s)
  H.Nakaya, H.Sasamura, M.Mifune, R.Shimizu-Hirota, M.Kuroda, M.Hayashi, T.Saruta.
- Journal Title
  
  Nephron 91
  
  Pages: 710-718
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571036
[Journal Article] Glucocorticoid regulation of proteoglycan synthesis in mesangial cells.2002
- Author(s)
  M.Kuroda, H.Sasamura, R.Shimizu-Hirota, M.Mifune, H.Nakaya, E.Kobayashi, M.Hayashi, T.Saruta.
- Journal Title
  
  Kidney International 62
  
  Pages: 780-789
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571036
[Journal Article] NF-κB dependent increase in intrarenal angiotensin II induced by proteinuria
- Author(s)
  Takase O, Marumo T, Imai N, Hirahashi J, Takayanangi A, Hishikawa K, Hayashi M, Shimizu N, Fujita T, Saruta T.
- Journal Title
  
  Kdiney Internatinal (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590859
[Journal Article] Role of Krüppel-Like Factor 4 and its Binding Proteins in Vascular Disease
- Author(s)
  Yoshida T, Hayashi M
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: (in press)
- NAID
  130004444739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591200
[Presentation] Smooth muscle-selective NF-kB inhibition reduces phosphate-induced vascular calcification in mice with chrnocic kidney disease.2017
- Author(s)
  Tadashi Yoshida, Maho Yamashita, and Matsuhiko Hayashi
- Organizer
  the 53rd European Renal Association - European Dialysis and Transplant Association Congress
- Data Source
  KAKENHI-PROJECT-15K09271
[Presentation] Klotho suppresses renal angiotensin by inhibiting WNT signaling in adriamycin nephropathy2016
- Author(s)
  Tsuneo Takenaka, Tsutomu Inoue, Takashi Miyazaki, Naohito Ishii, Akira Nishiyama, Matsuhiko Hayashi
- Organizer
  The 53rd European Renal Association - European Dialysis and Transplant Association Congress,
- Place of Presentation
  Viena, Austria
- Year and Date
  2016-05-22
- Data Source
  KAKENHI-PROJECT-15K09271
[Presentation] Podocyte-specific NFkB inhibition ameliorates proteinuria in Adriamycin-induced nephropathy in mice2016
- Author(s)
  Tadashi Yoshida, Maho Yamashita, Matsuhiko Hayashi
- Organizer
  The 53rd European Renal Association - European Dialysis and Transplant Association Congress,
- Place of Presentation
  Viena, Austria
- Year and Date
  2016-05-23
- Data Source
  KAKENHI-PROJECT-15K09271
[Presentation] 平滑筋細胞におけるNF-κBの抑制は慢性腎不全でのリンによる血管石灰化を減弱させる2015
- Author(s)
  吉田　理, 山下真帆, 岩井美恵子, 林　松彦
- Organizer
  第60回日本透析医学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-06-27
- Data Source
  KAKENHI-PROJECT-15K09271
[Presentation] 腎不全ラットの血管石灰化形成におけるグルコース濃度の影響2013
- Author(s)
  吉田理、山下真帆、林松彦
- Organizer
  第58回日本透析医学会学術集会・総会
- Place of Presentation
  福岡市
- Year and Date
  2013-06-23
- Data Source
  KAKENHI-PROJECT-23591200
[Presentation] Kruppel-like cactor 4 in endothelial cells protects mice from renal ischemia-reperfusion injury2013
- Author(s)
  Tadashi Yoshida, Maho Yamashita, Matsuhiko Hayashi
- Organizer
  the 46th Annual Meeting of the American Society of Nephrology
- Place of Presentation
  Atlanta, Georgia, USA
- Data Source
  KAKENHI-PROJECT-23591200
[Presentation] Krüppel-like cactor 4 in endothelial cells protects mice from renal ischemia-reperfusion injury2013
- Author(s)
  Tadashi Yoshida, Maho Yamashita, Matsuhiko Hayashi
- Organizer
  the 46th Annual Meeting of the American Society of Nephrology
- Place of Presentation
  Atlanta, USA
- Year and Date
  2013-11-08
- Data Source
  KAKENHI-PROJECT-23591200
[Presentation] リポポリサッカライドは血管平滑筋細胞石灰化を促進する2012
- Author(s)
  林松彦、高松一郎、堀米ちひろ、吉田理
- Organizer
  第55回日本腎臓学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2012-06-02
- Data Source
  KAKENHI-PROJECT-23591200
[Presentation] リン負荷による血管石灰化におけるグルコース濃度の影響2012
- Author(s)
  吉田理、山下真帆、堀米ちひろ、林松彦
- Organizer
  第57回日本透析医学会学術集会・総会
- Place of Presentation
  札幌市
- Year and Date
  2012-06-22
- Data Source
  KAKENHI-PROJECT-23591200
[Presentation] High Glucose May Not Directly Affect High Phosphate-Induced Calcification of Vascular Smooth Muscle Cells2012
- Author(s)
  Tadashi Yoshida, Maho Yamashita, Matsuhiko Hayashi
- Organizer
  the 45h Annual Meeting of the American Society of Nephrology
- Place of Presentation
  San Diego, USA
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PROJECT-23591200
[Presentation] Lipopolysaccharide and TNF-αAggravate Calcification in Vascular Smooth Muscle Cells by High Inorganic Phosphate and High Calcium Concentration Media2011
- Author(s)
  Matsuhiko Hayashi, Ichiro Takamatsu, Chihiro Horimai, Tadashi Yoshida, Toshifumi Wakamatsu
- Organizer
  the 44th Annual Meeting of the American Society of Nephrology
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-23591200
[Presentation] Kruppel-Like Factor 4 Mediates High Phosphate-Induced Conversion of Vascular Smooth Muscle Cells into Osteoblast-Like Cells2011
- Author(s)
  Tadashi Yoshida, Maho Yamashita, Matsuhiko Hayashi
- Organizer
  2011年アメリカ腎臓学会学年次総会
- Place of Presentation
  アメリカ合衆国フィラデルフィア
- Data Source
  KAKENHI-PROJECT-23591200
[Presentation] 腎内アンジオテンシン変換酵素2型(ACE2)はアルドステロンにより抑制される2010
- Author(s)
  林松彦、堀米ちひろ、福田誠一、原田香織、柳瀬健志、深澤弘志、武藤進、板井昭子
- Organizer
  第53回日本腎臓学会学術総会
- Place of Presentation
  神戸
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-20590961
[Presentation] Angiotensin-converting enzyme 2 and clusterin are regulated by aldosterone in the kidney.2009
- Author(s)
  Hayashi M, Horimai C, Fukuda S, Saito N, Yanase T, Fukasawa H, Muto S, Itai A
- Organizer
  the 42th Annual Meeting of the American Society of Nephrology
- Place of Presentation
  San Diego
- Year and Date
  2009-11-01
- Data Source
  KAKENHI-PROJECT-20590961
[Presentation] Angiotensin-converting enzyme 2 and clusterin are regulated by aldosterone in the kidney.2009
- Author(s)
  Hayashi M, Horimai C, Fukuda S, Saito N, Yanase T, Fukasawa H, Muto S, Itai A
- Organizer
  The 42th Annual Meeting of the American Society of Nephrology
- Place of Presentation
  San Diego
- Year and Date
  2009-11-04
- Data Source
  KAKENHI-PROJECT-20590961
[Presentation] NFkBの関与は心臓と腎臓では異なる2009
- Author(s)
  林松彦、門川俊明、堀米ちひろ、西東規子、柳瀬健志、深澤弘志、武藤進、板井昭子
- Organizer
  第52回日本腎臓学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2009-06-03
- Data Source
  KAKENHI-PROJECT-20590961
[Presentation] アルドステロンの組織障害はNF, κBを介する2008
- Author(s)
  林松彦, 福田誠一, 西東規子, 柳瀬健志, 深潭弘志, 武藤進, 板井昭子
- Organizer
  第51回日本腎臓学会学術総会
- Place of Presentation
  福岡市
- Year and Date
  2008-05-31
- Data Source
  KAKENHI-PROJECT-20590961
[Presentation] NFκB activation is involved in aldosterone-induced tissue injury in the kidney but not in the heart.2008
- Author(s)
  Hayashi M, Fukuda S, Monkawa T, Saito N, Yanase T, Fukasawa H, Muto S, Itai A, Shimoda K
- Organizer
  the 41th Annual Meeting of the American Society of Nephrology
- Place of Presentation
  Philadelphia
- Year and Date
  2008-11-04
- Data Source
  KAKENHI-PROJECT-20590961
[Presentation] 核転写因子NF-κBを中心とした炎症進展と細胞死の相互作用の解明2008
- Author(s)
  高瀬敦、菱川慶一、林松彦、Richard Quigg、藤田敏郎
- Organizer
  第31回日本高血圧学会総会
- Place of Presentation
  札幌市
- Year and Date
  2008-10-09
- Data Source
  KAKENHI-PROJECT-20590961
[Presentation] NFκB activation is involved in aldosterone-induced tissue injuryin the kidney but not in the heart.2008
- Author(s)
  Hayashi M, Fukuda S, Monkawa T, Saito N, Yanase T, Fukasawa H, Muto S, Itai A, Shimoda K
- Organizer
  The 41th Annual Meeting of the American Society of Nephrology
- Place of Presentation
  Philadelphia
- Year and Date
  2008-11-06
- Data Source
  KAKENHI-PROJECT-20590961
[Presentation] ジフテリア毒素受容体を介した近位尿細管S3セグメント特異的除去マウスの作2007
- Author(s)
  門川俊明、関根美知子、多屋長治、松岡邦枝、吉野純、犬飼舞、伊藤裕、林松彦、鈴木明身、米川博道
- Organizer
  第50回日本腎臓学会学術総会
- Place of Presentation
  浜松
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-18590903
[Presentation] Study on renal protective effects focused on NF-kappaB of eicosapentoeic acid in LPS-induced renal tubular damage2007
- Author(s)
  Takase, O, Hishikawa, K, Marumo, F, Yoshikawa, M, Hayashi, M, Richard, Q, Fujita, T
- Organizer
  The 50th Annual Meeting of Japanese Society of Nephrology
- Place of Presentation
  Hamamatsu
- Year and Date
  2007-05-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590903
[Presentation] LPS誘発尿細管障害におけるイコサペントエン酸(EPA)のNF-kappaBを中心とした腎保護作用の解明2007
- Author(s)
  高瀬敦、菱川慶一、丸茂丈史、吉川真弘、林松彦、Quigg Richard、藤田敏郎
- Organizer
  第50回日本腎臓学会学術総会
- Place of Presentation
  浜松
- Year and Date
  2007-05-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590903
[Presentation] The effects of spironolactone and triamterene in aldosterone-infused rats2006
- Author(s)
  Fukuda, S, Monkawa, T, Asai, M, Hayashi, M
- Organizer
  The 49th Annual Meeting of Japanese Society of Nephrology
- Place of Presentation
  Tokyo
- Year and Date
  2006-06-02
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590903
[Presentation] アルドステロン持続注入ラットにおけるスピロノラクトンとトリアムテレンの腎障害に対する効果の比較2006
- Author(s)
  福田誠一、門川俊明、浅井昌樹、林松彦
- Organizer
  第49回日本腎臓学会学術総会
- Place of Presentation
  東京
- Year and Date
  2006-06-02
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590903
[Presentation] 腎不全ラットの血管石灰化形成におけるグルコース濃度の影響
- Author(s)
  吉田理、山下真帆、林松彦
- Organizer
  第58回日本透析医学会学術集会・総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23591200
[Presentation] High glucose may not directly affect high phosphate-induced calcification of vascular smooth muscle cells.
- Author(s)
  Tadashi Yoshida, Maho Yamashita, Matsuhiko Hayashi
- Organizer
  45th Annual Meeting of the American Society of Nephrology
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-23591200

1. SARUTA Takao (70051571)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. YOSHIDA Tadashi (00306713)

# of Collaborated Projects: 4 results

# of Collaborated Products: 22 results
3. YAMAJI Yasuyoshi (20200701)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. KOBAYASHI Kazuo (00280636)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SASAMURA Hiroyuki (00235293)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. SASAKI Takayuki (40235255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HAYASHIDA Tomoko (20228604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OHNO Yoichi (10203895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HAYASHI Koichi (80164937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SATO Souichirou (50255452)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. CHIKARAISHI Akihiro (60286474)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YOSHIDA Noriko (20286488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MORII Toshiyuki (60348654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KURIHARA Isao (90338038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SHIBATA Hirotaka (20245484)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MONKAWA Toshiaki (80286484)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. ASAI Masaki (50317103)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. FUKUDA Seiichi (50338026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
19. 津金澤浩彦 (00217275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 江口高 (10317109)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 小林絵美 (00317116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 黒田真理 (40306692)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. YAMASHITA Maho

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
24. HORIMAI Chihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
25. MIYAZAKI Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. INOUE Tsutomu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
27. Nishiyama Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. Kobori Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. Ishii Naohito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. Suzuki Hiromichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 竹中恒夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayashi Matsuhiko 林 松彦

HAYASHI Matsuhiko 林 松彦

Research Projects

Research Products

Co-Researchers

Studies on molecular pathological network of vascular and valvular calcification in CKD and survey for therapeutic targetPrincipal Investigator

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The studies on the roles of transcriptional factors in pathogenesis of vascular calcification by chronic kidney disease and their application for the therapyPrincipal Investigator

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The study on the molecular relationships between TRPC6, NFκB, and NFAT in the progress of chronic kidney diseasesPrincipal Investigator

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Study on cell-specific roles of nudear factor KB in the progression of renal diseases with genetically modified animalsPrincipal Investigator

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Identification of target molecule for the treatment of progressive renal diseases and its application for gene therapy.Principal Investigator

Principal Investigator

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Mechanisms of attenuation of renal injury in biglycan transgenic mice

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Cellular insulin resistance in Epstein-Barr virus-transformed lymphoblasts from young insulin-resistant Japanese men

Principal Investigator

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INVESTIGATION OF MECHANISM OF PREVENTION OF ATHEROSCLEROSIS BY SELECTIVE ESTROGEN RECEPTOR MODULATORS (SERM)

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若年性遺伝性高血圧におけるインスリン抵抗性関連遺伝子の追究-不死化リンパ芽球を用いた細胞レベルのインスリン抵抗性-

Principal Investigator

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Investigation of effects of angiotensin type 2 receptors on extracellular matrix synthesis for renal therapy

Principal Investigator

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Establishment of gene therapy targeted for renal mesangial and proximal tubular cellsPrincipal Investigator

Principal Investigator

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Molecular biological studies on the roles of NFkappaBETA and NF-IL6 in the experimental glomerulonephritis and diabetic nephropathy.Principal Investigator

Principal Investigator

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陰イオン交換体2型とNa^+/H^+交換体3型の機能的・構造的協関関係Principal Investigator

Principal Investigator

Project Period (FY)

Hayashi Matsuhiko 林松彦

HAYASHI Matsuhiko 林松彦